Mucosal and peripheral immune responses to chlamydial heat shock proteins in women infected with Chlamydia trachomatis

Clinical and Experimental Immunology

Volumn 148, Issue 3, 2007, Pages 461-468

  Agrawal, T ^a   Vats, V ^a   Salhan, S ^a   Mittal, A ^a  

^a SAFDARJUNG HOSPITAL   (India)

Author keywords

Chlamydia trachomatis; Chlamydial heat shock proteins; Interferon gamma; Mucosal immune response; Recurrent infection

Indexed keywords

GAMMA INTERFERON; HEAT SHOCK PROTEIN 10; HEAT SHOCK PROTEIN 60; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; OUTER MEMBRANE PROTEIN;

ADULT; ANTIBODY TITER; ARTICLE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MUCOSAL IMMUNITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PERIPHERAL LYMPHOCYTE; PREVALENCE; PRIORITY JOURNAL; RECURRENT DISEASE;

ADULT; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; CELL PROLIFERATION; CELLS, CULTURED; CERVIX UTERI; CHAPERONIN 10; CHAPERONIN 60; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; FEMALE; HEAT-SHOCK PROTEINS; HUMANS; IMMUNITY, MUCOSAL; INTERFERON TYPE II; INTERLEUKIN-1BETA; LYMPHOCYTE ACTIVATION; MIDDLE AGED; PORINS; T-LYMPHOCYTE SUBSETS;

EID: 34247872889     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03357.x     Document Type: Article

References (30)

1. Gerbase AC, Rowley JT, Mertens TE. Global epidemiology of sexually transmitted diseases. Lancet 1998 351 (Suppl. 3 S2 4.
2. Singh V, Salhan S, Das BC, Mittal A. Predominance of Chlamydia trachomatis serovars associated with urogenital infections in females in New Delhi, India. J Clin Microbiol 2003 41:2700 2.
3. Schachter J. Chlamydial infections. N Engl J Med 1978 298:428 35.
4. Plummer FA. Cofactors in male-female sexual transmission of human immunodeficiency virus type 1. J Infect Dis 1991 163:233 9.
5. Anttila T. Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma. JAMA 2001 285:47 51.
6. Gopalkrishna V, Aggarwal N, Malhotra VL et al. Chlamydia trachomatis and human papillomavirus infection in Indian women with sexually transmitted diseases and cervical precancerous and cancerous lesions. Clin Microbiol Infect 2000 6:88 93.
7. Golden M, Schillinger J, Markowitz L, St Louis M. Duration of untreated genital infections with Chlamydia trachomatis: a review of the literature. Sex Transm Dis 2000 27:329 7.
8. Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet 1988 22:631 77.
9. Zugel U, Kaufmann SH. Role of heat shock proteins in protection from and pathogenesis of infectious diseases. Clin Microbiol Rev 1999 12:19 39.
10. Cerrone MC, Ma JJ, Stephens RS. Cloning and sequence of gene for heat shock protein 60 from Chlamydia trachomatis and immunological reactivity of protein. Infect Immun 1991 59:79 90.
11. Hartog JE, Land JA, Stassen FRM, Kessels AGH, Bruggeman CA. Serological markers of persistent C. trachomatis infections in women with tubal factor subfertility. Hum Reprod 2005 20:986 90.
12. Witkin SS, Jeremias J, Toth M, Ledger WJ. Proliferative response to conserved epitopes of Chlamydia trachomatis and human 60-kilodalton heat-shock proteins by lymphocytes from women with salpingitis. Am J Obstet Gynecol 1994 171:455 60.
13. Patton DL, Sweeney YT, Kuo CC. Demonstration of delayed hypersensitivity in Chlamydia trachomatis salpingitis in monkeys: a pathologic mechanism of tubal damage. J Infect Dis 1994 169:680 3.
14. Dadamessi I, Eb F, Betsou F. Combined detection of Chlamydia trachomatis specific antibodies against the 10 and 60-kDa heat shock proteins as a diagnostic tool for tubal factor infertility: results from a case-control study in Cameroon. FEMS Immunol Med Microbiol 2005 45:31 5.
15. Singh V, Rastogi S, Garg S et al. Polymerase chain reaction for detection of endocervical Chlamydia trachomatis infection in Indian women attending gynaecology outpatient department. Acta Cytol 2002 46:540 4.
16. Yi Y, Zhong G, Brunham RC. Continuous B-cell epitopes in Chlamydia trachomatis heat shock protein 60. Infect Immun 1993 61:1117 20.
17. La Verda D, Byrne GI. Use of monoclonal antibodies to facilitates identification, cloning and purification of Chlamydia trachomatis hsp10. J Clin Microbiol 1997 35:1209 15.
18. Bailey RL, Holand MJ, Whittle HC, Mabey DC. Subject recovering from human ocular chlamydial infection have enhance lymphoproliferative responses to chlamydial antigens compare with those of persistently diseased controls. Infect Immun 1995 63:389 92.
19. Witkin SS, Askienazy-Elbhar M, Henry-Suchet J, Belaisch-Allart J, Tort-Grumbach J, Sarjdine K. Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60 kDa heat shock protein (hsp60) in infertile couples and its relationship to antibodies to C. trachomatis surface antigens and the Escherichia coli and human HSP60. Hum Repod 1998 13:1175 9.
20. Betsou F, Borrego MJ, Guillaume N et al. Cross reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor. Clin Diagn Lab Immunol 2003 3:446 50.
21. Kinnunen A, Surcel HM, Halttunen M et al. Chlamydia trachomatis heat shock protein 60 induced interferon-gamma and interleukin 10 production in infertile women. Clin Exp Immunol 2003 131:299 303.
22. Witkin SS, Jeremias J, Toth M, Ledger WJ. Cell mediated immune response to the recombinant 57-kDa heat shock protein of Chlamydia trachomatis in women with salpingitis. J Infect Dis 1993 167:1379 83.
23. Beatty WL, Byrne GI, Morrison RP. Morphologic and antigenic characterization of interferon-γ mediated persistent Chlamydia trachomatis infection in vitro. Proc Natl Acad Sci USA 1993 90:3998 4002.
24. Shinnik TM. Heat shock proteins as antigens of bacterial and parasitic pathogens. Curr Topics Microbiol Immunol 1991 167:145 60.
25. Witkin SS, Neuer A, Giraldo P et al. Chlamydia trachomatis infection, immunity and pregnancy outcome. Infect Dis Obstet Gynecol 1997 5:128 32.
26. Witkin SS, Sultan KM, Neal GS, Jeremias J, Grifo JA, Rosenwaks Z. Unsuspected Chlamydia trachomatis infection and in vitro fertilization outcome. Am J Obstet Gynecol 1994 171:1208 14.
27. Witkin SS, Jeremias J, Neuer A, et al. Immune recognition of the 60kD heat shock protein: implications for subsequent fertility. Infect Dis Obstet Gynecol 1996 4:152 8.
28. Spandorfer SD, Neuer A, LaVerda D et al. Previously undetected Chlamydia trachomatis infection, immunity to heat shock proteins and tubal occlusion in women undergoing in vitro fertilization. Hum Reprod 1999 14:62 4.
29. Reddy BS, Rastogi S, Verma S, Das B, Salhan S, Mittal A. Cytokine expression pattern in the genital tract of C. trachomatis women - implication for T cell responses. Clin Exp Immunol 2004 37:552 8.
30. Morrison RP, Su H, Lyng K, Yuan Y. The Chlamydia trachomatis hyp operon is homologous to the groEL stress response of Escherichia coli. Infect Immun 1990 58:2701 5.