γδ T-APCs: A novel tool for immunotherapy?

Cellular and Molecular Life Sciences

Volumn 68, Issue 14, 2011, Pages 2443-2452

  Moser, Bernhard ^a   Eberl, Matthias ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

T cells; T cells; Antigen presentation; Cancer; Chemokines; Cytokines; Dendritic cells; Immunotherapy

Indexed keywords

4 HYDROXY 3 METHYL BUT 2 ENYLPYROPHOSPHATE; AMINOBISPHOSPHONATE DERIVATIVE; BACTERIAL ANTIGEN; BIOLOGIC FACTORS AND AGENTS ACTING ON THE IMMUNE SYSTEM; BISPHOSPHONIC ACID DERIVATIVE; CANCER VACCINE; INTERLEUKIN 2; PICOSTIM; PYROPHOSPHORIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

ACUTE PHASE RESPONSE; ALPHA BETA T LYMPHOCYTE; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; BACTERIAL IMMUNITY; CANCER IMMUNOTHERAPY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DENDRITIC CELL; DRUG MECHANISM; DRUG SAFETY; GAMMA DELTA T LYMPHOCYTE; HOST CELL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; MALIGNANT NEOPLASTIC DISEASE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; REVIEW; SIDE EFFECT; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TUMOR IMMUNITY; UNSPECIFIED SIDE EFFECT;

ANTIGEN-PRESENTING CELLS; ANTIGENS; CYTOKINES; DIPHOSPHATES; HUMANS; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES;

PRIMATES;

EID: 79960943854     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0706-6     Document Type: Review

References (70)

