Effects of garlic on blood glucose levels and HbA1c in patients with type 2 diabetes mellitus

Journal of Medicinal Plants Research

Volumn 5, Issue 13, 2011, Pages 2922-2928

  Ashraf, Rizwan ^a   Khan, Rafeeq Alam ^a   Ashraf, Imran ^b  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Complementary therapy; Diabetes mellitus; Fasting blood sugar; Garlic; HbA1 c

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; HERBACEOUS AGENT; METFORMIN; PLACEBO;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL EVALUATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG WITHDRAWAL; FEMALE; GARLIC; GLUCOSE BLOOD LEVEL; HEARTBURN; HEMOGLOBIN BLOOD LEVEL; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; SINGLE BLIND PROCEDURE; TREATMENT DURATION;

ALLIUM SATIVUM;

EID: 79961040261     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Ackerman RT, Mulrow CD, Ramirez G, Gardner CD, Morbidoni L, Lawrence VA (2001). Garlic Shows Promise for Improving Some Cardiovascular Risk Factors. Arch. Intern. Med., 161:813-824.
2. Afkhami-Ardekani M, Kamali-Ardekani A, Shojaoddiny-Ardekani A (2006). Effects of garlic on serum lipids and blood glucose of type 2 diabetic patients. Int. J. Diab. Dev. Ctries., 26: 86-88.
3. Ahmad MS, Ahmed N. (2006). Antiglycation properties of aged garlic extract: possible role in prevention of diabetic complications. J Nutr., 136 (3): 796S-799S.
4. Ahmad MS, Pischetsrieder M, Ahmed N (2007). Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation end products. Eur. J. Pharmacol., 561: 32-38.
5. Alarcon-Aguilara FJ, Roman-Ramos R, Perez-Gutierrez S (1998). Study of the anti-hyperglycemic effect of plants used as antidiabetics. J. Ethnopharmacol., 61: 101-110.
6. Ali M, Thomson M (1995). Consumption of garlic clove a day could be beneficial in preventing thrombosis. Prostaglandins Leukot Essent Fatty acids, 53: 211-12.
7. Alpers DH (2009). Garlic and its potential for prevention of colorectal cancer and other conditions. Current Opinion in Gastroenterol, 25:116-121.
8. Anwar MM, Meki AR (2003). Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol., 135: 539-547.
9. Ashraf R, Aamir K, Shaikh AR, Ahmed T (2005). Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus. J. Ayub. Med. Coll., 17(3): 60-64.
10. Augusti KT, Sheela CG (1996). Antiperoxide effect of S-allyl cysteine sulfoxide, a insulin secretagogue, in diabetic rats. Experientia, 52:115-120.
11. Banerjee SK, Maulik SK (2002). Effect of garlic on cardiovascular disorders: a review. Nutr., J., 1: 4-17.
12. Banerjee SK, Mukherjee PK, Maulik SK (2003). Garlic as an antioxidant: the good, the bad and the ugly. Phytother. Res., 17(2): 97-106.
13. Birdee GS, Yeh G (2010). Complementary and Alternative Medicine Therapies for Diabetes: A Clinical Review. Clinical Diabetes, 28(4): 147-155.
14. Bordia A, Verma SK, Srivastava KC (1998). Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids, 58: 257-263.
15. Defronzo RA (1997). Pathogenesis of diabetes. Diabetes Rev., 5: 177.
16. Eidia A, Eidib M, Esmaeili E (2006). Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine. 13: 624-629.
17. Elkayam A, Mirelman D, Peleg E, Wilchek M, Miron T, Rabinkov A, Oron-Herman M, Rosenthal T (2003). The effects of allicin on weight in fructose-induced hyperinsulinemic, hyperlipidemic, hypertensive rats. Am. J. Hypertens., 16 (12): 1053-1056.
18. Fukao H, Yoshida H, Tawaza Y, Hada T (2007). Antithrombotic Effects of Odorless Garlic Powder both in Vitro and in Vivo. BikoSci.Biotechnol. Biochem., 71 (1):84-90
19. Gupta N, Porter TD (2001). Garlic and garlic derived compounds inhibit human squalene monooxygenase. J. Nutr., 131:1662-7.
20. Gutiérrez RMP, Diaz SL, Reyes IC, Gonzalez AMN (2010). AntiglycationEffect of Spices and Chilies Uses in Traditional Mexican Cuisine. J. Nat. Prod., 3: 95-102.
21. Huebschmann AG, Regensteiner JG, Vlassara H, Reusch JE (2006). Diabetes and advanced glycoxidation end products. Diabetes Care, 29(6): 1420-1432.
22. Jain AK, Vargas R, Gotzkowsky S, McMahon FG (1993). Can garlic reduce levels of serum lipids? A controlled clinical study. Am. J. Med., 94: 632-635.
23. Jain RC, Vyas CR (1973). Hypoglycemic action of onion and garlic. Lancet, 2: 1491.
24. Jain RC, Vyas CR (1975). Garlic in alloxan-induced diabetic rabbits. Am. J. Clin. Nutr., 28: 684-685.
