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Volumn 52, Issue 6, 2011, Pages 3825-3831

Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; CASPASE 3; CASPASE 8; CASPASE 9; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; NORPHENAZONE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; 4-HYDROXY-2-NONENAL; ALDEHYDE; CASPASE; DRUG DERIVATIVE; PHENAZONE; PHENYLMETHYLPYRAZOLONE; SCAVENGER;

EID: 80051732188     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6797     Document Type: Article
Times cited : (63)

References (56)
  • 1
    • 0033823838 scopus 로고    scopus 로고
    • Metabolic dependence of photoreceptors on the choroid in the normal and detached retina
    • Linsenmeier RA, Padnick-Silver L. Metabolic dependence of photoreceptors on the choroid in the normal and detached retina. Invest Ophthalmol Vis Sci. 2000;41:3117-3123.
    • (2000) Invest Ophthalmol Vis Sci. , vol.41 , pp. 3117-3123
    • Linsenmeier, R.A.1    Padnick-Silver, L.2
  • 2
    • 77952299343 scopus 로고    scopus 로고
    • Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system
    • Bhatt L, Groeger G, McDermott K, Cotter TG. Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system. Mol Vis. 2010;16:283-293.
    • (2010) Mol Vis. , vol.16 , pp. 283-293
    • Bhatt, L.1    Groeger, G.2    McDermott, K.3    Cotter, T.G.4
  • 3
    • 33645968438 scopus 로고    scopus 로고
    • Activation of signaling pathways and stress-response genes in an experimental model of retinal detachment
    • Zacks DN, Han Y, Zeng Y, Swaroop A. Activation of signaling pathways and stress-response genes in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci. 2006;47:1691-1695.
    • (2006) Invest Ophthalmol Vis Sci. , vol.47 , pp. 1691-1695
    • Zacks, D.N.1    Han, Y.2    Zeng, Y.3    Swaroop, A.4
  • 4
    • 0033134010 scopus 로고    scopus 로고
    • Reactive oxygen species as mediators of photoreceptor apoptosis in vitro
    • Carmody RJ, McGowan AJ, Cotter TG. Reactive oxygen species as mediators of photoreceptor apoptosis in vitro. Exp Cell Res. 1999; 248:520-530.
    • (1999) Exp Cell Res. , vol.248 , pp. 520-530
    • Carmody, R.J.1    McGowan, A.J.2    Cotter, T.G.3
  • 5
    • 0037407743 scopus 로고    scopus 로고
    • Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors
    • Rotstein NP, Politi LE, German OL, Girotti R. Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. Invest Ophthalmol Vis Sci. 2003;44:2252-2259.
    • (2003) Invest Ophthalmol Vis Sci. , vol.44 , pp. 2252-2259
    • Rotstein, N.P.1    Politi, L.E.2    German, O.L.3    Girotti, R.4
  • 6
    • 0031942539 scopus 로고    scopus 로고
    • Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat
    • Peters O, Back T, Lindauer U, et al. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab. 1998;18: 196-205.
    • (1998) J Cereb Blood Flow Metab. , vol.18 , pp. 196-205
    • Peters, O.1    Back, T.2    Lindauer, U.3    et al4
  • 7
    • 0019268092 scopus 로고
    • The free radical pathology and the microcirculation in the major central nervous system disorders
    • Demopoulos HB, Flamm ES, Pietronigro DD, Seligman ML. The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol Scand Suppl. 1980; 492:91-119.
    • (1980) Acta Physiol Scand Suppl. , vol.492 , pp. 91-119
    • Demopoulos, H.B.1    Flamm, E.S.2    Pietronigro, D.D.3    Seligman, M.L.4
  • 8
    • 0017178610 scopus 로고
    • Oxygen toxicity: Membrane damage by free radicals
    • Feeney L, Berman ER. Oxygen toxicity: membrane damage by free radicals. Invest Ophthalmol. 1976;15(10):789-792.
    • (1976) Invest Ophthalmol , vol.15 , Issue.10 , pp. 789-792
    • Feeney, L.1    Berman, E.R.2
  • 9
    • 0027404468 scopus 로고
    • Amelioration of retinal photic injury by a combination of flunarizine and dimethylthiourea
    • Li J, Edward DP, Lam TT, Tso MO. Amelioration of retinal photic injury by a combination of flunarizine and dimethylthiourea. Exp Eye Res. 1993;56:71-78.
