Bactericidal activity of first-choice antibiotics against gamma interferon-induced persistent infection of human epithelial cells by Chlamydia trachomatis

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 5, 2005, Pages 1787-1793

  Reveneau, Nathalie ^a   Crane, Deborah D ^a   Fischer, Elizabeth ^a   Caldwell, Harlan D ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; AZITHROMYCIN; DOXYCYCLINE; GAMMA INTERFERON;

ANTIBIOTIC THERAPY; ARTICLE; BACTERICIDAL ACTIVITY; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CHRONIC INFLAMMATION; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; PELVIC INFLAMMATORY DISEASE; PERSISTENT INFECTION; PRIORITY JOURNAL; TRACHOMA;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; DOXYCYCLINE; EPITHELIAL CELLS; HELA CELLS; HUMANS; INTERFERON TYPE II; KINETICS; MICROSCOPY, ELECTRON, TRANSMISSION;

EID: 18244368691     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.5.1787-1793.2005     Document Type: Article

References (33)

1. Beatty, W. L., T. A. Belanger, A. A. Desai, R. P. Morrison, and G. I. Byrne. 1994. Tryptophan depletion as a mechanism of IFN-γ-mediated chlamydial persistence. Infect. Immun. 62:3705-3711.
2. Beatty, W. L., G. I. Byrne, and R. P. Morrison. 1993. Morphologic and antigenic characterization of IFN-γ-mediated persistent Chlamydia trachomatis infection in vitro. Proc. Natl. Acad. Sci. USA 90:3998-4002.
3. Beatty, W. L., G. I. Byrne, and R. P. Morrison. 1994. Repeated and persistent infection with Chlamydia and the development of chronic inflammation and disease. Trends Microbiol. 2:94-98.
4. Beatty, W. L., R. P. Morrison, and G. I. Byrne. 1994. Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol. Rev. 58:686-699.
5. Beatty, W. L., R. P. Morrison, and G. I. Byrne. 1995. Reactivation of persistent Chlamydia trachomatis infection in cell culture. Infect. Immun. 63: 199-205.
6. Belland, R. J., D. E. Nelson, D. Virok, D. D. Crane, D. Hogan, D. Sturdevant, W. L. Beatty, and H. D. Caldwell. 2003. Transcriptome analysis of chlamydial growth during IFN-γ-mediated persistence and reactivation. Proc. Natl. Acad. Sci. USA 100:15971-15976.
7. Bermudez, L. E., C. Inderlied, and L. S. Young. 1991. Stimulation with cytokines enhances penetration of azithromycin into human macrophages. Antimicrob. Agents Chemother. 35:2625-2629.
8. Brunham, R. C., B. Binns, F, Guijon, D. Danforth, M. L. Kosseim, F. Rand, J. McDowell, and E. Rayner. 1988. Etiology and outcome of acute pelvic inflammatory disease. J. Infect. Dis. 158:510-517.
9. Byrne, G. I. 2001. Chlamydial treatment failures: a persistent problem? J. Eur. Acad. Dermatol. Venereol. 15:381.
10. Byrne, G. I., L. K. Lehmann, and G. J. Landry. 1986. Induction of tryptophan catabolism is the mechanism for IFN-γ-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells. Infect. Immun. 53:347-351.
11. Campbell, L. A., D. L. Patton, D. E. Moore, A. L. Cappuccio, B. A. Mueller, and S. P. Wang. 1993. Detection of Chlamydia trachomatis deoxyribonucleic acid in women with tubal infertility. Fertil. Steril. 59:45-50.
12. Clark, R. B., P. F. Schatzki, and H. P. Dalton. 1982. Ultrastructural effect of penicillin and cycloheximide on Chlamydia trachomatis strain HAR-13. Med. Microbiol. Immunol. 171:151-159.
13. Francis, V., and V. Turner. 1995. Achieving community support for trachoma control: a guide for district health work. World Health Organization, Geneva, Switzerland.
