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Volumn 7, Issue 4, 2011, Pages 491-498

Fibroblast abnormalities in the pathogenesis of systemic sclerosis

Author keywords

collagen synthesis; fibroblasts; fibrosis; SMAD; systemic sclerosis; TGF

Indexed keywords

ABELSON KINASE; ALPHA SMOOTH MUSCLE ACTIN; AMYLOID P COMPONENT; CD34 ANTIGEN; CD45 ANTIGEN; EARLY GROWTH RESPONSE FACTOR 1; FOCAL ADHESION KINASE; FRIZZLED PROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 79960910328     PISSN: 1744666X     EISSN: 17448409     Source Type: Journal    
DOI: 10.1586/eci.11.39     Document Type: Review
Times cited : (21)

References (105)
  • 1
    • 0025718920 scopus 로고
    • Clinical aspects of localized and systemic scleroderma
    • Silver RM. Clinical aspects of localized and systemic scleroderma. Curr Opin. Rheumatol. 3, 973-978 (1991)
    • (1991) Curr Opin. Rheumatol , vol.3 , pp. 973-978
    • Silver, R.M.1
  • 2
    • 0034937852 scopus 로고    scopus 로고
    • Criteria for the classification of early systemic sclerosis
    • LeRoy EC, Medsger TA Jr. Criteria for the classification of early systemic sclerosis. J Rheumatol. 28, 1573-1576 (2001)
    • (2001) J Rheumatol , vol.28 , pp. 1573-1576
    • Leroy, E.C.1    Medsger, Jr.T.A.2
  • 3
    • 28444477739 scopus 로고    scopus 로고
    • Scleroderma: From cell and molecular mechanisms to disease models
    • DOI 10.1016/j.it.2005.09.004, PII S1471490605002395, Autoimmunity Special Issue
    • Abraham DJ, Varga J. Scleroderma: from cell and molecular mechanisms to disease models. Trends Immunol. 26, 587-595 (2005) (Pubitemid 41726446)
    • (2005) Trends in Immunology , vol.26 , Issue.11 , pp. 587-595
    • Abraham, D.J.1    Varga, J.2
  • 4
    • 0033767899 scopus 로고    scopus 로고
    • Severe organ involvement in systemic sclerosis with diffuse scleroderma
    • Steen VD, Medsger TA Jr. Severe organ involvement in systemic sclerosis with diffuse scleroderma. Arthritis Rheum. 43, 2437-2444 (2000)
    • (2000) Arthritis Rheum , vol.43 , pp. 2437-2444
    • Steen, V.D.1    Medsger, Jr.T.A.2
  • 5
    • 0034965980 scopus 로고    scopus 로고
    • Familial occurrence frequencies and relative risks for systemic sclerosis (Scleroderma) in three United States cohorts
    • DOI 10.1002/1529-0131(200106)44: 6<1359::AID-ART228>3.0.CO;2-S
    • Arnett FC, Cho M, Chatterjee S, Aguilar MB, Reveille JD, Mayes MD. Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts. Arthritis Rheum. 44, 1359-1362 (2001) (Pubitemid 32537534)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.6 , pp. 1359-1362
    • Arnett, F.C.1    Cho, M.2    Chatterjee, S.3    Aguilar, M.B.4    Reveille, J.D.5    Mayes, M.D.6
  • 6
    • 77951765348 scopus 로고    scopus 로고
    • Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
    • Radstake TR, Gorlova O, Rueda B et al. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet. 42, 426-429 (2010)
    • (2010) Nat Genet , vol.42 , pp. 426-429
    • Radstake, T.R.1    Gorlova, O.2    Rueda, B.3
  • 8
    • 65549154046 scopus 로고    scopus 로고
    • The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype
    • Rueda B, Broen J, Simeon C et al. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype. Hum Mol. Genet. 18, 2071-2077 (2009)
    • (2009) Hum Mol. Genet , vol.18 , pp. 2071-2077
    • Rueda, B.1    Broen, J.2    Simeon, C.3
  • 9
    • 0036846150 scopus 로고    scopus 로고
    • Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma
    • DOI 10.1002/art.10601
    • Zhou X, Tan FK, Reveille JD et al. Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma. Arthritis Rheum. 46, 2990-2999 (2002) (Pubitemid 35315893)
    • (2002) Arthritis and Rheumatism , vol.46 , Issue.11 , pp. 2990-2999
    • Zhou, X.1    Tan, F.K.2    Reveille, J.D.3    Wallis, D.4    Milewicz, D.M.5    Ahn, C.6    Wang, A.7    Arnett, F.C.8
  • 10
    • 0035052163 scopus 로고    scopus 로고
    • Association of fibrillin 1 single-nucleotide polymorphism haplotypes with systemic sclerosis in Choctaw and Japanese populations
    • DOI 10.1002/1529-0131(200104)44: 4<893::AID-ANR146>3.0.CO;2-3
    • Tan FK, Wang N, Kuwana M et al. Association of fibrillin 1 single-nucleotide polymorphism haplotypes with systemic sclerosis in Choctaw and Japanese populations. Arthritis Rheum. 44, 893-901 (2001) (Pubitemid 32319782)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.4 , pp. 893-901
    • Tan, F.K.1    Wang, N.2    Kuwana, M.3    Chakraborty, R.4    Bona, C.A.5    Milewicz, D.M.6    Arnett, F.C.7
