Edaravone inhibits JNK-c-Jun pathway and restores anti-oxidative defense after ischemia-reperfusion injury in aged rats

Biological and Pharmaceutical Bulletin

Volumn 29, Issue 4, 2006, Pages 713-718

  Wen, Juan ^a   Watanabe, Kenichi ^a   Ma, Meilei ^a   Yamaguchi, Kenichi ^b   Tachikawa, Hitoshi ^c   Kodama, Makoto ^c   Aizawa, Yoshifusa ^c  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

Author keywords

Aged rat; Cerebral ischemia reperfusion; Edaravone; Mitogen activated protein kinase; Neuronal damage; Oxidative stress

Indexed keywords

GLUTATHIONE PEROXIDASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NORPHENAZONE; PROTEIN C JUN; TRIPHENYLTETRAZOLIUM;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTERY OCCLUSION; ARTICLE; BRAIN INFARCTION SIZE; CAROTID ARTERY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; ISCHEMIA; MALE; NERVE CELL LESION; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; SPECTROPHOTOMETRY; WESTERN BLOTTING;

AGING; ANIMALS; ANTIOXIDANTS; ANTIPYRINE; BLOTTING, WESTERN; BRAIN; CEREBRAL INFARCTION; GENES, JUN; GLUTATHIONE PEROXIDASE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE TISSUE PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 33645538813     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.29.713     Document Type: Article

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