Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: The Polish multicenter analysis

Pediatric Blood and Cancer

Volumn 57, Issue 4, 2011, Pages 578-582

  Peregud Pogorzelski, Jaroslaw ^a   Tetera Rudnicka, Edyta ^a   Kurzawski, Mateusz ^a   Brodkiewicz, Andrzej ^a   Adrianowska, Natalia ^b   Mlynarski, Wojciech ^b   Januszkiewicz, Danuta ^c   Drozdzik, Marek ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

^c POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Acute lymphoblastic leukemia; Genetic polymorphism; Thiopurine; Thiopurine S methyltransferase

Indexed keywords

MERCAPTOPURINE; METHOTREXATE; THIOPURINE METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ANEMIA; ARTICLE; BONE MARROW TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CHILD; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; GENE; GENE FREQUENCY; GENOTYPE; HUMAN; LEUKOPENIA; LIVER TOXICITY; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; POLAND; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHOOL CHILD; THROMBOCYTOPENIA; TPMT GENE;

6-MERCAPTOPURINE; ADOLESCENT; ADULT; ANTIMETABOLITES, ANTINEOPLASTIC; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; HUMANS; INFANT; MALE; METHYLTRANSFERASES; POLAND; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RISK FACTORS; YOUNG ADULT;

EID: 79961186529     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.23013     Document Type: Article

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