메뉴 건너뛰기




Volumn 30, Issue 8, 2011, Pages 545-554

Azithromycin treatment modulates the extracellular signal-regulated kinase mediated pathway and inhibits inflammatory cytokines and chemokines in epithelial cells from infertile women with recurrent Chlamydia trachomatis infection

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CHEMOKINE; CXCL1 CHEMOKINE; CXCL9 CHEMOKINE; CYTOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; INTERLEUKIN 1BETA; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN MCL 1; RANTES;

EID: 79960936582     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2010.1167     Document Type: Article
Times cited : (12)

References (81)
  • 1
    • 26244439284 scopus 로고    scopus 로고
    • The chlamydial developmental cycle
    • DOI 10.1016/j.femsre.2005.03.002, PII S0168644505000239
    • Abdelrahman, Y.M., and Belland, R.J. (2005).The chlamydial developmental cycle. FEMS Microbiol Rev 29, 949-959. (Pubitemid 41416845)
    • (2005) FEMS Microbiology Reviews , vol.29 , Issue.5 , pp. 949-959
    • AbdelRahman, Y.M.1    Belland, R.J.2
  • 2
    • 34748898982 scopus 로고    scopus 로고
    • Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants
    • DOI 10.1203/PDR.0b013e318142582d
    • Aghai, Z.H., Kode, A., Saslow, J.G., Nakhla, T., Farhath, S., Stahl, G.E., Eydelman, R., Strande, L., Leone, P., and Rahman, I. (2007).Azithromycin suppresses activation of nuclear factorkappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants. Pediatr Res 62, 483-488. (Pubitemid 47476210)
    • (2007) Pediatric Research , vol.62 , Issue.4 , pp. 483-488
    • Aghai, Z.H.1    Kode, A.2    Saslow, J.G.3    Nakhla, T.4    Farhath, S.5    Stahl, G.E.6    Eydelman, R.7    Strande, L.8    Leone, P.9    Rahman, I.10
  • 3
    • 34247872889 scopus 로고    scopus 로고
    • Mucosal and peripheral immune responses to chlamydial heat shock proteins in women infected with Chlamydia trachomatis
    • DOI 10.1111/j.1365-2249.2007.03357.x
    • Agrawal, T., Vats, V., Salhan, S., and Mittal, A. (2007a).Mucosal and peripheral immune responses to chlamydial heat shock proteins in women infected with Chlamydia trachomatis. Clin Exp Immunol 148, 461-468. (Pubitemid 46701021)
    • (2007) Clinical and Experimental Immunology , vol.148 , Issue.3 , pp. 461-468
    • Agrawal, T.1    Vats, V.2    Salhan, S.3    Mittal, A.4
  • 4
    • 33947267483 scopus 로고    scopus 로고
    • Cervical cytokine responses in women with primary or recurrent chlamydial infection
    • DOI 10.1089/jir.2006.0132
    • Agrawal, T., Vats, V., Wallace, P.K., Salhan, S., and Mittal, A. (2007b).Cervical cytokine responses in women with primary or recurrent chlamydial infection. J Interferon Cytokine Res 27, 221-226. (Pubitemid 46435489)
    • (2007) Journal of Interferon and Cytokine Research , vol.27 , Issue.3 , pp. 221-226
    • Agrawal, T.1    Vats, V.2    Wallace, P.K.3    Salhan, S.4    Mittal, A.5
  • 5
    • 0034806628 scopus 로고    scopus 로고
    • The prevalence of Chlamydia trachomatis in fresh tissue specimens from patients with ectopic pregnancy or tubal factor infertility as determined by PCR and in-situ hybridisation
    • Barlow, R.E., Cooke, I.D., Odukoya, O., Heatley, M.K., Jenkins, J., Narayansingh, G., Ramsewak, S.S., and Eley, A. (2001).The prevalence of Chlamydia trachomatis in fresh tissue specimens from patients with ectopic pregnancy or tubal factor infertility as determined by PCR and in-situ hybridisation. J Med Microbiol 50, 902-908. (Pubitemid 32905219)
    • (2001) Journal of Medical Microbiology , vol.50 , Issue.10 , pp. 902-908
    • Barlow, R.E.L.1    Cooke, I.D.2    Odukoya, O.3    Heatley, M.K.4    Jenkins, J.5    Narayansingh, G.6    Ramsewak, S.S.7    Eley, A.8
  • 6
    • 67651204601 scopus 로고    scopus 로고
    • Rac1 signaling modulates BCL-6-mediated repression of gene transcription
    • Barros, P., Jordan, P., and Matos, P. (2009).Rac1 signaling modulates BCL-6-mediated repression of gene transcription. Mol Cell Biol 29, 4156-4166.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 4156-4166
    • Barros, P.1    Jordan, P.2    Matos, P.3
  • 7
    • 0028274183 scopus 로고
    • Repeated and persistent infection with Chlamydia and the development of chronic inflammation and disease
    • Beatty, W.L., Byrne, G.I., and Morrison, R.P. (1994).Repeated and persistent infection with Chlamydia and the development of chronic inflammation and disease. Trends Microbiol 2, 94-98. (Pubitemid 24072108)
    • (1994) Trends in Microbiology , vol.2 , Issue.3 , pp. 94-98
    • Beatty, W.L.1    Byrne, G.I.2    Morrison, R.P.3
  • 8
    • 68849119006 scopus 로고    scopus 로고
    • Azithromycin attenuates airway inflammation in a noninfectious mouse model of allergic asthma
    • Beigelman, A., Gunsten, S., Mikols, C.L., Vidavsky, I., Cannon, C.L., Brody, S.L., and Walter, M.J. (2009).Azithromycin attenuates airway inflammation in a noninfectious mouse model of allergic asthma. Chest 136, 498-506.
