Arsenic trioxide and radiation enhance apoptotic effects in HL-60 cells through increased ROS generation and regulation of JNK and p38 MAPK signaling pathways

Chemico-Biological Interactions

Volumn 193, Issue 2, 2011, Pages 162-171

  Ho, Sheng Yow ^a   Wu Jr , Wei ^b   Chiu, Hui Wen ^b   Chen, Yi An ^b   Ho, Yuan Soon ^c   Guo, How Ran ^b   Wang, Ying Jan ^b,d  

^a TAINAN SIN LAU HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Arsenic trioxide; HL 60; Irradiation

Indexed keywords

ARSENIC TRIOXIDE; CASPASE 3; CYCLIN B; CYCLIN DEPENDENT KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL LOSS; CELL STRAIN HL 60; CELLULAR DISTRIBUTION; CHEMORADIOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL CYCLE; CELL CYCLE PROTEINS; CELL SURVIVAL; CYCLINS; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; F-BOX PROTEINS; HL-60 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MODELS, BIOLOGICAL; OXIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR STEM CELL ASSAY; UBIQUITIN-PROTEIN LIGASES; X-RAYS;

EID: 79961016507     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.06.007     Document Type: Article

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