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Volumn 125, Issue 2, 2005, Pages 247-255

Increased phosphorylation and activation of mitogen-activated protein kinase p38 in scleroderma fibroblasts

Author keywords

Fibronectin; Gene expression; Procollagen; Signal transduction; Transcription factors

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLLAGEN; COLLAGEN TYPE 1; FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; ALPHA 2(I) COLLAGEN; ENZYME INHIBITOR;

EID: 24344471061     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23766.x     Document Type: Article
Times cited : (47)

References (41)
  • 1
    • 0028884033 scopus 로고
    • Saltiel AR: PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR: PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494, 1995
    • (1995) J Biol Chem , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4
  • 2
    • 0028109801 scopus 로고
    • Transforming growth factor β in tissue fibrosis
    • Border WA, Noble NA: Transforming growth factor β in tissue fibrosis. N Engl J Med 331:1286-1292, 1994
    • (1994) N Engl J Med , vol.331 , pp. 1286-1292
    • Border, W.A.1    Noble, A.2
  • 3
    • 0018863889 scopus 로고
    • Structurally distinct collagen types
    • Bornstein P, Sage H: Structurally distinct collagen types. Annu Rev Biochem 49:957-1003, 1980
    • (1980) Annu Rev Biochem , vol.49 , pp. 957-1003
    • Bornstein, P.1    Sage, H.2
  • 4
    • 0028904803 scopus 로고
    • Requirements for transforming growth factor-β regulation of the pro α2(I) collagen and plasminogen activator inhibitor-1 promoters
    • Chang E, Goldberg H: Requirements for transforming growth factor-β regulation of the pro α2(I) collagen and plasminogen activator inhibitor-1 promoters. J Biol Chem 270:4473-4477, 1995
    • (1995) J Biol Chem , vol.270 , pp. 4473-4477
    • Chang, E.1    Goldberg, H.2
  • 5
    • 0032921867 scopus 로고    scopus 로고
    • Stimulation of type I collagen transcription in human skin fibroblasts by TGF-β: Involvement of Smad 3
    • Chen S-J, Yuan W, Mori Y, Levenson A, Trojanowska M, Varga J: Stimulation of type I collagen transcription in human skin fibroblasts by TGF-β: Involvement of Smad 3. J Invest Dermatol 112:49-57, 1999
    • (1999) J Invest Dermatol , vol.112 , pp. 49-57
    • Chen, S.-J.1    Yuan, W.2    Mori, Y.3    Levenson, A.4    Trojanowska, M.5    Varga, J.6
  • 6
    • 0030047646 scopus 로고    scopus 로고
    • An AP-1 binding sequence is essential for regulation of the human α2(I) collagen promoter activity by transforming growth factor-β
    • Chung KY, Agarwal A, Uitto J, Mauviel A: An AP-1 binding sequence is essential for regulation of the human α2(I) collagen promoter activity by transforming growth factor-β. J Biol Chem 271:3272-3278, 1996
    • (1996) J Biol Chem , vol.271 , pp. 3272-3278
    • Chung, K.Y.1    Agarwal, A.2    Uitto, J.3    Mauviel, A.4
  • 8
    • 0034691764 scopus 로고    scopus 로고
    • Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-β involves functional cooperation with p300/CBP transcriptional coactivators
    • Ghosh AK, Yuan W, Mori Y, Varga J: Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-β involves functional cooperation with p300/CBP transcriptional coactivators. Oncogene 19:3546-3455, 2000
    • (2000) Oncogene , vol.19 , pp. 3546-13455
    • Ghosh, A.K.1    Yuan, W.2    Mori, Y.3    Varga, J.4
  • 9
    • 0030854850 scopus 로고    scopus 로고
    • Sp1 is required for the early response of α2(I) collagen to transforming growth factor-β1
    • Greenwel P, Inagaki Y, Hu W, Walsh M, Rramirez F: Sp1 is required for the early response of α2(I) collagen to transforming growth factor-β1. J Biol Chem 272:19738-19745, 1997
    • (1997) J Biol Chem , vol.272 , pp. 19738-19745
