-
1
-
-
34548239642
-
-
World health organization Fact sheet number 164, October
-
(a) World health organization Fact sheet number 164, October 2000.
-
(2000)
-
-
-
2
-
-
0033916804
-
Epidemiology of hepatitis C: Geographic differences and temporal trends
-
(b) Wasley, A. Alter, M. J. Epidemiology of hepatitis C: Geographic differences and temporal trends. Semin. Liver Dis. 2000, 20, 1-16
-
(2000)
Semin. Liver Dis
, vol.20
, pp. 1-16
-
-
Wasley, A.1
Alter, M.J.2
-
3
-
-
0242456086
-
-
Brown, R. S. Jr.; Gaglio, P. J. Scope of worldwide hepatitis C problem. Liver Transpl. Liver transplantation: Official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2003, 9(11), S10-S13.
-
Brown, R. S. Jr.; Gaglio, P. J. Scope of worldwide hepatitis C problem. Liver Transpl. Liver transplantation: Official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2003, 9(11), S10-S13.
-
-
-
-
4
-
-
0032547938
-
Interferon alpha-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis
-
(a) McHutchison, J. G.; Gordon, S. C.; Schiff, E. R.; Shiffman, M. L.; Lee, W. M.; Rustgi, V. K.; Goodman, Z. D.; Ling, M-H.; Cort, S.; Albrecht, J K.; Interferon alpha-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N. Engl. J. Med. 1998, 339, 1485-1492.
-
(1998)
C. N. Engl. J. Med
, vol.339
, pp. 1485-1492
-
-
McHutchison, J.G.1
Gordon, S.C.2
Schiff, E.R.3
Shiffman, M.L.4
Lee, W.M.5
Rustgi, V.K.6
Goodman, Z.D.7
Ling, M.-H.8
Cort, S.9
Albrecht, J.K.10
-
5
-
-
0032547944
-
-
Davis, G. L.; Esteban-Mur, R.; Rustgi, V.; Hoefs, J; Gordon, S. C.; Trepo, C.; Shiffman, Mitchell L.; Zeuzem, S.; Craxi, A.; Ling, M-H.; Albrecht, J. Interferon alpha-2b alone or in combination with ribavirin for treatment of replapse of chronic hepatitis C. N. Engl. J. Med. 1998, 339, 1493-1499.
-
(b) Davis, G. L.; Esteban-Mur, R.; Rustgi, V.; Hoefs, J; Gordon, S. C.; Trepo, C.; Shiffman, Mitchell L.; Zeuzem, S.; Craxi, A.; Ling, M-H.; Albrecht, J. Interferon alpha-2b alone or in combination with ribavirin for treatment of replapse of chronic hepatitis C. N. Engl. J. Med. 1998, 339, 1493-1499.
-
-
-
-
6
-
-
0034619946
-
Peginterferon alpha-2a in patients with chronic hepatitis C
-
(c) Zeuzem, S.; Feinman, S. V.; Rasenack, J.; Heathcote, E. J.; Lai, M.-Y.; Gane, E.; O'Grady, J.; Reichen, J.; Diago, M., Lin, A., Hoffman, J.; Brunda, M. J. Peginterferon alpha-2a in patients with chronic hepatitis C. N. Engl. J. Med. 2000, 343, 1666-1672.
-
(2000)
N. Engl. J. Med
, vol.343
, pp. 1666-1672
-
-
Zeuzem, S.1
Feinman, S.V.2
Rasenack, J.3
Heathcote, E.J.4
Lai, M.-Y.5
Gane, E.6
O'Grady, J.7
Reichen, J.8
Diago, M.9
Lin, A.10
Hoffman, J.11
Brunda, M.J.12
-
7
-
-
0034619980
-
Peginterferon alpha-2a in patients with chronic hepatitis C and cirrhosis
-
(d) Heathcote, E. J.; Shiffiman, M. L.; Cooksley, W. G. E.; Dusheiko, G. M.; Lee, S. S.; Balart, L., Reindollar, R.; Reddy, R. K.; Wright, T. L.; Lin, A.; Hoffman, J.; De Pamphilis, J. Peginterferon alpha-2a in patients with chronic hepatitis C and cirrhosis. N. Engl J. Med. 2000, 343, 1673-1680.
