Stabilization of low glass transition temperature indomethacin formulations: Impact of polymer-type and its concentration

Journal of Pharmaceutical Sciences

Volumn 97, Issue 6, 2008, Pages 2286-2298

  Chokshi, Rina J ^a,b   Shah, Navnit H ^b   Sandhu, Harpreet K ^b   Malick, Ahmad W ^b   Zia, Hossein ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

Crystallinity; Dissolution rate; Extrusion; Glass transition; Polymers; Solid dispersion; Solid solutions; Stability; Thermal analysis; X ray powder diffractometry

Indexed keywords

EUDRAGIT; INDOMETACIN; POLYMER; POLYVINYL POLYPYRROLIDONE VINYL ACETATE COPOLYMER; POVIDONE; UNCLASSIFIED DRUG; VINYL ACETATE; NONSTEROID ANTIINFLAMMATORY AGENT; POLY(VINYLPYRROLIDONE CO VINYL ACETATE); POLY(VINYLPYRROLIDONE-CO-VINYL-ACETATE); PYRROLIDINE DERIVATIVE; VINYL DERIVATIVE;

ARTICLE; CONCENTRATION RESPONSE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; GLASS TRANSITION TEMPERATURE; IMMOBILIZATION; MOLECULAR INTERACTION; THERMAL ANALYSIS; X RAY DIFFRACTION; X RAY POWDER DIFFRACTION; CHEMISTRY; COMPARATIVE STUDY; INFRARED SPECTROSCOPY; KINETICS; METHODOLOGY; PHARMACEUTICS; POWDER DIFFRACTION; SOLUBILITY; TRANSITION TEMPERATURE; X RAY CRYSTALLOGRAPHY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG COMPOUNDING; DRUG STABILITY; INDOMETHACIN; KINETICS; POVIDONE; POWDER DIFFRACTION; PYRROLIDINES; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; TRANSITION TEMPERATURE; VINYL COMPOUNDS;

EID: 49249138874     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21174     Document Type: Article

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