Serum-free microcarrier based production of replication deficient Influenza vaccine candidate virus lacking NS1 using Vero cells

BMC Biotechnology

Volumn 11, Issue , 2011, Pages

  Chen, Allen ^a   Poh, Swan Li ^a   Dietzsch, Christian ^b   Roethl, Elisabeth ^b   Yan, Mylene L ^a   Ng, Say Kong ^a  

^a AGENCY FOR SCIENCE   (Singapore)

^b Avir Green Hills Biotechnology AG   (Austria)

Author keywords

Bioreactor; Influenza; Microcarrier; NS1; Vero

Indexed keywords

ANTIVIRAL RESPONSE; BATCH BIOREACTORS; BIOREACTOR SYSTEM; CELL CONCENTRATIONS; CELL DENSITY; CLINICAL TRIAL; DELETION MUTANTS; EFFICIENT PRODUCTION; GENE DELETION; HEALTH CONCERNS; HUMAN SOCIETY; INFLUENZA; INFLUENZA VACCINES; INFLUENZA VIRUS; MANUFACTURABILITY; MICROCARRIER; MICROCARRIER CULTURE; MICROCARRIERS; NONSTRUCTURAL PROTEINS; NS1; PHASE I; PRODUCTION PROCESS; SERUM-FREE MEDIA; SERUM-FREE MEDIUM; SPINNER FLASKS; STATIONARY PHASIS; STIRRED TANK BIOREACTORS; TIME POINTS; VACCINE PRODUCTION; VERO; VERO CELLS; WILD TYPES;

ANIMALS; BIOCONVERSION; BIOREACTORS; BODY FLUIDS; CELL CULTURE; CELLS; ENGINEERING RESEARCH; GENES; GROWTH KINETICS; PRODUCTION ENGINEERING; VACCINES; VIRUSES;

DISEASES;

CYTODEX 1; DRUG CARRIER; NONSTRUCTURAL PROTEIN 1; TRYPSIN; UNCLASSIFIED DRUG; INFLUENZA VACCINE; INS1 PROTEIN, INFLUENZA VIRUS; LIVE VACCINE; VIRUS PROTEIN;

ARTICLE; BATCH REACTOR; CELL ADHESION; CELL CULTURE; CELL DENSITY; CELL GROWTH; CELL VIABILITY; HEMAGGLUTINATION INHIBITION; INFLUENZA A; INFLUENZA VIRUS A; INFLUENZA VIRUS A H1N1; NONHUMAN; STIRRED REACTOR; VERO CELL; VIROGENESIS; VIRUS REPLICATION; ANIMAL; BIOREACTOR; BIOSYNTHESIS; CERCOPITHECUS; COMPARATIVE STUDY; CULTURE MEDIUM; GENETICS; GROWTH, DEVELOPMENT AND AGING; INSTRUMENTATION; METABOLISM; METHODOLOGY; PHASE CONTRAST MICROSCOPY; PHYSIOLOGY; VIROLOGY; VIRUS CULTURE;

ANIMALIA; ORTHOMYXOVIRIDAE;

ANIMALS; BIOREACTORS; CERCOPITHECUS AETHIOPS; CULTURE MEDIA, SERUM-FREE; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; MICROSCOPY, PHASE-CONTRAST; VACCINES, ATTENUATED; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS CULTIVATION; VIRUS REPLICATION;

EID: 80051532514     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-11-81     Document Type: Article

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