Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly

Journal of the American Chemical Society

Volumn 130, Issue 43, 2008, Pages 14024-14025

  Heemstra Jr , John R ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; FLAVINE ADENINE NUCLEOTIDE; GENOMIC DNA; ISOLEUCINE; KUTZNERIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOESTER; TRYPTOPHAN; UNCLASSIFIED DRUG; 1,5 DIHYDRO FAD; 1,5-DIHYDRO-FAD; 6,7 DICHLOROTRYPTOPHAN; 6,7-DICHLOROTRYPTOPHAN; BACTERIAL PROTEIN; CHLORIDE; DEPSIPEPTIDE; DRUG DERIVATIVE; MULTIENZYME COMPLEX; OXIDOREDUCTASE; OXYGEN;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHLORINATION; DNA ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ASSAY; ENZYME BINDING; ENZYME SPECIFICITY; ESCHERICHIA COLI; HALOGENATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS PUTIDA; ACTINOBACTERIA; BIOSYNTHESIS; CHEMISTRY; CONFORMATION; CYCLIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; STEREOISOMERISM; TIME;

ACTINOBACTERIA; BACTERIAL PROTEINS; CHLORIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIZATION; DEPSIPEPTIDES; FLAVIN-ADENINE DINUCLEOTIDE; HALOGENATION; MOLECULAR CONFORMATION; MULTIENZYME COMPLEXES; OXIDOREDUCTASES; OXYGEN; STEREOISOMERISM; TIME FACTORS; TRYPTOPHAN;

EID: 54849415919     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja806467a     Document Type: Article

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