    • (2009) Chest , vol.136 , pp. 498-506
    • Beigelman, A.1    Gunsten, S.2    Mikols, C.L.3    Vidavsky, I.4    Cannon, C.L.5    Brody, S.L.6    Walter, M.J.7
  • 10
    • 0036151258 scopus 로고    scopus 로고
    • Chemokine and chemokine receptor dynamics during genital chlamydial infection
    • DOI 10.1128/IAI.70.2.844-850.2002
    • Belay, T., Eko, F.O., Ananaba, G.A., Bowers, S., Moore, T., Lyn, D., and Igietseme, J.U. (2002).Chemokine and chemokine receptor dynamics during genital chlamydial infection. Infect Immun 70, 844-850. (Pubitemid 34083848)
    • (2002) Infection and Immunity , vol.70 , Issue.2 , pp. 844-850
    • Belay, T.1    Eko, F.O.2    Ananaba, G.A.3    Bowers, S.4    Moore, T.5    Lyn, D.6    Igietseme, J.U.7
  • 11
    • 70349316444 scopus 로고    scopus 로고
    • Azithromycin and clarithromycin inhibit lipopolysaccharide-induced murine pulmonary neutrophilia mainly through effects on macrophage-derived granulocyte-macrophage colony-stimulating factor and interleukin-1beta
    • Bosnar, M., Bosnjak, B., Cuzic, S., Hrvacic, B., Marjanovic, N., Glojnaric, I., Culic, O., Parnham, M.J., and Erakovic Haber, V. (2009).Azithromycin and clarithromycin inhibit lipopolysaccharide- induced murine pulmonary neutrophilia mainly through effects on macrophage-derived granulocyte-macrophage colony-stimulating factor and interleukin-1beta. J Pharmacol Exp Ther 331, 104-113.
    • (2009) J. Pharmacol. Exp. Ther. , vol.331 , pp. 104-113
    • Bosnar, M.1    Bosnjak, B.2    Cuzic, S.3    Hrvacic, B.4    Marjanovic, N.5    Glojnaric, I.6    Culic, O.7    Parnham, M.J.8    Erakovic Haber, V.9
  • 12
    • 33749556406 scopus 로고    scopus 로고
    • Activation of the host cell proinflammatory interleukin-8 response by Chlamydia trachomatis
    • DOI 10.1111/j.1462-5822.2006.00747.x
    • Buchholz, K.R., and Stephens, R.S. (2006).Activation of the host cell proinflammatory interleukin-8 response by Chlamydia trachomatis. Cell Microbiol 8, 1768-1779. (Pubitemid 44530669)
    • (2006) Cellular Microbiology , vol.8 , Issue.11 , pp. 1768-1779
    • Buchholz, K.R.1    Stephens, R.S.2
  • 13
    • 36749049173 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase/mitogen-activated protein kinase pathway induces the inflammatory factor interleukin-8 following Chlamydia trachomatis infection
    • DOI 10.1128/IAI.01029-07
    • Buchholz, K.R., and Stephens, R.S. (2007).The extracellular signal-regulated kinase/mitogen-activated protein kinase pathway induces the inflammatory factor interleukin-8 following Chlamydia trachomatis infection. Infect Immun 75, 5924-5929. (Pubitemid 350207832)
    • (2007) Infection and Immunity , vol.75 , Issue.12 , pp. 5924-5929
    • Buchholz, K.R.1    Stephens, R.S.2
  • 14
    • 4844226351 scopus 로고    scopus 로고
    • Chlamydia and apoptosis: Life and death decisions of an intracellular pathogen
    • DOI 10.1038/nrmicro1007
    • Byrne, G.I., and Ojcius, D.M. (2004).Chlamydia and apoptosis: life and death decisions of an intracellular pathogen. Nat Rev Microbiol 2, 802-808. (Pubitemid 39317461)
    • (2004) Nature Reviews Microbiology , vol.2 , Issue.10 , pp. 802-808
    • Byrne, G.I.1    Ojcius, D.M.2
  • 15
    • 0027936338 scopus 로고
    • Detection of Chlamydia trachomatis deoxyribonucleic acid in monkey models (Macaca nemestrina) of salpingitis by in situ hybridization: Implications for pathogenesis
    • Cappuccio, A.L., Patton, D.L., Kuo, C.C., and Campbell, L.A. (1994).Detection of Chlamydia trachomatis deoxyribonucleic acid in monkey models (Macaca nemestrina) of salpingitis by in situ hybridization: implications for pathogenesis. Am J Obstet Gynecol 171, 102-110. (Pubitemid 24254426)
    • (1994) American Journal of Obstetrics and Gynecology , vol.171 , Issue.1 , pp. 102-110
    • Cappuccio, A.L.1    Patton, D.L.2    Kuo, C.-C.3    Campbell, L.A.4
  • 16
    • 33847688940 scopus 로고    scopus 로고
    • Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells
    • DOI 10.1128/AAC.01142-06
    • Cigana, C., Assael, B.M., and Melotti, P. (2007).Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. Antimicrob Agents Chemother 51, 975-981. (Pubitemid 46355283)