    • (1993) Exp Eye Res. , vol.56 , pp. 71-78
    • Li, J.1    Edward, D.P.2    Lam, T.T.3    Tso, M.O.4
  • 11
    • 0035031846 scopus 로고    scopus 로고
    • Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat
    • Kono H, Rusyn I, Uesugi T, et al. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am J Physiol Gastrointest Liver Physiol. 2001; 280:G1005-G1012.
    • (2001) Am J Physiol Gastrointest Liver Physiol. , vol.280
    • Kono, H.1    Rusyn, I.2    Uesugi, T.3    et al4
  • 13
    • 0035746845 scopus 로고    scopus 로고
    • Gadolinium chloride prevents mortality in hepatectomized rats given endotoxin
    • Kono H, Fujii H, Matsuda M, Yamamoto M, Matsumoto Y. Gadolinium chloride prevents mortality in hepatectomized rats given endotoxin. J Surg Res. 2001;96:204-210.
    • (2001) J Surg Res. , vol.96 , pp. 204-210
    • Kono, H.1    Fujii, H.2    Matsuda, M.3    Yamamoto, M.4    Matsumoto, Y.5
  • 14
    • 0028280787 scopus 로고
    • The toxicity of high-dose superoxide dismutase suggests that superoxide can both initiate and terminate lipid peroxidation in the reperfused heart
    • Nelson SK, Bose SK, McCord JM. The toxicity of high-dose superoxide dismutase suggests that superoxide can both initiate and terminate lipid peroxidation in the reperfused heart. Free Radic Biol Med. 1994;16:195-200.
    • (1994) Free Radic Biol Med. , vol.16 , pp. 195-200
    • Nelson, S.K.1    Bose, S.K.2    McCord, J.M.3
  • 15
    • 15844380233 scopus 로고    scopus 로고
    • Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium
    • Balcerczyk A, Soszynski M, Rybaczek D, et al. Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium. Biochem Pharmacol. 2005;69:1263-1273.
    • (2005) Biochem Pharmacol. , vol.69 , pp. 1263-1273
    • Balcerczyk, A.1    Soszynski, M.2    Rybaczek, D.3    et al4
  • 16
    • 26444537414 scopus 로고    scopus 로고
    • The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB
    • Kokura S, Yoshida N, Sakamoto N, et al. The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-kappaB. Cancer Lett. 2005;229:223-233.
    • (2005) Cancer Lett. , vol.229 , pp. 223-233
    • Kokura, S.1    Yoshida, N.2    Sakamoto, N.3    et al4
  • 17
    • 27944485677 scopus 로고    scopus 로고
    • Experimental study on the protective effects of edaravone against ischemic spinal cord injury
    • Suzuki K, Kazui T, Terada H, et al. Experimental study on the protective effects of edaravone against ischemic spinal cord injury. J Thorac Cardiovasc Surg. 2005;130:1586-1592.
    • (2005) J Thorac Cardiovasc Surg. , vol.130 , pp. 1586-1592
    • Suzuki, K.1    Kazui, T.2    Terada, H.3    et al4
  • 18
    • 33645538813 scopus 로고    scopus 로고
    • Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats
    • Wen J, Watanabe K, Ma M, et al. Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats. Biol Pharm Bull. 2006;29:713-718.
    • (2006) Biol Pharm Bull. , vol.29 , pp. 713-718
    • Wen, J.1    Watanabe, K.2    Ma, M.3    et al4
  • 19
    • 2642551352 scopus 로고    scopus 로고
    • Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion
    • Toyoda K, Fujii K, Kamouchi M, et al. Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion. J Neurol Sci. 2004;221:11-17.
    • (2004) J Neurol Sci. , vol.221 , pp. 11-17
    • Toyoda, K.1    Fujii, K.2    Kamouchi, M.3    et al4
  • 20
    • 0035069843 scopus 로고    scopus 로고
    • Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo
    • Hisatomi T, Sakamoto T, Murata T, et al. Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo. Am J Pathol. 2001;158:1271-1278.
    • (2001) Am J Pathol. , vol.158 , pp. 1271-1278
    • Hisatomi, T.1    Sakamoto, T.2    Murata, T.3    et al4
  • 21
    • 77956383408 scopus 로고    scopus 로고
    • The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis
    • Shimazaki H, Watanabe K, Veeraveedu PT, et al. The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis. Free Radic Res. 2010;44:1082-1090.
    • (2010) Free Radic Res. , vol.44 , pp. 1082-1090
    • Shimazaki, H.1    Watanabe, K.2    Veeraveedu, P.T.3    et al4
  • 22
    • 65649147852 scopus 로고    scopus 로고
    • Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo
    • Inokuchi Y, Imai S, Nakajima Y, et al. Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo. J Pharmacol Exp Ther. 2009;329:687-698.