-
(2000)
N. Engl J. Med
, vol.343
, pp. 1673-1680
-
-
Heathcote, E.J.1
Shiffiman, M.L.2
Cooksley, W.G.E.3
Dusheiko, G.M.4
Lee, S.S.5
Balart, L.6
Reindollar, R.7
Reddy, R.K.8
Wright, T.L.9
Lin, A.10
Hoffman, J.11
De Pamphilis, J.12
-
8
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferon α -2b plus ribavirin for initial treatment of chronic hepatitis C: A randomized trial
-
and International Hepatitis Interventional Therapy Group
-
(e) Manus, M. P.; McHutchison, J. G.; Gordon, S. C.; Rustgi, V.K.; Shiffman, M.; Reindollar, R.; Goodman, Z. D.; Koury, K.; Ling, M-H.; Albrecht J. K. and International Hepatitis Interventional Therapy Group. Peginterferon alfa-2b plus ribavirin compared with interferon α -2b plus ribavirin for initial treatment of chronic hepatitis C: A randomized trial. Lancet 2001, 358, 958-965.
-
(2001)
Lancet
, vol.358
, pp. 958-965
-
-
Manus, M.P.1
McHutchison, J.G.2
Gordon, S.C.3
Rustgi, V.K.4
Shiffman, M.5
Reindollar, R.6
Goodman, Z.D.7
Koury, K.8
Ling, M.-H.9
Albrecht, J.K.10
-
9
-
-
12144290054
-
-
Llinàs-Brunet, M.; Bailey, M.D; Bolger, G.; Brochu, C.; Faucher, A.M.; M.; Ferland, J. M.; Garneau, M.; Ghiro, E.; Gorys, V.; Grand-Maitre, C.; Halmos, T.; Lapeyre-Paquette, N.; Liard, F.; Poirier, M.; Rheaume, M.; Tsantrizos, Y. S.; Lamarre, D, Structure-Activity study on a novel series of macrocyclic inhibitors of the hepatitis c virus NS3 protease leading to the discovery of BILN 2061 J. Med. Chem. 2004, 47, 605-1608.
-
Llinàs-Brunet, M.; Bailey, M.D; Bolger, G.; Brochu, C.; Faucher, A.M.; M.; Ferland, J. M.; Garneau, M.; Ghiro, E.; Gorys, V.; Grand-Maitre, C.; Halmos, T.; Lapeyre-Paquette, N.; Liard, F.; Poirier, M.; Rheaume, M.; Tsantrizos, Y. S.; Lamarre, D, Structure-Activity study on a novel series of macrocyclic inhibitors of the hepatitis c virus NS3 protease leading to the discovery of BILN 2061 J. Med. Chem. 2004, 47, 605-1608.
-
-
-
-
10
-
-
12144286493
-
Inhibitors of hepatitis C virus NS3- 4A protease. Part 3: P2 proline variargs
-
(b) Perni, R. B.; Farmer, L. J.; Cottrell, K. M.; Court, J. J.; Courtney, L. F.; Deininger, D. D.; Gates, C. A.; Harbeson, S. L.; Kim, J. L.; Lin, C.; Lin, K.; Luong, Y.-P.; Maxwell, J. P.; Murcko, M. A.; Pitlik, J.; Rao, B. G.; Schairer, W. C.; Tung, R. D.; Van Drie, J. H.; Wilson, K.; Thomson, J. A. Inhibitors of hepatitis C virus NS3- 4A protease. Part 3: P2 proline variargs. Bioorg. Med. Chem Lett. 2004, 14, 1939-1942.
-
(1939)
Bioorg. Med. Chem Lett
, vol.2004
, pp. 14
-
-
Perni, R.B.1
Farmer, L.J.2
Cottrell, K.M.3
Court, J.J.4
Courtney, L.F.5
Deininger, D.D.6
Gates, C.A.7
Harbeson, S.L.8
Kim, J.L.9
Lin, C.10
Lin, K.11
Luong, Y.-P.12
Maxwell, J.P.13
Murcko, M.A.14
Pitlik, J.15
Rao, B.G.16
Schairer, W.C.17
Tung, R.D.18
Van Drie, J.H.19
Wilson, K.20
Thomson, J.A.21
more..