    • (2007) Antimicrobial Agents and Chemotherapy , vol.51 , Issue.3 , pp. 975-981
    • Cigana, C.1    Assael, B.M.2    Melotti, P.3
  • 17
    • 33846052176 scopus 로고    scopus 로고
    • qPrimerDepot: A primer database for quantitative real time PCR
    • DOI 10.1093/nar/gkl767
    • Cui, W., Taub, D.D., and Gardner, K. (2007).qPrimerDepot: a primer database for quantitative real time PCR. Nucleic Acids Res 35, D805-D809. (Pubitemid 46056313)
    • (2007) Nucleic Acids Research , vol.35 , Issue.SUPPL. 1
    • Cui, W.1    Taub, D.D.2    Gardner, K.3
  • 19
    • 0035179698 scopus 로고    scopus 로고
    • Mouse strain-dependent chemokine regulation of the genital tract T helper cell type 1 immune response
    • DOI 10.1128/IAI.69.12.7419-7424.2001
    • Darville, T., Andrews, C.W., Jr., Sikes, J.D., Fraley, P.L., Braswell, L., and Rank, R.G. (2001).Mouse strain-dependent chemokine regulation of the genital tract T helper cell type 1 immune response. Infect Immun 69, 7419-7424. (Pubitemid 33086567)
    • (2001) Infection and Immunity , vol.69 , Issue.12 , pp. 7419-7424
    • Darville, T.1    Andrews Jr., C.W.2    Sikes, J.D.3    Fraley, P.L.4    Braswell, L.5    Rank, R.G.6
  • 20
    • 77953102683 scopus 로고    scopus 로고
    • Pathogenesis of genital tract disease due to chlamydia trachomatis
    • Darville, T., and Hiltke, T.J. (2010).Pathogenesis of genital tract disease due to Chlamydia trachomatis. J Infect Dis 201 Suppl 2, S114-S125.
    • (2010) J. Infect Dis. , vol.201 , Issue.2
    • Darville, T.1    Hiltke, T.J.2
  • 21
    • 0035078436 scopus 로고    scopus 로고
    • Persistent Chlamydia trachomatis infections resist apoptotic stimuli
    • DOI 10.1128/IAI.69.4.2442-2447.2001
    • Dean, D., and Powers, V.C. (2001).Persistent Chlamydia trachomatis infections resist apoptotic stimuli. Infect Immun 69, 2442-2447. (Pubitemid 32239715)
    • (2001) Infection and Immunity , vol.69 , Issue.4 , pp. 2442-2447
    • Dean, D.1    Powers, V.C.2
  • 22
    • 0021840239 scopus 로고
    • Interferon-induced inhibition of Chlamydia trachomatis: Dissociation from antiviral and antiproliferative effects
    • de la Maza, L.M., Peterson, E.M., Goebel, J.M., Fennie, C.W., and Czarniecki, C.W. (1985).Interferon-induced inhibition of Chlamydia trachomatis: dissociation from antiviral and antiproliferative effects. Infect Immun 47, 719-722. (Pubitemid 15075866)
    • (1985) Infection and Immunity , vol.47 , Issue.3 , pp. 719-722
    • De La Maza, L.M.1    Peterson, E.M.2    Goebel, J.M.3
  • 24
    • 0032536526 scopus 로고    scopus 로고
    • Inhibition of apoptosis in chlamydia-infected cells: Blockade of mitochondrial cytochrome c release and caspase activation
    • DOI 10.1084/jem.187.4.487
    • Fan, T., Lu, H., Hu, H., Shi, L., McClarty, G.A., Nance, D.M., Greenberg, A.H., and Zhong, G. (1998).Inhibition of apoptosis in chlamydia-infected cells: blockade of mitochondrial cytochrome c release and caspase activation. J Exp Med 187, 487-496. (Pubitemid 28093351)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.4 , pp. 487-496
    • Fan, T.1    Lu, H.2    Hu, H.3    Shi, L.4    McClarty, G.A.5    Nance, D.M.6    Greenberg, A.H.7    Zhong, G.8
  • 26
    • 0025096817 scopus 로고
    • The pharmacokinetics of azithromycin in human serum and tissues
    • Foulds, G., Shepard, R.M., and Johnson, R.B. (1990).The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 25 Suppl A, 73-82. (Pubitemid 20043952)
    • (1990) Journal of Antimicrobial Chemotherapy , vol.25 , Issue.SUPPL. A , pp. 73-82
    • Foulds, G.1    Shepard, R.M.2    Johnson, R.B.3
  • 27
    • 67349226398 scopus 로고    scopus 로고
    • Azithromycin fails to reduce increased expression of neutrophil-related cytokines in primary-cultured epithelial cells from cystic fibrosis mice
    • Gavilanes, X., Huaux, F., Meyer, M., Lebecque, P., Marbaix, E., Lison, D., Scholte, B., Wallemacq, P., and Leal, T. (2009). Azithromycin fails to reduce increased expression of neutrophil- related cytokines in primary-cultured epithelial cells from cystic fibrosis mice. J Cyst Fibros 8, 203-210.
