Engineering of plant-specific phenylpropanoids biosynthesis in Streptomyces venezuelae

Journal of Biotechnology

Volumn 141, Issue 3-4, 2009, Pages 181-188

  Park, Sung Ryeol ^a   Yoon, Jin A ^a   Paik, Ji Hye ^a   Park, Je Won ^a   Jung, Won Seok ^a   Ban, Yeon Hee ^a   Kim, Eun Ji ^a   Yoo, Young Ji ^a   Han, Ah Reum ^b   Yoon, Yeo Joon ^a  

^a Ewha Womans University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Flavanone; Heterologous production; Stilbene; Streptomyces venezuelae

Indexed keywords

ARABIDOPSIS THALIANA; ARACHIS HYPOGAEA; BIOSYNTHETIC GENES; BIOSYNTHETIC PATHWAYS; CHALCONE; CHALCONE SYNTHASE; CINNAMIC ACIDS; COENZYME A; COUMARIC ACIDS; FLAVANONE; FLAVONOID; FLAVONOIDS; HETEROLOGOUS EXPRESSIONS; HETEROLOGOUS PRODUCTION; ISOMERASE; MEDICAGO; NUTRACEUTICAL; PHENYLPROPANOID; PHENYLPROPANOIDS; PIKROMYCIN; PLANT POLYKETIDE; PLANT SECONDARY METABOLITES; POLYKETIDE SYNTHASE GENES; PROMOTER UPSTREAM; RECOMBINANT STRAINS; RESVERATROL; STILBENE; STILBENE SYNTHASE; STREPTOMYCES COELICOLOR; STREPTOMYCES VENEZUELAE;

ACIDS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; GENES; METABOLITES; OPTIMIZATION; PLANTS (BOTANY); POLYMERS;

ENZYMES;

CHALCONE SYNTHASE; CINNAMIC ACID; FLAVONOID; LONG CHAIN FATTY ACID COENZYME A LIGASE; NARINGENIN; NUTRACEUTICAL; PARA COUMARIC ACID; PIKROMYCIN; PINOCEMBRINE; PINOSYLVIN; POLYKETIDE; RESVERATROL; STILBENE DERIVATIVE; SYNTHETASE;

ALFALFA; ARABIDOPSIS; ARTICLE; BACTERIAL STRAIN; BIOENGINEERING; BIOSYNTHESIS; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE SYNTHESIS; HETEROLOGOUS EXPRESSION; HOST; METABOLITE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEANUT; PLANT; PLANT GENE; PLANT METABOLISM; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; STREPTOMYCES COELICOLOR; STREPTOMYCES VENEZUELAE;

ACYLTRANSFERASES; ARABIDOPSIS; CODON; COENZYME A LIGASES; ESCHERICHIA COLI; FLAVANONES; GENETIC ENGINEERING; PLANT PROTEINS; PROMOTER REGIONS, GENETIC; RECOMBINANT PROTEINS; STILBENES; STREPTOMYCES;

ARABIDOPSIS THALIANA; ARACHIS HYPOGAEA; MEDICAGO SATIVA; STREPTOMYCES; STREPTOMYCES COELICOLOR; STREPTOMYCES VENEZUELAE;

EID: 67349185075     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2009.03.013     Document Type: Article

References (30)