-
11
-
-
0348147635
-
-
Lamar, J.; Victor, F.; Snyder, N.; Johnson, R.B; Wang, Q. M.; Glass, J. I.; Chen, S.-H. Novel P4 truncated tripeptidyl α-ketoamides as HCV protease inhibitors. Bioorg. Med. Chem. Lett. 2004, 14, 263-266;
-
(c) Lamar, J.; Victor, F.; Snyder, N.; Johnson, R.B; Wang, Q. M.; Glass, J. I.; Chen, S.-H. Novel P4 truncated tripeptidyl α-ketoamides as HCV protease inhibitors. Bioorg. Med. Chem. Lett. 2004, 14, 263-266;
-
-
-
-
12
-
-
1842690556
-
Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease
-
(d) Nizi, E.; Koch, U.; Ontoria, J. M.; Marchetti, A.; Narjes, F.; Malancona, S.; Matassa, V. G.; Gardelli, C. Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease. Biorg. Med. Chem. Lett. 2004, 14, 2151-2154;
-
(2004)
Biorg. Med. Chem. Lett
, vol.14
, pp. 2151-2154
-
-
Nizi, E.1
Koch, U.2
Ontoria, J.M.3
Marchetti, A.4
Narjes, F.5
Malancona, S.6
Matassa, V.G.7
Gardelli, C.8
-
13
-
-
0037020760
-
-
1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease, Biorg. Med. Chem. Lett. 2002, 12, 3199.
-
1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease, Biorg. Med. Chem. Lett. 2002, 12, 3199.
-
-
-
-
14
-
-
0034678789
-
-
Han, W.; Hu, Z.; Jiang, X.; Decicco, C. P. α-Ketoamides, α-ketoesters and α-diketones as HCV NS3 protease inhibitors Bioorg. Med. Chem. Lett. 2000, 10, 711.
-
(f) Han, W.; Hu, Z.; Jiang, X.; Decicco, C. P. α-Ketoamides, α-ketoesters and α-diketones as HCV NS3 protease inhibitors Bioorg. Med. Chem. Lett. 2000, 10, 711.
-
-
-
-
15
-
-
0037041216
-
Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease
-
(g) Zhang, R.; Durkin, J. P.; Windsor, W. T. Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease. Bioorg. Med. Chem. Lett. 2002, 12, 1005
-
(2002)
Bioorg. Med. Chem. Lett
, vol.12
, pp. 1005
-
-
Zhang, R.1
Durkin, J.P.2
Windsor, W.T.3
-
16
-
-
24344450722
-
Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P2-P1 cyclopropyl alanine combination for improved potency
-
(h) Bogen, B.; Saksena, A. K.; Arasappan, A.; Gu, H.; Njoroge, F. G.; Girijavallabhan, V.; Pichardo, J.; Butkiewicz, N.; Prongay, A.; Madison, V. Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P2-P1 cyclopropyl alanine combination for improved potency. Bioorg. Med. Chem. Lett. 2005, 15, 4515-4519.
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 4515-4519
-
-
Bogen, B.1
Saksena, A.K.2
Arasappan, A.3
Gu, H.4
Njoroge, F.G.5
Girijavallabhan, V.6
Pichardo, J.7
Butkiewicz, N.8
Prongay, A.9
Madison, V.10
-
17
-
-
0028231087
-
Hepatitis C virus particle detected by immunoelectron microscopic study
-
Kaito, M.; Watnabe, S.; Tsukiyama-Kohara, K.; Yamaguchi, K.; Kobayashi, Y.; Konishi, M.; Yokoi, M.; Ishida, S.; Suzuki, S.; Kohara, M. Hepatitis C virus particle detected by immunoelectron microscopic study. J. Gen. Virol. 1994, 75, 1755-1760.
-
(1755)
J. Gen. Virol
, vol.1994
, pp. 75
-
-
Kaito, M.1
Watnabe, S.2
Tsukiyama-Kohara, K.3
Yamaguchi, K.4
Kobayashi, Y.5
Konishi, M.6
Yokoi, M.7
Ishida, S.8
Suzuki, S.9
Kohara, M.10
-
18
-
-
0032974384
-
The NS3/4A proteinase of the hepatitis C virus: Unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy
-
Bartenschlager, R. The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy. J. Virol. Hepatitis, 1999, 6, 165-181
-
(1999)
J. Virol. Hepatitis
, vol.6
, pp. 165-181
-
-
Bartenschlager, R.1
-
19
-
-
0027287798
-
Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions
-
(b) Bartenschlager, R., Ahlborn-Laake, L., Mous, J.; Jacobsen, H. Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J. Virol. 1993, 67, 3835-3844.
