Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis

Biochemistry

Volumn 49, Issue 43, 2010, Pages 9306-9317

  Vey, Jessica L ^a   Al Mestarihi, Ahmad ^b   Hu, Yunfeng ^b,c   Funk, Michael A ^a,d   Bachmann, Brian O ^a,b   Iverson, T M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACYL-COA; AMINO SUGAR; ANTIBIOTIC ACTIVITY; CLASS-D; DIPHOSPHATES; FLAVIN-DEPENDENT; IN-VITRO; IN-VIVO; MONOOXYGENASES; NATURAL PRODUCTS; NITROSO; OCTASACCHARIDE; OXIDATION PRODUCTS; OXIDATION REACTIONS; OXIDATION STATE; STAPHYLOCOCCUS AUREUS; STRUCTURAL FEATURE; TETRAMERIC ENZYMES; X RAY CRYSTAL STRUCTURES;

AMINES; ANTIBIOTICS; BIOCHEMISTRY; BIOSYNTHESIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYMES; MOLECULAR OXYGEN; REACTION INTERMEDIATES; SUBSTRATES; SUGAR (SUCROSE);

CATALYTIC OXIDATION;

ACYL COENZYME A DEHYDROGENASE; AMINOSUGAR; EVERNINOMICIN; FLAVINE ADENINE NUCLEOTIDE; FLAVOPROTEIN; HYDROXYLAMINE OXIDASE; NITROSO DERIVATIVE; ORF36; OXYGEN; OXYGEN 18; TETRAMER; THYMIDINE DIPHOSPHATE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; WATER;

ARTICLE; BIOSYNTHESIS; CATALYSIS; ENZYME METABOLISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; IN VITRO STUDY; IN VIVO STUDY; OXIDATION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO SUGARS; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; METABOLIC NETWORKS AND PATHWAYS; MICROMONOSPORA; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION;

MICROMONOSPORA CARBONACEA VAR. AFRICANA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 78049312804     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101336u     Document Type: Article

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