    • (2009) J. Cyst. Fibros. , vol.8 , pp. 203-210
    • Gavilanes, X.1    Huaux, F.2    Meyer, M.3    Lebecque, P.4    Marbaix, E.5    Lison, D.6    Scholte, B.7    Wallemacq, P.8    Leal, T.9
  • 28
    • 0141519226 scopus 로고    scopus 로고
    • Evaluation of diagnostic efficacy of PCR methods for Chlamydia trachomatis infection in genital and urine specimens of symptomatic men and women in India
    • George, J.A., Panchatcharam, T.S., Paramasivam, R., Balasubramanian, S., Chakrapani, V., and Murugan, G. (2003). Evaluation of diagnostic efficacy of PCR methods for Chlamydia trachomatis infection in genital and urine specimens of symptomatic men and women in India. Jpn J Infect Dis 56, 88-92. (Pubitemid 37161785)
    • (2003) Japanese Journal of Infectious Diseases , vol.56 , Issue.3 , pp. 88-92
    • George, J.A.1    Panchatcharam, T.S.2    Paramasivam, R.3    Balasubramanian, S.4    Chakrapani, V.5    Murugan, G.6
  • 29
    • 36849073243 scopus 로고    scopus 로고
    • Macrolides beyond the conventional antimicrobials: A class of potent immunomodulators
    • DOI 10.1016/j.ijantimicag.2007.08.001, PII S0924857907003822
    • Giamarellos-Bourboulis, E.J. (2008).Macrolides beyond the conventional antimicrobials: a class of potent immunomodulators. Int J Antimicrob Agents 31, 12-20. (Pubitemid 350236720)
    • (2008) International Journal of Antimicrobial Agents , vol.31 , Issue.1 , pp. 12-20
    • Giamarellos-Bourboulis, E.J.1
  • 30
    • 77952698348 scopus 로고    scopus 로고
    • Azithromycin induces anti-viral responses in bronchial epithelial cells
    • Gielen, V., Johnston, S.L., and Edwards, M.R. (2010).Azithromycin induces anti-viral responses in bronchial epithelial cells. Eur Respir J 36, 646-654.
    • (2010) Eur. Respir J. , vol.36 , pp. 646-654
    • Gielen, V.1    Johnston, S.L.2    Edwards, M.R.3
  • 32
    • 0024522884 scopus 로고
    • In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: Possible mechanism of delivery and release at sites of infection
    • Gladue, R.P., Bright, G.M., Isaacson, R.E., and Newborg, M.F. (1989).In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob Agents Chemother 33, 277-282. (Pubitemid 19071957)
    • (1989) Antimicrobial Agents and Chemotherapy , vol.33 , Issue.3 , pp. 277-282
    • Gladue, R.P.1    Bright, G.M.2    Isaacson, R.E.3    Newborg, M.F.4
  • 33
    • 77953099410 scopus 로고    scopus 로고
    • Risk of sequelae after chlamydia trachomatis genital infection in women
    • Haggerty, C.L., Gottlieb, S.L., Taylor, B.D., Low, N., Xu, F., and Ness, R.B. (2010) Risk of sequelae after Chlamydia trachomatis genital infection in women. J Infect Dis 201 Suppl 2, S134-S155.
    • (2010) J. Infect Dis. , vol.201 , Issue.2
    • Haggerty, C.L.1    Gottlieb, S.L.2    Taylor, B.D.3    Low, N.4    Xu, F.5    Ness, R.B.6
  • 34
    • 65549138205 scopus 로고    scopus 로고
    • Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections
    • Hara, Y., Shiraishi, A., Kobayashi, T., Kadota, Y., Shirakata, Y., Hashimoto, K., and Ohashi, Y. (2009).Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections. Mol Vis 15, 937-948.