-
(1993)
J. Virol
, vol.67
, pp. 3835-3844
-
-
Bartenschlager, R.1
Ahlborn-Laake, L.2
Mous, J.3
Jacobsen, H.4
-
20
-
-
0031906287
-
Molecular characterization of hepatitis C virus
-
(c) Reed, K. E.; Rice, C. M. Molecular characterization of hepatitis C virus. In Hepatitis C Virus, 1998, pp. 1-37.
-
(1998)
Hepatitis C Virus
, pp. 1-37
-
-
Reed, K.E.1
Rice, C.M.2
-
21
-
-
23944476834
-
-
Edited by H. W. Reesink. Basel, Switzerland: Karger (d) Lindenbach, B. D.; Rice, C. M. Unravelling hepatitis C virus replication from genome to function. Nature 2005, 436, 933-938
-
Edited by H. W. Reesink. Basel, Switzerland: Karger (d) Lindenbach, B. D.; Rice, C. M. Unravelling hepatitis C virus replication from genome to function. Nature 2005, 436, 933-938
-
-
-
-
22
-
-
2642590958
-
Complex of NS3 protease and NS4A peptide of BK stain hepatitis C virus: A 2.2 A resolution structure in a hexagonal crystal form
-
a) Yan, Y.; Li, Y.; Munshi, S.; Sardana, V.; Cole J. L.; Sardana, M.; Steinkuehler, C.; Tomei, L.; De-Francesco R.; Kuo L. C.; Chen Z. Complex of NS3 protease and NS4A peptide of BK stain hepatitis C virus: A 2.2 A resolution structure in a hexagonal crystal form. Protein Sci. 1998, 7, 837-847.
-
(1998)
Protein Sci
, vol.7
, pp. 837-847
-
-
Yan, Y.1
Li, Y.2
Munshi, S.3
Sardana, V.4
Cole, J.L.5
Sardana, M.6
Steinkuehler, C.7
Tomei, L.8
De-Francesco, R.9
Kuo, L.C.10
Chen, Z.11
-
23
-
-
0030592514
-
The crystal structure of Hepatitis C Virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
-
(b) Love, R. A.; Parge, H. E.; Wickersham, J. A.; Hostomsky, Z.; Habuka, N.; Moomaw, E. W.; Adachi, T.; Hostomska, Z. The crystal structure of Hepatitis C Virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell 1996, 87, 331-342
-
(1996)
Cell
, vol.87
, pp. 331-342
-
-
Love, R.A.1
Parge, H.E.2
Wickersham, J.A.3
Hostomsky, Z.4
Habuka, N.5
Moomaw, E.W.6
Adachi, T.7
Hostomska, Z.8
-
24
-
-
0032518490
-
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: The crystal structure provides insights into the mode of unwinding
-
(c) Kim, J. L.; Morgenstern, K. A.; Griffith, J. P.; Dweyer, M. D.; Thomson, J. A.; Murcko, M. A.; Lin, C.; Caron, P. R. Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: The crystal structure provides insights into the mode of unwinding. Structure 1998, 6, 89-100
-
(1998)
Structure
, vol.6
, pp. 89-100
-
-
Kim, J.L.1
Morgenstern, K.A.2
Griffith, J.P.3
Dweyer, M.D.4
Thomson, J.A.5
Murcko, M.A.6
Lin, C.7
Caron, P.R.8
-
25
-
-
0032400892
-
Hepatitis C virus NS3/4A protease
-
(d) Kwong, A. D.; Kim, J. L.; Rao, G.; Lipovsek, D.; Raybuck, S. A. Hepatitis C virus NS3/4A protease. Antiviral Res. 1998, 40, 1-18.
-
(1998)
Antiviral Res
, vol.40
, pp. 1-18
-
-
Kwong, A.D.1
Kim, J.L.2
Rao, G.3
Lipovsek, D.4
Raybuck, S.A.5
-
26
-
-
0029814495
-
Activity of purified hepatitis C virus protease NS3 on peptide substrates
-
a) Steinkuhler, C.; Urbani, A.; Tomei, L.; Biasiol, G.; Sardana, M.; Bianchi, E.; Pessi, A.; De Francesco, R. Activity of purified hepatitis C virus protease NS3 on peptide substrates J. Virol. 1996, 70, 6694-6700.
