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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4804-4807

Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase i

(5) Sayahi, Halimah a Zimhony, Oren b Jacobs Jr , William R c Shekhtman, Alexander a Welch, John T a

a STATE UNIVERSITY OF NEW YORK (United States)

b HEBREW UNIVERSITY OF JERUSALEM (Israel)

c ALBERT EINSTEIN COLLEGE OF MEDICINE (United States)

Author keywords

Enzyme inhibition; Fatty acid synthase I (FAS I); NADPH; Pyrazinamide; STD NMR

Indexed keywords

FATTY ACID SYNTHASE; FUNGAL ENZYME; PYRAZINAMIDE; PYRAZINOIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANTIBACTERIAL ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; DRUG BINDING SITE; DRUG PROTEIN BINDING; ENZYME INHIBITION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SATURATION TRANSFER DIFFERENCE; X RAY DIFFRACTION;

BACTERIAL PROTEINS; BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NADP; PYRAZINAMIDE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79960921042 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.06.055 Document Type: Article

Times cited : (40)

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