Computational model of airflow in upper 17 generations of human respiratory tract

Journal of Biomechanics

Volumn 41, Issue 9, 2008, Pages 2047-2054

  Gemci, T ^a   Ponyavin, V ^c   Chen, Y ^a,b   Chen, H ^b   Collins, R ^a,b  

^a UNIVERSITY OF NEVADA   (United States)

^b University of Nevada Las Vegas   (United States)

^c GENERAL ELECTRIC COMPANY   (United States)

Author keywords

Asymmetric bronchial tree; Computational; Human tracheobronchial airway model; LES model; Tracheobronchial airways

Indexed keywords

CODES (SYMBOLS); COMPUTATION THEORY; TREES (MATHEMATICS); TURBULENT FLOW;

ASYMMETRIC BRONCHIAL TREE; HUMAN TRACHEOBRONCHIAL AIRWAY MODEL; LES MODEL; TRACHEOBRONCHIAL AIRWAYS;

AERODYNAMICS;

AIRFLOW; ARTICLE; AUDIOVISUAL EQUIPMENT; COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; FLOW RATE; LUNG MODEL; PRIORITY JOURNAL; RESPIRATORY SYSTEM; STEADY STATE; TRACHEOBRONCHIAL TREE; TURBULENT FLOW;

AIR; AIR PRESSURE; COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; RESPIRATORY SYSTEM;

EID: 44649148315     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2007.12.019     Document Type: Article

References (35)