-
(1996)
J. Virol
, vol.70
, pp. 6694-6700
-
-
Steinkuhler, C.1
Urbani, A.2
Tomei, L.3
Biasiol, G.4
Sardana, M.5
Bianchi, E.6
Pessi, A.7
De Francesco, R.8
-
27
-
-
0030944102
-
Substrate specificity of the Hepatitis C virus serine protease NS3
-
(b) Urbani, A.; Bianchi, E.; Narjes, F.; Tromontano, A.; De Francesco, R.; Steinkuehler, C.; Pessi, A. Substrate specificity of the Hepatitis C virus serine protease NS3 J. Biol. Chem. 1997, 272, 9204-9209.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 9204-9209
-
-
Urbani, A.1
Bianchi, E.2
Narjes, F.3
Tromontano, A.4
De Francesco, R.5
Steinkuehler, C.6
Pessi, A.7
-
28
-
-
0027999994
-
Specificity of the hepatitis C virus NS3 serine protease: Effects of substitutions at the 3/ 4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing
-
(c) Kolykhalov, A. A.; Agapov, E. V.; Rice, C. M. Specificity of the hepatitis C virus NS3 serine protease: Effects of substitutions at the 3/ 4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing. J. Virol. 1994, 68, 7525-7533.
-
(1994)
J. Virol
, vol.68
, pp. 7525-7533
-
-
Kolykhalov, A.A.1
Agapov, E.V.2
Rice, C.M.3
-
29
-
-
33644636312
-
-
Perni, R. B.; Almquist, S. J.; Byrn, R. A.; Chandorkar, G.; Chaturvedi, P. R.; Courtney, L. F.; Decker, C. J.; Dinehart, K.; Gates, C. A.; Harbeson, S. L.; Heiser, A.; Kalkeri, G.; Kolaczkowski, E.; Lin, K.; Luong, Y.-P.; Rao, B. G.; Taylor, W. P.; Thomson, J. A.; Tung, R. D.; Wei, Y.; Kwong, A. D.; Lin, C. Preclinical profile of VX-950, a potent, selective, and orally, bioavailable inhibitor of hepatitis C virus NS3-4A serine protease. Antimicob. Agents Chemother. 2006, 50, 899-909
-
Perni, R. B.; Almquist, S. J.; Byrn, R. A.; Chandorkar, G.; Chaturvedi, P. R.; Courtney, L. F.; Decker, C. J.; Dinehart, K.; Gates, C. A.; Harbeson, S. L.; Heiser, A.; Kalkeri, G.; Kolaczkowski, E.; Lin, K.; Luong, Y.-P.; Rao, B. G.; Taylor, W. P.; Thomson, J. A.; Tung, R. D.; Wei, Y.; Kwong, A. D.; Lin, C. Preclinical profile of VX-950, a potent, selective, and orally, bioavailable inhibitor of hepatitis C virus NS3-4A serine protease. Antimicob. Agents Chemother. 2006, 50, 899-909
-
-
-
-
30
-
-
0034929804
-
Macrocycles mimic The extended peptide conformation recognized by aspartic, serine, cysteine, and metallo Proteases
-
Tyndall, J. D. A.; Fairlie, D. P. Macrocycles mimic The extended peptide conformation recognized by aspartic, serine, cysteine, and metallo Proteases. Curr. Med. Chem. 2001, 8, 893-907
-
(2001)
Curr. Med. Chem
, vol.8
, pp. 893-907
-
-
Tyndall, J.D.A.1
Fairlie, D.P.2
-
31
-
-
34548244013
-
-
Unpublished results from laboratories of Schering Plough
-
Unpublished results from laboratories of Schering Plough
-
-
-
-
32
-
-
26444615182
-
Synthesis, and Biological Activity of m-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease
-
Chen, K. X.; Njoroge, F. G.; Pichardo, J.; Prongay, A.; Butkiewicz, N.; Yao, N.; Madison, V.; Girijavallabhan, V. Design, Synthesis, and Biological Activity of m-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease. J. Med. Chem. 2005, 48, 6229-6235.
