-
1
-
-
68949214150
-
-
(1) http://www.tekmirapharm.com/Programs/Pipeline.asp
-
-
-
-
2
-
-
68949210165
-
-
(2) http://www.antigenics.com/products/cancer/aroplatin/
-
-
-
-
3
-
-
68949206835
-
-
(3) http://www.celsion.com/pipeline.cfm
-
-
-
-
4
-
-
68949218610
-
-
(4) http://www.merck.com/finance/pipeline.swf
-
-
-
-
5
-
-
68949202027
-
-
(5) http://www.alnylam.com/Programs-and-Pipeline/Programs/index.php
-
-
-
-
6
-
-
68949211548
-
-
(6) http://clinicaltrials.gov/ct2/results?term=siRNA
-
-
-
-
7
-
-
57149086661
-
Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3 inhibits cancer progression
-
Aleku M., Schulz P., Keil O., Santel A., Schaeper U., Dieckhoff B., Janke O., Endruschat J., Durieux B., Roder N., Loffler K., Lange C., Fechtner M., Mopert K., Fisch G., Dames S., Arnold W., Jochims K., Giese K., Wiedenmann B., Scholz A., and Kaufmann J. Atu027, a liposomal small interfering RNA formulation targeting protein kinase N3 inhibits cancer progression. Cancer Res. 68 (2008) 9788-9798
-
(2008)
Cancer Res.
, vol.68
, pp. 9788-9798
-
-
Aleku, M.1
Schulz, P.2
Keil, O.3
Santel, A.4
Schaeper, U.5
Dieckhoff, B.6
Janke, O.7
Endruschat, J.8
Durieux, B.9
Roder, N.10
Loffler, K.11
Lange, C.12
Fechtner, M.13
Mopert, K.14
Fisch, G.15
Dames, S.16
Arnold, W.17
Jochims, K.18
Giese, K.19
Wiedenmann, B.20
Scholz, A.21
Kaufmann, J.22
more..
-
8
-
-
45849151106
-
Genomic RNAi screening in Drosophila S2 cells: what have we learned about host-pathogen interactions?
-
Cherry S. Genomic RNAi screening in Drosophila S2 cells: what have we learned about host-pathogen interactions?. Curr. Opin. Microbiol. 11 (2008) 262-270
-
(2008)
Curr. Opin. Microbiol.
, vol.11
, pp. 262-270
-
-
Cherry, S.1
-
10
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
11
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
Elbashir S.M., Lendeckel W., and Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15 (2001) 188-200
-
(2001)
Genes Dev.
, vol.15
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
13
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A., Xu S.Q., Montgomery M.K., Kostas S.A., Driver S.E., and Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.Q.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
14
-
-
0033615491
-
A species of small antisense RNA in posttranscriptional gene silencing in plants
-
Hamilton A.J., and Baulcombe D.C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286 (1999) 950-952
-
(1999)
Science
, vol.286
, pp. 950-952
-
-
Hamilton, A.J.1
Baulcombe, D.C.2
-
15
-
-
0034998390
-
Phase I-II study of pegylated liposomal cisplatin (SPI-077 (TM)) in patients with inoperable head and neck cancer
-
Harrington K.J., Lewanski C.R., Northcote A.D., Whittaker J., Wellbank H., Vile R.G., Peters A.M., and Stewart J.S.W. Phase I-II study of pegylated liposomal cisplatin (SPI-077 (TM)) in patients with inoperable head and neck cancer. Ann. Oncol. 12 (2001) 493-496
-
(2001)
Ann. Oncol.
, vol.12
, pp. 493-496
-
-
Harrington, K.J.1
Lewanski, C.R.2
Northcote, A.D.3
Whittaker, J.4
Wellbank, H.5
Vile, R.G.6
Peters, A.M.7
Stewart, J.S.W.8
-
16
-
-
0034489252
-
Pegylated liposome-encapsulated doxorubicin and cisplatin enhance the effect of radiotherapy in a tumor xenograft model
-
Harrington K.J., Rowlinson-Busza G., Syrigos K.N., Vile R.G., Uster P.S., Peters A.M., and Stewart J.S.W. Pegylated liposome-encapsulated doxorubicin and cisplatin enhance the effect of radiotherapy in a tumor xenograft model. Clin. Cancer Res. 6 (2000) 4939-4949
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 4939-4949
-
-
Harrington, K.J.1
Rowlinson-Busza, G.2
Syrigos, K.N.3
Vile, R.G.4
Uster, P.S.5
Peters, A.M.6
Stewart, J.S.W.7
-
17
-
-
39449097277
-
Overcoming the innate immune response to small interfering RNA
-
Judge A., and MacLachlan I. Overcoming the innate immune response to small interfering RNA. Hum. Gene Ther. 19 (2008) 111-124
-
(2008)
Hum. Gene Ther.
, vol.19
, pp. 111-124
-
-
Judge, A.1
MacLachlan, I.2
-
18
-
-
32944454941
-
Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
-
Judge A.D., Bola G., Lee A.C.H., and MacLachlan I. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. 13 (2006) 494-505
-
(2006)
Mol. Ther.