  • 12
    • 70349386180 scopus 로고    scopus 로고
    • A large multicenter analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype
    • Rueda B, Simeon C, Hesselstrand R et al. A large multicenter analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype. Ann Rheum. Dis. 68, 1618-1620 (2009)
    • (2009) Ann Rheum. Dis , vol.68 , pp. 1618-1620
    • Rueda, B.1    Simeon, C.2    Hesselstrand, R.3
  • 14
    • 0016302998 scopus 로고
    • Increased collagen synthesis by scleroderma skin fibroblasts in vitro: A possible defect in the regulation or activation of the scleroderma fibroblast
    • LeRoy EC. Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast. J Clin Invest. 54, 880-889 (1974)
    • (1974) J Clin Invest , vol.54 , pp. 880-889
    • Leroy, E.C.1
  • 15
    • 0029739858 scopus 로고    scopus 로고
    • Transcriptional activation of the α1(I) procollagen gene in systemic sclerosis dermal fibroblasts: Role of intronic sequences
    • Hitraya EG, Jiménez SA. Transcriptional activation of the a 1(I) procollagen gene in systemic sclerosis dermal fibroblasts. Role of intronic sequences. Arthritis Rheum. 39, 1347-1354 (1996) (Pubitemid 26270094)
    • (1996) Arthritis and Rheumatism , vol.39 , Issue.8 , pp. 1347-1354
    • Hitraya, E.G.1    Jimenez, S.A.2
  • 17
    • 0015359850 scopus 로고
    • Connective tissue synthesis by scleroderma skin fibroblasts in cell culture
    • Leroy EC. Connective tissue synthesis by scleroderma skin fibroblasts in cell culture. J Exp. Med 135, 1351-1362 (1972)
    • (1972) J Exp. Med , vol.135 , pp. 1351-1362
    • Leroy, E.C.1
  • 18
    • 0020049617 scopus 로고
    • Fibroblast selection in scleroderma. An alternative model of fibrosis
    • Botstein GR, Sherer GK, Leroy EC. Fibroblast selection in scleroderma. An alternative model of fibrosis. Arthritis Rheum. 25, 189-195 (1982) (Pubitemid 12170277)
    • (1982) Arthritis and Rheumatism , vol.25 , Issue.2 , pp. 189-195
    • Botstein, G.R.1    Sherer, G.K.2    Leroy, E.C.3
  • 19
    • 0029765057 scopus 로고    scopus 로고
    • Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts: Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts
    • Jelaska A, Arakawa M, Broketa G, Korn JH. Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts. Arthritis Rheum. 39, 1338-1346 (1996) (Pubitemid 26270093)
    • (1996) Arthritis and Rheumatism , vol.39 , Issue.8 , pp. 1338-1346
    • Jelaska, A.1    Arakawa, M.2    Broketa, G.3    Korn, J.H.4
  • 20
    • 0033366710 scopus 로고    scopus 로고
    • Alterations in the regulation of expression of the α1(I) collagen gene (COL1A1) in systemic sclerosis (scleroderma)
    • Jimenez SA, Saitta B. Alterations in the regulation of expression of the a 1(I) collagen gene (COL1A1) in systemic sclerosis (scleroderma). Springer Semin. Immunopathol. 21, 397-414 (1999) (Pubitemid 30433749)
    • (1999) Springer Seminars in Immunopathology , vol.21 , Issue.4 , pp. 397-414
    • Jimenez, S.A.1    Saitta, B.2
  • 21
    • 0033788161 scopus 로고    scopus 로고
    • Role of apoptosis and transforming growth factor b1 in fibroblast selection and activation in systemic sclerosis
    • Jelaska A, Korn JH. Role of apoptosis and transforming growth factor b1 in fibroblast selection and activation in systemic sclerosis. Arthritis Rheum. 43, 2230-2239 (2000)
    • (2000) Arthritis Rheum , vol.43 , pp. 2230-2239
    • Jelaska, A.1    Korn, J.H.2
  • 22
    • 0034945771 scopus 로고    scopus 로고
    • Decreased susceptibility to Fas-induced apoptosis of systemic sclerosis dermal fibroblasts
    • DOI 10.1002/1529-0131(200107)44: 7<1667::AID-ART291>3.0.CO;2-Y
    • Santiago B, Galindo M, Rivero M, Pablos JL. Decreased susceptibility to Fas induced apoptosis of systemic sclerosis dermal fibroblasts. Arthritis Rheum. 44, 1667-1676 (2001) (Pubitemid 32642230)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.7 , pp. 1667-1676
    • Santiago, B.1    Galindo, M.2    Rivero, M.3    Pablos, J.L.4
  • 23
    • 0026540461 scopus 로고
    • Selective upregulation of platelet-derived growth factor a receptors by transforming growth factor b in scleroderma fibroblasts
    • Yamakage A, Kikuchi K, Smith EA, LeRoy EC, Trojanowska M. Selective upregulation of platelet-derived growth factor a receptors by transforming growth factor b in scleroderma fibroblasts. J Exp. Med 175, 1227-1234 (1992)
    • (1992) J Exp. Med , vol.175 , pp. 1227-1234
