Neuropeptide Y administration into the amygdala suppresses ethanol drinking in alcohol-preferring (P) rats following multiple deprivations

Pharmacology Biochemistry and Behavior

Volumn 90, Issue 3, 2008, Pages 470-474

  Gilpin, Nicholas W ^b   Stewart, Robert B ^a   Badia Elder, Nancy E ^a  

^a PURDUE UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Abstinence; Alcohol preferring rats; Allostasis; Amygdala; Anxiety; Deprivation; Neuropeptide Y

Indexed keywords

ALCOHOL; NEUROPEPTIDE Y;

ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ALCOHOLISM; AMYGDALOID NUCLEUS; ARTICLE; CEREBROSPINAL FLUID; DRINKING BEHAVIOR; FOOD INTAKE; NONHUMAN; PRIORITY JOURNAL; RAT;

ALCOHOL DRINKING; AMYGDALA; ANIMALS; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FEMALE; MICROINJECTIONS; NEUROPEPTIDE Y; RATS; STEREOTAXIC TECHNIQUES; SUBSTANCE WITHDRAWAL SYNDROME;

RATTUS;

EID: 46549089702     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.04.005     Document Type: Article

References (44)

1. Badia-Elder N.E., Stewart R.B., Powrozek T.A., Roy K.F., Murphy J.M., and Li T.-K. Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) rats. Alcohol Clin Exp Res 25 (2001) 386-390
2. Badia-Elder N.E., Stewart R.B., Powrozek T.A., Murphy J.M., and Li T.-K. Effects of neuropeptide Y on sucrose and ethanol intake and on the elevated plus maze test of anxiety in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Alcohol Clin Exp Res 27 (2003) 894-899
3. Britton K.T., Southerland S., Van Uden E., Kirby D., Rivier J., and Koob G. Anxiolytic activity of NPY receptor agonists in the conflict test. Psychopharmacol 132 (1997) 6-13
4. Broqua P., Wettstein J.G., Rocher M.N., Gauthier-Martin B., and Junien J.L. Behavioral effects of neuropeptide receptor agonists in the elevated plus-maze and fear-potentiated startle procedure. Behav Pharmacol 6 (1995) 215-222
5. Davis M. The role of the amygdala in fear and anxiety. Annu Rev Neurosci 15 (1992) 353-375
6. Ehlers C.L., Li T.-K., Lumeng L., Hwang B.H., Somes C., Jiminez P., et al. Neuropeptide Y levels of ethanol-naïve alcohol-preferring and -nonpreferring rats and in Wistar rats after ethanol exposure. Alcohol Clin Exp Res 22 (1998) 1778-1782
7. Finney J.W., and Moos R.H. The long-term course of treated alcoholism: I. Mortality, relapse and remission rates and comparisons with community controls. J Stud Alcohol 52 (1991) 44-54
8. Gatto G.J., Murphy J.M., Waller M.B., McBride W.J., Lumeng L., and Li T.K. Chronic ethanol tolerance through free-choice drinking in the P line of alcohol-preferring rats. Pharmacol Biochem Behav 28 (1987) 111-115
9. Gilpin N.W., Stewart R.B., Murphy J.M., Li T.-K., and Badia-Elder N.E. Neuropeptide Y reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence. Alcohol Clin Exp Res 27 (2003) 787-794
10. Gilpin N.W., Stewart R.B., Murphy J.M., and Badia-Elder N.E. Neuropeptide Y in the paraventricular nucleus of the hypothalamus increases ethanol intake in high- and low-alcohol-drinking rats. Alcohol Clin Exp Res 28 (2004) 1492-1498
11. Gilpin N.W., Stewart R.B., Murphy J.M., and Badia-Elder N.E. Sensitized effects of neuropeptide Y on multiple ingestive behaviors in P rats following ethanol abstinence. Pharmacol Biochem Behav 81 (2005) 740-749
12. Heilig M., Söderpalm B., Engel J.A., and Widerlöv E. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology 98 (1989) 524-529
13. Heilig M., McLeod S., Koob G.F., and Britton K.T. Anxiolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test. Regulatory Pept 41 (1992) 61-69
14. Heilig M., McLeod S., Brot M., Heinrichs S.C., Menzaghi F., Koob G.F., et al. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology 8 (1993) 357-363
15. Hwang B.H., Zhang J.K., Ehlers C.L., Lumeng L., and Li T.-K. Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdale between selectively bred rats with high and low alcohol preference. Alcohol Clin Exp Res 23 (1999) 1023-1030
16. Kampov-Polevoy A.B., Matthews D.B., Gause L., Morrow A.L., and Overstreet D.H. P rats develop physical dependence on alcohol via voluntary drinking: changes in seizure thresholds, anxiety, and patterns of alcohol drinking. Alcohol Clin Exp Res 24 (2000) 278-284
17. Katner S.N., Slawecki C.J., and Ehlers C.L. Neuropeptide Y administration into the third ventricle does not increase sucrose or ethanol self-administration but does affect the cortical EEG and increases food intake. Psychopharmacology 160 (2002) 146-154
18. Katner S.N., Slawecki C.J., and Ehlers C.L. Neuropeptide Y administration into the amygdala does not affect ethanol consumption. Alcohol 28 (2002) 29-38
