Transcriptional regulation and multiple functions of MAO genes

Journal of Neural Transmission

Volumn 118, Issue 7, 2011, Pages 979-986

  Shih, C Jean ^a,b   Wu, Jason Boyang ^a   Chen, Kevin ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Hormone; Monoamine oxidase; Promoter; Sp1; Transcriptional regulation

Indexed keywords

AMINE; AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; ANDROGEN; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLUCOCORTICOID; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYDROGEN PEROXIDE; NEUROTRANSMITTER; REPRESSOR PROTEIN; RETINOIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTIONAL REPRESSOR R1; TRANSFORMING GROWTH FACTOR BETA INDUCIBLE EARLY PROTEIN 2; UNCLASSIFIED DRUG;

APOPTOSIS; CELL PROLIFERATION; CONFERENCE PAPER; DNA METHYLATION; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; HORMONAL REGULATION; HUMAN; MENTAL DISEASE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SRY GENE; STEM CELL; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MONOAMINE OXIDASE; ORGAN SPECIFICITY; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 80051673220     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-010-0562-9     Document Type: Conference Paper

References (71)

1. Amos S, Martin PM, Polar GA, Parsons SJ, Hussaini IM (2005) Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. J Biol Chem 280(9):7729-7738 (Pubitemid 40349666)
2. Arai Y, Kinemuchi H (1988) Differences between monoamine oxidase concentrations in striatum and forebrain of aged and young rats. J Neural Transm 72(2):99-105
3. Avramovich-Tirosh Y, Amit T, Bar-Am O, Zheng H, Fridkin M, Youdim MB (2007a) Therapeutic targets and potential of the novel brain-permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease. J Neurochem 100(2):490-502 (Pubitemid 46016026)
4. Avramovich-Tirosh Y, Reznichenko L, Mit T, Zheng H, Fridkin M, Weinreb O, Mandel S, Youdim MB (2007b) Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron-chelatingantioxidants, M-30 and green tea polyphenol, EGCG. Curr Alzheimer Res 4(4):403-411 (Pubitemid 47416633)
5. Bach AW, Lan NC, Johnson DL, Abell CW, Bembenek ME, Kwan SW, Seeburg PH, Shih JC (1988) cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc Natl Acad Sci USA 85(13):4934-4938
6. Bar-Am O, Weinreb O, Amit T, Youdim MB (2005) Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine. FASEB J 19(13):1899-1901 (Pubitemid 41598788)
7. Bar-Am O, Amit T, Weinreb O, Youdim MB, Mandel S (2010) Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation. J Alzheimers Dis 21(2):361-371
8. Bortolato M, Chen K, Shih JC (2008) Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliv Rev 60(13-14):1527-1533
9. Bortolato M, Godar SC, Davarian S, Chen K, Shih JC (2009) Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice. Neuropsychopharmacology 34(13):2746-2757
10. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA (1993) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262(5133):578-580 (Pubitemid 23350673)
11. Carrillo MC, Minami C, Kitani K, Maruyama W, Ohashi K, Yamamoto T, Naoi M, Kanai S, Youdim MB (2000) Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat. Life Sci 67(5):577-585 (Pubitemid 30431547)
12. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Muller U, Aguet M, Babinet C, Shih JC et al (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAO A. Science 268(5218):1763-1766
13. Chen K, Ou XM, Chen G, Choi SH, Shih JC (2005) R1, a novel repressor of the human monoamine oxidase A. J Biol Chem 280(12):11552-11559 (Pubitemid 40418467)
