Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse

Journal of Biological Chemistry

Volumn 286, Issue 31, 2011, Pages 27582-27593

  Song, Weihua ^a   Dyer, Emma ^a   Stuckey, Daniel J ^a   Copeland, O'Neal ^a   Leung, Man Ching ^a   Bayliss, Christopher ^a   Messer, Andrew ^a   Wilkinson, Ross ^a   Tremoleda, Jordi Lopez ^e   Schneider, Michael D ^a   Harding, Sian E ^a   Redwood, Charles S ^b   Clarke, Kieran ^b   Nowak, Kristen ^c   Monserrat, Lorenzo ^d   Wells, Dominic ^e   Marston, Steven B ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d HOSPITAL JUAN CANALEJO   (Spain)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATRIAL FLUTTER; CARDIAC DEATH; DEATH RATES; DILATED CARDIOMYOPATHY; ECTOPIC BEATS; END-DIASTOLIC; END-SYSTOLIC PRESSURE; END-SYSTOLIC VOLUMES; HEART FAILURE; IN-VITRO; MOLECULAR MECHANISM; MYOFIBRILLAR; PAPILLARY MUSCLE; RELAXATION RATES; THIN FILAMENTS; TRANSGENIC MICE; TROPONIN I;

BIOLOGICAL ORGANS; BLOOD PRESSURE; CALCIUM; CARDIOLOGY; ELECTROCARDIOGRAPHY; ELECTROCHROMIC DEVICES; GENES; HEART; MAMMALS; PATHOLOGY; PHOSPHORYLATION; PLANTS (BOTANY); POPULATION STATISTICS;

PROTEINS;

ACTIN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM ION; MYOSIN BINDING PROTEIN C; TROPONIN I;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE MODEL; ELECTROCARDIOGRAPHY; FEMALE; GENE MUTATION; HEART ATRIUM ENLARGEMENT; HEART ATRIUM FLUTTER; HEART FAILURE; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART MUSCLE RELAXATION; HEART PAPILLARY MUSCLE; HEART RIGHT VENTRICLE ENDDIASTOLIC VOLUME; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HUMAN; HUMAN TISSUE; HYPERTROPHIC CARDIOMYOPATHY; IN VITRO STUDY; MALE; MOLECULAR MECHANICS; MORTALITY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SARCOMERE; SUDDEN DEATH; SUPRAVENTRICULAR PREMATURE BEAT; SURVIVAL RATE; SYSTOLIC BLOOD PRESSURE; THIN FILAMENT; TRANSGENIC MOUSE;

ACTINS; ANIMALS; CARDIOMEGALY; FEMALE; HUMANS; MALE; MICE; MICE, TRANSGENIC; MUTATION;

MUS; MUS MUSCULUS;

EID: 79960977475     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.252320     Document Type: Article

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