    • Yamakage, A.1    Kikuchi, K.2    Smith, E.A.3    Leroy, E.C.4    Trojanowska, M.5
  • 26
    • 33750952919 scopus 로고    scopus 로고
    • Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis
    • DOI 10.1002/art.22186
    • Kissin EY, Merkel PA, Lafyatis R. Myofibroblasts and hyalinized collagen as markers of skin disease in systemic sclerosis. Arthritis Rheum. 54, 3655-3660 (2006) (Pubitemid 44737178)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.11 , pp. 3655-3660
    • Kissin, E.Y.1    Merkel, P.A.2    Lafyatis, R.3
  • 27
    • 28444434653 scopus 로고    scopus 로고
    • Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis
    • Rajkumar VS, Howell K, Csiszar K, Denton CP, Black CM, Abraham DJ. Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis. Arthritis Res. Ther. 7, R1113-R1123 (2005)
    • (2005) Arthritis Res. Ther , vol.7
    • Rajkumar, V.S.1    Howell, K.2    Csiszar, K.3    Denton, C.P.4    Black, C.M.5    Abraham, D.J.6
  • 28
    • 61449196805 scopus 로고    scopus 로고
    • Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor b
    • Farina G, Lemaire R, Pancari P, Bayle J, Widom RL, Lafyatis R. Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor b. Ann Rheum. Dis. 68, 435-441 (2009)
    • (2009) Ann Rheum. Dis , vol.68 , pp. 435-441
    • Farina, G.1    Lemaire, R.2    Pancari, P.3    Bayle, J.4    Widom, R.L.5    Lafyatis, R.6
  • 29
    • 13844270572 scopus 로고    scopus 로고
    • Tissue repair, contraction, and the myofibroblast
    • DOI 10.1111/j.1067-1927.2005.130102.x
    • Desmoulière A, Chaponnier C, Gabbiani G. Tissue repair, contraction, and the myofibroblast. Wound Repair Regen. 13, 7-12 (2005) (Pubitemid 40250424)
    • (2005) Wound Repair and Regeneration , vol.13 , Issue.1 , pp. 7-12
    • Desmouliere, A.1    Chaponnier, C.2    Gabbiani, G.3
  • 31
    • 77954614145 scopus 로고    scopus 로고
    • Epigenetic regulation of myofibroblast differentiation by DNA methylation
    • Hu B, Gharaee-Kermani M, Wu Z, Phan SH. Epigenetic regulation of myofibroblast differentiation by DNA methylation. Am J Pathol. 177, 21-28 (2010)
    • (2010) Am J Pathol , vol.177 , pp. 21-28
    • Hu, B.1    Gharaee-Kermani, M.2    Wu, Z.3    Phan, S.H.4
  • 33
    • 0035877019 scopus 로고    scopus 로고
    • Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites
    • Abe R, Donnelly SC, Peng T, Bucala R, Metz CN. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol. 166, 7556-7562 (2001) (Pubitemid 32525636)
    • (2001) Journal of Immunology , vol.166 , Issue.12 , pp. 7556-7562
    • Abe, R.1    Donnelly, S.C.2    Peng, T.3    Bucala, R.4    Metz, C.N.5
  • 34
    • 45949089317 scopus 로고    scopus 로고
    • Pivotal advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation
    • DOI 10.1189/jlb.1107782
    • Shao DD, Suresh R, Vakil V, Gomer RH, Pilling D. Pivotal advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation. J Leukoc. Biol. 83, 1323-1333 (2008) (Pubitemid 351960310)
    • (2008) Journal of Leukocyte Biology , vol.83 , Issue.6 , pp. 1323-1333
    • Shao, D.D.1    Suresh, R.2    Vakil, V.3    Gomer, R.H.4    Pilling, D.5
  • 35
    • 0242662539 scopus 로고    scopus 로고
    • Inhibition of Fibrocyte Differentiation by Serum Amyloid P
    • Pilling D, Buckley CD, Salmon M, Gomer RH. Inhibition of fibrocyte differentiation by serum amyloid P. J Immunol. 171, 5537-5546 (2003) (Pubitemid 37432844)
    • (2003) Journal of Immunology , vol.171 , Issue.10 , pp. 5537-5546
    • Pilling, D.1    Buckley, C.D.2    Salmon, M.3    Gomer, R.H.4
  • 37
    • 0038544594 scopus 로고    scopus 로고
    • Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma
    • Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol. 171, 380-389 (2003) (Pubitemid 36745311)
    • (2003) Journal of Immunology , vol.171 , Issue.1 , pp. 380-389
    • Schmidt, M.1    Sun, G.2    Stacey, M.A.3    Mori, L.4    Mattoli, S.5
  • 38
    • 3042703080 scopus 로고    scopus 로고
    • Presence of CD45RO+ CD34+ cells with collagen synthesis activity in nepharogenic fibrosing dermopathy: A new pathogenic hypothesis [16]
    • DOI 10.1111/j.1365-2133.2004.05900.x
    • Ortonne N, Lipsker D, Chantrel F, Boehm N, Grosshans E, Cribier B. Presence of CD45RO+ CD34+ cells with collagen syntesis activity in nephrogenic fibrosing dermopathy: a new pathogenic hyphotesis. Br J. Dermatol. 150, 1050-1052 (2004) (Pubitemid 38903558)
    • (2004) British Journal of Dermatology , vol.150 , Issue.5 , pp. 1050-1052