    • (2009) J Pharmacol Exp Ther. , vol.329 , pp. 687-698
    • Inokuchi, Y.1    Imai, S.2    Nakajima, Y.3    et al4
  • 23
    • 33746896241 scopus 로고    scopus 로고
    • Characterization of cytokine responses to retinal detachment in rats
    • Nakazawa T, Matsubara A, Noda K, et al. Characterization of cytokine responses to retinal detachment in rats. Mol Vis. 2006; 12:867-878.
    • (2006) Mol Vis. , vol.12 , pp. 867-878
    • Nakazawa, T.1    Matsubara, A.2    Noda, K.3    et al4
  • 26
    • 0027320610 scopus 로고
    • Free radicals in inflammation: Second messengers and mediators of tissue destruction
    • Winrow VR, Winyard PG, Morris CJ, Blake DR. Free radicals in inflammation: second messengers and mediators of tissue destruction. Br Med Bull. 1993;49:506-522.
    • (1993) Br Med Bull. , vol.49 , pp. 506-522
    • Winrow, V.R.1    Winyard, P.G.2    Morris, C.J.3    Blake, D.R.4
  • 27
    • 33847386310 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis
    • Nakazawa T, Hisatomi T, Nakazawa C, et al. Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis. Proc Natl Acad Sci U S A 2007;104(7):2425-2430.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.7 , pp. 2425-2430
    • Nakazawa, T.1    Hisatomi, T.2    Nakazawa, C.3    et al4
  • 28
    • 24944490193 scopus 로고    scopus 로고
    • The ERK cascade: A prototype of MAPK signaling
    • Rubinfeld H, Seger R. The ERK cascade: a prototype of MAPK signaling. Mol Biotechnol. 2005;31:151-174.
    • (2005) Mol Biotechnol. , vol.31 , pp. 151-174
    • Rubinfeld, H.1    Seger, R.2
  • 29
    • 2942530310 scopus 로고    scopus 로고
    • ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
    • Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev. 2004;68:320-344.
    • (2004) Microbiol Mol Biol Rev. , vol.68 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 30
    • 77949363596 scopus 로고    scopus 로고
    • Gene transcription profile of the detached retina (an AOS Thesis)
    • Zacks DN. Gene transcription profile of the detached retina (an AOS Thesis). Trans Am Ophthalmol Soc. 2009;107:343-382.
    • (2009) Trans Am Ophthalmol Soc. , vol.107 , pp. 343-382
    • Zacks, D.N.1
  • 32
    • 0032573853 scopus 로고    scopus 로고
    • To die or not to die: An overview of apoptosis and its role in disease
    • Hetts SW. To die or not to die: an overview of apoptosis and its role in disease. JAMA. 1998;279:300-307.
    • (1998) JAMA. , vol.279 , pp. 300-307
    • Hetts, S.W.1
  • 33
    • 0029922872 scopus 로고    scopus 로고
    • Studies on the mechanism of early onset macular degeneration in cynomolgus (Macaca fascicularis) monkeys. I. Abnormal concentrations of two proteins in the retina
    • Nicolas MG, Fujiki K, Murayama K, et al. Studies on the mechanism of early onset macular degeneration in cynomolgus (Macaca fascicularis) monkeys. I. Abnormal concentrations of two proteins in the retina. Exp Eye Res. 1996;62:211-219.
    • (1996) Exp Eye Res. , vol.62 , pp. 211-219
    • Nicolas, M.G.1    Fujiki, K.2    Murayama, K.3    et al4
  • 34
    • 35248831880 scopus 로고    scopus 로고
    • Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa
    • Komeima K, Rogers BS, Campochiaro PA. Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa. J Cell Physiol. 2007;213:809-815.
    • (2007) J Cell Physiol. , vol.213 , pp. 809-815
    • Komeima, K.1    Rogers, B.S.2    Campochiaro, P.A.3
  • 35
  • 36
    • 0035853719 scopus 로고    scopus 로고
    • ABCR, the ATP-binding cassette transporter responsible for Stargardt macular dystrophy, is an efficient target of all-trans-retinal-mediated photooxidative damage in vitro: Implications for retinal disease
    • Sun H, Nathans J. ABCR, the ATP-binding cassette transporter responsible for Stargardt macular dystrophy, is an efficient target of all-trans-retinal-mediated photooxidative damage in vitro: implications for retinal disease. J Biol Chem. 2001;276:11766-11774.