, vol.13
, pp. 494-505
-
-
Judge, A.D.1
Bola, G.2
Lee, A.C.H.3
MacLachlan, I.4
-
19
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
-
Judge A.D., Sood V., Shaw J.R., Fang D., McClintock K., and MacLachlan I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23 (2005) 457-462
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
Sood, V.2
Shaw, J.R.3
Fang, D.4
McClintock, K.5
MacLachlan, I.6
-
20
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
Morrissey D.V., Lockridge J.A., Shaw L., Blanchard K., Jensen K., Breen W., Hartsough K., Machemer L., Radka S., Jadhav V., Vaish N., Zinnen S., Vargeese C., Bowman K., Shaffer C.S., Jeffs L.B., Judge A., MacLachlan I., and Polisky B. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat. Biotechnol. 23 (2005) 1002-1007
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
Blanchard, K.4
Jensen, K.5
Breen, W.6
Hartsough, K.7
Machemer, L.8
Radka, S.9
Jadhav, V.10
Vaish, N.11
Zinnen, S.12
Vargeese, C.13
Bowman, K.14
Shaffer, C.S.15
Jeffs, L.B.16
Judge, A.17
MacLachlan, I.18
Polisky, B.19
-
21
-
-
36549019575
-
High-throughput transfection and engineering of primary cells and cultured cell lines-an invaluable tool for research as well as drug development
-
Muller-Hartmann H., Faust N., Kazinski M., and Kretzschmar T. High-throughput transfection and engineering of primary cells and cultured cell lines-an invaluable tool for research as well as drug development. Expert Opin. Drug Discov. 2 (2007) 1453-1465
-
(2007)
Expert Opin. Drug Discov.
, vol.2
, pp. 1453-1465
-
-
Muller-Hartmann, H.1
Faust, N.2
Kazinski, M.3
Kretzschmar, T.4
-
22
-
-
0001359591
-
Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans
-
Napoli C., Lemieux C., and Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 2 (1990) 279-289
-
(1990)
Plant Cell
, vol.2
, pp. 279-289
-
-
Napoli, C.1
Lemieux, C.2
Jorgensen, R.3
-
23
-
-
0344926320
-
Cationic liposome-mediated delivery of siRNAs in adult mice
-
Sioud M., and Sorensen D.R. Cationic liposome-mediated delivery of siRNAs in adult mice. Biochem. Biophys. Res. Commun. 312 (2003) 1220-1225
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.312
, pp. 1220-1225
-
-
Sioud, M.1
Sorensen, D.R.2
-
24
-
-
0025405838
-
Flavonoid genes in petunia-addition of a limited number of gene copies may lead to a suppression of gene-expression
-
Vanderkrol A.R., Mur L.A., Beld M., Mol J.N.M., and Stuitje A.R. Flavonoid genes in petunia-addition of a limited number of gene copies may lead to a suppression of gene-expression. Plant Cell 2 (1990) 291-299
-
(1990)
Plant Cell
, vol.2
, pp. 291-299
-
-
Vanderkrol, A.R.1
Mur, L.A.2
Beld, M.3
Mol, J.N.M.4
Stuitje, A.R.5
-
25
-
-
57149141399
-
The silent (r)evolution of polymeric nucleic acid therapeutics
-
Wagner E. The silent (r)evolution of polymeric nucleic acid therapeutics. Pharm. Res. 25 (2008) 2920-2923
-
(2008)
Pharm. Res.
, vol.25
, pp. 2920-2923
-
-
Wagner, E.1
-
26
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann T.S., Lee A.C.H., Akinc A., Bramlage B., Bumcrot D., Fedoruk M.N., Harborth J., Heyes J.A., Jeffs L.B., John M., Judge A.D., Lam K., McClintock K., Nechev L.V., Palmer L.R., Racie T., Rohl I., Seiffert S., Shanmugam S., Sood V., Soutschek J., Toudjarska I., Wheat A.J., Yaworski E., Zedalis W., Koteliansky V., Manoharan M., Vornlocher H.P., and MacLachlan I. RNAi-mediated gene silencing in non-human primates. Nature 441 (2006) 111-114
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.H.2
Akinc, A.3
Bramlage, B.4
Bumcrot, D.5
Fedoruk, M.N.6
Harborth, J.7
Heyes, J.A.8
Jeffs, L.B.9
John, M.10
Judge, A.D.11
Lam, K.12
McClintock, K.13
Nechev, L.V.14
Palmer, L.R.15
Racie, T.16
Rohl, I.17
Seiffert, S.18
Shanmugam, S.19
Sood, V.20
Soutschek, J.21
Toudjarska, I.22
Wheat, A.J.23
Yaworski, E.24
Zedalis, W.25
Koteliansky, V.26
Manoharan, M.27
Vornlocher, H.P.28
MacLachlan, I.29
more..
|