    • Ortonne, N.1    Lipsker, D.2    Chantrel, F.3    Boehm, N.4    Grosshans, E.5    Cribier, B.6
  • 39
    • 0028221298 scopus 로고
    • + spindle-shaped cells selectively disappear from the skin lesion of scleroderma
    • DOI 10.1001/archderm.130.5.593
    • Aiba S, Tabata N, Ohtani H, Tagami H. CD34+ spindle-shaped cells selectively disappear from the skin lesion of scleroderma. Arch Dermatol. 130, 593-597 (1994) (Pubitemid 24150938)
    • (1994) Archives of Dermatology , vol.130 , Issue.5 , pp. 593-597
    • Aiba, S.1    Tabata, N.2    Ohtani, H.3    Tagami, H.4
  • 41
    • 7044224913 scopus 로고    scopus 로고
    • Cellular origins of fibroblasts: Possible implications for organ fibrosis in systemic sclerosis
    • DOI 10.1097/01.bor.0000139310.77347.9c
    • Postlethwaite AE, Shigemitsu H, Kanangat S. Cellular origins of fibroblasts: possible implications for organ fibrosis in systemic sclerosis. Curr Opin. Rheumatol. 16, 733-738 (2004) (Pubitemid 39425547)
    • (2004) Current Opinion in Rheumatology , vol.16 , Issue.6 , pp. 733-738
    • Postlethwaite, A.E.1    Shigemitsu, H.2    Kanangat, S.3
  • 42
    • 36849019559 scopus 로고    scopus 로고
    • Parabiosis and transplantation models show no evidence of circulating dermal fibroblast progenitors in bleomycin-induced skin fibrosis
    • DOI 10.1002/jcp.21182
    • Boban I, Barisic-Dujmovic T, Clark SH. Parabiosis and transplantation models show no evidence of circulating dermal fibroblast progenitors in bleomycin-induced skin fibrosis. J Cell Physiol. 214, 230-237 (2008) (Pubitemid 350220077)
    • (2008) Journal of Cellular Physiology , vol.214 , Issue.1 , pp. 230-237
    • Boban, I.1    Barisic-Dujmovic, T.2    Clark, S.H.3
  • 43
    • 18444374439 scopus 로고    scopus 로고
    • In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions
    • DOI 10.1634/stemcells.2004-0183
    • Ishii G, Sangai T, Sugiyama K et al. In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions. Stem Cells 23, 699-706 (2005) (Pubitemid 40647266)
    • (2005) Stem Cells , vol.23 , Issue.5 , pp. 699-706
    • Ishii, G.1    Sangai, T.2    Sugiyama, K.3    Ito, T.4    Hasebe, T.5    Endoh, Y.6    Magae, J.7    Ochiai, A.8
  • 46
    • 39849097361 scopus 로고    scopus 로고
    • Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance
    • DOI 10.1038/sj.mt.6300374, PII 6300374
    • Cheng Z, Ou L, Zhou X et al. Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance. Mol. Ther. 16, 571-579 (2008) (Pubitemid 351314998)
    • (2008) Molecular Therapy , vol.16 , Issue.3 , pp. 571-579
    • Cheng, Z.1    Ou, L.2    Zhou, X.3    Li, F.4    Jia, X.5    Zhang, Y.6    Liu, X.7    Li, Y.8    Ward, C.A.9    Melo, L.G.10    Kong, D.11
  • 47
    • 38849108184 scopus 로고    scopus 로고
    • Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium
    • DOI 10.1093/cvr/cvm025
    • Pasha Z, Wang Y, Sheikh R, Zhang D, Zhao T, Ashraf M. Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium. Cardiovasc. Res. 77, 134-142 (2008) (Pubitemid 351195153)
    • (2008) Cardiovascular Research , vol.77 , Issue.1 , pp. 134-142
    • Pasha, Z.1    Wang, Y.2    Sheikh, R.3    Zhang, D.4    Zhao, T.5    Ashraf, M.6
  • 48
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: Potential role in idiopathic pulmonary fibrosis
    • Willis BC, Liebler JM, Luby-Phelps K et al. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-b1: potential role in idiopathic pulmonary fibrosis. Am J Pathol. 166, 1321-1332 (2005) (Pubitemid 40586504)
    • (2005) American Journal of Pathology , vol.166 , Issue.5 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3    Nicholson, A.G.4    Crandall, E.D.5    Du Bois, R.M.6    Borok, Z.7
  • 50
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • DOI 10.1172/JCI200320530
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 112, 1776-1784 (2003) (Pubitemid 38063698)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.12 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 52
    • 0032929924 scopus 로고    scopus 로고
    • Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis
    • DOI 10.1002/1529-0131(199905)42: 5<930::AID-ANR11>3.0.CO;2-1
    • Rajkumar VS, Sundberg C, Abraham DJ, Rubin K, Black CM. Activation of microvascular pericytes in autoimmune Raynauds phenomenon and systemic sclerosis. Arthritis Rheum. 42, 930-941 (1999) (Pubitemid 29215003)
    • (1999) Arthritis and Rheumatism , vol.42 , Issue.5 , pp. 930-941
    • Rajkumar, V.S.1    Sundberg, C.2    Abraham, D.J.3    Rubin, K.4    Black, C.M.5
