SiRNA delivery with functionalized carbon nanotubes

International Journal of Pharmaceutics

Volumn 416, Issue 2, 2011, Pages 419-425

  Varkouhi, Amir Khashayar ^a   Foillard, Stéphanie ^b   Lammers, Twan ^a,c   Schiffelers, Raymond M ^a   Doris, Eric ^b   Hennink, Wim E ^a   Storm, Gert ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Carbon nanotube; Cytotoxicity; Gene silencing; SIRNA

Indexed keywords

CARBON NANOTUBE; DRUG CARRIER; LIPOFECTAMINE; POLY[2 (DIMETHYLAMINO)ETHYL METHACRYLATE]; POLYETHYLENEIMINE; PYRIDINIUM DERIVATIVE; SMALL INTERFERING RNA;

ARTICLE; BIODEGRADABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DRUG DELIVERY SYSTEM; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; STANDARD;

CELL LINE, TUMOR; CELL MEMBRANE; CETYLPYRIDINIUM; CYTOPLASM; GENE SILENCING; HUMANS; NANOTUBES, CARBON; POLYETHYLENEIMINE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 79961032439     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.02.009     Document Type: Article

References (50)

1. K.T. Al-Jamal, F.M. Toma, A. Yilmazer, H. Ali-Boucetta, A. Nunes, M. Herrero, B. Tian, A. Eddaoui, W.T. Al-Jamal, A. Bianco, M. Prato, and K. Kostarelos Enhanced cellular internalization and gene silencing with a series of cationic dendron-multiwalled carbon nanotube:siRNA complexes FASEB J. 24 2010 4354 4365
2. Y.H. Bai, Y. Zhang, J.P. Zhang, Q.X. Mu, W.D. Zhang, E.R. Butch, S.E. Snyder, and B. Yan Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility Nat. Nanotechnol. 5 2010 683 689
3. G. Bartholomeusz, P. Cherukuri, J. Kingston, L. Cognet, R. Lemos, T.K. Leeuw, L. Gumbiner-Russo, R.B. Weisman, and G. Powis In vivo therapeutic silencing of hypoxia-inducible factor 1 alpha (HIF-1 alpha) using single-walled carbon nanotubes noncovalently coated with siRNA Nano Res. 2 2009 279 291
4. E.V. Basiuk, M. Monroy-Pelaez, I. Puente-Lee, and V.A. Basiuk Direct solvent-free amination of closed-cap carbon nanotubes: a link to fullerene chemistry Nano Lett. 4 2004 863 866 (Pubitemid 38716341)
5. M.L. Becker, J.A. Fagan, N.D. Gallant, B.J. Bauer, V. Bajpai, E.K. Hobbie, S.H. Lacerda, K.B. Migler, and J.P. Jakupciak Length-dependent uptake of DNA-wrapped single-walled carbon nanotubes Adv. Mater. 19 2007 939 949
6. O. Boussif, F. Lezoualc'h, M.A. Zanta, M.D. Mergny, D. Scherman, B. Demeneix, and J.P. Behr A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine Proc. Natl. Acad. Sci. U. S. A. 92 1995 7297 7301
7. D. Cai, J.M. Mataraza, Z.H. Qin, Z. Huang, J. Huang, T.C. Chiles, D. Carnahan, K. Kempa, and Z. Ren Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing Nat. Methods 2 2005 449 454 (Pubitemid 40916564)
8. J.C. Carrero-Sanchez, A.L. Elias, R. Mancilla, G. Arrellin, H. Terrones, J.P. Laclette, and M. Terrones Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen Nano Lett. 6 2006 1609 1616 (Pubitemid 44327519)
9. J.Y. Cherng, P. Van De Wetering, H. Talsma, D.J.A. Crommelin, and W.E. Hennink Effect of size and serum proteins on transfection efficiency of poly ((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles Pharm. Res. 13 1996 1038 1042 (Pubitemid 26259003)
10. W. Cheung, F. Pontoriero, O. Taratula, A.M. Chen, and H. He DNA and carbon nanotubes as medicine Adv. Drug Deliv. Rev. 62 2010 633 649
11. B. Dalby, S. Cates, A. Harris, E.C. Ohki, M.L. Tilkins, P.J. Price, and V.C. Ciccarone Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications Methods 33 2004 95 103 (Pubitemid 38569654)
12. S.M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 2001 494 498 (Pubitemid 32494397)
13. C.P. Firme Iii, and P.R. Bandaru Toxicity issues in the application of carbon nanotubes to biological systems Nanomedicine 6 2009 245 256
