The level of glycolytic metabolism in acute myeloid leukemia blasts at diagnosis is prognostic for clinical outcome

Journal of Leukocyte Biology

Volumn 89, Issue 1, 2011, Pages 51-55

  Herst, Patries M ^a   Howman, Rebecca A ^b   Neeson, Paul J ^b   Berridge, Michael V ^a   Ritchie, David S ^b,c  

^a MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Chemotherapy; Glucose; Remission; Survival

Indexed keywords

ARSENIC TRIOXIDE; RETINOIC ACID;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGE; AGED; APOPTOSIS; ARTICLE; BONE MARROW BIOPSY; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLYCOLYSIS; HIGH RISK POPULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA RELAPSE; LEUKEMIA REMISSION; MALE; MYELOBLAST; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; BLAST CRISIS; CELL LINE, TUMOR; DEMOGRAPHY; FEMALE; GLYCOLYSIS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; PROGNOSIS; REMISSION INDUCTION; SURVIVAL ANALYSIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79251539264     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0710417     Document Type: Article

References (12)

1. Appelbaum, F. R., Gundacker, H., Head, D. R., Slovak, M. L., Willman, C. L., Goodwin, J. E., Anderson, J. E., Petersdorf, S. H. (2006) Age and acute myeloid leukemia. Blood 107, 3481-3485.
2. Schlenk, R. F., Döhner, K. (2009) Impact of new prognostic markers in treatment decisions in acute myeloid leukemia. Curr. Opin. Hematol. 16, 98-104.
3. Legrand, O., Zompi, S., Perrot, J. Y., Faussat, A. M., Benderra, Z., Chaoui, D., Marie, J. P. (2004) P-glycoprotein and multidrug resistance associated protein-1 activity in 132 acute myeloid leukemias according to FAB subtypes and cytogenetics risk groups. Haematologica 89, 34-41. (Pubitemid 38165853)
4. Cilloni, D., Messa, F., Rosso, V., Arruga, F., Defilippi, I., Carturan, S., Catalano, R., Pautasso, M., Panuzzo, C., Nicoli, P., Messa, E., Morotti, A., Iacobucci, I., Martinelli, G., Bracco, E., Saglio, G. (2008) Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-κB in AML carrying NPM1 mutations. Leukemia 22, 1234-1240.
5. Li, J., Zhang, X., Sejas, D. P., Pang, Q. (2005) Negative regulation of p53 by nucleophosmin antagonizes stress-induced apoptosis in human normal and malignant hematopoietic cells. Leuk. Res. 29, 1415-1423. (Pubitemid 41562244)
6. Gatenby, R. A., Gillies, R. J. (2004) Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4, 891-899.
7. Beesley, A. H., Firth, M. J., Ford, J., Weller, R. E., Freitas, J. R., Perera, K. U., Kees, U. R. (2009) Glucocorticoid resistance in T-lineage acute lymphoblastic leukemia is associated with a proliferative metabolism. Br. J. Cancer 100, 1926-1936.
8. Hulleman, E., Kazemier, K. M., Holleman, A., VanderWeele, D. J., Rudin, C. M., Broekhuis, M. J., Evans, W. E., Pieters, R., Den Boer, M. L. (2009) Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells. Blood 113, 2014-2021.
9. 0 cells. Leuk. Res. 32, 327-333.
10. Kaplan, E. L., Meier, P. (1950) Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53, 457-481.
11. Herst, P. M., Berridge, M. V. (2007) Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines. Biochim. Biophys. Acta 1767, 170-177.
12. Tavor, S., Petit, I. (2010) Can inhibition of the SDF-1/CXCR4 axis eradicate acute leukemia? Semin. Cancer Biol. 20, 178-185.