  • 54
    • 0024539072 scopus 로고
    • Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma
    • Gay S, Jones RE Jr, Huang GQ, Gay RE. Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma. J Invest. Dermatol. 92, 301-303 (1989) (Pubitemid 19061278)
    • (1989) Journal of Investigative Dermatology , vol.92 , Issue.2 , pp. 301-303
    • Gay, S.1    Jones Jr., R.E.2    Huang, G.-Q.3    Gay, R.E.4
  • 55
    • 0032211908 scopus 로고    scopus 로고
    • Expression of platelet-derived growth factor B-chain and platelet-derived growth factor b-receptor in fibroblasts of scleroderma
    • Zheng XY, Zhang JZ, Tu P, Ma SQ. Expression of platelet-derived growth factor B-chain and platelet-derived growth factor b-receptor in fibroblasts of scleroderma. J Dermatol. Sci. 18, 90-97 (1998)
    • (1998) J Dermatol. Sci , vol.18 , pp. 90-97
    • Zheng, X.Y.1    Zhang, J.Z.2    Tu, P.3    Ma, S.Q.4
  • 56
    • 33847348491 scopus 로고    scopus 로고
    • Systemic sclerosis: A prototypic multisystem fibrotic disorder
    • DOI 10.1172/JCI31139
    • Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest. 117, 557-567 (2007) (Pubitemid 46348510)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.3 , pp. 557-567
    • Varga, J.1    Abraham, D.2
  • 57
    • 3543107212 scopus 로고    scopus 로고
    • Fibrotic disease and the T(h)1/T(h)2 paradigm
    • Wynn TA. Fibrotic disease and the T(h)1/T(h)2 paradigm. Nat Rev. Immunol. 4, 583-594 (2004)
    • (2004) Nat Rev. Immunol , vol.4 , pp. 583-594
    • Wynn, T.A.1
  • 59
    • 67650480995 scopus 로고    scopus 로고
    • Transforming growth factor b as a therapeutic target in systemic sclerosis
    • Varga J, Pasche B. Transforming growth factor b as a therapeutic target in systemic sclerosis. Nat Rev. Rheumatol. 5, 200-206 (2009)
    • (2009) Nat Rev. Rheumatol , vol.5 , pp. 200-206
    • Varga, J.1    Pasche, B.2
  • 61
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor β in human disease
    • DOI 10.1056/NEJM200005043421807
    • Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor b in human disease. N Engl J. Med 342, 1350-1358 (2000) (Pubitemid 30408720)
    • (2000) New England Journal of Medicine , vol.342 , Issue.18 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 62
    • 0027212686 scopus 로고
    • Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
    • Desmoulière A, Geinoz A, Gabbiani F, Gabbiani G. Transforming growth factor-b induces a smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell. Biol. 122, 103-111 (1993) (Pubitemid 23188802)
    • (1993) Journal of Cell Biology , vol.122 , Issue.1 , pp. 103-111
    • Desmouliere, A.1    Geinoz, A.2    Gabbiani, F.3    Gabbiani, G.4
  • 63
    • 0031886413 scopus 로고    scopus 로고
    • Increased expression of TGF-β receptors by scleroderma fibroblasts: Evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype
    • DOI 10.1046/j.1523-1747.1998.00073.x
    • Kawakami T, Ihn H, Xu W, Smith E, LeRoy C, Trojanowska M. Increased expression of TGF-b receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-b signalling to scleroderma phenotype. J Invest. Dermatol. 110, 47-51 (1998) (Pubitemid 28086062)
    • (1998) Journal of Investigative Dermatology , vol.110 , Issue.1 , pp. 47-51
    • Kawakami, T.1    Ihn, H.2    Xu, W.3    Smith, E.4    LeRoy, C.5    Trojanowska, M.6
  • 64
    • 25444501226 scopus 로고    scopus 로고
    • Involvement of αvβ5 integrin-mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts
    • DOI 10.1002/art.21246
    • Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K. Involvement of avb5 integrin-mediated activation of latent transforming growth factor b1 in autocrine transforming growth factor b signalling in systemic sclerosis fibroblasts. Arthritis Rheum. 52, 2897-2905 (2005) (Pubitemid 41369121)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.9 , pp. 2897-2905
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 65
    • 0036894848 scopus 로고    scopus 로고
    • Upregulated expression of transforming growth factor-β receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis
    • Kubo M, Ihn H, Yamane K, Tamaki K. Upregulated expression of transforming growth factor-b receptors in dermal fibroblasts of skin sections from patients with systemic sclerosis. J Rheumatol. 29, 2558-2564 (2002) (Pubitemid 35416962)
    • (2002) Journal of Rheumatology , vol.29 , Issue.12 , pp. 2558-2564
    • Kubo, M.1    Ihn, H.2    Yamane, K.3    Tamaki, K.4