19. Kelley S.P., Nannini M.A., Bratt A.M., and Hodge C.W. Neuropeptide-Y in the paraventricular nucleus increases ethanol self-administration. Peptides 22 (2001) 515-522
20. Koob G.F., and LeMoal M. Drug abuse: hedonic homeostatic dysregulation. Science 278 (1997) 52-58
21. Li T.K., Lumeng L., McBride W.J., Waller M.B., and Hawkins D.T. Progress toward a voluntary oral-consumption model of alcoholism. Drug Alcohol Dep 4 (1979) 45-60
22. Lumeng L., and Li T.K. The development of metabolic tolerance in the alcohol-preferring P rats: comparison of forced and free-choice drinking of ethanol. Pharmacol Biochem Behav 25 (1986) 1013-1020
23. Lumeng L., Murphy J.M., McBride W.J., and Li T.-K. Genetic influences on alcohol preference in animals. In: Begleiter H., and Kissin B. (Eds). The Genetics of Alcoholism (1995), Oxford University Press, New York 165-201
24. McBride W.J. Central nucleus of the amygdala and the effects of alcohol and alcohol-drinking behavior in rodents. Pharmacol Biochem Behav 71 (2002) 509-515
25. Murphy J.M., Gatto G.J., Waller M.B., McBride W.J., Lumeng L., and Li T.-K. Effects of scheduled access on ethanol intake by the alcohol-preferring (P) line of rats. Alcohol 3 (1986) 331-336
26. National Research Council. Guide for the Care and Use of Laboratory Animals (1996), National Research Council, Washington D.C.
27. 1-mediated mechanism. Eur J Neurosci 13 (2001) 2241-2246
28. Pandey S.C., Zhang H., Roy A., and Xu T. Deficits in amygdaloid cAMP-responsive element-binding protein signaling play a role in genetic predisposition to anxiety and alcoholism. J Clin Invest 115 (2005) 2762-2773
29. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 4th ed (1998), Academic Press, San Diego, CA
30. Primeaux S.D., Wilson S.P., Bray G.A., York D.A., and Wilson M.A. Overexpression of neuropeptide Y in the central nucleus of the amygdala decreases ethanol self administration in "anxious" rats. Alcohol Clin Exp Res 30 (2006) 791-801
31. Rimondini R., Thorsell A., and Heilig M. Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence. Neurosci Letters 375 (2005) 129-133
32. Roy A., and Pandey S.C. The decreased cellular expression of neuropeptide Y protein in rat brain structures during ethanol withdrawal after chronic ethanol exposure. Alcohol Clin Exp Res 26 (2002) 796-803
33. Sajdyk T.J., Vandergriff M.G., and Gehlert D.R. Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur J Pharmacol 368 (1999) 143-147
34. Sajdyk T.J., Johnson P.L., Leitermann R.J., Fitz S.D., Dietrich A., Morin M., et al. Neuropeptide Y in the amygdala induces long-term resilience to stress-induced reductions in social responses but not hypothalamic-adrenal-pituitary axis activity or hyperthermia. J Neurosci 28 (2008) 893-903
35. Schroeder J.P., Olive F., Koenig H., and Hodge C.W. Intra-amygdala infusion of the NPY Y1 receptor antagonist BIBP 3226 attenuates operant ethanol self-administration. Alcohol Clin Exp Res 27 (2003) 1884-1891
36. Slawecki C.J., Betancourt M., Walpole T., and Ehlers C.L. Increases in sucrose consumption, but not ethanol consumption, following ICV NPY administration. Pharmacol Biochem Behav 66 (2000) 591-594
37. Spanagel R., and Hölter S.M. Pharmacological validation of a new animal model of alcoholism. J Neural Trans 107 (2000) 669-680
38. Stanley B.G., Chin A.S., and Leibowitz S.F. Feeding and drinking elicited by central injection of neuropeptide Y: evidence for a hypothalamic site(s) of action. Brain Res Bull 14 (1985) 521-524
39. Thorsell A., Slawecki C.J., and Ehlers C.L. Effects of neuropeptide Y on appetitive and consummatory behaviors associated with alcohol drinking in Wistar rats with a history of ethanol exposure. Alcohol Clin Exp Res 29 (2005) 584-590
40. Thorsell A., Slawecki C.J., and Ehlers C.L. Effects of neuropeptide Y and corticotropin-releasing factor on ethanol intake in Wistar rats: interaction with chronic ethanol exposure. Behav Brain Res 161 (2005) 133-140
41. Thorsell A., Repunte-Canonigo V., O'Dell L.E., Chen S.A., King A.R., Lekic D., et al. Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats. Brain 130 (2007) 1330-1337
42. Valdez G.R., and Koob G.F. Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism. Pharmacol Biochem Behav 79 (2004) 671-689
43. Valdez G.R., Roberts A.J., Chan K., Davis H., Brennan M., Zorrilla E.P., et al. Increased ethanol self-administration and anxiety-like behavior during acute withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcohol Clin Exp Res 26 (2002) 1494-1501
44. Waller M.B., McBride W.J., Lumeng L., and Li T.-K. Induction of dependence on ethanol by free-choice drinking in alcohol-preferring rats. Pharmacol Biochem Behav 16 (1982) 501-507