Should TPMT genotype and activity be used to monitor 6-mercaptopurine treatment in children with acute lymphoblastic leukaemia?

Journal of Clinical Pharmacy and Therapeutics

Volumn 32, Issue 6, 2007, Pages 633-639

  Fakhoury, M ^a   Andreu Gallien, J ^a   Mahr, A ^b   Medard, Y ^a   Azougagh, S ^a   Vilmer, E ^a   Jacqz Aigrain, E ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b Cochin Hospital ^*  (France)

Author keywords

6 mercaptopurine; Acute lymphoblastic leukaemia; Genotype; Pharmacogenetics; Phenotype; Thiopurine S methyltransferase

Indexed keywords

CYTARABINE; HYDROCORTISONE; MERCAPTOPURINE; METHOTREXATE; PURINE DERIVATIVE; THIOGUANOSINE; THIOPURINE METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; COMBINATION CHEMOTHERAPY; DISEASE COURSE; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG METABOLISM; DRUG MONITORING; DRUG SAFETY; ENZYME ACTIVITY; GENETIC POLYMORPHISM; GENOTYPE; HEMATOLOGIC DISEASE; HUMAN; LEUKOCYTE COUNT; LIQUID CHROMATOGRAPHY; LIVER DISEASE; LIVER DYSFUNCTION; MAINTENANCE THERAPY; MUCOSA INFLAMMATION; PHENOTYPE; RISK FACTOR;

6-MERCAPTOPURINE; ADOLESCENT; ANTIMETABOLITES, ANTINEOPLASTIC; CHILD; CHILD, PRESCHOOL; ERYTHROCYTES; FEMALE; GENOTYPE; HUMANS; INFANT; MALE; METHYLTRANSFERASES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 36249017274     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2007.00858.x     Document Type: Article

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