Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Atsumi, Yuko ^a   Fujimori, Hiroaki ^a,b   Fukuda, Hirokazu ^a   Inase, Aki ^a   Shinohe, Keitaro ^b   Yoshioka, Yoshiko ^b   Shikanai, Mima ^b   Ichijima, Yosuke ^b   Unno, Junya ^b   Mizutani, Shuki ^b   Tsuchiya, Naoto ^a   Hippo, Yoshitaka ^a   Nakagama, Hitoshi ^a   Masutani, Mitsuko ^a   Teraoka, Hirobumi ^b   Yoshioka, Ken ichi ^a,b  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARF PROTEIN; HISTONE H2AX; PROTEIN P53; CYTOTOXIN; H2AX PROTEIN, MOUSE; HISTONE; ZINOSTATIN;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL CYCLE ARREST; CELL GROWTH; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL QUIESCENCE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CHROMOSOME POSITIONING; CYTOKINESIS; DIPLOIDY; DNA REPLICATION; DOWN REGULATION; EMBRYO; FIBROBLAST; GENOMIC INSTABILITY; GROWTH REGULATION; HOMEOSTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN TARGETING; TETRAPLOIDY; ANIMAL; ANIMAL EMBRYO; CELL AGING; CELL CULTURE; CELL LINE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; MOUSE MUTANT; POLYPLOIDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL AGING; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CELLS, CULTURED; CYTOTOXINS; DIPLOIDY; DOWN-REGULATION; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION; GENOMIC INSTABILITY; HISTONES; MICE; MICE, KNOCKOUT; POLYPLOIDY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53; ZINOSTATIN;

EID: 80051640493     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023432     Document Type: Article

References (38)

1. Negrini S, Gorgoulis VG, Halazonetis TD, (2010) Genomic instability-an evolving hallmark of cancer. Nat Rev Mol Cell Biol 11: 220-228.
2. Lengauer C, Kinzler KW, Vogelstein B, (1997) Genetic instabilities in colorectal cancers. Nature 386: 632-627.
3. Lengauer C, Kinzler KW, Vogelstein B, (1998) Genetic instabilities in human cancers. Nature 396: 643-649.
4. Stephans PJ, Greenman CD, Fu B, Yang F, Bignell GR, et al. (2011) Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144: 27-40.
5. Vitale I, Galluzzi L, Senovilla L, Criollo A, Jemaà M, et al. Illicit survival of cancer cells during polyploidization and depolyploidization. Cell death differ doi:10.1038/cdd.2010.145.
6. Danes BS, (1978) Increased in vitro tetraploidy: tissue specific within the heritable colorectal cancer syndromes with polyposis coli. Cancer 41: 2330-2334.
7. Dutrillaux B, Gerbault-Seureau M, Remvikos Y, Zafrani B, Prieur M, (1991) Breast cancer genetic evolution: I. Data from cytogenetics and DNA content. Breast Cancer Res Treat 19: 245-255.
8. Heselmeyer K, Schröck E, du Manoir S, Blegen H, Shah K, et al. (1996) Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix. Proc Natl Acad Sci USA 93: 479-484.
9. Maley CC, Galipeau PC, Li X, Sanchez CA, Paulson TG, et al. (2004) The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma. Cancer Res 64: 7629-7633.
10. Ichijima Y, Yoshioka K, Yoshioka Y, Shinohe K, Fujimori H, et al. (2010) DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. PLoS One 5: e8821.
11. Bartkova J, Horejsí Z, Koed K, Krämer A, Tort F, et al. (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434: 864-870.
12. Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, et al. (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434: 907-913.
13. Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, et al. (2004) Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nature Cell Biol 6: 168-170.
14. Nakamura AJ, Chiang YJ, Hathcock KS, Horikawa I, Sedelnikova OA, et al. (2008) Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin 1: 6.
15. Geigl JB, Langer S, Barwisch S, Pfleghaar K, Lederer G, et al. (2004) Analysis of gene expression patterns and chromosomal changes associated with aging. Cancer Res 64: 8550-8557.
16. Sherr CJ, Weber JD, (2000) The ARF/p53 pathway. Curr Opin Genet Dev 10: 94-99.
17. Sherr CJ, (1998) Tumor surveillance via the ARF-p53 pathway. Genes Dev 12: 2984-2991.
18. Matheu A, Maraver A, Serrano M, (2008) The Arf/p53 pathway in cancer and aging. Cancer Res 68: 6031-6034.
19. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, et al. (2002) p53 mutant mice that display early ageing-associated phenotypes. Nature 415: 45-53.
20. Maier B, Gluba W, Bernier B, Turner T, Mohammad K, et al. (2004) Modulation of mammalian life span by the short isoform of p53. Genes Dev 18: 306-319.
21. Varela I, Cadiñanos J, Pendás AM, Gutiérrez-Fernández A, Folgueras AR, et al. (2005) Accelerated ageing in mic deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 437: 564-568.
22. Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, et al. (2007) Delayed ageing through damage protection by the Arf/p53 pathway. Nature 448: 375-379.
23. Parrincello S, Samper E, Krtolica A, Goldstein J, Melov S, et al. (2003) Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nature Cell Biol 5: 741-746.
24. Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, et al. (2002) Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci USA 99: 8173-8178.
25. Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, et al. (2002) Genomic instability in mice lacking histone H2AX. Science 296: 922-927.
26. Bronson R, Lee C, Alt WF, (2003) Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors. Cell 114: 359-370.
27. Bassing CH, Alt FW, (2004) H2AX May Function as an Anchor to Hold Broken Chromosomal DNA Ends in Close Proximity. Cell Cycle 3: 149-153.
28. Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, et al. (2008) GammaH2AX and cancer. Nature Rev Cancer 8: 957-967.
29. Tsukuda T, Fleming AB, Nickoloff JA, Osley MA, (2005) Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae. Nature 438: 379-383.
30. Keogh MC, Mennella TA, Sawa C, Berthelet S, Krogan NJ, et al. (2006) The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4. Genes Dev 20: 660-665.
31. Ikura T, Tashiro S, Kakino A, Shima H, Jacob N, et al. (2007) DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol Cell Biol 27: 7028-7040.
32. Brady CA, Jiang D, Mello SS, Johnson TM, Jarvis LA, et al. (2011) Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell 145: 571-583.
33. Ceribelli M, Alcalay M, Viganò MA, Mantovani R, (2006) Repression of new p53 targets revealed by ChIP on chip experiments. Cell Cycle 5: 1102-1110.
34. Yoshioka K, Yoshioka Y, Hsieh P, (2006) ATR kinase activation mediated by MutSα and MutLα in response to cytotoxic O6-methylguanine adducts. Mol Cell 22: 501-510.
35. Tatemichi M, Tazawa H, Masuda M, Saleem M, Wada S, et al. (2004) Suppression of thymic lymphomas and increased nonthymic lymphomagenesis in Trp53-deficient mice lacking inducible nitric oxide synthase gene. Int J Cancer 111: 819-828.
36. Todaro GJ, Green H, (1963) Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol 17: 299-313.
37. Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, et al. (2004) Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J 23: 2674-2683.
38. Dimitrova N, de Lange T, (2006) MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev 20: 3238-3243.