    • (2009) Mol. Vis. , vol.15 , pp. 937-948
    • Hara, Y.1    Shiraishi, A.2    Kobayashi, T.3    Kadota, Y.4    Shirakata, Y.5    Hashimoto, K.6    Ohashi, Y.7
  • 35
    • 0142217487 scopus 로고    scopus 로고
    • More than just innate immunity: Comparative analysis of Chlamydophila pneumoniae and Chlamydia trachomatis effects on host-cell gene regulation
    • DOI 10.1046/j.1462-5822.2003.00319.x
    • Hess, S., Peters, J., Bartling, G., Rheinheimer, C., Hegde, P., Magid-Slav, M., Tal-Singer, R., and Klos, A. (2003).More than just innate immunity: comparative analysis of Chlamydophila pneumoniae and Chlamydia trachomatis effects on host-cell gene regulation. Cell Microbiol 5, 785-795. (Pubitemid 37304362)
    • (2003) Cellular Microbiology , vol.5 , Issue.11 , pp. 785-795
    • Hess, S.1    Peters, J.2    Bartling, G.3    Rheinheimer, C.4    Hegde, P.5    Magid-Slav, M.6    Tal-Singer, R.7    Klos, A.8
  • 36
    • 0034762867 scopus 로고    scopus 로고
    • The reprogrammed host: Chlamydia trachomatis-induced up-regulation of glycoprotein 130 cytokines, transcription factors, and antiapoptotic genes
    • DOI 10.1002/1529-0131(200110)44:10<2392::AID-ART404>3.0.CO;2-I
    • Hess, S., Rheinheimer, C., Tidow, F., Bartling, G., Kaps, C., Lauber, J., Buer, J., and Klos, A. (2001).The reprogrammed host: Chlamydia trachomatis-induced up-regulation of glycoprotein 130 cytokines, transcription factors, and antiapoptotic genes. Arthritis Rheum 44, 2392-2401. (Pubitemid 32977509)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.10 , pp. 2392-2401
    • Hess, S.1    Rheinheimer, C.2    Tidow, F.3    Bartling, G.4    Kaps, C.5    Lauber, J.6    Buer, J.7    Klos, A.8
  • 39
    • 35948943102 scopus 로고    scopus 로고
    • Interleukin-1 is the initiator of Fallopian tube destruction during Chlamydia trachomatis infection
    • DOI 10.1111/j.1462-5822.2007.00996.x
    • Hvid, M., Baczynska, A., Deleuran, B., Fedder, J., Knudsen, H.J., Christiansen, G., and Birkelund, S. (2007).Interleukin-1 is the initiator of Fallopian tube destruction during Chlamydia trachomatis infection. Cell Microbiol 9, 2795-2803. (Pubitemid 350066565)
    • (2007) Cellular Microbiology , vol.9 , Issue.12 , pp. 2795-2803
    • Hvid, M.1    Baczynska, A.2    Deleuran, B.3    Fedder, J.4    Knudsen, H.J.5    Christiansen, G.6    Birkelund, S.7
  • 41
    • 27244449295 scopus 로고    scopus 로고
    • Inhibition of chlamydia trachomatis growth by human interferon-α: Mechanisms and synergistic effect with interferon-γ and tumor necrosis factor-α
    • DOI 10.2220/biomedres.26.179
    • Ishihara, T., Aga, M., Hino, K., Ushio, C., Taniguchi, M., Iwaki, K., Ikeda, M., and Kurimoto, M. (2005).Inhibition of Chlamydia trachomatis growth by human interferon-alpha: mechanisms and synergistic effect with interferon-gamma and tumor necrosis factor-alpha. Biomed Res 26, 179-185. (Pubitemid 41645652)
    • (2005) Biomedical Research , vol.26 , Issue.4 , pp. 179-185
    • Ishihara, T.1    Aga, M.2    Hino, K.3    Ushio, C.4    Taniguchi, M.5    Iwaki, K.6    Ikeda, M.7    Kurimoto, M.8
  • 42
    • 33744768353 scopus 로고    scopus 로고
    • Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue
    • DOI 10.1093/molehr/gal032
    • Jasper, M.J., Tremellen, K.P., and Robertson, S.A. (2006).Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod 12, 301-308. (Pubitemid 43821793)
    • (2006) Molecular Human Reproduction , vol.12 , Issue.5 , pp. 301-308
    • Jasper, M.J.1    Tremellen, K.P.2    Robertson, S.A.3
  • 43
    • 67651205122 scopus 로고    scopus 로고
    • Cervical epithelial cells from chlamydia trachomatis-infected sites coexpress higher levels of chlamydial heat shock proteins 60 and 10 in infertile women than in fertile women
    • Jha, R., Vardhan, H., Bas, S., Salhan, S., and Mittal, A. (2009). Cervical epithelial cells from Chlamydia trachomatis-infected sites coexpress higher levels of chlamydial heat shock proteins 60 and 10 in infertile women than in fertile women. Gynecol Obstet Invest 68, 160-166.
    • (2009) Gynecol. Obstet Invest , vol.68 , pp. 160-166
    • Jha, R.1    Vardhan, H.2    Bas, S.3    Salhan, S.4    Mittal, A.5
  • 44
    • 78651374712 scopus 로고    scopus 로고
    • Chlamydia trachomatis heat shock proteins 60 and 10 induce apoptosis in endocervical epithelial cells
    • Jha, R., Vardhan, H., Bas, S., Salhan, S., and Mittal, A. (2011). Chlamydia trachomatis heat shock proteins 60 and 10 induce apoptosis in endocervical epithelial cells. Inflamm Res 60, 69-78.
    • (2011) Inflamm Res. , vol.60 , pp. 69-78
    • Jha, R.1    Vardhan, H.2    Bas, S.3    Salhan, S.4    Mittal, A.5
  • 45
    • 0028886393 scopus 로고
    • Effect of erythromycin on haemophilus influenzae endotoxin-induced release of IL-6 IL-8 and sICAM-1 by cultured human bronchial epithelial cells
    • Khair, O.A., Devalia, J.L., Abdelaziz, M.M., Sapsford, R.J., and Davies, R.J. (1995).Effect of erythromycin on Haemophilus influenzae endotoxin-induced release of IL-6, IL-8 and sICAM-1 by cultured human bronchial epithelial cells. Eur Respir J 8, 1451-1457.
