Neutralization of gating charges in domain II of the sodium channel α subunit enhances voltage-sensor trapping by a β-scorpion toxin

Journal of General Physiology

Volumn 118, Issue 3, 2001, Pages 291-301

  Cestèle, Sandrine ^a,b   Scheuer, Todd ^a   Mantegazza, Massimo ^a   Rochat, Hervé ^b   Catterall, William A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b AIX MARSEILLE UNIVERSITY   (France)

Author keywords

scorpion toxin; Centruroides suffusus suffusus toxin IV; Sodium channels; Voltage sensor; Voltage dependent gating

Indexed keywords

AMINO ACID; GLUTAMINE; SCORPION VENOM; SODIUM CHANNEL; SULFONIC ACID DERIVATIVE;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CHANNEL GATING; CONTROLLED STUDY; MEMBRANE POTENTIAL; MUTAGENESIS; NONHUMAN; RAT; RECEPTOR BINDING; REPOLARIZATION;

ARGININE; CELL LINE; ELECTROPHYSIOLOGY; HUMANS; ION CHANNEL GATING; MEMBRANES; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; SCORPION VENOMS; SODIUM CHANNELS;

EID: 0034843175     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.118.3.291     Document Type: Article

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