    • (2001) J Biol Chem. , vol.276 , pp. 11766-11774
    • Sun, H.1    Nathans, J.2
  • 37
    • 0032738607 scopus 로고    scopus 로고
    • Detection of cytokine mRNA production in infiltrating cells in proliferative vitreoretinopathy using reverse transcription polymerase chain reaction
    • El-Ghrably IA, Dua HS, Orr GM, Fischer D, Tighe PJ. Detection of cytokine mRNA production in infiltrating cells in proliferative vitreoretinopathy using reverse transcription polymerase chain reaction. Br J Ophthalmol. 1999;83:1296-1299.
    • (1999) Br J Ophthalmol. , vol.83 , pp. 1296-1299
    • El-Ghrably, I.A.1    Dua, H.S.2    Orr, G.M.3    Fischer, D.4    Tighe, P.J.5
  • 38
    • 0036095185 scopus 로고    scopus 로고
    • Differential expression of matrix metalloproteinases 2 and 9 by glial Müller cells: Response to soluble and extracellular matrixbound tumor necrosis factor-alpha
    • Limb GA, Daniels JT, Pleass R, Charteris DG, Luthert PJ, Khaw PT. Differential expression of matrix metalloproteinases 2 and 9 by glial Müller cells: response to soluble and extracellular matrixbound tumor necrosis factor-alpha. Am J Pathol. 2002;160:1847-1855.
    • (2002) Am J Pathol. , vol.160 , pp. 1847-1855
    • Limb, G.A.1    Daniels, J.T.2    Pleass, R.3    Charteris, D.G.4    Luthert, P.J.5    Khaw, P.T.6
  • 39
    • 0030911504 scopus 로고    scopus 로고
    • Monocyte chemotactic protein-1 in proliferative vitreoretinal disorders
    • Abu el-Asrar AM, Van Damme J, Put W, et al. Monocyte chemotactic protein-1 in proliferative vitreoretinal disorders. Am J Ophthalmol. 1997;123:599-606.
    • (1997) Am J Ophthalmol. , vol.123 , pp. 599-606
    • Abu el-Asrar, A.M.1    van Damme, J.2    Put, W.3    et al4
  • 40
    • 77949537099 scopus 로고    scopus 로고
    • Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases
    • Yoshimura T, Sonoda KH, Sugahara M, et al. Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases. PLoS One. 2009;4:e8158.
    • (2009) PLoS One. , vol.4
    • Yoshimura, T.1    Sonoda, K.H.2    Sugahara, M.3    et al4
  • 41
    • 9444256433 scopus 로고    scopus 로고
    • FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment
    • Zacks DN, Zheng QD, Han Y, Bakhru R, Miller JW. FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci. 2004;45(12):4563-4569.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , Issue.12 , pp. 4563-4569
    • Zacks, D.N.1    Zheng, Q.D.2    Han, Y.3    Bakhru, R.4    Miller, J.W.5
  • 42
    • 35348929461 scopus 로고    scopus 로고
    • Role of the Fassignaling pathway in photoreceptor neuroprotection
    • Zacks DN, Boehlke C, Richards AL, Zheng QD. Role of the Fassignaling pathway in photoreceptor neuroprotection. Arch Ophthalmol. 2007;125:1389-1395.
    • (2007) Arch Ophthalmol. , vol.125 , pp. 1389-1395
    • Zacks, D.N.1    Boehlke, C.2    Richards, A.L.3    Zheng, Q.D.4
  • 43
    • 0142169969 scopus 로고    scopus 로고
    • Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression
    • Rajesh KG, Sasaguri S, Suzuki R, Maeda H. Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. Am J Physiol Heart Circ Physiol. 2003;285: H2171-H2178.
    • (2003) Am J Physiol Heart Circ Physiol. , vol.285
    • Rajesh, K.G.1    Sasaguri, S.2    Suzuki, R.3    Maeda, H.4
  • 44
    • 3042717151 scopus 로고    scopus 로고
    • Neuroprotection of edaravone on hypoxic-ischemic brain injury in neonatal rats
    • Yasuoka N, Nakajima W, Ishida A, Takada G. Neuroprotection of edaravone on hypoxic-ischemic brain injury in neonatal rats. Brain Res Dev Brain Res. 2004;151:129-139.
    • (2004) Brain Res Dev Brain Res. , vol.151 , pp. 129-139
    • Yasuoka, N.1    Nakajima, W.2    Ishida, A.3    Takada, G.4
  • 45
    • 39749173050 scopus 로고    scopus 로고
    • Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats
    • Xiao B, Bi FF, Hu YQ, et al. Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats. Neurotox Res. 2007;12:155-162.