    • Greenwel, P.1    Inagaki, Y.2    Hu, W.3    Walsh, M.4    Rramirez, F.5
  • 10
    • 0023654923 scopus 로고
    • Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-β
    • Ignotz RA, Endo T, Massaguë J: Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-β. J Biol Chem 262:6443-6446, 1987
    • (1987) J Biol Chem , vol.262 , pp. 6443-6446
    • Ignotz, R.A.1    Endo, T.2    Massaguë, J.3
  • 11
    • 0035723342 scopus 로고    scopus 로고
    • Sp1 phosphorylation induced by serum stimulates the human α2(I) collagen gene expression
    • Ihn H, Ihn Y, Trojanowska M: Sp1 phosphorylation induced by serum stimulates the human α2(I) collagen gene expression. J Invest Dermatol 117: 301-308, 2001a
    • (2001) J Invest Dermatol , vol.117 , pp. 301-308
    • Ihn, H.1    Ihn, Y.2    Trojanowska, M.3
  • 12
    • 0030870170 scopus 로고    scopus 로고
    • Oncostatin M stimulates transcription of the human α2(I) collagen gene via the Sp1/Sp3-binding site
    • Ihn H, LeRoy EC, Trojanowska M: Oncostatin M stimulates transcription of the human α2(I) collagen gene via the Sp1/Sp3-binding site. J Biol Chem 272:24666-24672, 1997
    • (1997) J Biol Chem , vol.272 , pp. 24666-24672
    • Ihn, H.1    Leroy, E.C.2    Trojanowska, M.3
  • 13
    • 0029861965 scopus 로고    scopus 로고
    • Transcriptional regulation of the human α2(I) collagen gene: Combined action of upstream stimulatory and inhibitory cis-acting elements
    • Ihn H, Ohnishi K, Tamaki T, LeRoy EC, Trojanowska M: Transcriptional regulation of the human α2(I) collagen gene: Combined action of upstream stimulatory and inhibitory cis-acting elements. J Biol Chem 271:26717-26723, 1996
    • (1996) J Biol Chem , vol.271 , pp. 26717-26723
    • Ihn, H.O.1    Hnishi, K.2    Tamaki, T.3    Leroy, E.C.4    Trojanowska, M.5
  • 14
    • 0033791928 scopus 로고    scopus 로고
    • Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: Association with increased expression of the type I collagen gene
    • Ihn H, Tamaki K: Increased phosphorylation of transcription factor Sp1 in scleroderma fibroblasts: Association with increased expression of the type I collagen gene. Arthritis Rheum 43:2240-2247, 200Oa
    • (2000) Arthritis Rheum , vol.43 , pp. 2240-2247
    • Ihn, H.1    Tamaki, K.2
  • 15
    • 0034068629 scopus 로고    scopus 로고
    • Competition analysis of the human α 2(I) collagen promoter using synthetic oligonucleotides
    • Ihn H, Tamaki K: Competition analysis of the human α 2(I) collagen promoter using synthetic oligonucleotides. J Invest Dermatol 114:1011-1016, 2000b
    • (2000) J Invest Dermatol , vol.114 , pp. 1011-1016
    • Ihn, H.1    Tamaki, K.2
  • 16
    • 0034664022 scopus 로고    scopus 로고
    • Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway
    • Ihn H, Tamaki K: Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway. J Immunol 165: 2149-2155, 2000c
    • (2000) J Immunol , vol.165 , pp. 2149-2155
    • Ihn, H.1    Tamaki, K.2
  • 17
    • 0030820182 scopus 로고    scopus 로고
    • Sp3 is a transcriptional activator of the human α2(I) collagen gene
    • Ihn H, Trojanowska M: Sp3 is a transcriptional activator of the human α2(I) collagen gene. Nucleic Acids Res 25:3712-3717, 1997
    • (1997) Nucleic Acids Res , vol.25 , pp. 3712-3717
    • Ihn, H.1    Trojanowska, M.2
  • 18
    • 0037083458 scopus 로고    scopus 로고
    • Interleukin-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase-dependent pathway
    • Ihn H, Yamane K, Asano Y, Kubo M, Tamaki K: Interleukin-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase-dependent pathway. J Immunol 168:1895-1902, 2002
    • (2002) J Immunol , vol.168 , pp. 1895-1902
    • Ihn, H.1    Yamane, K.2    Asano, Y.3    Kubo, M.4    Tamaki, K.5
  • 19
    • 0035089825 scopus 로고    scopus 로고
    • Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts. Association with increased expression of transforming growth factor β receptors
    • Ihn H, Yamane K, Kubo M, Tamaki K: Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts. Association with increased expression of transforming growth factor β receptors. Arthritis Rheum 44:474-480, 2001b
    • (2001) Arthritis Rheum , vol.44 , pp. 474-480
    • Ihn, H.1    Yamane, K.2    Kubo, M.3    Tamaki, K.4
  • 20
    • 0028176086 scopus 로고
    • Transforming growth factor-β stimulates α2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site
    • Inagaki Y, Truter S, Ramirez F: Transforming growth factor-β stimulates α2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J Biol Chem 269:14828-14834, 1994
    • (1994) J Biol Chem , vol.269 , pp. 14828-14834
    • Inagaki, Y.1    Truter, S.2    Ramirez, F.3
  • 21
    • 0028850885 scopus 로고
    • Overlapping pathways mediate the opposing actions of tumor necrosis-α and transforming growth factor-β on α2(I) collagen gene transcription
    • Inagaki Y, Truter S, Tanaka S, DiLiberto M, Ramirez F: Overlapping pathways mediate the opposing actions of tumor necrosis-α and transforming growth factor-β on α2(I) collagen gene transcription. J Biol Chem 270:3353-3358, 1995
    • (1995) J Biol Chem , vol.270 , pp. 3353-3358
    • Inagaki, Y.1    Truter, S.2    Tanaka, S.3    Diliberto, M.4    Ramirez, F.5
  • 22
    • 0029765057 scopus 로고    scopus 로고
    • Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts: Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts
    • Jelaska A, Arakawa M, Broketa G, Korn JH: Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts: Increased proportion of high collagen-producing cells in systemic sclerosis fibroblasts. Arthritis Rheum 39:1338-1346, 1996
    • (1996) Arthritis Rheum , vol.39 , pp. 1338-1346
    • Jelaska, A.1    Arakawa, M.2    Broketa, G.3    Korn, J.H.4
  • 23
    • 0025152119 scopus 로고
    • Tumor necrosis factor-α and interferon-γ suppress the activation of human type I collagen gene expression by transforming growth factor-β1
    • Kähäri VM, Chen YQ, Su MW, Ramirez F, Uitto J: Tumor necrosis factor-α and interferon-γ suppress the activation of human type I collagen gene expression by transforming growth factor-β1. J Clin Invest 86:1489-1495, 1990
    • (1990) J Clin Invest , vol.86 , pp. 1489-1495
    • Kähäri, V.M.1    Chen, Y.Q.2    Su, M.W.3    Ramirez, F.4    Uitto, J.5
  • 24
    • 0032528041 scopus 로고    scopus 로고
    • Smads proteins exist as monomers in vivo and undergo homo- and hetro-oligomerization upon activation by serine/threonine kinase receptor
    • Kawabata M, Inoue H, Hanyu A, Imamura T, Miyazono K: Smads proteins exist as monomers in vivo and undergo homo- and hetro-oligomerization upon activation by serine/threonine kinase receptor. EMBO J 17:4056-4065, 1998
    • (1998) EMBO J , vol.17 , pp. 4056-4065
    • Kawabata, M.1    Inoue, H.2    Hanyu, A.3    Imamura, T.4    Miyazono, K.5
  • 25
    • 0031911356 scopus 로고    scopus 로고
    • SMADs: Mediators and regulators of TGF-β signaling
    • Kretzschmar M, Massaguë J: SMADs: Mediators and regulators of TGF-β signaling. Curr Opin Genet Dev 8:103-111, 1998
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 103-111
    • Kretzschmar, M.1    Massaguë, J.2
  • 26
    • 0029744885 scopus 로고    scopus 로고
    • Sounding the alarm: Protein kinase cascades activated by stress and inflammation
    • Kyriakis JM, Avruch J: Sounding the alarm: Protein kinase cascades activated by stress and inflammation. J Biol Chem 271:24313-24316, 1996
    • (1996) J Biol Chem , vol.271 , pp. 24313-24316
    • Kyriakis, J.M.1    Avruch, J.2
  • 27
    • 0024323330 scopus 로고
    • A strategy for determining the pathogenesis of systemic sclerosis: Is transforming growth factor β the answer?