14. I.R. Gilmore, S.P. Fox, A.J. Hollins, M. Sohail, and S. Akhtar The design and exogenous delivery of siRNA for post-transcriptional gene silencing J. Drug Target. 12 2004 315 340 (Pubitemid 39294830)
15. W. Huang, Y. Lin, S. Taylor, J. Gaillard, A.M. Rao, and Y.P. Sun Sonication-assisted functionalization and solubilization of carbon nanotubes Nano Lett. 2 2002 231 234 (Pubitemid 135706298)
16. D.A. Heller, E.S. Jeng, T.K. Yeung, B.M. Martinez, A.E. Moll, J.B. Gastala, and M.S. Strano Optical detection of DNA conformational polymorphism on single-walled carbon nanotubes Science 311 2006 508 511 (Pubitemid 43157726)
17. C. Hu, Z. Chen, A. Shen, X. Shen, J. Li, and S. Hu Water-soluble single-walled carbon nanotubes via noncovalent functionalization by a rigid, planar and conjugated diazo dye Carbon 44 2006 428 434 (Pubitemid 41636731)
18. J.H. Jeong, H. Mok, Y.K. Oh, and T.G. Park SiRNA conjugate delivery systems Bioconjug. Chem. 20 2009 5 14
19. N.W.S. Kam, T.C. Jessop, P.A. Wender, and H. Dai Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into mammalian cells J. Am. Chem. Soc. 126 2004 6850 6851 (Pubitemid 38855367)
20. N.W.S. Kam, Z. Liu, and H. Dai Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing J. Am. Chem. Soc. 127 2005 12492 12493 (Pubitemid 41292159)
21. N.W.S. Kam, Z.A. Liu, and H.J. Dai Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway Angew. Chem. Int. Ed. Engl. 45 2006 577 581 (Pubitemid 43121447)
22. J. Kayat, V. Gajbhiye, R.K. Tekade, and N.K. Jain Pulmonary toxicity of carbon nanotubes: a systematic report Nanomedicine 7 2011 40 49
23. M. Keller Nanomedicinal delivery approaches for therapeutic siRNA Int. J. Pharm. 379 2009 210 211
24. D.H. Kim, and J.J. Rossi Strategies for silencing human disease using RNA interference Nat. Rev. Genet. 8 2007 173 184
25. J. Kolosnjaj-Tabi, K.B. Hartman, S. Boudjemaa, J.S. Ananta, G. Morgant, H. Szwarc, L.J. Wilson, and F. Moussa In vivo behavior of large doses of ultra-short and full-length single-walled carbon nanotubes after oral and intraperitoneal administration to Swiss mice ACS Nano 4 2010 1481 1492
26. K. Kostarelos, L. Lacerda, G. Pastorin, W. Wu, S. Wieckowski, J. Luangsivilay, S. Godefroy, D. Pantarotto, J.P. Briand, S. Muller, M. Prato, and A. Bianco Celluar uptake of functionalized carbon nanotubes is independent of functional group and cell type Nat. Nanotechnol. 2 2007 108 113 (Pubitemid 46230832)
27. R. Krajcik, A. Jung, A. Hirsch, W. Neuhuber, and O. Zolk Functionalization of carbon nanotubes enables non-covalent binding and intracellular delivery of small interfering RNA for efficient knock-down of genes Biochem. Biophys. Res. Commun. 369 2008 595 602
28. J. Kurreck RNA interference: from basic research to therapeutic applications Angew. Chem. Int. Ed. Engl. 48 2009 1378 1398
29. M.S. Ladeira, V.A. Andrade, E.R.M. Gomes, C.J. Aguiar, E.R. Moraes, J.S. Soares, E.E. Silva, R.G. Lacerda, L.O. Ladeira, A. Jorio, P. Lima, M.F. Leite, R.R. Resende, and S. Guatimosim Highly efficient siRNA delivery system into human and murine cells using single-wall carbon nanotubes Nanotechnology 21 2010 385101
30. Y. Liu, D.C. Wu, W.D. Zhang, X. Jiang, C.B. He, T.S. Chung, S.H. Goh, and K.W. Leong Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA Angew. Chem. Int. Ed. Engl. 44 2005 4782 4785 (Pubitemid 41059186)
31. Z. Liu, M. Winters, M. Holodniy, and H. Dai siRNA delivery into human T cells and primary cells with carbon-nanotube transporters Angew. Chem. Int. Ed. Engl. 46 2007 2023 2027 (Pubitemid 46973660)
32. Z. Liu, C. Davis, W. Cai, L. He, X. Chen, and H. Dai Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy Proc. Natl. Acad. Sci. U. S. A. 105 2008 1410 1415 (Pubitemid 351346531)