    • (1995) Eur. Respir J. , vol.8 , pp. 1451-1457
    • Khair, O.A.1    Devalia, J.L.2    Abdelaziz, M.M.3    Sapsford, R.J.4    Davies, R.J.5
  • 46
  • 47
    • 0031921423 scopus 로고    scopus 로고
    • Anti-inflammatory activity of macrolides: A new therapeutic potential?
    • DOI 10.1093/jac/41.suppl-2.37
    • Labro, M.T. (1998).Anti-inflammatory activity of macrolides: a new therapeutic potential? J Antimicrob Chemother 41 Suppl B, 37-46. (Pubitemid 28152222)
    • (1998) Journal of Antimicrobial Chemotherapy , vol.41 , Issue.SUPPL. B , pp. 37-46
    • Labro, M.T.1
  • 48
    • 79956047783 scopus 로고    scopus 로고
    • Suppressive effects of azithromycin on zymosaninduced production of proinflammatory mediators by human corneal epithelial cells
    • Li, D.Q., Zhou, N., Zhang, L., Ma, P., and Pflugfelder, S.C. (2010).Suppressive effects of azithromycin on zymosaninduced production of proinflammatory mediators by human corneal epithelial cells. Invest Ophthalmol Vis Sci 51, 5623-5629.
    • (2010) Invest Ophthalmol. Vis. Sci. , vol.51 , pp. 5623-5629
    • Li, D.Q.1    Zhou, N.2    Zhang, L.3    Ma, P.4    Pflugfelder, S.C.5
  • 50
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak, K.J., and Schmittgen, T.D. (2001).Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 51
    • 0036593445 scopus 로고    scopus 로고
    • Genital chlamydial infection
    • Low, N., and Cowan, F. (2002).Genital chlamydial infection. Clin Evid 7, 1409-1415.
    • (2002) Clin. Evid. , vol.7 , pp. 1409-1415
    • Low, N.1    Cowan, F.2
  • 53
    • 0026778726 scopus 로고
    • A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis
    • The Azithromycin for Chlamydial Infections Study Group
    • Martin, D.H., Mroczkowski, T.F., Dalu, Z.A., McCarty, J., Jones, R.B., Hopkins, S.J., and Johnson, R.B. (1992).A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial Infections Study Group. N Engl J Med 327, 921-925.
    • (1992) N. Engl. J. Med. , vol.327 , pp. 921-925
    • Martin, D.H.1    Mroczkowski, T.F.2    Dalu, Z.A.3    McCarty, J.4    Jones, R.B.5    Hopkins, S.J.6    Johnson, R.B.7
  • 54
    • 0036178098 scopus 로고    scopus 로고
    • Chemokine expression patterns differ within anatomically distinct regions of the genital tract during Chlamydia trachomatis infection
    • DOI 10.1128/IAI.70.3.1538-1546.2002
    • Maxion, H.K., and Kelly, K.A. (2002).Chemokine expression patterns differ within anatomically distinct regions of the genital tract during Chlamydia trachomatis infection. Infect Immun 70, 1538-1546. (Pubitemid 34163433)
    • (2002) Infection and Immunity , vol.70 , Issue.3 , pp. 1538-1546
    • Maxion, H.K.1    Kelly, K.A.2
  • 56
    • 33748472784 scopus 로고    scopus 로고
    • NF-κB and inhibitor of apoptosis proteins are required for apoptosis resistance of epithelial cells persistently infected with Chlamydophila pneumoniae
    • DOI 10.1111/j.1462-5822.2006.00739.x
    • Paland, N., Rajalingam, K., Machuy, N., Szczepek, A., Wehrl, W., and Rudel, T. (2006).NF-kappaB and inhibitor of apoptosis proteins are required for apoptosis resistance of epithelial cells persistently infected with Chlamydophila pneumoniae. Cell Microbiol 8, 1643-1655. (Pubitemid 44350023)
    • (2006) Cellular Microbiology , vol.8 , Issue.10 , pp. 1643-1655
    • Paland, N.1    Rajalingam, K.2    Machuy, N.3    Szczepek, A.4    Wehrl, W.5    Rudel, T.6
  • 57
    • 20844434204 scopus 로고    scopus 로고
    • Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment
    • DOI 10.1086/431365
    • Patton, D.L., Sweeney, Y.T., and Stamm, W.E. (2005).Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment. J Infect Dis 192, 129-135. (Pubitemid 40863865)
    • (2005) Journal of Infectious Diseases , vol.192 , Issue.1 , pp. 129-135
    • Patton, D.L.1    Sweeney, Y.T.2    Stamm, W.E.3
  • 60
    • 0031020373 scopus 로고    scopus 로고
    • Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis
    • Rasmussen, S.J., Eckmann, L., Quayle, A.J., Shen, L., Zhang, Y.X., Anderson, D.J., Fierer, J., Stephens, R.S., and Kagnoff, M.F. (1997).Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J Clin Invest 99, 77-87. (Pubitemid 27058297)
    • (1997) Journal of Clinical Investigation , vol.99 , Issue.1 , pp. 77-87
    • Rasmussen, S.J.1    Eckmann, L.2    Quayle, A.J.3    Shen, L.4    Zhang, Y.-X.5    Anderson, D.J.6    Fierer, J.7    Stephens, R.S.8    Kagnoff, M.F.9
  • 61
    • 4344653938 scopus 로고    scopus 로고
    • Cytokine expression pattern in the genital tract of Chlamydia trachomatis positive infertile women - Implication for T-cell responses
    • DOI 10.1111/j.1365-2249.2004.02564.x