    • LeRoy EC, Smith EA, Kahaleh MB, Trojanowska M, Silver RM: A strategy for determining the pathogenesis of systemic sclerosis: Is transforming growth factor β the answer? Arthritis Rheum 32:817-825, 1989
    • (1989) Arthritis Rheum , vol.32 , pp. 817-825
    • Leroy, E.C.1    Smith, E.A.2    Kahaleh, M.B.3    Trojanowska, M.4    Silver, R.M.5
  • 28
    • 0025222517 scopus 로고
    • The transforming growth factor-β family
    • Massaguë J: The transforming growth factor-β family. Annu Rev Cell Biol 6: 597-641, 1990
    • (1990) Annu Rev Cell Biol , vol.6 , pp. 597-641
    • Massaguë, J.1
  • 29
    • 0033553558 scopus 로고    scopus 로고
    • Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration
    • Matsumoto T, Yokote K, Tamura K, Takemoto M, Ueno H, Saito Y, Mori S: Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration. J Biol Chem 274:13954-13960, 1999
    • (1999) J Biol Chem , vol.274 , pp. 13954-13960
    • Matsumoto, T.1    Yokote, K.2    Tamura, K.3    Takemoto, M.4    Ueno, H.5    Saito, Y.6    Mori, S.7
  • 30
    • 0035831503 scopus 로고    scopus 로고
    • Sp1 and Smad proteins cooperate to mediate transforming growth factor-β1-induced α2(I) collagen expression in human glomerular mesangimal cells
    • Poncelet AC, Schnaper HW: Sp1 and Smad proteins cooperate to mediate transforming growth factor-β1-induced α2(I) collagen expression in human glomerular mesangimal cells. J Biol Chem 276:6983-6992, 2001
    • (2001) J Biol Chem , vol.276 , pp. 6983-6992
    • Poncelet, A.C.1    Schnaper, H.W.2
  • 31
    • 0025344441 scopus 로고
    • Complex and diversified regulatory programs control the expression of vertebrate collagen genes
    • Ramirez F, DiLiberto M: Complex and diversified regulatory programs control the expression of vertebrate collagen genes. FASEB J 4:16116-23, 1990
    • (1990) FASEB J , vol.4 , pp. 16116-16123
    • Ramirez, F.1    Diliberto, M.2
  • 32
    • 0039552125 scopus 로고    scopus 로고
    • Transforming growth factor-β induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase
    • Ravanti L, Hakkinen L, Larjava H, Saarialho-Kere U, Foschi M, Han J, Kahari VM: Transforming growth factor-β induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase. J Biol Chem 274:37292-37300, 1999b
    • (1999) J Biol Chem , vol.274 , pp. 37292-37300
    • Ravanti, L.1    Hakkinen, L.2    Larjava, H.3    Saarialho-Kere, U.4    Foschi, M.5    Han, J.6    Kahari, V.M.7
  • 33
    • 0033593335 scopus 로고    scopus 로고
    • Induction of collagenase-3 (MMP-13) expression in human dermal fibroblasts by three dimensional collagen is mediated by p38 mitogen-activated protein kinase
    • Ravanti L, Heino J, Lopez-Otin C, Kahari VM: Induction of collagenase-3 (MMP-13) expression in human dermal fibroblasts by three dimensional collagen is mediated by p38 mitogen-activated protein kinase. J Biol Chem 274:2446-2455, 1999a
    • (1999) J Biol Chem , vol.274 , pp. 2446-2455
    • Ravanti, L.1    Heino, J.2    Lopez-Otin, C.3    Kahari, V.M.4
  • 34
    • 0025375617 scopus 로고