1. Caccamo N, Dieli F, Wesch D, Jomaa H, Eberl M (2006) Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. J Leukoc Biol 79:663-666 (Pubitemid 44835598)
2. Morita CT, Jin C, Sarikonda G, Wang H (2007) Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vgamma2Vdelta2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens. Immunol Rev 215:59-76 (Pubitemid 46212230)
3. Sicard H, Fournie JJ (2000) Metabolic routes as targets for immunological discrimination of host and parasite. Infect Immun 68:4375-4377 (Pubitemid 30497700)
4. Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas AK, Beck E, Wiesner J, Eberl M, Jomaa H (2001) Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Lett 509:317-322 (Pubitemid 34015963)
5. Eberl M, Hintz M, Reichenberg A, Kollas AK, Wiesner J, Jomaa H (2003) Microbial isoprenoid biosynthesis and human gammadelta T cell activation. FEBS Lett 544:4-10 (Pubitemid 36628027)
6. Brandes M, Willimann K, Lang AB, Nam KH, Jin C, Brenner MB, Morita CT, Moser B (2003) Flexible migration program regulates gamma delta T-cell involvement in humoral immunity. Blood 102:3693-3701 (Pubitemid 37409390)
7. Glatzel A, Wesch D, Schiemann F, Brandt E, Janssen O, Kabelitz D (2002) Patterns of chemokine receptor expression on peripheral blood gamma delta T lymphocytes: strong expression of CCR5 is a selective feature of V delta 2/V gamma 9 gamma delta T cells. J Immunol 168:4920-4929 (Pubitemid 34498305)
8. Cipriani B, Borsellino G, Poccia F, Placido R, Tramonti D, Bach S, Battistini L, Brosnan CF (2000) Activation of C-C β-chemokines in human peripheral blood gammaδ T cells by isopentenyl pyrophosphate and regulation by cytokines. Blood 95:39-47
9. Poggi A, Carosio R, Fenoglio D, Brenci S, Murdaca G, Setti M, Indiveri F, Scabini S, Ferrero E, Zocchi MR (2004) Migration of V delta 1 and V delta 2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: competition by HIV-1 Tat. Blood 103:2205-2213 (Pubitemid 38326239)
10. Moser B, Loetscher P (2001) Lymphocyte traffic control by chemokines. Nat Immunol 2:123-128 (Pubitemid 33707929)
11. Moser B, Wolf M, Walz A, Loetscher P (2004) Chemokines: multiple levels of leukocyte migration control. Trends Immunol 25:75-84 (Pubitemid 38167488)
12. Eberl M, Moser B (2009) Monocytes and gammadelta T cells: close encounters in microbial infection. Trends Immunol 30:562-568
13. Sallusto F, Mackay CR, Lanzavecchia A (2000) The role of chemokine receptors in primary, effector, and memory immune responses. Annu Rev Immunol 18:593-620 (Pubitemid 30365392)
14. Groh V, Porcelli S, Fabbi M, Lanier LL, Picker LJ, Anderson T, Warnke RA, Bhan AK, Strominger JL, Brenner MB (1989) Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system. J Exp Med 169:1277-1294 (Pubitemid 19104962)
15. Dieli F, Poccia F, Lipp M, Sireci G, Caccamo N, Di Sano C, Salerno A (2003) Differentiation of effector/memory Vdelta2 T cells and migratory routes in lymph nodes or inflammatory sites. J Exp Med 198:391-397 (Pubitemid 36980610)
16. Vermijlen D, Ellis P, Langford C, Klein A, Engel R, Willimann K, Jomaa H, Hayday AC, Eberl M (2007) Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. J Immunol 178:4304-4314 (Pubitemid 46492381)
17. Caccamo N, Battistini L, Bonneville M, Poccia F, Fournie JJ, Meraviglia S, Borsellino G, Kroczek RA, La Mendola C, Scotet E, Dieli F, Salerno A (2006) CXCR5 identifies a subset of Vgamma9 Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production. J Immunol 177:5290-5295 (Pubitemid 44527601)
18. Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B (2000) CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 192:1553-1562
19. Vinuesa CG, Tangye SG, Moser B, Mackay CR (2005) Follicular B helper T cells in antibody responses and autoimmunity. Nat Rev Immunol 5:853-865 (Pubitemid 41581667)
20. Brandes M, Willimann K, Moser B (2005) Professional antigen-presentation function by human gammadelta T cells. Science 309:264-268 (Pubitemid 40967855)
21. Meuter S, Eberl M, Moser B (2010) Prolonged antigen survival and cytosolic export in cross-presenting human gammadelta T cells. Proc Natl Acad Sci USA 107:8730-8735
22. + alphabeta T cell responses. Proc Natl Acad Sci USA 106:2307-2312
23. Wu Y, Wu W, Wong WM, Ward E, Thrasher AJ, Goldblatt D, Osman M, Digard P, Canaday DH, Gustafsson K (2009) Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis. J Immunol 183:5622-5629
24. + T-cell responses to subdominant Epstein Barr virus epitopes: potential for immunotherapy of cancer. J Immunother 32:310-321
25. Langenkamp A, Messi M, Lanzavecchia A, Sallusto F (2000) Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 1:311-316
26. Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA (2005) Mechanisms of MHC class I-restricted antigen processing and cross-presentation. Immunol Rev 207:145-157 (Pubitemid 41415014)
27. Villadangos JA, Heath WR, Carbone FR (2007) Outside looking in: the inner workings of the cross-presentation pathway within dendritic cells. Trends Immunol 28:45-47 (Pubitemid 46176737)
28. + dendritic cells. J Exp Med 207:1131-1134
29. Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES (2005) Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science 307:1630-1634 (Pubitemid 40354746)
30. Davey MS, Lin CY, Roberts GW, Heuston S, Brown AC, Chess JA, Toleman MA, Gahan CG, Hill C, Parish T, Williams JD, Davies SJ, Johnson DW, Topley N, Moser B, Eberl M (2011) Human neutrophil clearance of bacterial pathogens triggers antimicrobial gammadelta T cell responses in early infection. PLoS Pathog 7:e1002040
31. Eberl M, Roberts GW, Meuter S, Williams JD, Topley N, Moser B (2009) A Rapid crosstalk of human gammadelta T Cells and monocytes drives the acute inflammation in bacterial infections. PLoS Pathog 5:e1000308
32. Dieli F, Sireci G, Di Sano C, Champagne E, Fournie JJ, Salerno JI (1999) Predominance of Vgamma9/Vdelta2 T lymphocytes in the cerebrospinal fluid of children with tuberculous meningitis: reversal after chemotherapy. Mol Med 5:301-312 (Pubitemid 29342965)
33. Parker CM, Groh V, Band H, Porcelli SA, Morita C, Fabbi M, Glass D, Strominger JL, Brenner MB (1990) Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire. J Exp Med 171:1597-1612 (Pubitemid 20167553)
34. Green AE, Lissina A, Hutchinson SL, Hewitt RE, Temple B, James D, Boulter JM, Price DA, Sewell AK (2004) Recognition of nonpeptide antigens by human V gamma 9 V delta 2 T cells requires contact with cells of human origin. Clin Exp Immunol 136:472-482 (Pubitemid 38703681)
35. Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT (2008) Photoaffinity antigens for human gammadelta T cells. J Immunol 181:7738-7750
36. Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, Adoro S, Adams A, Sharrow SO, Feigenbaum L, Singer A (2007) Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC. Immunity 27:735-750 (Pubitemid 350102257)
37. Pechhold K, Wesch D, Schondelmaier S, Kabelitz D (1994) Primary activation of V gamma 9-expressing gamma delta T cells by Mycobacterium tuberculosis. Requirement for Th1-type CD4 T cell help and inhibition by IL-10. J Immunol 152:4984-4992
38. Boullier S, Poquet Y, Debord T, Fournie JJ, Gougeon ML (1999) Regulation by cytokines (IL-12, IL-15, IL-4 and IL-10) of the Vgamma9 Vdelta2 T cell response to mycobacterial phosphoantigens in responder and anergic HIV-infected persons. Eur J Immunol 29:90-99 (Pubitemid 29043526)
39. Eberl M, Altincicek B, Kollas AK, Sanderbrand S, Bahr U, Reichenberg A, Beck E, Foster D, Wiesner J, Hintz M, Jomaa H (2002) Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 106:200-211 (Pubitemid 34621828)
40. Rojas RE, Torres M, Fournie JJ, Harding CV, Boom WH (2002) Phosphoantigen presentation by macrophages to Mycobacterium tuberculosis-reactive Vgamma9 Vdelta2 + T cells: modulation by chloroquine. Infect Immun 70:4019-4027 (Pubitemid 34790908)
41. Wei H, Huang D, Lai X, Chen M, Zhong W, Wang R, Chen ZW (2008) Definition of APC presentation of phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate to Vgamma2 Vdelta 2 TCR. J Immunol 181:4798-4806
42. Huang D, Shen Y, Qiu L, Chen CY, Shen L, Estep J, Hunt R, Vasconcelos D, Du G, Aye P, Lackner AA, Larson M, Jacobs WR Jr, Haynes BF, Letvin NL, Chen ZW (2008) Immune distribution and localization of phosphoantigen-specific V{gamma}2 V{delta}2 T cells in lymphoid and non-lymphoid tissues in M tuberculosis infection. Infect Immun 76:426-436
43. Shen Y, Zhou D, Qiu L, Lai X, Simon M, Shen L, Kou Z, Wang Q, Jiang L, Estep J, Hunt R, Clagett M, Sehgal PK, Li Y, Zeng X, Morita CT, Brenner MB, Letvin NL, Chen ZW (2002) Adaptive immune response of Vgamma2 Vdelta2 + T cells during mycobacterial infections. Science 295:2255-2258 (Pubitemid 34258837)
44. Cairo C, Hebbeler AM, Propp N, Bryant JL, Colizzi V, Pauza CD (2007) Innate-like gammadelta T cell responses to mycobacterium Bacille Calmette-Guerin using the public V gamma 2 repertoire in Macaca fascicularis. Tuberculosis (Edinb) 87:373-383 (Pubitemid 46936237)
45. Cendron D, Ingoure S, Martino A, Casetti R, Horand F, Romagne F, Sicard H, Fournie JJ, Poccia F (2007) A tuberculosis vaccine based on phosphoantigens and fusion proteins induces distinct gammadelta and alphabeta T cell responses in primates. Eur J Immunol 37:549-565 (Pubitemid 46915593)