-
(2005)
J. Med. Chem
, vol.48
, pp. 6229-6235
-
-
Chen, K.X.1
Njoroge, F.G.2
Pichardo, J.3
Prongay, A.4
Butkiewicz, N.5
Yao, N.6
Madison, V.7
Girijavallabhan8
Design, V.9
-
33
-
-
24344504516
-
Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease
-
Chen, K. X.; Njoroge, F. G.; Prongay, A.; Pichardo, J.; Madison, V.; Girijavallabhan, V Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease. Bioorg. Med. Chem Lett. 2005, 15, 4475-4478.
-
(2005)
Bioorg. Med. Chem Lett
, vol.15
, pp. 4475-4478
-
-
Chen, K.X.1
Njoroge, F.G.2
Prongay, A.3
Pichardo, J.4
Madison, V.5
Girijavallabhan, V.6
-
34
-
-
0032975149
-
Synthesis of two novel cyclic biphenyl ether analogs of an inhibitor of HCV NS3 protease
-
Marchetti, A; Ontoria, J. M.; Matassa, V. G. Synthesis of two novel cyclic biphenyl ether analogs of an inhibitor of HCV NS3 protease. Synlett 1999, 1000-1002.
-
(1999)
Synlett
, pp. 1000-1002
-
-
Marchetti, A.1
Ontoria, J.M.2
Matassa, V.G.3
-
35
-
-
23444441022
-
Design and Synthesis of Depeptidized Macrocyclic Inhibitors of Hepatitis C NS3-4A Protease Using Structure-Based Drug Design
-
Venkatraman, S.; Njoroge, F. G.; Girijavallabhan, V. M.; Madison, V. S.; Yao, N H.; Prongay, A. J.; Butkiewicz, N.; Pichardo, J. Design and Synthesis of Depeptidized Macrocyclic Inhibitors of Hepatitis C NS3-4A Protease Using Structure-Based Drug Design. J. Med. Chem. 2005, 48, 5088-5091.
-
(2005)
J. Med. Chem
, vol.48
, pp. 5088-5091
-
-
Venkatraman, S.1
Njoroge, F.G.2
Girijavallabhan, V.M.3
Madison, V.S.4
Yao, N.H.5
Prongay, A.J.6
Butkiewicz, N.7
Pichardo, J.8
-
36
-
-
32344431531
-
Novel Potent Hepatitis C Virus NS3 Serine Protease Inhibitors Derived from Proline-Based Macrocycle
-
Chen, K. X.; Njoroge, F. G.; Arasappan, A.; Venkatraman, S.; Vibulbhan, B.; Yang, W.; Parekh, T. N.; Pichardo, J.; Prongay, A.; Cheng, K.-C.; Butkiewicz, N.; Yao, N.; Madison, V.; Girijavallabhan, V Novel Potent Hepatitis C Virus NS3 Serine Protease Inhibitors Derived from Proline-Based Macrocycle. J. Med. Chem. 2006, 49, 995-1005.
-
(2006)
J. Med. Chem
, vol.49
, pp. 995-1005
-
-
Chen, K.X.1
Njoroge, F.G.2
Arasappan, A.3
Venkatraman, S.4
Vibulbhan, B.5
Yang, W.6
Parekh, T.N.7
Pichardo, J.8
Prongay, A.9
Cheng, K.-C.10
Butkiewicz, N.11
Yao, N.12
Madison, V.13
Girijavallabhan, V.14
-
37
-
-
0037204717
-
Novel Dipeptide Macrocycles from 4-Oxo, - Thio, and -Amino-Substituted Proline Derivatives
-
Arasappan, A.; Chen, K. X.; Njoroge, F. G.; Parekh, T. N.; Girijavallabhan, V. Novel Dipeptide Macrocycles from 4-Oxo, - Thio, and -Amino-Substituted Proline Derivatives. J. Org. Chem. 2002, 67, 3923-3926.
-
(2002)
J. Org. Chem
, vol.67
, pp. 3923-3926
-
-
Arasappan, A.1
Chen, K.X.2
Njoroge, F.G.3
Parekh, T.N.4
Girijavallabhan, V.5
-
38
-
-
0037134219
-
Syntheses of Novel 4-tert-Alkyl Ether Proline-Based 16- and 17-Membered Macrocyclic Compounds
-
Chen, K. X.; Njoroge, F. G.; Vibulbhan, B.; Buevich, A.; Chan, T.-M.; Girijavallabhan, V. Syntheses of Novel 4-tert-Alkyl Ether Proline-Based 16- and 17-Membered Macrocyclic Compounds. J. Org. Chem. 2002, 67, 2730-2733.