1. Allen G.M., Shortall B.P., Gemci T., Corcoran T.E., and Chigier N.A. Computational simulations of airflow in an in vitro model of the pediatric upper airways. ASME Journal of Biomechanical Engineering 126 (2004) 604-613
2. Calay R.K., Kurujareon J., and Holdø A.E. Numerical simulation of respiratory flow patterns within the human lung. Respiratory Physiology and Neurobiology 130 (2002) 201-221
3. Cebral J.R., and Summer R.M. Tracheal and central bronchial aerodynamics using virtual bronchoscopy and computational fluid dynamics. IEEE Transactions on Medical Imaging 23 8 (2004) 1021-1023
4. Fluent Inc., 2004. Fluent 6.1.18 User's Guide, Lebanon, NH.
5. Gemci T., Corcoran T.E., and Chigier N. A numerical and experimental study of spray dynamics in a simple throat-model. Aerosol Science and Technology 36 1 (2002) 18-38
6. Gemci T., Shortall B., Allen G., Corcoran T.E., and Chigier N.A. CFD study of the throat during aerosol drug delivery using heliox and air. Journal of Aerosol Science 34 (2003) 1175-1192
7. Guan X., and Martonen T.B. Flow transition in bends and applications to airways. Journal of Aerosol Science 31 7 (2000) 833-847
8. Horsfield K., Dart G., Olson D.E., Filley G.F., and Cumming G. Models of the human bronchial tree. Journal of Applied Physiology 31 (1971) 207-217
9. Hyatt R.E., and Wilcox R.E. The pressure-flow relationship of the intrathoracic airways in man. Journal of Clinical Investigation 42 (1973) 29-39
10. Kitaoka H., Takaki R., and Suki B. A three-dimensional model of the human airway tree. Journal Applied Physiology 87 6 (1999) 2207-2217
11. Kleinstreuer C., and Zhang Z. Targeted drug aerosol deposition analysis for a four-generation pulmonary airway model with hemispherical tumors. ASME Journal of Biomechanical Engineering 125 (2003) 197-206
12. Kriete A., Schmidt A.H., Zidowitz S., Haworth D.C., and Kunz R.F. Simulations at a newly derived reference model of the human lung. Proceedings of SPIE 5318 (2004) 163-169
13. Lee D.Y., and Lee J.W. Dispersion of aerosol bolus during one respiration cycle in a model of pulmonary airways. Journal of Aerosol Science 33 (2002) 1219-1234
14. Liu Y., So R.M.C., and Zhang C.H. Modeling the bifurcating flow in an asymmetric human pulmonary airway. Journal of Biomechanics 36 (2003) 951-959
15. Longest P.W., and Vinchurkar S. Effects of mesh style and grid convergence on particle deposition in bifurcating airway models with comparisons to experimental data. Medical Engineering and Physics 29 3 (2007) 350-366
16. Longest P.W., and Vinchurkar S. Validating CFD predictions of respiratory aerosol deposition: effects of upstream transition and turbulence. Journal of Biomechanics 40 (2007) 305-316
17. Longest P.W., Vinchurkar S., and Martonen T.B. Transport and deposition of respiratory aerosols in models of childhood asthma. Journal of Aerosol Science 37 (2006) 1234-1257
18. Ma B., and Lutchen K.R. An anatomically based hybrid computational model of the human lung and its application to low frequency oscillatory mechanics. Annals of Biomedical Engineering 34 11 (2006) 1691-1704
19. Nowak N., Kakade P.P., and Annapragada A.V. Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs. Annals of Biomedical Engineering 31 (2003) 374-390
20. Pedley T.J. Pulmonary fluid dynamics. Annual Review of Fluid Mechanics 9 (1977) 229-274
21. Pedley T.J., Schroter R.C., and Sudlow M.F. Flow and pressure drop in systems of repeatedly branching tubes. Journal of Fluid Mechanics 46 (1971) 365-383
22. Schmidt A., Zidowitz S., Kriete A., Denhard T., Krass S., and Peitgen H.-O. A digital reference model of the human bronchial tree. Computerized Medical Imaging and Graphics 28 (2004) 203-211
23. Sera T., Fujioka H., Yokota H., Makinouchi A., Himeno R., Schroter R.C., and Tanishita K. Three-dimensional visualization and morphometry of small airways from microfocal X-ray computed tomography. Journal of Biomechanics 36 (2003) 1587-1594
24. Shi H., Kleinstreuer C., and Zhang Z. Nanoparticle transport and deposition in bifurcating tubes with different inlet conditions. Physics of Fluids 16 7 (2004) 2199-2213
25. Snyder B., Dantzker D.R., and Jaeger M.J. Flow partitioning in symmetric cascades of branches. Journal of Applied Physiology 51 3 (1981) 506-598
26. Spencer R.M., Schroeter J.D., and Martonen T.B. Computer simulations of pulmonary airway structures using data-driven surface modeling techniques. Computers in Biology and Medicine 31 (2001) 499-511
27. Stapleton K.W., Guentsch E., Hoskinson M.K., and Finlay W.H. On the suitability of k-epsilon modeling for aerosol deposition in the mouth and throat: a comparison with experiment. Journal of Aerosol Science 31 (2000) 739-749
28. Tawhai M.H., Pullan A.J., and Hunter P.J. Generation of an anatomically based three-dimensional model of the conducting airways. Annals of Biomedical Engineering 28 (2000) 793-802
29. Tawhai M.H., Hunter P., Tschirren J., Reinhardt J., McLennan G., and Hoffman E.A. CT-based geometry analysis and finite element models of the human and ovine bronchial tree. Journal Applied Physiology 97 6 (2004) 2310-2321
30. Tgavalekos N.T., Venegas J.G., Suki B., and Lutchen K.R. Relation between structure, function, and imaging in a three-dimensional model of the lung. Annals of Biomedical Engineering 31 (2003) 363-373
31. van Ertbruggen C., Hirsch C., and Paiva M. Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics. Journal of Applied Physiology 98 3 (2005) 970-980
32. Zhang Z., and Kleinstreuer C. Airflow structures and nano-particle deposition in a human upper airway model. Journal of Computational Physics 198 (2004) 178-210
33. Zhang Z., Kleinstreuer C., and Kim C.S. Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model. Journal of Aerosol Science 33 (2002) 257-281
34. Zhao Y., and Lieber B.B. Steady inspiratory flow in a model symmetric bifurcation. ASME Journal of Biomechanical Engineering 116 (1994) 488-496
35. Weibel E.R. Morphometry of the Human Lung (1963), Springer, Berlin