The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress

Journal of Cellular Biochemistry

Volumn 112, Issue 7, 2011, Pages 1869-1879

  Broadley, Kate ^a   Larsen, Lesley ^b   Herst, Patries M ^a   Smith, Robin A J ^c   Berridge, Michael V ^a   McConnell, Melanie J ^a  

^a MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^b THE NEW ZEALAND INSTITUTE FOR PLANT AND FOOD RESEARCH LIMITED   (New Zealand)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Autophagy; Cell death; Energetic stress; Glycolytic metabolism; Mitochondrial membrane potential; Nutrient stress

Indexed keywords

2 (10 (2,4,6 TRIHYDROXYPHENYL)DECYL) 5,6 DIMETHOXY 3 METHYL 2,5 CYCLOHEXADIENE 1,4 DIONE; CYTOTOXIC AGENT; PHLOROGLUCINOL DERIVATIVE; PMT 7; SIRTUIN 1; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CANCER CELL; CELL MEMBRANE DEPOLARIZATION; CELL METABOLISM; CELL STRESS; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ELECTRON TRANSPORT; GENE INACTIVATION; GLYCOLYSIS; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NUTRIENT; PRIORITY JOURNAL; STARVATION;

ANTINEOPLASTIC AGENTS; AUTOPHAGY; BENZOQUINONES; CELL LINE, TUMOR; CULTURE MEDIA, SERUM-FREE; ELECTRON TRANSPORT; GENE KNOCKOUT TECHNIQUES; GLYCOLYSIS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATION-REDUCTION; RNA INTERFERENCE; SIRTUIN 1; STRESS, PHYSIOLOGICAL; SUPEROXIDES; TETRAZOLIUM SALTS; THIAZOLES;

EID: 80051519810     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23107     Document Type: Article

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