  • 66
    • 0038004796 scopus 로고    scopus 로고
    • Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts
    • DOI 10.1002/art.11157
    • Mori Y, Chen SJ, Varga J. Expression and regulation of intracellular SMAD signalling in scleroderma skin fibroblasts. Arthritis Rheum. 48, 1964-1978 (2003) (Pubitemid 36828692)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.7 , pp. 1964-1978
    • Mori, Y.1    Chen, S.-J.2    Varga, J.3
  • 68
    • 34248548638 scopus 로고    scopus 로고
    • Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor β signaling in scleroderma fibroblasts
    • DOI 10.1002/art.22588
    • Jinnin M, Ihn H, Mimura Y, Asano Y, Tamaki K. Involvement of the constitutive complex formation of c-Ski/ SnoN with Smads in the impaired negative feedback regulation of transforming growth factor b signalling in scleroderma fibroblasts. Arthritis Rheum. 56,1694-1705 (2007) (Pubitemid 46764101)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.5 , pp. 1694-1705
    • Jinnin, M.1    Ihn, H.2    Mimura, Y.3    Asano, Y.4    Tamaki, K.5
  • 70
    • 51849169053 scopus 로고    scopus 로고
    • Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis
    • Del Galdo F, Sotgia F, de Almeida CJ et al. Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. Arthritis Rheum. 58, 2854-2865 (2008)
    • (2008) Arthritis Rheum , vol.58 , pp. 2854-2865
    • Del Galdo, F.1    Sotgia, F.2    De Almeida, C.J.3
  • 72
    • 0031685620 scopus 로고    scopus 로고
    • TGF-b signal transduction
    • Massague J. TGF-b signal transduction. Annu. Rev. Biochem. 67, 753-791 (1998)
    • (1998) Annu. Rev. Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 73
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-b signals
    • Moustakas A, Heldin CH. Non-Smad TGF-b signals. J Cell. Sci. 118, 3573-3584 (2005)
    • (2005) J Cell. Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 74
    • 59649118981 scopus 로고    scopus 로고
    • Molecular framework for response to imatinib mesylate in systemic sclerosis
    • Chung L, Fiorentino DF, Benbarak MJ et al. Molecular framework for response to imatinib mesylate in systemic sclerosis. Arthritis Rheum. 60, 584-591 (2009)
    • (2009) Arthritis Rheum , vol.60 , pp. 584-591
    • Chung, L.1    Fiorentino, D.F.2    Benbarak, M.J.3
  • 77
    • 49449107395 scopus 로고    scopus 로고
    • Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate
    • Pannu J, Asano Y, Nakerakanti S et al. Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate. Arthritis Rheum. 58, 2528-2537 (2008)
    • (2008) Arthritis Rheum , vol.58 , pp. 2528-2537
    • Pannu, J.1    Asano, Y.2    Nakerakanti, S.3
  • 78
    • 18244368698 scopus 로고    scopus 로고
    • Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts
    • DOI 10.1111/j.0022-202X.2005.23701.x
    • Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K. Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts. J Invest. Dermatol. 124, 886-892 (2005) (Pubitemid 40629086)
    • (2005) Journal of Investigative Dermatology , vol.124 , Issue.5 , pp. 886-892
    • Mimura, Y.1    Ihn, H.2    Jinnin, M.3    Asano, Y.4    Yamane, K.5    Tamaki, K.6
  • 80
    • 24344471061 scopus 로고    scopus 로고
    • Increased phosphorylation and activation of mitogen-activated protein kinase p38 in scleroderma fibroblasts
    • DOI 10.1111/j.0022-202X.2005.23766.x
    • Ihn H, Yamane K, Tamaki K. Increased phosphorylation and activation of mitogen-activated protein kinase p38 in scleroderma fibroblasts. J Invest. Dermatol. 125, 247-255 (2005) (Pubitemid 41648157)
    • (2005) Journal of Investigative Dermatology , vol.125 , Issue.2 , pp. 247-255
    • Ihn, H.1    Yamane, K.2    Tamaki, K.3
  • 81
    • 0036226458 scopus 로고    scopus 로고
    • Role of p38 MAPK in transforming growth factor β stimulation of collagen production by scleroderma and healthy dermal fibroblasts
    • DOI 10.1046/j.1523-1747.2002.01719.x
    • Sato M, Shegogue D, Gore EA, Smith EA, McDermott PJ, Trojanowska M. Role of p38 MAPK in transforming growth factor b stimulation of collagen production by scleroderma and healthy dermal fibroblasts. J Invest. Dermatol. 118, 704-711 (2002) (Pubitemid 34309993)
    • (2002) Journal of Investigative Dermatology , vol.118 , Issue.4 , pp. 704-711
    • Sato, M.1    Shegogue, D.2    Gore, E.A.3    Smith, E.A.4    Mcdermott, P.J.5    Trojanowska, M.6
  • 82
    • 70349237004 scopus 로고    scopus 로고
    • Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing
    • Wu M, Melichian DS, de la Garza M et al. Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing. Am J Pathol. 175, 1041-1055 (2009)
    • (2009) Am J Pathol , vol.175 , pp. 1041-1055
    • Wu, M.1    Melichian, D.S.2    De La Garza, M.3
  • 83
    • 70449575813 scopus 로고    scopus 로고
    • The transcriptional cofactor Nab2 is induced by TGF-b and suppresses fibroblast activation: Physiological roles and impaired expression in scleroderma
    • Bhattacharyya S, Wei J, Melichian DS, Milbrandt J, Takehara K, Varga J. The transcriptional cofactor Nab2 is induced by TGF-b and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma. PLoS ONE 26(4), e7620 (2009)
    • (2009) PLoS ONE , vol.26 , Issue.4
    • Bhattacharyya, S.1    Wei, J.2    Melichian, D.S.3    Milbrandt, J.4    Takehara, K.5    Varga, J.6
  • 84
    • 35349019900 scopus 로고    scopus 로고
    • How does endothelial cell injury start? the role of endothelin in systemic sclerosis
    • Abraham D, Distler O. How does endothelial cell injury start? The role of endothelin in systemic sclerosis. Arthritis Res. Ther. 9(Suppl. 2), S2 (2007)
    • (2007) Arthritis Res. Ther , vol.9 , Issue.SUPPL. 2
    • Abraham, D.1    Distler, O.2
  • 86
    • 0035161153 scopus 로고    scopus 로고
    • Transforming growth factor-β and connective tissue growth factor: Key cytokines in scleroderma pathogenesis
    • DOI 10.1097/00002281-200111000-00010
    • Denton CP, Abraham DJ. Transforming growth factor-b and connective tissue growth factor: key cytokines in scleroderma pathogenesis. Curr Opin. Rheumatol. 13, 505-511 (2001) (Pubitemid 33070969)
    • (2001) Current Opinion in Rheumatology , vol.13 , Issue.6 , pp. 505-511
    • Denton, C.P.1    Abraham, D.J.2
  • 88
    • 33745277147 scopus 로고    scopus 로고
    • Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis
    • Baroni SS, Santillo M, Bevilacqua F et al. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J. Med 354, 2667-2676 (2006)
    • (2006) N Engl J. Med , vol.354 , pp. 2667-2676
    • Baroni, S.S.1    Santillo, M.2    Bevilacqua, F.3
  • 89
    • 65249139405 scopus 로고    scopus 로고
    • Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis
    • Classen JF, Henrohn D, Rorsman F et al. Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis. Arthritis Rheum. 60, 1137-1144 (2009)
    • (2009) Arthritis Rheum , vol.60 , pp. 1137-1144
    • Classen, J.F.1    Henrohn, D.2    Rorsman, F.3
  • 90
    • 65249190778 scopus 로고    scopus 로고
    • Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor a in a subset of normal and systemic sclerosis patient sera
    • Loizos N, Lariccia L, Weiner J et al. Lack of detection of agonist activity by antibodies to platelet-derived growth factor receptor a in a subset of normal and systemic sclerosis patient sera. Arthritis Rheum. 60, 1145-1151 (2009)
    • (2009) Arthritis Rheum , vol.60 , pp. 1145-1151
    • Loizos, N.1    Lariccia, L.2    Weiner, J.3
  • 91
    • 0033567017 scopus 로고    scopus 로고
    • Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1- and Th2-type pulmonary granuloma models
    • Hogaboam CM, Bone-Larson CL, Lipinski S et al. Differential monocyte chemoattractant protein-1 and chemokine receptor 2 expression by murine lung fibroblasts derived from Th1-and Th2-type pulmonary granuloma models. J Immunol. 163, 2193-2201 (1999) (Pubitemid 29382227)
    • (1999) Journal of Immunology , vol.163 , Issue.4 , pp. 2193-2201
    • Hogaboam, C.M.1    Bone-Larson, C.L.2    Lipinski, S.3    Lukacs, N.W.4    Chensue, S.W.5    Strieter, R.M.6    Kunkel, S.L.7
  • 92
    • 70350523842 scopus 로고    scopus 로고
    • Polarized subsets of human T-helper cells induce distinct patterns of chemokine production by normal and systemic sclerosis dermal fibroblasts
    • Chizzolini C, Parel Y, Scheja A, Dayer JM. Polarized subsets of human T-helper cells induce distinct patterns of chemokine production by normal and systemic sclerosis dermal fibroblasts. Arthritis Res. Ther. 8, R10 (2006)
    • (2006) Arthritis Res. Ther , vol.8
    • Chizzolini, C.1    Parel, Y.2    Scheja, A.3    Dayer, J.M.4
  • 93
    • 0034966873 scopus 로고    scopus 로고
    • Chemokine expression by systemic sclerosis fibroblasts: Abnormal regulation of monocyte chemoattractant protein 1 expression
    • DOI 10.1002/1529-0131(200106)44: 6<1382::AID-ART231>3.0.CO;2-T
