P2-P1′ macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 16, 2011, Pages 4917-4927

  Lampa, Anna ^a   Ehrenberg, Angelica E ^b   Vema, Aparna ^a   Kerblom, Eva ^a   Lindeberg, Gunnar ^a   Helena Danielson, U ^b   Karlén, Anders ^a   Sandström, Anja ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

HCV; Macrocyclization; Metathesis; Phenylglycine; Protease inhibitors

Indexed keywords

HEPATITIS C VIRUS NS3 PROTEASE INHIBITOR; PHENYLGLYCINE; PROTEINASE INHIBITOR; REAGENT; TOLUENE DERIVATIVE; TRIFLUOROTOLUENE; UNCLASSIFIED DRUG; VIRUS RNA; ANTIVIRUS AGENT; DRUG DERIVATIVE; ENZYME INHIBITOR; GLYCINE; MACROCYCLIC COMPOUND; NS3 PROTEIN, HEPATITIS C VIRUS; VIRUS PROTEIN;

ARTICLE; CATALYST; CHEMICAL BOND; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DRUG BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HEATING; HUMAN; HUMAN CELL; ISOMER; MACROCYCLIZATION; METHODOLOGY; MICROWAVE IRRADIATION; MOLECULAR INTERACTION; MOLECULAR MODEL; RING CLOSING METATHESIS; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; HEPATITIS C; HEPATITIS C VIRUS; MICROWAVE RADIATION; MOLECULARLY TARGETED THERAPY; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE; VIRUS REPLICATION;

HEPATITIS C VIRUS;

ANTIVIRAL AGENTS; CELL LINE, TUMOR; DRUG DESIGN; ENZYME INHIBITORS; GLYCINE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; MACROCYCLIC COMPOUNDS; MICROWAVES; MOLECULAR TARGETED THERAPY; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 79961169191     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.064     Document Type: Article

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