-
(2002)
J. Org. Chem
, vol.67
, pp. 2730-2733
-
-
Chen, K.X.1
Njoroge, F.G.2
Vibulbhan, B.3
Buevich, A.4
Chan, T.-M.5
Girijavallabhan, V.6
-
39
-
-
27744486088
-
Proline-Based Macrocyclic Inhibitors of the Hepatitis C Virus: Stereoselective Synthesis and Biological Activity
-
Chen, K. X.; Njoroge, F. G.; Vibulbhan, B.; Prongay, A.; Pichardo, J.; Madison, V.; Buevich, A.; Chan, T.-M. Proline-Based Macrocyclic Inhibitors of the Hepatitis C Virus: Stereoselective Synthesis and Biological Activity, Angew. Chem., Int., Ed. Engl. 2005, 44, 7024-7028.
-
(2005)
Angew. Chem., Int., Ed. Engl
, vol.44
, pp. 7024-7028
-
-
Chen, K.X.1
Njoroge, F.G.2
Vibulbhan, B.3
Prongay, A.4
Pichardo, J.5
Madison, V.6
Buevich, A.7
Chan, T.-M.8
-
40
-
-
31544468120
-
-
Chen, K. X.; Njoroge, F. G.; Pichardo, J.; Prongay, A.; Butkiewicz, N.; Yao, N.; Madison, V.; Girijavallabhan, V. Potent 7-Hydroxy-1,2,3,4 -tetahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease, J. Med. Chem. 2006, 49, 546-574.
-
Chen, K. X.; Njoroge, F. G.; Pichardo, J.; Prongay, A.; Butkiewicz, N.; Yao, N.; Madison, V.; Girijavallabhan, V. Potent 7-Hydroxy-1,2,3,4 -tetahydroisoquinoline-3-carboxylic Acid-Based Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease, J. Med. Chem. 2006, 49, 546-574.
-
-
-
-
41
-
-
4644279027
-
-
Goudreau, N.; Brochu, C.; Cameron, D. R.;. Duceppe, J.-S.; Faucher, A.-M.; Ferland, J.-M.; Grand-Maître, C.; Poirier, M.; Simoneau, B.; Tsantrizos, Y. S. Potent Inhibitors of the Hepatitis C Virus NS3 Protease: Design and Synthesis of Macrocyclic Substrate-Based β-Strand Mimics J. Org. Chem. 2004, 69, 6185-6201.
-
Goudreau, N.; Brochu, C.; Cameron, D. R.;. Duceppe, J.-S.; Faucher, A.-M.; Ferland, J.-M.; Grand-Maître, C.; Poirier, M.; Simoneau, B.; Tsantrizos, Y. S. Potent Inhibitors of the Hepatitis C Virus NS3 Protease: Design and Synthesis of Macrocyclic Substrate-Based β-Strand Mimics J. Org. Chem. 2004, 69, 6185-6201.
-
-
-
-
42
-
-
12144290054
-
Structure-Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061
-
Llinàs-Brunet, M.; Bailey, M. D.; Bolger, G.; Brochu, C.; Faucher, A.-M.; Ferland, J. M.; Garneau, M.; Ghiro, E.; Gorys, V.; Grand-Maître, C.; Halmos, T.; Lapeyre-Paquette, N.; Liard, F.; Poirier, M.; Rhéaume, M.; Youla S. Tsantrizos, Y. S.; Lamarre, D. Structure-Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061. J. Med. Chem. 2004, 47, 1605-1608.
-
(2004)
J. Med. Chem
, vol.47
, pp. 1605-1608
-
-
Llinàs-Brunet, M.1
Bailey, M.D.2
Bolger, G.3
Brochu, C.4
Faucher, A.-M.5
Ferland, J.M.6
Garneau, M.7
Ghiro, E.8
Gorys, V.9
Grand-Maître, C.10
Halmos, T.11
Lapeyre-Paquette, N.12
Liard, F.13
Poirier, M.14
Rhéaume, M.15
Youla, S.16
Tsantrizos, Y.S.17
Lamarre, D.18
-
43
-
-
0344201903
-
-
Lamarre, D.; Anderson, P. C.; Bailey, M.; Beaulieu, P.; Bolger, G.; Bonneau, P.; Bös, M.; Cameron, D. R.; Cartier, M.; Cordingley, M. G.; Faucher, A-M.; Goudreau, N.; Kawai, S. H. Kukolj, G.; Lagacé, L.; LaPlante, S. R. Narjes, H.; Poupart, M-A Rancourt, J.; Sentjens, R. E.; St George, R. Simoneau, B.; Steinmann, G.; Thibeault, D.; Tsantrizos, Y. S. Weldon, S. M.; Yong C-L.; Llinàs-Brunet M. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature 2003, 426, 186-189.