    • Reddy, B.S., Rastogi, S., Das, B., Salhan, S., Verma, S., and Mittal, A. (2004).Cytokine expression pattern in the genital tract of Chlamydia trachomatis positive infertile women - implication for T-cell responses. Clin Exp Immunol 137, 552-558. (Pubitemid 39128082)
    • (2004) Clinical and Experimental Immunology , vol.137 , Issue.3 , pp. 552-558
    • Reddy, B.S.1    Rastogi, S.2    Das, B.3    Salhan, S.4    Verma, S.5    Mittal, A.6
  • 62
    • 18244368691 scopus 로고    scopus 로고
    • Bactericidal activity of first-choice antibiotics against gamma interferon-induced persistent infection of human epithelial cells by Chlamydia trachomatis
    • DOI 10.1128/AAC.49.5.1787-1793.2005
    • Reveneau, N., Crane, D.D., Fischer, E., and Caldwell, H.D. (2005).Bactericidal activity of first-choice antibiotics against gamma interferon-induced persistent infection of human epithelial cells by Chlamydia trachomatis. Antimicrob Agents Chemother 49, 1787-1793. (Pubitemid 40631590)
    • (2005) Antimicrobial Agents and Chemotherapy , vol.49 , Issue.5 , pp. 1787-1793
    • Reveneau, N.1    Crane, D.D.2    Fischer, E.3    Caldwell, H.D.4
  • 63
    • 67149133088 scopus 로고    scopus 로고
    • Azithromycin treatment alters gene expression in inflammatory lipid metabolism and cell cycle pathways in well-differentiated human airway epithelia
    • Ribeiro, C.M., Hurd, H., Wu, Y., Martino, M.E., Jones, L., Brighton, B., Boucher, R.C., and O'Neal, W.K. (2009).Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia. PLoS One 4, e5806.
    • (2009) PLoS One , vol.4
    • Ribeiro, C.M.1    Hurd, H.2    Wu, Y.3    Martino, M.E.4    Jones, L.5    Brighton, B.6    Boucher, R.C.7    O'Neal, W.K.8
  • 64
    • 33644791106 scopus 로고    scopus 로고
    • Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GMCSF production by human bronchial epithelial cells
    • Shinkai, M., Foster, G.H., and Rubin, B.K. (2006).Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GMCSF production by human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 290, L75-L85.
    • (2006) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.290
    • Shinkai, M.1    Foster, G.H.2    Rubin, B.K.3
  • 65
    • 39549115019 scopus 로고    scopus 로고
    • Macrolide antibiotics as immunomodulatory medications: Proposed mechanisms of action
    • Shinkai, M., Henke, M.O., and Rubin, B.K. (2008).Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of action. Pharmacol Ther 117, 393-405.
    • (2008) Pharmacol. Ther. , vol.117 , pp. 393-405
    • Shinkai, M.1    Henke, M.O.2    Rubin, B.K.3
  • 66
    • 56149116901 scopus 로고    scopus 로고
    • Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease
    • Skwor, T.A., Atik, B., Kandel, R.P., Adhikari, H.K., Sharma, B., and Dean, D. (2008).Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease. PLoS Negl Trop Dis 2, e264.
    • (2008) PLoS Negl. Trop. Dis. , vol.2
    • Skwor, T.A.1    Atik, B.2    Kandel, R.P.3    Adhikari, H.K.4    Sharma, B.5    Dean, D.6
  • 67
    • 65549126778 scopus 로고    scopus 로고
    • Azithromycin treatment modulates cytokine production in chlamydia trachomatis infected women
    • Srivastava, P., Jha, H.C., Salhan, S., and Mittal, A. (2009).Azithromycin treatment modulates cytokine production in Chlamydia trachomatis infected women. Basic Clin Pharmacol Toxicol 104, 478-482.
    • (2009) Basic Clin. Pharmacol. Toxicol. , vol.104 , pp. 478-482
    • Srivastava, P.1    Jha, H.C.2    Salhan, S.3    Mittal, A.4
  • 68
    • 0037233027 scopus 로고    scopus 로고
    • The cellular paradigm of chlamydial pathogenesis
    • DOI 10.1016/S0966-842X(02)00011-2, PII S0966842X02000112
    • Stephens, R.S. (2003).The cellular paradigm of chlamydial pathogenesis. Trends Microbiol 11, 44-51. (Pubitemid 36084355)
    • (2003) Trends in Microbiology , vol.11 , Issue.1 , pp. 44-51
    • Stephens, R.S.1
  • 69
    • 1542334775 scopus 로고    scopus 로고
    • Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids
    • DOI 10.1074/jbc.M312008200
    • Su, H., McClarty, G., Dong, F., Hatch, G.M., Pan, Z.K., and Zhong, G. (2004).Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids. J Biol Chem 279, 9409-9416. (Pubitemid 38296007)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.10 , pp. 9409-9416
    • Su, H.1    McClarty, G.2    Dong, F.3    Hatch, G.M.4    Pan, Z.K.5    Zhong, G.6
  • 72
    • 0028606863 scopus 로고
    • The effect of a single oral dose of azithromycin on chlamydial infertility and oviduct ultrastructure in mice
    • Tuffrey, M., Woods, C., Inman, C., and Ward, M. (1994).The effect of a single oral dose of azithromycin on chlamydial infertility and oviduct ultrastructure in mice. J Antimicrob Chemother 34, 989-999.
