Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy

Journal of Molecular and Cellular Cardiology

Volumn 49, Issue 5, 2010, Pages 737-745

  Hoskins, Anita C ^a   Jacques, Adam ^b   Bardswell, Sonya C ^a   McKenna, William J ^c   Tsang, Victor ^c   dos Remedios, Cristobal G ^d   Ehler, Elisabeth ^a   Adams, Kim ^e   Jalilzadeh, Shapour ^e   Avkiran, Metin ^a   Watkins, Hugh ^e   Redwood, Charles ^e   Marston, Steven B ^b   Kentish, Jonathan C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF SYDNEY   (Australia)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Ca2+ sensitivity; Cross bridge kinetics; Hypertrophic cardiomyopathy; Skinned cardiac myocytes; Viscoelasticity

Indexed keywords

ALPHA ACTININ; CONNECTIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; MYOSIN BINDING PROTEIN C; TROPONIN I;

ARTICLE; CALCIUM MOBILIZATION; CELL STRUCTURE; CONTROLLED STUDY; DONOR; GENE MUTATION; GENETIC VARIABILITY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILE FORCE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTROPHIC CARDIOMYOPATHY; MUSCLE FIBRIL; MUSCLE RELAXATION; MUSCLE STIFFNESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKINNED MUSCLE FIBER; STEADY STATE; VISCOELASTICITY;

BIOMECHANICS; CALCIUM; CARDIOMYOPATHY, HYPERTROPHIC; ELASTICITY; HUMANS; ISOMETRIC CONTRACTION; KINETICS; MYOCYTES, CARDIAC; MYOFIBRILS; SARCOMERES; STRESS, PHYSIOLOGICAL; VISCOSITY;

EID: 77957233852     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.06.006     Document Type: Article

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