-
Lamarre, D.; Anderson, P. C.; Bailey, M.; Beaulieu, P.; Bolger, G.; Bonneau, P.; Bös, M.; Cameron, D. R.; Cartier, M.; Cordingley, M. G.; Faucher, A-M.; Goudreau, N.; Kawai, S. H. Kukolj, G.; Lagacé, L.; LaPlante, S. R. Narjes, H.; Poupart, M-A Rancourt, J.; Sentjens, R. E.; St George, R. Simoneau, B.; Steinmann, G.; Thibeault, D.; Tsantrizos, Y. S. Weldon, S. M.; Yong C-L.; Llinàs-Brunet M. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature 2003, 426, 186-189.
-
-
-
-
44
-
-
34548248125
-
Macrocyclic isoquinoline peptide inhibitors of Hepatitis C virus,
-
US Patent Pub. 2005/ 0090432
-
McPhee, F.; Campbell, J. A.; Li W.; D'Andrea, S.; Zheng, Z. B.; Good, A. C.; Carini, D. J.; Johnson, B. L.; Scola, P. M. Macrocyclic isoquinoline peptide inhibitors of Hepatitis C virus, US Patent Pub. 2005/ 0090432.
-
-
-
McPhee, F.1
Campbell, J.A.2
Li, W.3
D'Andrea, S.4
Zheng, Z.B.5
Good, A.C.6
Carini, D.J.7
Johnson, B.L.8
Scola, P.M.9
-
45
-
-
34548290300
-
-
Llinas-Brunet, M.; Bailey, M. D. Macrocyclic peptides active against the Hepatits C virus WO patent Pub. 2004/037855.
-
Llinas-Brunet, M.; Bailey, M. D. Macrocyclic peptides active against the Hepatits C virus WO patent Pub. 2004/037855.
-
-
-
-
46
-
-
34548287435
-
-
Blatt, L. M.; Wenglowsky, S. M.; Andrews, S. W.; Jiang, Y.; Kennedy, A. L.; Condroski, K. R.; Josey, J. A.; Stengel, P. J.; Madduru, M. R.; Doherty, G. A.; Woodard B. T.; Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication. WO patent Pub 2005/037214.
-
Blatt, L. M.; Wenglowsky, S. M.; Andrews, S. W.; Jiang, Y.; Kennedy, A. L.; Condroski, K. R.; Josey, J. A.; Stengel, P. J.; Madduru, M. R.; Doherty, G. A.; Woodard B. T.; Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication. WO patent Pub 2005/037214.
-
-
-
-
47
-
-
34548247627
-
Macrocyclic peptides active against the Hepatits C virus
-
US Patent Pub. 2005/ 0192212
-
Llinas-Brunet, M.; Bailey, M. Bharadwaj, P. K.; Bilodeau, F.; Forgione, P.; Ghiro, E.; Goudreau, N.; Holmas, T.; Rancourt, J.; Macrocyclic peptides active against the Hepatits C virus US Patent Pub. 2005/ 0192212.
-
-
-
Llinas-Brunet, M.1
Bailey, M.2
Bharadwaj, P.K.3
Bilodeau, F.4
Forgione, P.5
Ghiro, E.6
Goudreau, N.7
Holmas, T.8
Rancourt, J.9
-
48
-
-
34548216238
-
-
Nakajima, S.; Ying, S.; Datong, T.; Gouyou, X.; Brian, P.; Yat, Sun O.; Zhe, M.; Zhenwei, Z.; Preparation of quinoxalinyl macrocyclic Hepatitis C serine protease inhibitors, WO Patent Pub. 2004/093798.
-
Nakajima, S.; Ying, S.; Datong, T.; Gouyou, X.; Brian, P.; Yat, Sun O.; Zhe, M.; Zhenwei, Z.; Preparation of quinoxalinyl macrocyclic Hepatitis C serine protease inhibitors, WO Patent Pub. 2004/093798.
-
-
-
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