14. Cheng A, Scott AL, Ladenheim B, Chen K, Ouyang X, Lathia JD, Mughal M, Cadet JL, Mattson MP, Shih JC (2010) Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development. J Neurosci 30(32):10752-10762
15. Chiueh CC, Huang SJ, Murphy DL (1992) Enhanced hydroxyl radical generation by 2'-methyl analog of MPTP: suppression by clorgyline and deprenyl. Synapse 11(4):346-348
16. de Kloet ER, Reul JM, Sutanto W (1990) Corticosteroids and the brain. J Steroid Biochem Mol Biol 37(3):387-394
17. De Zutter GS, Davis RJ (2001) Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Proc Natl Acad Sci USA 98(11):6168-6173 (Pubitemid 32488211)
18. Devor EJ, Cloninger CR, Hoffman PL, Tabakoff B (1993) Association of monoamine oxidase (MAO) activity with alcoholism and alcoholic subtypes. Am J Med Genet 48(4):209-213
19. Dulcan M (1997) Practice parameters for the assessment and treatment of children, adolescents, and adults with attentiondeficit/hyperactivity disorder. American Academy of Child and Adolescent Psychiatry. J Am Acad Child Adolesc Psychiatry 36(10 Suppl):85S-121S
20. Duval F, Mokrani MC, Monreal-Ortiz JA, Fattah S, Champeval C, Schulz P, Macher JP (2006) Cortisol hypersecretion in unipolar major depression with melancholic and psychotic features: dopaminergic, noradrenergic and thyroid correlates. Psychoneuroendocrinology 31(7):876-888 (Pubitemid 44202373)
21. Faraj BA, Davis DC, Camp VM, Mooney AJ 3rd, Holloway T, Barika G (1994) Platelet monoamine oxidase activity in alcoholics, alcoholics with drug dependence, and cocaine addicts. Alcohol Clin Exp Res 18(5):1114-1120 (Pubitemid 24345516)
22. Foley P, Gerlach M, Youdim MB, Riederer P (2000) MAO-B inhibitors: multiple roles in the therapy of neurodegenerative disorders? Parkinsonism Relat Disord 6(1):25-47
23. Fowler JS, Volkow ND, Wang GJ, Logan J, Pappas N, Shea C, MacGregor R (1997) Age-related increases in brain monoamine oxidase B in living healthy human subjects. Neurobiol Aging 18(4):431-435 (Pubitemid 27435085)
24. Gal S, Zheng H, Fridkin M, Youdim MB (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion. J Neurochem 95(1):79-88 (Pubitemid 41384427)
25. Gal S, Abassi ZA, Youdim MB (2010a) Limited potentiation of blood pressure in response to oral tyramine by the anti-Parkinson brain selective multifunctional monoamine oxidase-AB inhibitor, M30. Neurotox Res 18(2):143-150
26. Gal S, Zheng H, Fridkin M, Youdim MB (2010b) Restoration of nigrostriatal dopamine neurons in post-MPTP treatment by the novel multifunctional brain-permeable iron chelator-monoamine oxidase inhibitor drug, M30. Neurotox Res 17(1):15-27
27. Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC (1991) Human monoamine oxidase A and B genes exhibit identical exon-intron organization. Proc Natl Acad Sci USA 88(9):3637-3641 (Pubitemid 21916678)
28. Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, Adams JD, Karoum F, Gal J, Shih JC (1997) Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet 17(2):206-210
29. Holschneider DP, Kumazawa T, Chen K, Shih JC (1998) Tissuespecific effects of estrogen on monoamine oxidase A and B in the rat. Life Sci 63(3):155-160 (Pubitemid 28305563)
30. Huang A, Ho CS, Ponzielli R, Barsyte-Lovejoy D, Bouffet E, Picard D, Hawkins CE, Penn LZ (2005) Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res 65(13):5607-5619 (Pubitemid 40911161)
31. Isakov N, Galron D, Mustelin T, Pettit GR, Altman A (1993) Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C. J Immunol 150(4):1195-1204 (Pubitemid 23127409)