    • Transforming growth factor-β. Major role in regulation of extracellular matrix
    • Roberts AB, Heine UI, Flanders KC, Sporn MB: Transforming growth factor-β. Major role in regulation of extracellular matrix. Ann NY Acad Sci 58: 225-232, 1990
    • (1990) Ann NY Acad Sci , vol.58 , pp. 225-232
    • Roberts, A.B.1    Heine, U.I.2    Flanders, K.C.3    Sporn, M.B.4
  • 35
    • 0027503601 scopus 로고
    • Physiological actions and clinical applications of transforming growth factor-β (TGF-β)
    • Roberts AB, Sporn MB: Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 8:1-9, 1993
    • (1993) Growth Factors , vol.8 , pp. 1-9
    • Roberts, A.B.1    Sporn, M.B.2
  • 36
    • 0023856558 scopus 로고
    • A nuclear factor I binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β
    • Rossi P, Karsenty G, Roberts AB, Roche NS, Sporn MB, de Crombrugghe B: A nuclear factor I binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β. Cell 52: 405-415, 1988
    • (1988) Cell , vol.52 , pp. 405-415
    • Rossi, P.1    Karsenty, G.2    Roberts, A.B.3    Roche, N.S.4    Sporn, M.B.5    De Crombrugghe, B.6
  • 37
    • 0036226458 scopus 로고    scopus 로고
    • Role of p38 MAPK in transforming growth factor β stimulation of collagen production by scleroderma and healthy dermal fibroblasts
    • Sato M, Shegogue D, Gore EA, Smith EA, Mcdermott PJ, Trojanowska M: Role of p38 MAPK in transforming growth factor β stimulation of collagen production by scleroderma and healthy dermal fibroblasts. J Invest Dermatol 118:704-711, 2002
    • (2002) J Invest Dermatol , vol.118 , pp. 704-711
    • Sato, M.1    Shegogue, D.2    Gore, E.A.3    Smith, E.A.4    Mcdermott, P.J.5    Trojanowska, M.6
  • 39
    • 0031939753 scopus 로고    scopus 로고
    • Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
    • Wang Y, Huang S, Sah VP, Ross J Jr, Brown JH, Han J, Chien KR: Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem 273:2161-2168, 1998
    • (1998) J Biol Chem , vol.273 , pp. 2161-2168
    • Wang, Y.1    Huang, S.2    Sah, V.P.3    Ross Jr., J.4    Brown, J.H.5    Han, J.6    Chien, K.R.7
  • 40
    • 0036745067 scopus 로고    scopus 로고
    • Increased transcriptional activities of transforming growth factor-β receptors in scleroderma fibroblasts
    • Yamane K, Ihn H, Kubo M, Tamaki K: Increased transcriptional activities of transforming growth factor-β receptors in scleroderma fibroblasts. Arthritis Rheum 46:2421-2428, 2002
    • (2002) Arthritis Rheum , vol.46 , pp. 2421-2428
    • Yamane, K.1    Ihn, H.2    Kubo, M.3    Tamaki, K.4
  • 41
    • 0034671506 scopus 로고    scopus 로고
    • Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor-β1 stimulation of α2(I) collagen (Col1A2) transcription
    • Zhang W, Ou J, Inagaki Y, Greenwel P, Ramirez F: Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor-β1 stimulation of α2(I) collagen (Col1A2) transcription. J Biol Chem 275:39237-39245, 2000
    • (2000) J Biol Chem , vol.275 , pp. 39237-39245
    • Zhang, W.1    Ou, J.2    Inagaki, Y.3    Greenwel, P.4    Ramirez, F.5


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