An extensive repeat structure down-regulates human monoamine oxidase A promoter activity independent of an initiator-like sequence

Journal of Neurochemistry

Volumn 69, Issue 4, 1997, Pages 1368-1373

  Zhu, Qin Shi ^a   Shih, Jean Chen ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Human growth hormone reporter gene; Human monoamine oxidase A; Initiator; Promoter; Repeat sequence

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; HUMAN GROWTH HORMONE;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION INITIATION;

GYMNOMYZA SAMOENSIS;

EID: 0030885943     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69041368.x     Document Type: Article

References (22)

1. Bach A. W. J., Lan N. C., Johnson D. L., Abell C. W., Bembenek M. E., Kwan S.-W., Seeberg P. H., and Jean J. C. (1988) cDNA cloning of human monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc. Natl. Acad. Sci. USA 85, 4934-4938.
2. Brunner H. G., Nelen M. R., van Zandvoort P., Abeling N. G. G. M., van Gennip A. H., Wolters E. C., Kuiper M. A., Ropers H. H., and van Oost B. A. (1993a) X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine oxidase metabolism. Am. J. Genet. 52, 1032-1039.
3. Brunner H. G., Nelen M., Breakefield X. O., Ropers H. H., and van Oost B. A. (1993b) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262, 578-580.
4. Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Muller U., Aguet M., Babinet C., Shin J. C., and De Maeyer E. (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268, 1763-1766.
5. Chen C. and Okayama H. (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7, 2745-2752.
6. Chen K., Wu H. F., Grimsby J., and Shih J. C. (1994) Cloning of a novel monoamine oxidase cDNA from trout liver. Mol. Pharmacol. 46, 1226-1233.
7. Chen S., Shih J. C., and Xu Q.-P. (1984) Interaction of N-(2-nitro-4-azidophenyl)-serotonin with two types of monoamine oxidase in rat brain. J. Neurochem. 43, 1680-1687.
8. Denney R. M., Sharma A., Dave S. K., and Waguespack A. (1994) A new look at the promoter of the human monoamine oxidase A gene: mapping transcription initiation sites and capacity to drive luciferase expression. J. Neurochem. 63, 843-856.
9. Ding G., Toth M., Zhou Y., Parks C., Hoffman B. J., and Shenk T. (1993) Glial cell-specific expression of the serotonin 2 receptor gene: selective reactivation of a repressed promoter. Mol. Brain Res. 20, 181-191.
10. Duncan D. D., Stupakoff A., Hedrick S. M., Marcu K. B., and Siu G. (1995) A myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter. Mol. Cell. Biol. 15, 3179-3186.
11. Eichbaum Q. G., Iyer R., Raveh D. P., Mathieu C., and Ezekowitz R. A. (1994) Restriction of interferon gamma responsiveness and basal expression of the myeloid human FC gamma R1b gene is mediated by a functional PU.1 site and a transcription initiator consensus. J. Exp. Med. 179, 1985-1996.
12. Grimsby J., Chen K., Wang L. J., Lan N. C., and Shih J. C. (1991) Human monoamine oxidase A and B genes exhibit identical exon-intron organization. Proc. Natl. Acad. Sci. USA 88, 3637-3641.
13. Huang C. J. and Wagner E. K. (1994) The herpes simplex virus type 1 major capsid protein (VP5-UL19) promoter contains two cis-acting elements influencing late expression. J. Virol. 68, 5738-5747.
14. Means A. L. and Farnham P. J. (1990) Transcription initiation from the dihydrofolate reductase promoter is positioned by HIP1 binding at the initiation site. Mol. Cell. Biol. 10, 653-661.
15. Raich N., Clegg C. H., Grofti J., and Romeo P. H. (1995) GATA1 and YY1 are developmental repressors of the human epsilon-globin gene. EMBO J. 14, 801-809.
16. Shih J. C. (1991) Molecular basis of human MAO A and B. Neuropsychopharmacology 4, 1-7.
17. Shin T. H. and Kudlow J. E. (1994) Identification and characterization of the human transforming growth factor-alpha initiator. Mol. Endocrinol. 8, 704-712.
18. Smale S. T. and Baltimore D. (1989) The "initiator" as a transcription control element. Cell 57, 103-113.
19. Wu H. F., Chen K., and Shih J. C. (1993) Site-directed mutagenesis of monoamine oxidase A and B: the role of cystines. Mol. Pharmacol. 43, 888-893.
20. Zhu Q. S., Grimsby J., Chen K., and Shih J. C. (1992) Promoter organization and activity of human monoamine oxidase (MAO) A and B genes. J. Neurosci. 12, 4437-4446.
21. Zhu Q. S., Chen K., and Shih J. C. (1994) Bidirectional promoter of human monoamine oxidase A (MAO) A controlled by transcription factor Sp1. J. Neurosci. 14, 7393-7403.
22. 2A receptor gene promoter. J. Neurosci. 15, 4885-4895.