32. Lan NC, Heinzmann C, Gal A, Klisak I, Orth U, Lai E, Grimsby J, Sparkes RS, Mohandas T, Shih JC (1989) Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease. Genomics 4(4):552-559
33. Launay JM, Del Pino M, Chironi G, Callebert J, Peoc'h K, Megnien JL, Mallet J, Simon A, Rendu F (2009) Smoking induces longlasting effects through a monoamine-oxidase epigenetic regulation. PLoS One 4(11):e7959
34. Li Y, Oh HJ, Lau YF (2006) The poly (ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions. Mol Cell Endocrinol 257-258:35-46 (Pubitemid 44292418)
35. Malorni W, Giammarioli AM, Matarrese P, Pietrangeli P, Agostinelli E, Ciaccio A, Grassilli E, Mondovi B (1998) Protection against apoptosis by monoamine oxidase A inhibitors. FEBS Lett 426(1):155-159 (Pubitemid 28198175)
36. Mandel S, Grunblatt E, Riederer P, Gerlach M, Levites Y, Youdim MB (2003) Neuroprotective strategies in Parkinson's disease: an update on progress. CNS Drugs 17(10):729-762 (Pubitemid 37000010)
37. Maruyama W, Yamamoto T, Kitani K, Carrillo MC, Youdim M, Naoi M (2000) Mechanism underlying anti-apoptotic activity of a (-) deprenyl-related propargylamine, rasagiline. Mech Ageing Dev 116(2-3):181-191
38. Mizuta I, Ohta M, Ohta K, Nishimura M, Mizuta E, Hayashi K, Kuno S (2000) Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes. Biochem Biophys Res Commun 279(3):751-755 (Pubitemid 32042852)
39. Naoi M, Maruyama W, Akao Y, Zhang J, Parvez H (2000) Apoptosis induced by an endogenous neurotoxin, N-methyl (R) salsolinol, in dopamine neurons. Toxicology 153(1-3):123-141
40. Oh HJ, Li Y, Lau YF (2005) Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol Reprod 72(2):407-415 (Pubitemid 40129717)
41. Ou XM, Chen K, Shih JC (2004) Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG) 2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene. J Biol Chem 279(20):21021-21028 (Pubitemid 38656503)
42. Ou XM, Chen K, Shih JC (2006a) Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1. J Biol Chem 281(30):21512-21525 (Pubitemid 44115488)
43. Ou XM, Chen K, Shih JC (2006b) Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Proc Natl Acad Sci USA 103(29):10923-10928 (Pubitemid 44148396)
44. Ou XM, Lu D, Johnson C, Chen K, Youdim MB, Rajkowska G, Shih JC (2009) Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan. Neurotox Res 16(2):148-159
45. Ou XM, Stockmeier CA, Meltzer HY, Overholser JC, Jurjus GJ, Dieter L, Chen K, Lu D, Johnson C, Youdim MB, Austin MC, Luo J, Sawa A, May W, Shih JC (2010) A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biol Psychiatry 67(9):855-863
46. Ploeger A, Raijmakers ME, van der Maas HL, Galis F (2010) The association between autism and errors in early embryogenesis: what is the causal mechanism? Biol Psychiatry 67(7):602-607
47. Sabol SZ, Hu S, Hamer D (1998) A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 103(3):273-279 (Pubitemid 28470076)
48. Scott AL, Bortolato M, Chen K, Shih JC (2008) Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. Neuroreport 19(7):739-743 (Pubitemid 351555982)
49. Shih JC, Chen K, Ridd MJ (1999) Monoamine oxidase: from genes to behavior. Annu Rev Neurosci 22:197-217 (Pubitemid 29144886)
50. Shumay E, Fowler JS (2010) Identification and characterization of putative methylation targets in the MAOA locus using bioinformatic approaches. Epigenetics 5(4):325-342
51. Siddiqui EJ, Shabbir M, Mikhailidis DP, Thompson CS, Mumtaz FH (2006) The role of serotonin (5-hydroxytryptamine 1A and 1B) receptors in prostate cancer cell proliferation. J Urol 176(4 Pt 1):1648-1653 (Pubitemid 44307246)