1. Becker J.V., Armstrong G.O., van der Merwe M.J., Lambrechts M.G., Vivier M.A., and Pretorius I.S. Metabolic engineering of Saccharomyces cerevisiae for the synthesis of the wine-related antioxidant resveratrol. FEMS Yeast Res. 4 (2003) 79-85
2. Beekwilder J., Wolswinkel R., Jonker H., Hall R., de Vos C.H., and Bovy A. Production of resveratrol in recombinant microorganisms. Appl. Environ. Microbiol. 72 (2006) 5670-5672
3. Dixon R.A., and Paiva N.L. Stress-induced phenylpropanoid metabolism. Plant Cell 7 (1995) 1085-1097
4. Gouy M., and Gautier C. Codon usage in bacteria: correlation with gene expressivity. Nucleic Acids Res. 10 (1982) 7055-7074
5. Harborne J.B., Mabry T.J., and Mabry H. The Flavonoids (1975), Champman and Hall, London pp. 127-213
6. Harborne J.B., and Willams C.A. Advances in flavonoid research since 1992. Phyotochemistry 55 (2000) 481-504
7. Hoover D.M., and Lubkowski J. DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis. Nucleic Acids Res. 30 (2002) e43
8. Hwang E.I., Kaneko M., Ohnishi Y., and Horinouchi S. Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster. Appl. Environ. Microbiol. 69 (2003) 2699-2706
9. Jiang H., Wood K.V., and Morgan J.A. Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 71 (2005) 2962-2969
10. Jung W.S., Lee S.K., Hong J.S.J., Park S.R., Jeong S.J., Han A.R., Sohng J.K., Kim B.G., Choi C.Y., Sherman D.H., and Yoon Y.J. Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Appl. Microbiol. Biotechnol. 72 (2006) 763-769
11. Kaneko M., Ohnishi Y., and Horinouchi S. Cinnamate:coenzyme A ligase from the filamentous bacterium Streptomyces coelicolor A3(2). J. Bacteriol. 185 (2003) 20-27
12. Katsuyama Y., Funa N., Miyahisa I., and Horinouchi S. Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli. Chem. Biol. 14 (2007) 613-621
13. Kieser T.M., Bibb M.J., Buttner M.J., Chater K.F., and Hoopwood D.A. Practical Streptomyces Genetics (2000), John Innes Centre, Norwich
14. Kim B.G., Jung B.R., Lee Y., Hur H.G., Lim Y., and Ahn J.H. Regiospecific flavonoid 7-O-methylation with Streptomyces avermitilis O-methyltransferase expressed in Escherichia coli. J. Agric. Food Chem. 54 (2006) 823-828
15. Leonard E., Lim K.H., Saw P.N., and Koffas M.A. Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli. Appl. Environ. Microbiol. 73 (2007) 3877-3886
16. Miyahisa I., Kaneko M., Funa N., Kawasaki H., Kojima H., Ohnishi Y., and Horinouchi S. Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster. Appl. Microbiol. Biotechnol. 68 (2005) 498-504
17. Park J.W., Jung W.S., Park S.R., Park B.C., and Yoon Y.J. Analysis of intracellular short organic acid-coenzyme A esters from actinomycetes using liquid chromatography electrospray ionization-mass spectrometry. J. Mass Spectrom. 42 (2007) 1136-1147
18. 2 by heterologous expression of its minimal gene set. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 8399-8404
19. Park S.R., Park J.W., Jung W.S., Han A.R., Ban Y.-H., Kim E.J., Sohng J.K., Sim S.J., and Yoon Y.J. Heterologous production of epothilone B and D in Streptomyces venezuelae. Appl. Microbiol. Biotechnol. 81 (2008) 109-117
20. Pfeifer B.A., and Khosla C. Biosynthesis of polyketides in heterologous hosts. Microbiol. Mol. Biol. Rev. 65 (2001) 106-118
21. Ross Z., James M.L., and István M. Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosum So ce26 in Streptomyces lividans. Microbiology 150 (2004) 2761-2774
22. Springob K., Nakajima J., Yamazaki M., and Saito K. Recent advances in the biosynthesis and accumulation of anthocyanins. Nat. Prod. Rep. 20 (2003) 288-303
23. Tropf S., Kärcher B., Schröder G., and Schröder J. Reaction mechanisms of homodimeric plant polyketide synthases (stilbene and chalcone synthase). J. Biol. Chem. 270 (1995) 7922-7928
24. Wattanachaisaereekul S., Lantz A.E., Nielsen M.L., and Nielsen J. Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply. Metab. Eng. 10 (2008) 246-254
25. Watts K.T., Lee P.C., and Schmidt-Dannert C. Exploring recombinant flavonoid biosynthesis in metabolically engineered Escherichia coli. Chembiochem 5 (2004) 500-507
26. Weisshaar B., and Jenkins G.I. Phenylpropanoid biosynthesis and its regulation. Curr. Opin. Plant Biol. 1 (1998) 251-257
27. Wenzel S.C., and Müller R. Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. Curr. Opin. Biotechnol. 16 (2005) 1-13
28. Wolter F., and Stein J. Biological activities of resveratrol and its analogs. Drug Future 27 (2002) 949-959
29. Yan Y., Kohli A., and Koffas M.A. Biosynthesis of natural flavanones in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 71 (2005) 5610-5613
30. Yoon Y.J., Beck B.J., Kim B.S., Kang H.Y., Reynolds K.A., and Sherman D.H. Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chem. Biol. 9 (2002) 203-214