46. Cheng L, Cui Y, Shao H, Han G, Zhu L, Huang Y, O'Brien RL, Born WK, Kaplan HJ, Sun D (2008) Mouse gammadelta T cells are capable of expressing MHC class II molecules, and of functioning as antigen-presenting cells. J Neuroimmunol 203:2-11
47. + alphabeta T cells. J Leukoc Biol 63:707-714
48. Takamatsu HH, Denyer MS, Wileman TE (2002) A sub-population of circulating porcine gammadelta T cells can act as professional antigen presenting cells Vet. Immunol Immunopathol 87:223-224 (Pubitemid 34665242)
49. Takamatsu HH, Denyer MS, Stirling C, Cox S, Aggarwal N, Dash P, Wileman TE, Barnett PV (2006) Porcine gammadelta T cells: possible roles on the innate and adaptive immune responses following virus infection. Vet Immunol Immunopathol 112:49-61 (Pubitemid 43817197)
50. Lanzavecchia A, Roosnek E, Gregory T, Berman P, Abrignani S (1988) T cells can present antigens such as HIV gp120 targeted to their own surface molecules. Nature 334:530-532
51. Price SJ, Hope JC (2009) Enhanced secretion of interferon-gamma by bovine gammadelta T cells induced by coculture with Mycobacterium bovis-infected dendritic cells: evidence for reciprocal activating signals. Immunology 126:201-208
52. Steinman RM, Banchereau J (2007) Taking dendritic cells into medicine. Nature 449:419-426 (Pubitemid 47509552)
53. Sallusto F, Lanzavecchia A (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179:1109-1118
54. Kondo M, Sakuta K, Noguchi A, Ariyoshi N, Sato K, Sato S, Sato K, Hosoi A, Nakajima J, Yoshida Y, Shiraishi K, Nakagawa K, Kakimi K (2008) Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy. Cytotherapy 10:842-856
55. Reid IR, Gamble GD, Mesenbrink P, Lakatos P, Black M (2010) Characterization of and risk factors for the acute-phase response after zoledronic acid. J Clin Endocrinol Metab (in press)
56. Coleman R (2010) The use of bisphosphonates in cancer treatment. Ann N Y Acad Sci
57. Kunzmann V, Bauer E, Wilhelm M (1999) Gamma/delta T-cell stimulation by pamidronate. N Engl J Med 340:737-738
58. Dieli F, Gebbia N, Poccia F, Caccamo N, Montesano C, Fulfaro F, Arcara C, Valerio MR, Meraviglia S, Di Sano C, Sireci G, Salerno A (2003) Induction of gammadelta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo. Blood 102:2310-2311 (Pubitemid 37122416)
59. Roelofs AJ, Jauhiainen M, Monkkonen H, Rogers MJ, Monkkonen J, Thompson K (2009) Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP. Br J Haematol 144:245-250
60. Hu X, Ivashkiv LB (2009) Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity 31:539-550
61. Wesch D, Glatzel A, Kabelitz D (2001) Differentiation of resting human peripheral blood gamma delta T cells toward Th1- or Th2-phenotype. Cell Immunol 212:110-117 (Pubitemid 34044542)
62. Ness-Schwickerath KJ, Jin C, Morita CT (2010) Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells. J Immunol 184:7268-7280
63. Pietschmann K, Beetz S, Welte S, Martens I, Gruen J, Oberg HH, Wesch D, Kabelitz D (2009) Toll-like receptor expression and function in subsets of human gammadelta T lymphocytes. Scand J Immunol 70:245-255
64. Kobayashi H, Tanaka Y, Yagi J, Osaka Y, Nakazawa H, Uchiyama T, Minato N, Toma H (2007) Safety profile and antitumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma: a pilot study. Cancer Immunol Immunother 56:469-476 (Pubitemid 46204533)
65. Kobayashi H, Tanaka Y, Shimmura H, Minato N, Tanabe K (2010) Complete remission of lung metastasis following adoptive immunotherapy using activated autologous gammadelta T-cells in a patient with renal cell carcinoma. Anticancer Res 30:575-579
66. Bennouna J, Bompas E, Neidhardt EM, Rolland F, Philip I, Galea C, Salot S, Saiagh S, Audrain M, Rimbert M, Lafaye-de Micheaux S, Tiollier J, Negrier S (2008) Phase-I study of Innacell gammadelta, an autologous cell-therapy product highly enriched in gamma9delta2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma. Cancer Immunol Immunother 57:1599-1609
67. Nakajima J, Murakawa T, Fukami T, Goto S, Kaneko T, Yoshida Y, Takamoto S, Kakimi K (2010) A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells. Eur J Cardiothorac Surg 37:1191-1197
68. Kunzmann V, Bauer E, Feurle J, Weissinger F, Tony HP, Wilhelm M (2000) Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 96:384-392 (Pubitemid 30463353)
69. Lamb LS Jr, Lopez RD (2005) Gammadelta T cells: a new frontier for immunotherapy? Biol Blood Marrow Transplant 11:161-168
70. June CH, Blazar BR, Riley JL (2009) Engineering lymphocyte subsets: tools, trials and tribulations. Nat Rev Immunol 9:704-716