    • Galindo M, Santiago B, Rivero M, Rullas J, Alcami J, Pablos JL. Chemokine expression by systemic sclerosis fibroblasts: abnormal regulation of monocyte chemoattractant protein 1 expression. Arthritis Rheum. 44, 1382-1386 (2001) (Pubitemid 32537537)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.6 , pp. 1382-1386
    • Galindo, M.1    Santiago, B.2    Rivero, M.3    Rullas, J.4    Alcami, J.5    Pablos, J.L.6
  • 96
    • 0026776365 scopus 로고
    • A-smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by g-interferon
    • Desmoulière A, Rubbia-Brandt L, Abdiu A, Walz T, Macieira-Coelho A, Gabbiani G. A-smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by g-interferon. Exp. Cell. Res. 201, 64-73 (1992)
    • (1992) Exp. Cell. Res , vol.201 , pp. 64-73
    • Desmoulière, A.1    Rubbia-Brandt, L.2    Abdiu, A.3    Walz, T.4    MacIeira-Coelho, A.5    Gabbiani, G.6
  • 97
    • 0347994946 scopus 로고    scopus 로고
    • Intracellular Regulation of Fas-Induced Apoptosis in Human Fibroblasts by Extracellular Factors and Cycloheximide
    • Santiago B, Galindo M, Palao G, Pablos JL. Intracellular regulation of Fas-induced apoptosis in human fibroblasts by extracellular factors and cycloheximide. J Immunol. 172, 560-566 (2004) (Pubitemid 38020513)
    • (2004) Journal of Immunology , vol.172 , Issue.1 , pp. 560-566
    • Santiago, B.1    Galindo, M.2    Palao, G.3    Pablos, J.L.4
  • 98
    • 77952429470 scopus 로고    scopus 로고
    • Antagonistic effect of the matricellular signalling protein CCN3 on TGF-b-and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome
    • Lemaire R, Farina G, Bayle J et al. Antagonistic effect of the matricellular signalling protein CCN3 on TGF-b-and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome. J Invest. Dermatol. 130, 1514-1523 (2010)
    • (2010) J Invest. Dermatol , vol.130 , pp. 1514-1523
    • Lemaire, R.1    Farina, G.2    Bayle, J.3
  • 99
    • 79955559412 scopus 로고    scopus 로고
    • Genetic deletion or pharmacologic antagonism of LPA(1) ameliorates dermal fibrosis in a scleroderma mouse model
    • Castelino FV, Seiders J, Bain G et al. Genetic deletion or pharmacologic antagonism of LPA(1) ameliorates dermal fibrosis in a scleroderma mouse model. Arthritis Rheum. 63(5), 1405-1415 (2011)
    • (2011) Arthritis Rheum , vol.63 , Issue.5 , pp. 1405-1415
    • Castelino, F.V.1    Seiders, J.2    Bain, G.3
  • 100
    • 71549123258 scopus 로고    scopus 로고
    • Prostaglandin F(2a) receptor signalling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-b
    • Oga T, Matsuoka T, Yao C et al. Prostaglandin F(2a) receptor signalling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-b. Nat Med 15, 1426-1430 (2009)
    • (2009) Nat Med , vol.15 , pp. 1426-1430
    • Oga, T.1    Matsuoka, T.2    Yao, C.3
  • 102
    • 59649085854 scopus 로고    scopus 로고
    • Rosiglitazone abrogates bleomycin-induced scleroderma and blocks pro-fibrotic responses through peroxisome proliferator-activated receptor-g
    • Wu M, Melichian DS, Chang E, Warner-Blankenship M, Ghosh AK, Varga J. Rosiglitazone abrogates bleomycin-induced scleroderma and blocks pro-fibrotic responses through peroxisome proliferator-activated receptor-g. Am J Pathol. 174, 519-533 (2009)
    • (2009) Am J Pathol , vol.174 , pp. 519-533
    • Wu, M.1    Melichian, D.S.2    Chang, E.3    Warner-Blankenship, M.4    Ghosh, A.K.5    Varga, J.6
  • 103
    • 77952946050 scopus 로고    scopus 로고
    • MicroRNA-29, a key regulator of collagen expression in systemic sclerosis
    • Maurer B, Stanczyk J, Jüngel A et al. MicroRNA-29, a key regulator of collagen expression in systemic sclerosis. Arthritis Rheum. 62, 1733-1743 (2010)
    • (2010) Arthritis Rheum , vol.62 , pp. 1733-1743
    • Maurer, B.1    Stanczyk, J.2    Jüngel, A.3
  • 104
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • DOI 10.1002/art.21948
    • Wang Y, Fan PS, Kahaleh B. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum. 54, 2271-2279 (2006) (Pubitemid 44051084)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.7 , pp. 2271-2279
    • Wang, Y.1    Fan, P.-S.2    Kahaleh, B.3
  • 105
    • 0042846026 scopus 로고    scopus 로고
    • Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin
    • Kubo M, Czuwara-Ladykowska J, Moussa O et al. Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin. Am J Pathol. 163, 571-578 (2003)
    • (2003) Am J Pathol , vol.163 , pp. 571-578
    • Kubo, M.1    Czuwara-Ladykowska, J.2    Moussa, O.3


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