52. Sieradzan K, Channon S, Ramponi C, Stern GM, Lees AJ, Youdim MB (1995) The therapeutic potential of moclobemide, a reversible selective monoamine oxidase A inhibitor in Parkinson's disease. J Clin Psychopharmacol 15(4 Supp 2):51S-59S
53. Soll C, Jang JH, Riener MO, Moritz W, Wild PJ, Graf R, Clavien PA (2010) Serotonin promotes tumor growth in human hepatocellular cancer. Hepatology 51(4):1244-1254
54. Weinreb O, Bar-Am O, Amit T, Chillag-Talmor O, Youdim MB (2004) Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members. FASEB J 18(12):1471-1473 (Pubitemid 39561618)
55. Wilhelm D, Palmer S, Koopman P (2007) Sex determination and gonadal development in mammals. Physiol Rev 87(1):1-28 (Pubitemid 46207711)
56. Williams JG, Allison C, Scott FJ, Bolton PF, Baron-Cohen S, Matthews FE, Brayne C (2008) The Childhood Autism Spectrum Test (CAST): sex differences. J Autism Dev Disord 38(9):1731-1739
57. Wolkowitz OM, Reus VI (1999) Treatment of depression with antiglucocorticoid drugs. Psychosom Med 61(5):698-711 (Pubitemid 29455090)
58. Wong WK, Chen K, Shih JC (2001) Regulation of human monoamine oxidase B gene by Sp1 and Sp3. Mol Pharmacol 59(4):852-859 (Pubitemid 32274014)
59. Wong WK, Ou XM, Chen K, Shih JC (2002) Activation of human monoamine oxidase B gene expression by a protein kinase C MAPK signal transduction pathway involves c-Jun. and Egr-1. J Biol Chem 277(25):22222-22230 (Pubitemid 34967188)
60. Wong WK, Chen K, Shih JC (2003) Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation. J Biol Chem 278(38):36227-36235 (Pubitemid 37139945)
61. Wright SL, Langenecker SA, Deldin PJ, Rapport LJ, Nielson KA, Kade AM, Own LS, Akil H, Young EA, Zubieta JK (2009) Gender-specific disruptions in emotion processing in younger adults with depression. Depress Anxiety 26(2):182-189
62. Wu RM, Murphy DL, Chiueh CC (1995) Neuronal protective and rescue effects of deprenyl against MPP+ dopaminergic toxicity. J Neural Transm Gen Sect 100(1):53-61
63. Wu JB, Chen K, Li Y, Lau YF, Shih JC (2009a) Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J 23(11):4029-4038
64. Wu JB, Chen K, Ou XM, Shih JC (2009b) Retinoic acid activates monoamine oxidase B promoter in human neuronal cells. J Biol Chem 284(25):16723-16735
65. Youdim MB (2006) The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30. Curr Alzheimer Res 3(5):541-550 (Pubitemid 46066429)
66. Youdim MB, Riederer PF (2004) A review of the mechanisms and role of monoamine oxidase inhibitors in Parkinson's disease. Neurology 63(7 Suppl 2):S32-S35 (Pubitemid 39346709)
67. Zhang Z, Chen K, Shih JC, Teng CT (2006) Estrogen-related receptors-stimulated monoamine oxidase B promoter activity is down-regulated by estrogen receptors. Mol Endocrinol 20(7):1547-1561 (Pubitemid 43967563)
68. Zheng H, Weiner LM, Bar-Am O, Epsztejn S, Cabantchik ZI, Warshawsky A, Youdim MB, Fridkin M (2005) Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases. Bioorg Med Chem 13(3):773-783 (Pubitemid 40093620)
69. Zhu Q, Shih JC (1997) An extensive repeat structure down-regulates human monoamine oxidase A promoter activity independent of an initiator-like sequence. J Neurochem 69(4):1368-1373 (Pubitemid 27406936)
70. Zhu QS, Grimsby J, Chen K, Shih JC (1992) Promoter organization and activity of human monoamine oxidase (MAO) A and B genes. J Neurosci 12(11):4437-4446
71. Zhu QS, Chen K, Shih JC (1994) Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Sp1. J Neurosci 14(12):7393-7403