Characterization of neuropeptide Y, Y2 receptor knockout mice in two animal models of learning and memory processing

Journal of Molecular Neuroscience

Volumn 22, Issue 3, 2004, Pages 159-166

  Redrobe, John Paul ^a   Dumont, Yvan ^a   Herzog, Herbert ^b   Quirion, Rémi ^a  

^a MCGILL UNIVERSITY   (Canada)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Learning; Mice; Neuropeptide Y; Object recognition; Water maze; Y2 receptors

Indexed keywords

NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; WATER; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DETERIORATION; EXPOSURE; HYPOTHESIS; KNOCKOUT MOUSE; LEARNING; LOCOMOTION; MALE; MAZE TEST; MEMORY; MENTAL PERFORMANCE; MENTAL STRESS; MOUSE; NEUROMODULATION; NONHUMAN; OPEN FIELD BEHAVIOR; RECOGNITION; STATISTICAL SIGNIFICANCE; SWIMMING; TASK PERFORMANCE; VELOCITY; ANIMAL; ANIMAL MODEL; BRAIN; BRAIN LEVEL; GENETICS; LEARNING DISORDER; MEMORY DISORDER; METABOLISM; MOTOR ACTIVITY; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALIA;

ANIMALS; BRAIN; BRAIN CHEMISTRY; LEARNING; LEARNING DISORDERS; MALE; MAZE LEARNING; MEMORY; MEMORY DISORDERS; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; MOTOR ACTIVITY; NEUROPEPTIDE Y; RECEPTORS, NEUROPEPTIDE Y; RECOGNITION (PSYCHOLOGY);

EID: 2942578993     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:22:3:159     Document Type: Article

References (43)

