Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats

Neuroscience Letters

Volumn 332, Issue 1, 2002, Pages 1-4

  Tokuno, Hironobu ^a,b   Chiken, Satomi ^a,c   Kametani, Kiyokazu ^d   Moriizumi, Tetsuji ^e  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^d SHINSHU UNIVERSITY   (Japan)

^e SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Alcoholism; Neuropeptide Y; Y2 receptor antagonism

Indexed keywords

ALCOHOL; N [2 [1,2 DIHYDRO 3,5(4H) DIOXO 1,2 DIPHENYL 1,2,4 TRIAZOL 4 YL]ETHYL] N2 [[1 [2 [4 [5,11 DIHYDRO 6(6H) OXODIBENZ[B,E]AZEPIN 11 YL] 1 PIPERAZINYL] 2 OXOETHYL]CYCLOPENTYL]ACETYL]ARGININAMIDE; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR ANTAGONIST; RECEPTOR BLOCKING AGENT; SACCHARIN; UNCLASSIFIED DRUG;

ALCOHOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SELECTIVITY; INSTRUMENTAL CONDITIONING; LOCOMOTION; MALE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SEDATION;

ALCOHOL DRINKING; ANIMALS; ARGININE; BENZAZEPINES; CONDITIONING, OPERANT; ETHANOL; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR; RECEPTORS, NEUROPEPTIDE Y; SELF ADMINISTRATION;

EID: 0037174775     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00904-7     Document Type: Article

References (22)

1. Badia-Elder N.E., Stewart R.B., Powrozek T.A., Roy K.F., Murphy J.M., Li T.K. Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol-preferring (P), and nonpreferring (NP) rats. Alcohol. Clin. Exp. Res. 25:2001;386-390.
2. Broqua P., Wettstein J.G., Rocher M.N., Gauthier-Martin B., Junien J.L. Behavioral effects of neuropeptide receptor agonists in the elevated plus-maze and fear-potentiated startle procedure. Behav. Pharm. 6:1995;215-222.
3. Caberlotto L., Thorsell A., Rimondini R., Sommer W., Hyytia P., Heilig M. Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol. Clin. Exp. Res. 25:2001;1564-1569.
4. Caberlotto L., Thorsell A., Rimondini R., Sommer W., Hyytia P., Heilig M. Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats. Alcohol. Clin. Exp. Res. 25:2001;1564-1569.
5. Dumont Y., Cadieux A., Doods H., Pheng L.H., Abounader R., Hamel E., Jacques D., Regoli D., Quirion R. BIIE0246, a potent and highly selective non-peptide neuropeptide YY2 receptor antagonist. Br. J. Pharm. Sci. 129:2000;1075-1088.
6. Ehlers C.L., Li T.K., Lumeng L., Hwang B.H., Somes C., Jimenez P., Mathe A.A. Neuropeptide Y levels in ethanol-naive, alcohol-preferring, and nonpreferring rats and in Wistar rats after ethanol exposure. Alcohol. Clin. Exp. Res. 22:1998;1778-1782.
7. Ehlers C.L., Somes C., Cloutier D. Are some of the effects of ethanol mediated through NPY? Psychopharmacology. 139:1998;136-144.
8. Ehlers C.L., Somes C., Li T.K., Lumeng L., Hwang B.H., Jimenez P., Mathe A.A. Calcitonin gene-related peptide (CGRP) levels and alcohol. Int. J. Neuropsychopharmacol. 2:1999;173-179.
9. Gonzales R.A., Weiss F. Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens. J. Neurosci. 18:1998;10663-10671.
10. Heilig M., McLeod S., Brot M., Heinrichs S.C., Menzaghi F., Koob G.F., Britton K.T. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. J. Neuropsychopharmacol. 8:1993;357-363.
11. Heilig M., Widerlöv E. Neurobiology and clinical aspects of neuropeptide Y. Crit. Rev. Neurobiol. 9:1995;115-136.
12. Hwang B.H., Zhang J.K., Ehlers C.L., Lumeng L., Li T.K. Innate differences of neuropeptide Y (NPY) in hypothalamic nuclei and central nucleus of the amygdala between selectively bred rats with high and low alcohol preference. Alcohol. Clin. Exp. Res. 23:1999;1023-1030.
13. Kauhanen J., Karvonen M.K., Pesonen U., Koulu M., Tuomainen T.P., Uusitupa M.I., Salonen J.T. Neuropeptide Y polymorphism and alcohol consumption in middle-aged men. Am. J. Med. Gen. 93:2000;117-121.
14. Kelley S.P., Nannini M.A., Bratt A.M., Hodge C.W. Neuropeptide-Y in the paraventricular nucleus increases ethanol self-administration. Peptides. 22:2001;515-522.
15. King P.J., Widdowson P.S., Doods H.N., Williams G. Regulation of neuropeptide Y release by neuropeptide Y receptor ligands and calcium channel antagonists in hypothalamic slices. J. Neurochem. 73:1999;641-646.
16. McQuiston A.R., Colmers W.F. Neuropeptide Y2 receptors inhibit the frequency of spontaneous but not miniature EPSCs in CA3 pyramidal cells of rat hippocampus. J. Neurophysiol. 76:1996;3159-3168.
17. Michel M.C., Beck-Sickinger A.G., Cox H., Doods H.N., Herzog H., Larhammar D., Quirion R., Schwartz T., Westfall T. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharm. Rev. 50:1998;143-150.
18. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 2nd edition: 1986;Academic Press, San Diego, CA.
19. Sajdyk T.J., Vandergriff M.G., Gehlert D.R. Amygdalar neuropeptide Y Y-1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur. J. Pharm. 368:1999;143-147.
20. Slawecki C.J., Betancourt M., Walpole T., Ehlers C.L. Increases in sucrose consumption, but not ethanol consumption, following ICV NPY administration. Pharm. Biochem. Behav. 66:2000;591-594.
21. Thiele T.E., Marsh D.J., Ste M., Bernstein I.L., Palmiter R.D. Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature. 396:1998;366-369.
22. Wahlestedt C., Pich E.M., Koob G.F., Yee F., Heilig M. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science. 259:1993;528-531.