Pharmacokinetics, dose adjustments, and 6-mercaptopurine/ methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency

Acta Paediatrica, International Journal of Paediatrics

Volumn 87, Issue 1, 1998, Pages 108-111

  Brandt Andersen, J ^a   Szumlanski, C ^b   Weinshilboum, R M ^b   Schmiegelow, K ^a  

^a Rigshospitalet   (Denmark)

^b MAYO CLINIC COLLEGE OF MEDICINE   (United States)

Author keywords

6 mercaptopurine; Acute lymphoblastic leukaemia; Methotrexate; Thiopurine methyltransferase deficiency

Indexed keywords

MERCAPTOPURINE; METHOTREXATE; THIOPURINE METHYLTRANSFERASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW SUPPRESSION; CANCER CHEMOTHERAPY; CASE REPORT; DRUG POTENTIATION; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENOTYPE; HUMAN; MALE; PANCYTOPENIA; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL;

6-MERCAPTOPURINE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FOLLOW-UP STUDIES; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; METHOTREXATE; METHYLTRANSFERASES;

EID: 0031933720     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1080/08035259850158001     Document Type: Article

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