Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients

Leukemia

Volumn 23, Issue 5, 2009, Pages 971-974

  Karas Kuzelicki, N ^a   Jazbec, J ^b   Milek, M ^a   Mlinaric Rascan, I ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY CHILDREN S HOSPITAL   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); MERCAPTOPURINE; METHOTREXATE; THIOPURINE METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD TOXICITY; CANCER INCIDENCE; CANCER MORTALITY; CANCER RELAPSE; CHILD; CHILDHOOD LEUKEMIA; CYTOTOXICITY; DRUG DOSE REDUCTION; DRUG MECHANISM; DRUG WITHDRAWAL; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HETEROZYGOSITY; HUMAN; INFECTION; LEUKOPENIA; LOW DRUG DOSE; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SECOND CANCER; STOMATITIS; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 67349097159     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2008.317     Document Type: Article

References (6)

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5. Arenas M, Simpson G, Lewis CM, Shobowale-Bakre el-M, Escuredo E, Fairbanks LD et al. Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity. Clin Chem 2005; 51: 2371-2373.
6. Evans WE, Hon YY, Bomgaars L, Coutre S, Holdsworth M, Janco R et al Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine. J Clin Oncol 2001; 19: 2293-2301.