Azithromycin treatment modulates cytokine production in chlamydia trachomatis infected women

Basic and Clinical Pharmacology and Toxicology

Volumn 104, Issue 6, 2009, Pages 478-482

  Srivastava, Pragya ^a   Jha, Hem Chandra ^a   Salhan, Sudha ^a   Mittal, Aruna ^a  

^a SAFDARJUNG HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC THERAPY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; FEMALE; HUMAN; IMMUNOMODULATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEXUAL INTERCOURSE; SINGLE DRUG DOSE; TREATMENT OUTCOME; UTERINE CERVICITIS; VAGINITIS;

ADULT; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AZITHROMYCIN; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; CYTOKINES; FEMALE; HUMANS; INFERTILITY, FEMALE; INTERFERON-GAMMA; INTERLEUKINS; MIDDLE AGED; TUMOR NECROSIS FACTOR-ALPHA; VAGINAL SMEARS;

CHLAMYDIA TRACHOMATIS;

EID: 65549126778     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2009.00395.x     Document Type: Article

References (25)

1. Schachter J. Chlamydial infections. N Engl J Med 1978 298 : 428 35. (Pubitemid 8285937)
2. Rasmussen SJ, Eckmann L, Quayle AJ, Shen L, Zhang YX, Anderson DJ et al. Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J Clin Invest 1997 99 : 77 87. (Pubitemid 27058297)
3. Stephens RS. The cellular paradigm of chlamydial pathogenesis. Trends Microbiol 2003 11 : 44 51. (Pubitemid 36084355)
4. Gervassi A, Alderson MR, Suchland R, Maisonneuve JF, Grabstein KH, Probst P. Differential regulation of inflammatory cytokine secretion by human dendritic cells upon Chlamydia trachomatis infection. Infect Immun 2004 72 : 7231 9. (Pubitemid 39552394)
5. Buchholz KR, Stephens RS. Activation of the host cell proinflammatory interleukin-8 response by Chlamydia trachomatis. Cell Microbiol 2006 8 : 1768 79. (Pubitemid 44530669)
6. Srivastava P, Jha R, Bas S, Salhan S, Mittal A. In infertile women, cells from Chlamydia trachomatis infected site release higher levels of Interferon-, Interleukin-10 and Tumor Necrosis Factor-α upon heat shock protein stimulation than fertile women. Reprod Biol Endocrinol 2008 6 : 20.
7. Roan NR, Starnbach MN. Immune-mediated control of Chlamydia infection. Cell Microbiol 2008 10 : 9 19 (Pubitemid 350239052)
8. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines. MMWR Morb Mortal Wkly Rep 2006 55 : 1 100.
9. Labro MT. Anti-inflammatory activity of macrolides: a new therapeutic potential? J Antimicrob Chemother 1998 41 (Suppl B 37 46. (Pubitemid 28152222)
10. Giamarellos-Bourboulis EJ. Macrolides beyond the conventional antimicrobials: a class of potent immunomodulators. Int J Antimicrob Agents 2008 31 : 12 20. (Pubitemid 350236720)
11. Shinkai M, Henke MO, Rubin BK. Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of action. Pharmacol Ther 2008 117 : 393 405.
12. Khan AA, Slifer TR, Araujo FG, Remington JS. Effect of clarithromycin and azithromycin on production of cytokines by human monocytes. Int J Antimicrob Agents 1999 11 : 121 32. (Pubitemid 29114971)
13. Koch CC, Esteban DJ, Chin AC, Olson ME, Read RR, Ceri H et al. Apoptosis, oxidative metabolism and interleukin-8 production in human neutrophils exposed to azithromycin: effects of Streptococcus pneumoniae. J Antimicrob Chemother 2000 46 : 19 26. (Pubitemid 30466191)
14. Uriarte SM, Molestina RE, Miller RD, Bernabo J, Farinati A, Eiguchi K et al. Effect of macrolide antibiotics on human endothelial cells activated by Chlamydia pneumonia infection and tumor necrosis factor-α. J Infect Dis 2002 185 : 1631 6. (Pubitemid 34587525)
15. Ohara T, Kojio S, Taneike I, Nakagawa S, Gondaira F, Tamura Y, et al. Effects of azithromycin on shiga toxin production by Escherichia coli and subsequent host inflammatory response. Antimicrob Agents Chemother 2002 46 : 3478 83. (Pubitemid 35192914)
16. Sugiyama K, Shirai R, Mukae H, Ishimoto H, Nagata T, Sakamoto N et al. Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cells. Clin Exp Immunol 2007 147 : 540 6. (Pubitemid 46208057)
17. Cigana C, Assael BM, Melotti P. Azithromycin selectively reduces tumor necrosis factor α levels in cystic fibrosis airway epithelial cells. Antimicrob Agents Chemother 2007 51 : 975 81. (Pubitemid 46355283)
18. Stamm WE. Azithromycin in the treatment of uncomplicated genital chlamydial infections. Am J Med 1991 91 : 19S 22S.
19. Martin DH, Mroczkowski TF, Dalu ZA, McCarty J, Jones RB, Hopkins SJ et al. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. N Engl J Med 1992 327 : 921 5.
20. Ridgway GL. Azithromycin in the management of Chlamydia trachomatis infections. Int J STD AIDS 1996 7 (Suppl 1 5 8. (Pubitemid 26060118)
21. Patton DL, Sweeney YT, Stamm WE. Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment. J Infect Dis 2005 192 : 129 35. (Pubitemid 40863865)
22. George JA, Panchatcharam TS, Paramasivam R, Balasubramanian S, Chakrapani V, Murugan G et al. Evaluation of diagnostic efficay of PCR methods for Chlamydia trachomatis infection in genital and urine specimens of symptomatic men and women in India. Jpn J Infect Dis 2003 56 : 88 92. (Pubitemid 37161785)
23. Reddy BS, Rastogi S, Das B, Salhan S, Verma S, Mittal A. Cytokine expression pattern in the genital tract of Chlamydia trachomatis positive infertile women - implication for T-cell responses. Clin Exp Immunol 2004 137 : 552 8. (Pubitemid 39128082)
24. Gladue RP, Bright GM, Isaacson RE, Newborg MF. In vitro and in vivo uptake of azithromycin (CP-62, 993) by phagocytic cells: possible mechanism of delivery and release at sites of infection. Antimicrob Agents Chemother 1989 33 : 277 82. (Pubitemid 19071957)
25. Foulds G, Shepard RM, Johnson RB. The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 1990 25 (Suppl. A 73 82. (Pubitemid 20043952)