    • (1994) J. Antimicrob. Chemother , vol.34 , pp. 989-999
    • Tuffrey, M.1    Woods, C.2    Inman, C.3    Ward, M.4
  • 74
    • 0030975948 scopus 로고    scopus 로고
    • Repeated Chlamydia trachomatis infection of Macaca nemestrina fallopian tubes produces a Th1-like cytokine response associated with fibrosis and scarring
    • Van Voorhis, W.C., Barrett, L.K., Sweeney, Y.T., Kuo, C.C., and Patton, D.L. (1997).Repeated Chlamydia trachomatis infection of Macaca nemestrina fallopian tubes produces a Th1-like cytokine response associated with fibrosis and scarring. Infect Immun 65, 2175-2182. (Pubitemid 27237294)
    • (1997) Infection and Immunity , vol.65 , Issue.6 , pp. 2175-2182
    • Van Voorhis, W.C.1    Barrett, L.K.2    Sweeney, Y.T.C.3    Kuo, C.-C.4    Patton, D.L.5
  • 75
    • 0032795313 scopus 로고    scopus 로고
    • The anti-inflammatory effects of macrolides
    • Wales, D., and Woodhead, M. (1999).The anti-inflammatory effects of macrolides. Thorax 54 Suppl 2, S58-S62. (Pubitemid 29341397)
    • (1999) Thorax , vol.54 , Issue.SUPPL. 2
    • Wales, D.1    Woodhead, M.2
  • 76
    • 0029122924 scopus 로고
    • Azithromycin levels in cervical mucus and plasma after a single 1 0g oral dose for chlamydial cervicitis
    • Worm, A.M., and Osterlind, A. (1995).Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis. Genitourin Med 71, 244-246.
    • (1995) Genitourin Med. , vol.71 , pp. 244-246
    • Worm, A.M.1    Osterlind, A.2
  • 77
    • 0032900971 scopus 로고    scopus 로고
    • Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis
    • DOI 10.1086/314676
    • Wyrick, P.B., Knight, S.T., Paul, T.R., Rank, R.G., and Barbier, C.S. (1999).Persistent chlamydial envelope antigens in antibiotic- exposed infected cells trigger neutrophil chemotaxis. J Infect Dis 179, 954-966. (Pubitemid 29159342)
    • (1999) Journal of Infectious Diseases , vol.179 , Issue.4 , pp. 954-966
    • Wyrick, P.B.1    Knight, S.T.2    Paul, T.R.3    Rank, R.G.4    Barbier, C.S.5
  • 78
    • 0037312521 scopus 로고    scopus 로고
    • Chlamydia trachomatis infection alters host cell transcription in diverse cellular pathways
    • DOI 10.1086/367962
    • Xia, M., Bumgarner, R.E., Lampe, M.F., and Stamm, W.E. (2003). Chlamydia trachomatis infection alters host cell transcription in diverse cellular pathways. J Infect Dis 187, 424-434. (Pubitemid 36184583)
    • (2003) Journal of Infectious Diseases , vol.187 , Issue.3 , pp. 424-434
    • Xia, M.1    Bumgarner, R.E.2    Lampe, M.F.3    Stamm, W.E.4
  • 79
    • 0035896736 scopus 로고    scopus 로고
    • Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors
    • DOI 10.1084/jem.193.8.935
    • Zhong, G., Fan, P., Ji, H., Dong, F., and Huang, Y. (2001). Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors. J Exp Med 193, 935-942. (Pubitemid 32525866)
    • (2001) Journal of Experimental Medicine , vol.193 , Issue.8 , pp. 935-942
    • Zhong, G.1    Fan, P.2    Ji, H.3    Dong, F.4    Huang, Y.5
  • 80
    • 0033591635 scopus 로고    scopus 로고
    • Chlamydia inhibits interferon gamma-inducible major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1
    • Zhong, G., Fan, T., and Liu, L. (1999).Chlamydia inhibits interferon gamma-inducible major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1. J Exp Med 189, 1931-1938.
    • (1999) J. Exp. Med. , vol.189 , pp. 1931-1938
    • Zhong, G.1    Fan, T.2    Liu, L.3
  • 81
    • 0034193165 scopus 로고    scopus 로고
    • Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon γ-inducible major histocompatibility complex class I expression in chlamydia-infected cells
    • DOI 10.1084/jem.191.9.1525
    • Zhong, G., Liu, L., Fan, T., Fan, P., and Ji, H. (2000).Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class I expression in chlamydia-infected cells. J Exp Med 191, 1525-1534. (Pubitemid 30257349)
    • (2000) Journal of Experimental Medicine , vol.191 , Issue.9 , pp. 1525-1534
    • Zhong, G.1    Liu, L.2    Fan, T.3    Fan, P.4    Ji, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.