Synthesis of 6-[18F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4819-4822

  Damont, Annelaure ^a   Boisgard, Raphaël ^a,b   Kuhnast, Bertrand ^a   Lemée, Frédéric ^a   Raggiri, Guillaume ^a   Scarf, Alana M ^c   Da Pozzo, Eleonora ^d   Selleri, Silvia ^e   Martini, Claudia ^d   Tavitian, Bertrand ^a,b,g   Kassiou, Michael ^c,f   Dollé, Frédéric ^a  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^b INSERM   (France)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF PISA   (Italy)

^e UNIVERSITY OF FLORENCE   (Italy)

^f UNIVERSITY OF SYDNEY   (Australia)

^g UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Fluorine 18; Neuroinflammation; PET tracer; Radioligand; Translocator protein (TSPO)

Indexed keywords

BROMINE; CHLORINE; FLUORINE 18; N (6 FLUORO 4 PHENOXYPYRIDIN 3 YL) N (2 METHOXYBENZYL)ACETAMIDE; PBR 28; TRACER; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; ACETAMIDE DERIVATIVE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINOPYRIDINE DERIVATIVE; DIAGNOSTIC AGENT; FLUORINE; LIGAND; N-(6-FLUORO-4-PHENOXYPYRIDIN-3-YL)-N-(2-METHOXYBENZYL)ACETAMIDE; RADIOPHARMACEUTICAL AGENT; TSPO PROTEIN, HUMAN;

ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BINDING; DRUG SYNTHESIS; ENCEPHALITIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RAT; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CORPUS STRIATUM; DISEASE MODEL; DRUG EFFECT; METHODOLOGY; MOLECULAR IMAGING; PATHOLOGY; STEREOISOMERISM; SYNTHESIS;

RATTUS;

ACETAMIDES; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; AMINOPYRIDINES; ANIMALS; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; FLUORINE RADIOISOTOPES; LIGANDS; MOLECULAR IMAGING; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RECEPTORS, GABA; STEREOISOMERISM;

EID: 79960898217     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.048     Document Type: Article

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