14. Hammerschlag, M. R., N. H. Golden, M. K. Oh, M. Gelling, M. Sturdevant, P. R. Brown, Z. Aras, S. Neuhoff, W. Dumornay, and P. M. Roblin. 1993. Single dose of azithromycin for the treatment of genital chlamydial infections in adolescents. J. Pediatr. 122:961-965.
15. Harper, A., C. I. Pogson, M. L. Jones, and J. H. Pearce. 2000. Chlamydial development is adversely affected by minor changes in amino acid supply, blood plasma amino acid levels, and glucose deprivation. Infect. Immun. 68:1457-1464.
16. Lauharanta, J., K. Saarinen, M. T. Mustonen, and H. P. Happonen. 1993. Single-dose oral azithromycin versus seven-day doxycycline in the treatment of non-gonococcal urethritis in males. J. Antimicrob. Chemother. 31(Suppl. E):177-183.
17. Loomis, W. P., and M. N. Starnbach. 2002. T-cell responses to Chlamydia trachomatis. Curr. Opin. Microbiol. 5:87-91.
18. Mabey, D. C., J. N. Robertson, and M. E. Ward. 1987. Detection of Chlamydia trachomatis by enzyme immunoassay in patients with trachoma. Lancet ii:1491-1492.
19. Martin, D. H., T. F. Mroczkowski, Z. A. Dalu, J. McCarty, R. B. Jones, S. J. Hopkins, R. B. Johnson, et al. 1992. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. N. Engl. J. Med. 327:921-925.
20. Morrison, R. P., and H. D. Caldwell. 2002. Immunity to murine chlamydial genital infection. Infect. Immun. 70:2741-2751.
21. Morrison, R. P., D. S. Manning, and H. D. Caldwell. 1992. Immunology of Chlamydia trachomatis infections, p. 57-84. In T. C. Quinn (ed.), Advances in host defense mechanisms. Raven, New York, N.Y.
22. Moulder, J. W. 1991. Interaction of chlamydiae and host cells in vitro. Microbiol. Rev. 55:143-190.
23. Nilsen, A., A. Halsos, A. Johansen, E. Hansen, E. Torud, D. Moseng, G. Anestad, and G. Storvold. 1992. A double blind study of single dose azithromycin and doxycycline in the treatment of chlamydial urethritis in males. Genitourin. Med. 68:325-327.
24. Oriel, J. D., and G. L. Ridgway. 1982. Epidemiology of chlamydial infection of the human genital tract: evidence for the existence of latent infections. Eur. J. Clin. Microbiol. 1:69-75.
25. Raulston, J. E. 1997. Response of Chlamydia trachomatis serovar E to iron restriction in vitro and evidence for iron-regulated chlamydial proteins. Infect. Immun. 65:4539-4547.
26. Schachter, J. 1978. Chlamydial infections. N. Engl. J. Med. 298:428-435.
27. Schachter, J., J. Moncada, C. R. Dawson, J. Sheppard, P. Courtright, M. E. Said, S. Zaki, S. F. Hafez, and A. Lorincz. 1988. Nonculture methods for diagnosing chlamydial infection in patients with trachoma: a clue to the pathogenesis of the disease? J. Infect. Dis. 158:1347-1352.
28. Schroder, K., P. J. Hertzog, T. Ravasi, and D. A. Hume. 2004. IFN-γ: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75:163-189.
29. + T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract. Infect. Immun. 63:3302-3308.
30. Thejls, H., J. Gnarpe, O. Lundkvist, G. Heimer, G. Larsson, and A. Victor. 1991. Diagnosis and prevalence of persistent chlamydia infection in infertile women: tissue culture, direct antigen detection, and serology. Fertil. Steril. 55:304-310.
31. Thylefors, B. 1995. Global trachoma control past, present and future approaches. Rev. Int. Trach. Pathol. Ocul. Trop. Subtrop. Sante Publique 72:13-80.
32. Workowski, K. A., and S. M. Berman. 2002. CDC sexually transmitted diseases treatment guidelines. Clin. Infect. Dis. 35:5135-137.
33. Wyrick, P. B., and S. T. Knight. 2004. Pre-exposure of infected human endometrial epithelial cells to penicillin in vitro renders Chlamydia trachomatis refractory to azithromycin. J. Antimicrob. Chemother. 54:79-85.