Oleate-induced beta cell dysfunction and apoptosis: A proteomic approach to glucolipotoxicity by an unsaturated fatty acid

Journal of Proteome Research

Volumn 10, Issue 8, 2011, Pages 3372-3385

  Maris, Michael ^a   Waelkens, Etienne ^b,c   Cnop, Miriam ^d,e   D'Hertog, Wannes ^a   Cunha, Daniel A ^d   Korf, Hannelie ^a   Koike, Tatsuro ^f   Overbergh, Lut ^a   Mathieu, Chantal ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^e ERASME HOSPITAL   (Belgium)

^f HOKKAIDO UNIVERSITY   (Japan)

Author keywords

beta cells; lipotoxicity; oleate; proteomics; type 2 diabetes

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE; CHAPERONE; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; INSULIN; MESSENGER RNA; OLEIC ACID; PROTEASOME; REACTIVE OXYGEN METABOLITE; UBIQUITIN; UNSATURATED FATTY ACID;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL FUNCTION; DOWN REGULATION; FATTY ACID SYNTHESIS; FRAGMENTATION REACTION; GLUCOLIPOTOXICITY; INSULIN RELEASE; LIPOTOXICITY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEOMICS; RAT; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; UREA CYCLE;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FATTY ACIDS, UNSATURATED; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; LIPIDS; OLEIC ACID; POLYMERASE CHAIN REACTION; PROTEOMICS; RATS; REACTIVE OXYGEN SPECIES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 79961238766     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr101290n     Document Type: Article

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