The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety

Alcohol

Volumn 45, Issue 6, 2011, Pages 567-576

  Cippitelli, Andrea ^a   Rezvani, Amir H ^b   Robinson, J Elliott ^a   Eisenberg, Lindsay ^a   Levin, Edward D ^b   Bonaventure, Pascal ^c   Motley, S Timothy ^c   Lovenberg, Timothy W ^c   Heilig, Markus ^a   Thorsell, Annika ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Alcohol drinking; Alcohol preferring rats; Anxiety; Neuropeptide Y; Relapse; Y2 receptor

Indexed keywords

JNJ 31020028; N [4 [4 [2 (DIETHYLAMINO) 2 OXO 1 PHENYLETHYL]PIPERAZINYL 1 YL] 3 FLUOROPHENYL] 2 PYRIDIN 3 YLBENZAMIDE; NALTREXONE; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y2 RECEPTOR; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; DRUG DOSE COMPARISON; DRUG PENETRATION; DRUG SEEKING BEHAVIOR; DRUG SELECTIVITY; FOOTSHOCK; HANGOVER; INSTRUMENTAL CONDITIONING; MALE; MAZE TEST; NONHUMAN; RAT; REINFORCEMENT; STRESS; TRANQUILIZING ACTIVITY;

ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; ANXIETY DISORDERS; BENZAMIDES; CONDITIONING, OPERANT; ETHANOL; INJECTIONS, INTRAVENTRICULAR; MODELS, ANIMAL; NEUROPEPTIDE Y; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, NEUROPEPTIDE Y; RECURRENCE; REINFORCEMENT (PSYCHOLOGY); SELF ADMINISTRATION; SUBSTANCE WITHDRAWAL SYNDROME;

ANIMALIA; RATTUS;

EID: 79961208929     PISSN: 07418329     EISSN: 18736823     Source Type: Journal    
DOI: 10.1016/j.alcohol.2010.09.003     Document Type: Article

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