Heterologous production of epothilones B and D in Streptomyces venezuelae

Applied Microbiology and Biotechnology

Volumn 81, Issue 1, 2008, Pages 109-117

  Park, Sung Ryeol ^a   Park, Je Won ^a   Jung, Won Seok ^a   Han, Ah Reum ^a   Ban, Yeon Hee ^a   Kim, Eun Ji ^a   Sohng, Jae Kyung ^b   Sim, Sang Jun ^c   Yoon, Yeo Joon ^a  

^a Ewha Womans University   (South Korea)

^b SunMoon University   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

Epothilone; Heterologous production; Streptomyces venezuelae

Indexed keywords

AMINES; GENE ENCODING; HYDROGELS; POLYMERS; STRAIN;

ANTICANCER AGENTS; BIOSYNTHETIC GENE CLUSTERS; CORRESPONDING COMPOUNDS; CYTOCHROME P450; ENCODING; ENHANCED PRODUCTIONS; EPOTHILONE; EPOTHILONES; HETEROLOGOUS PRODUCTION; HETEROLOGOUS PRODUCTIONS; MICROTUBULES; MUTANT STRAINS; NONRIBOSOMAL PEPTIDES; PACLITAXEL; PIKROMYCIN; POLYKETIDE; POLYKETIDE SYNTHASE GENES; POLYKETIDES; PRODUCTION LEVELS; REGULATORY GENES; SORANGIUM; STREPTOMYCES VENEZUELAE;

CYTOTOXICITY;

CYTOCHROME P450; CYTOCHROME P450 EPOXIDASE; EPOTHILONE B; EPOTHILONE D; PIKROMYCIN; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

BACTERIUM; GENE EXPRESSION; GENETIC ENGINEERING; MUTATION;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; GENE CLUSTER; GENE DELETION; GENE EXPRESSION; GENETIC ENGINEERING; LIQUID CHROMATOGRAPHY; NONHUMAN; OPEN READING FRAME; STREPTOMYCES VENEZUELAE;

BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; CYTOCHROME P-450 ENZYME SYSTEM; EPOTHILONES; GENE DOSAGE; GENETIC ENGINEERING; GENETIC VECTORS; INDUSTRIAL MICROBIOLOGY; OPEN READING FRAMES; OXIDOREDUCTASES; POLYKETIDE SYNTHASES; SEQUENCE DELETION; STREPTOMYCES;

POLYANGIUM CELLULOSUM; STREPTOMYCES VENEZUELAE;

EID: 54349102474     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-008-1674-0     Document Type: Article

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