33. N. Mackiewicz, G. Surendran, H. Remita, B. Keita, G. Zhang, L. Nadjo, A. Hagge, E. Doris, and C. Mioskowski Supramolecular self-assembly of amphiphiles on carbon nanotubes: a versatile strategy for the construction of CNT/metal nanohybrids, application to electrocatalysis J. Am. Chem. Soc. 130 2008 8110 8111 (Pubitemid 351898505)
34. J. Muller, M. Delos, N. Panin, V. Rabilli, F. Huaux, and D. Lison Absence of. carcinogenenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat Toxicol. Sci. 110 2009 442 448
35. P. Nikolaev, M.J. Bronikowski, R.K. Bradley, F. Rohmund, D.T. Colbert, K.A. Smith, and R.E. Smalley Gas-phase catalytic growth of single-walled carbon nanotubes from carbon monoxide Chem. Phys. Lett. 313 1999 91 97 (Pubitemid 129556626)
36. D. Pantarotto, J.P. Briand, M. Prato, and A. Bianco Translocation of bioactive peptides across cell membranes by carbon nanotubes Chem. Commun. (Camb) 2004 16 17 (Pubitemid 38121939)
37. D. Pantarotto, R. Singh, D. McCarthy, M. Erhardt, J.P. Briand, M. Prato, K. Kostarelos, and A. Bianco Functionalized carbon nanotubes for plasmid DNA gene delivery Angew. Chem. Int. Ed. Engl. 43 2004 5242 5246 (Pubitemid 39382552)
38. A. Patlolla, B. McGinnis, and P. Tchounwou Biochemical and histopathological evaluation of functionalized single-walled carbon in Swiss-Webster mice J. Appl. Toxicol. 31 2010 75 83
39. A. Pfeifer, and I.M. Verma Gene therapy: promises and problems Annu. Rev. Genomics Hum. Genet. 2 2001 177 211 (Pubitemid 35265005)
40. C.A. Poland, R. Duffin, I. Kinloch, A. Maynard, W.A. Wallace, A. Seaton, V. Stone, S. Brown, W. Macnee, and K. Donaldson Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study Nat. Nanotechnol. 3 2008 423 428
41. Y. Sakamoto, D. Nakae, N. Fukumori, K. Tayama, A. Maekawa, K. Imai, A. Hirose, T. Nishimura, N. Ohashi, and A. Ogata Induction of mesothelioma by a single intrascrotal administration of multi-walled carbon nanotube in intract male Fischer 344 rats J. Toxicol. Sci. 34 2009 65 76
42. H. Sawada, N. Naitoh, R. Kasai, and M. Suzuki Dispersion of single-walled carbon nanotubes in water by the use of novel fluorinated dendrimer-type copolymers J. Mater. Sci. 43 2008 1080 1086
43. D.A. Scudiero, R.H. Shoemaker, K.D. Paull, A. Monks, S. Tierney, T.H. Nofziger, M.J. Currens, D. Seniff, and M.R. Boyd Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines Cancer. Res. 48 1988 4827 4833
44. M.L. Schipper, N. Nakayama-Ratchford, C.R. Davis, N.W.S. Kam, P. Chu, Z. Liu, X.M. Sun, H.J. Dai, and S.S. Gambhir A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice Nat. Nanotechnol. 3 2008 216 221 (Pubitemid 351506336)
45. A. Takagi, A. Hirose, T. Nishimura, N. Fukumori, A. Ogata, N. Ohashi, S. Kitajima, and J. Kanno Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube J. Toxicol. Sci. 33 2008 105 116 (Pubitemid 351340768)
46. A.K. Varkouhi, M. Scholte, G. Storm, and H.J. Haisma Endosomal escape pathways for delivery of biologicals J. Control. Release 2010 [Epub ahead of print]
47. A.K. Varkouhi, R.J. Verheul, R.M. Schiffelers, T. Lammers, G. Storm, and W.E. Hennink Gene silencing activity of siRNA polyplexes based on thiolated N,N N-trimethylated chitosan Bioconjug. Chem. 21 2010 2339 2346
48. H. Wang, J. Wang, X. Deng, H. Sun, Z. Shi, Z. Gu, Y. Liu, and Y. Zhao Biodistribution of carbon single-wall carbon nanotubes in mice J. Nanosci. Nanotechnol. 4 2004 1019 1024 (Pubitemid 40056461)
49. X. Wang, J. Ren, and X. Qu Targeted RNA interference of cyclin A2 mediated by functionalized single-walled carbon nanotubes induces proliferation arrest and apoptosis in chronic myelogenous leukemia K562 cells ChemMedChem 3 2008 940 945
50. L. Zhang, D. Alizadeh, and B. Badie Carbon nanotube uptake and toxicity in the brain Methods Mol. Biol. 625 2010 55 65