    • (2007) Neurotox Res. , vol.12 , pp. 155-162
    • Xiao, B.1    Bi, F.F.2    Hu, Y.Q.3    et al4
  • 46
    • 34247485841 scopus 로고    scopus 로고
    • Role of the mitochondrial membrane permeability transition in cell death
    • Tsujimoto Y, Shimizu S. Role of the mitochondrial membrane permeability transition in cell death. Apoptosis. 2007;12:835-840.
    • (2007) Apoptosis. , vol.12 , pp. 835-840
    • Tsujimoto, Y.1    Shimizu, S.2
  • 48
    • 0029949082 scopus 로고    scopus 로고
    • bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations
    • Chen J, Flannery JG, LaVail MM, Steinberg RH, Xu J, Simon MI. bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. Proc Natl Acad Sci U S A. 1996;93:7042-7047.
    • (1996) Proc Natl Acad Sci U S A. , vol.93 , pp. 7042-7047
    • Chen, J.1    Flannery, J.G.2    LaVail, M.M.3    Steinberg, R.H.4    Xu, J.5    Simon, M.I.6
  • 49
    • 0030008918 scopus 로고    scopus 로고
    • Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2
    • Bonfanti L, Strettoi E, Chierzi S, et al. Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J Neurosci. 1996;16:4186-4194.
    • (1996) J Neurosci. , vol.16 , pp. 4186-4194
    • Bonfanti, L.1    Strettoi, E.2    Chierzi, S.3    et al4
  • 51
    • 33745190971 scopus 로고    scopus 로고
    • Opposing roles for ERK1/2 in neuronal oxidative toxicity: Distinct mechanisms of ERK1/2 action at early versus late phases of oxidative stress
    • Luo Y, DeFranco DB. Opposing roles for ERK1/2 in neuronal oxidative toxicity: distinct mechanisms of ERK1/2 action at early versus late phases of oxidative stress. J Biol Chem. 2006;281: 16436-16442.
    • (2006) J Biol Chem. , vol.281 , pp. 16436-16442
    • Luo, Y.1    DeFranco, D.B.2
  • 52
    • 0034697364 scopus 로고    scopus 로고
    • Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures
    • Stanciu M, Wang Y, Kentor R, et al. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J Biol Chem. 2000; 275:12200-12206.
    • (2000) J Biol Chem. , vol.275 , pp. 12200-12206
    • Stanciu, M.1    Wang, Y.2    Kentor, R.3    et al4
  • 53
    • 33750584426 scopus 로고    scopus 로고
    • Sustained versus transient ERK1/2 signaling underlies the anti-and proapoptotic effects of oxidative stress in human RPE cells
    • Glotin AL, Calipel A, Brossas JY, Faussat AM, Treton J, Mascarelli F. Sustained versus transient ERK1/2 signaling underlies the anti-and proapoptotic effects of oxidative stress in human RPE cells. Invest Ophthalmol Vis Sci. 2006;47:4614-4623.
    • (2006) Invest Ophthalmol Vis Sci. , vol.47 , pp. 4614-4623
    • Glotin, A.L.1    Calipel, A.2    Brossas, J.Y.3    Faussat, A.M.4    Treton, J.5    Mascarelli, F.6
  • 54
    • 0037229213 scopus 로고    scopus 로고
    • Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction: Randomized, placebo-controlled, double-blind study at multicenters
    • The Edaravone Acute Brain Infarction Study Group
    • The Edaravone Acute Brain Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction: randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis. 2003;15:222-229.
    • (2003) Cerebrovasc Dis. , vol.15 , pp. 222-229
  • 55
    • 70350460036 scopus 로고    scopus 로고
    • Edaravone (MCI-186) is effective as a free radical scavenger following arteriovenous sheathotomy for treatment of macular oedema associated with branch retinal vein occlusion
    • Maeno T, Tano R, Takenaka H, Mano T. Edaravone (MCI-186) is effective as a free radical scavenger following arteriovenous sheathotomy for treatment of macular oedema associated with branch retinal vein occlusion. Br J Ophthalmol. 2009;93:1479-1482.
    • (2009) Br J Ophthalmol. , vol.93 , pp. 1479-1482
    • Maeno, T.1    Tano, R.2    Takenaka, H.3    Mano, T.4
  • 56
    • 37249053501 scopus 로고    scopus 로고
    • Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance
    • Hishida A. Clinical analysis of 207 patients who developed renal disorders during or after treatment with edaravone reported during post-marketing surveillance. Clin Exp Nephrol. 2007;11:292-296.
    • (2007) Clin Exp Nephrol. , vol.11 , pp. 292-296
    • Hishida, A.1


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