25. Jalal R, Bagheri SM, Moghimi A, Rasuli MB (2007). Hypoglycemic Effect of Aqueous Shallot and Garlic Extracts in Rats with Fructose-Induced Insulin Resistance. J. Clin. Biochem. Nutr., 41: 218-23.
26. Jelodar GA, Maleki M, Motadayen MH, Sirus S (2005). Effect of fenugreek, onion and garlic on blood glucose and histopathology of pancreas of alloxan-induced diabetic rats. Indian J. Med. Sci., 59(2): 64-69.
27. Kasuga S, Ushijima M, Morihara N, Itakura Y, Nakata Y (1999). Effect of aged garlic extract (AGE) on hyperglycemia induced by immobilization stress in mice. Nippon Yakurigaku Zassh, 114: 191-97.
28. Kiesewetter H, Jung F, Pindur G, Jung EM, Mrowietz C, Wenzel E (1991). Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. Int. J. Clin. Pharmacol. Ther.Toxicol., 29: 151-55.
29. Lee YM, Gweon O, Seo YJ, Im J, Kang MJ, Kim MJ, Kim JI (2009).Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus. Nutr. Res. Pract., 3(2): 156-161.
30. Li G, Shi Z, Jia H, Ju J, Wang X, Xia Z, Qin L, Ge C, Xu Y, Cheng L, Chen P, Yuan GA (2000). Clinical investigation on garlicin injection for treatment of unstable angina pectoris and its actions on plasma endothelin and blood sugar levels. J. Tradit. Chin. Med., 20: 243-6.
31. Liu C.T, Hse H, Lii CK, Chen PS, Sheen LY (2005). Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats. Eur. J.Pharmacol., 516:165-173.
32. Liu CT, Sheen LY, Lii CK (2007). Does garlic have a role as an antidiabetic agent? Mol. Nutr. Food Res., 51(11): 1353-1364.
33. Liu CT, Wong PL, Lii CK, Hse H, Sheen LY (2006). Antidiabetic effect of garlic oil but not diallyl disulfide in rats with streptozotocin-induced diabetes. Food Chem. Toxicol., 44: 1377-1384.
34. Marles RJ, Farnsworth N (1995). Antidiabetic plants and their active constituents. Phytomed., 2: 137-189.
35. Mathew PT, Augusti KT (1973). Studies on the effect of allicin (diallyl disulphide-oxide) on alloxan diabetes I. Hypoglycaemic action and enhancement of serum insulin effect and glycogen synthesis. Indian J. Biochem. Biophys., 10: 209-212
36. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Koplan JP (2001). The continuing epidemics of obesity and diabetes in the United States. JAMA, 286: 1195-200.
37. Ohaeri OC (2001). Effect of garlic oil on the levels of various enzyme in the serum and tissue of streptozotocin diabetic rats. Biosci. Rep., 21: 19-24.
38. Ou CC, Tsao SM, Lin MC, Yin MC (2003). Protective action on humanLDL against oxidation and glycation by four organosulfur compounds derived from garlic. Lipids. Mar., 38(3): 219-24.
39. Pari L, Umamaheswari J (2000). Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats. Phytother. Res., 14: 1-3.
40. Sheela CG, Augusti KT (1992). Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J. Exp.Biol., 30: 523-526.
41. Sheela CG, Kumud K, Augusti KT (1995). Anti-diabetic effect of onion and garlic sulfoxide amino acids in rats. Planta Med., 61: 356-57.
42. Shera AS, Jawad F, Maqsood A (2007). Prevalence of diabetes in Pakistan. Diabetes Res. Clin. Pract., 76: 219-222.
43. Sobenin IA, Nedosugova LV, Filatova LV, Balabolkin MI, Gorchakova TV, Alexander N (2008). Orekhov. Metabolic effects of timereleased garlic powder tablets in type 2 diabetes mellitus: the results of double-blinded placebo-controlled study. Acta. Diabetol., 45:1-6.
44. Steiner M, Li W (2001). Recent advances on the nutritional effects associated with use of Garlic as a Supplement. Aged Garlic Extract, a modulator of cardiovascular risk factors. A dose finding study on the effects of AGE on platelet functions. J. Nutr., 131: 980S-984S.
45. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR (1990). Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia, 33: 462-464.
46. Thomson M, Al-Amin ZM, Al-Qattan KK, Shaban LH, Ali M (2007). Antidiabetic and hypolipidaemic properties of garlic (Allium sativum) in streptozotocin-induced diabetic rats. Int. J. Diabetes Metab., 15(3): 108-115.
47. Verma SK, Jain V, Verma D (2008). Garlic - "The spice of life": composition, cooking chemistry and preparations. J. Herb Med. Toxicol., 2(2): 21-28.
48. Zhang XH, Lowe D, Giles P, Fell S, Connock MJ, Maslin DJ (2001).Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. J. Nutr., 131:1471-78.
49. Zimmet P, Alberti KG, Shaw J (2001). Global and societal implications of the diabetes epidemic. Nature, 414: 782-787.