1. 2 receptors regulate bone formation. J. Clin. Invest. 109, 915-921.
2. Bouchard P., Maurice T., St-Pierre S., Privat A., and Quirion R. (1997) Neuropeptide Y and calcitonin gene-related peptide attenuate learning impairments induced by MK-801 via a sigma receptor-related mechanism. Eur. J. Neurosci. 9, 2142-2151.
3. Buckley T. J. and Gaffan D. (1998) Perirhinal cortex albation impairs visual object identification. J. Neurosci. 18, 2268-2275.
4. Colmers W. F. and Bleakman D. (1994) Effects of neuropeptide Y on the electrical properties of neurons. Trends Neurosci. 17, 373-379.
5. D'Hooge R. and De Deyn P. P. (2001) Applications of the Morris water maze in the study of learning and memory. Brain Res. Rev. 36, 60-90.
6. Dumont Y., Jacques D., St-Pierre J. A., and Quirion R. (1997) Neuropeptide Y receptor types in the mammalian brain: species differences and status in the human central nervous system, in Neuropeptide Y and Drug Development, Grundemar, L., and Bloom, S. R., eds., Academic Press, London, UK, pp. 57-86.
7. Dumont Y., Jacques D., St-Pierre J. A., Tong Y., Parker R., Herzog H., and Quirion R. (2000) Neuropeptide Y, peptide YY and pancreatic polypeptide receptor proteins and mRNAs in mammalian brain, in Handbook of Chemical Neuroanatomy, vol 16, Quirion, R., Bjorklund, A., and Hokfelt, T., eds., Elsevier, London, UK, pp. 375-475.
8. Ennaceur A. and Aggleton J. P. (1997) The effects of neurotoxic lesions of the perirhinal cortex combined to fornix transection on object recognition memory in the rat. Behav. Brain Res. 88, 181-193.
9. Ennaceur A. and Delacour J. (1988) A new one-trial test for neurobiological studies of memory in rats. I. Behavioral data. Behav. Brain Res. 31, 47-59.
10. Ennaceur A., Neave N., and Aggleton J. P. (1996) Neurotoxic lesions of the perirhinal cortex do not mimic the behavioral effects of fornix transection in the rat. Behav. Brain Res. 80, 9-25.
11. Flood J. F., Baker M. L., Hernandez E. N., and Morley J. E. (1989) Modulation of memory processing by neuropeptide Y varies with brain injection site. Brain Res. 503, 73-82.
12. Flood J. F., Hernandez E. N., and Morley J. E. (1987) Modulation of memory processing by neuropeptide Y. Brain Res. 421, 280-290.
13. Gallagher M., Burwell R., and Burchinal M. (1993) Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze. Behav. Neurosci. 107, 618-626.
14. Gerlai R. (2001) Behavioral tests of hippocampal function: simple paradigms complex problems. Behav. Brain Res. 125, 269-277.
15. Gray J. A. and Lalljee B. (1974) Sex differences in emotional behaviour in the rat: correlation between open-field defecation and active avoidance. Anim. Behav. 22, 856-861.
16. Gustafson E. L., Smith K. E., Durkin M. M., Walker M. W., Gerald C., Weinshank R., and Branchek T. A. (1997) Distribution of the neuropeptide Y Y2 receptor mRNA in rat central nervous system. Mol. Brain Res. 46, 223-235.
17. Heilig M. (1993) Neuropeptide Y in relation to behavior and psychiatric disorders, in The Biology of Neuropeptide Y and Related Peptides, Colmers, W. F., and Wahlesdtedt, C., eds., Humana Press, Totowa, NJ, pp. 511-554.
18. Heilig M., McLeod S., Koob G. K., and Britton K. T. (1992) Anxiolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test. Regul. Pept. 41, 61-69.
19. Heilig M., Soderpalm B., Engel J. A., and Widerlov E. (1989) Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology 98, 524-529.
20. Kask A., Harro J., von Horsten S., Redrobe J. P., Dumont Y., and Ouirion R. (2002) The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neurosci. Biobehav. Rev. 26, 259-283.
21. King P. J., Williams G., Doods H., and Widdowson P. S. (2000) Effect of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246 on neuropeptide Y release. Eur. J. Pharmacol. 396, R1-R3.
22. Kornecook T. J., Kippin T. E., and Pinel J. P. J. (1999) Basal forebrain damage and object-recognition in rats. Behav. Brain Res. 98, 67-76.
23. Majlessi N. and Naghdi N. (2002) Impaired spatial learning in the Morris water maze induced by serotonin reuptake inhibitors. Behav. Pharmacol. 13, 237-242.
24. Michel M. C., Beck-Sickinger A., Cox H., Doods H. N., Herzog H., Larhammar D., et al. (1998) International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 50, 143-150.
25. Morley J. E. and Flood J. F. (1990) Neuropeptide Y and memory processing. Ann. N. Y. Acad. Sci. 611, 226-231.
26. Morris R. G. M., Garrud P., Rawlins J. N. P., and O'Keefe J. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297, 681-683.
27. Nakajima M., Inui A., Teranishi A., Miura M., Hirosue Y., Okita M., et al. (1994) Effects of PP family peptides on feeding and learning behavior in mice. J. Pharmacol. Exp. Ther. 268, 1010-1014.
28. Poucet B. (1993) Spatial cognitive maps in animals: new hypotheses on their structure and neural mechanisms. Psychol. Rev. 100, 163-182.
29. Redrobe J. P., Dumont Y., Fournier A., and Ouirion R. (2002). The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology 26, 615-624.
30. Redrobe J. P., Dumont Y., Herzog H., and Ouirion R. (2003) Neuropeptide Y (NPY) Y2 receptors mediate behaviour in two animal models of anxiety: evidence from NPY Y2 receptor knockout mice. Behav. Brain Res. 141, 251-255.
31. Redrobe J. P., Dumont Y., and Quirion R. (2001) Neuropeptide Y as a potential target for the treatment of depressive illness: Y not? Neurosci. News 4, 61-68.
32. Redrobe J. P., Dumont Y., St-Pierre J. A., and Quirion R. (1999) Multiple receptors for neuropeptide Y in the hippocampus: putative roles in seizures and cognition. Brain Res. 848, 153-166.
33. Sainsbury A., Schwarzer C., Couzens M., Fetissov S., Furtinger S., Jenkins A., et al. (2002). Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc. Natl. Acad. Sci. USA 99, 8938-8943.
34. Smith-White M. A., Herzog H., and Potter E. K. (2002) Role of neuropeptide Y Y(2) receptors in modulation of cardiac parasympathetic neurotransmission. Regul. Pept. 103, 105-111.
35. Stanley B. G. and Leibowitz S. F. (1984) Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci. 35, 2635-2642.
36. Steckler T., Drinkenburg W. H. I. M., Sahal A., and Aggleton J. P. (1998) Recognition memory in rats. II. Neuroanatomical substrates. Prog. Neurobiol. 54, 313-332.
37. Stogner K. A. and Holmes P. V. (2000) Neuropeptide-Y exerts antidepressant-like effects in the forced swim test in rats. Eur. J. Pharmacol. 387, R9-R10.
38. Thorsell A., Michalkiewicz M., Dumont Y., Quirion R., Caberlotto L., Rimondini R., et al. (2000) Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression. Proc. Natl. Acad. Sci. USA 97, 12852-12857.
39. Vaucher E., Fluit P., Chisti M. A., Westaway D., Mount H. T. J., and Kar S. (2002a) Object recognition memory and cholinergic parameters in mice expressing human presenilin 1 transgenes. Exp. Neurol. 175, 398-406.
40. Vaucher E., Reymond I., Najaffe R., Kar S., Quirion R., Miller M. M., and Franklin K. B. J. (2002b) Estrogen effects on object memory and cholinergic receptors in young and old female mice. Neurobiol. Aging 23, 87-95.
41. Vezzani A., Sperk G., and Colmers W. F. (1999) Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci. 22, 25-30.
42. Weiser T., Wieland H. A., and Doods H. N. (2000) Effects of the neuropeptide Y Y2 receptor antagonist BIIE0246 on presynaptic inhibition by neuropeptide Y in rat hippocampal slices. Eur. J. Pharmacol. 404, 133-136.
43. Whishaw I. Q., Cassel J. C., and Jarrard L. E. (1995) Rats with fimbria-fornix lesions display a place response in a swimming pool: a dissociation between getting there and knowing where. J. Neurosci. 15, 5779-5788.