메뉴 건너뛰기




Volumn 12, Issue , 2011, Pages

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: Effects on CCL2, fibronectin and the T cell repertoire

Author keywords

CCL2; Colitis; Fibronectin; ILK; T regulatory cells

Indexed keywords

CYTOKINE; DEXTRAN SULFATE; FIBRONECTIN; GAMMA INTERFERON; INTEGRIN LINKED KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; IMMUNOLOGIC FACTOR; INTEGRIN-LINKED KINASE; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE;

EID: 79960875630     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-12-42     Document Type: Article
Times cited : (23)

References (32)
  • 1
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • 10.1038/nature06005, 17653185
    • Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007, 448:427-34. 10.1038/nature06005, 17653185.
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 2
    • 44349124113 scopus 로고    scopus 로고
    • The genetics and immunopathogenesis of inflammatory bowel disease
    • 10.1038/nri2340, 18500230
    • Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 2008, 8:458-66. 10.1038/nri2340, 18500230.
    • (2008) Nat Rev Immunol , vol.8 , pp. 458-466
    • Cho, J.H.1
  • 3
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group
    • 10.1056/NEJM199710093371502, 9321530
    • Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997, 337:1029-35. 10.1056/NEJM199710093371502, 9321530.
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    van Deventer, S.J.3    Mayer, L.4    Present, D.H.5    Braakman, T.6    DeWoody, K.L.7    Schaible, T.F.8    Rutgeerts, P.J.9
  • 4
    • 34248136340 scopus 로고    scopus 로고
    • Inflammatory bowel disease: clinical aspects and established and evolving therapies
    • 10.1016/S0140-6736(07)60751-X, 17499606
    • Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 2007, 369:1641-57. 10.1016/S0140-6736(07)60751-X, 17499606.
    • (2007) Lancet , vol.369 , pp. 1641-1657
    • Baumgart, D.C.1    Sandborn, W.J.2
  • 5
    • 47749087950 scopus 로고    scopus 로고
    • Integrin-linked kinase - essential roles in physiology and cancer biology
    • 10.1242/jcs.017996, 18799788
    • McDonald PC, Fielding AB, Dedhar S. Integrin-linked kinase - essential roles in physiology and cancer biology. J Cell Sci 2008, 121:3121-32. 10.1242/jcs.017996, 18799788.
    • (2008) J Cell Sci , vol.121 , pp. 3121-3132
    • McDonald, P.C.1    Fielding, A.B.2    Dedhar, S.3
  • 6
    • 11144225205 scopus 로고    scopus 로고
    • Integrin-linked kinase: a cancer therapeutic target unique among its ILK
    • 10.1038/nrc1524, 15630415
    • Hannigan G, Troussard AA, Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 2005, 5:51-63. 10.1038/nrc1524, 15630415.
    • (2005) Nat Rev Cancer , vol.5 , pp. 51-63
    • Hannigan, G.1    Troussard, A.A.2    Dedhar, S.3
  • 7
    • 0345803932 scopus 로고    scopus 로고
    • PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival
    • 10.1074/jbc.M309122200, 14551191
    • Fukuda T, Chen K, Shi X, Wu C. PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival. J Biol Chem 2003, 278:51324-33. 10.1074/jbc.M309122200, 14551191.
    • (2003) J Biol Chem , vol.278 , pp. 51324-51333
    • Fukuda, T.1    Chen, K.2    Shi, X.3    Wu, C.4
  • 9
    • 28544448740 scopus 로고    scopus 로고
    • Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival
    • 10.1128/MCB.25.24.11145-11155.2005, 1316981, 16314534
    • Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, et al. Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival. Mol Cell Biol 2005, 25:11145-55. 10.1128/MCB.25.24.11145-11155.2005, 1316981, 16314534.
    • (2005) Mol Cell Biol , vol.25 , pp. 11145-11155
    • Liu, E.1    Sinha, S.2    Williams, C.3    Cyrille, M.4    Heller, E.5    Snapper, S.B.6    Georgopoulos, K.7    St-Arnaud, R.8    Force, T.9    Dedhar, S.10
  • 10
    • 46349089819 scopus 로고    scopus 로고
    • Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis
    • 10.1136/gut.2007.142778, 18326560
    • Assi K, Mills J, Owen D, Ong C, St Arnaud R, Dedhar S, Salh B. Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis. Gut 2008, 57:931-40. 10.1136/gut.2007.142778, 18326560.
    • (2008) Gut , vol.57 , pp. 931-940
    • Assi, K.1    Mills, J.2    Owen, D.3    Ong, C.4    St Arnaud, R.5    Dedhar, S.6    Salh, B.7
  • 11
    • 0029127778 scopus 로고
    • Experimental models of inflammatory bowel disease
    • 10.1016/0016-5085(95)90599-5, 7557106
    • Elson CO, Sartor RB, Tennyson GS, Riddell RH. Experimental models of inflammatory bowel disease. Gastroenterology 1995, 109:1344-67. 10.1016/0016-5085(95)90599-5, 7557106.
    • (1995) Gastroenterology , vol.109 , pp. 1344-1367
    • Elson, C.O.1    Sartor, R.B.2    Tennyson, G.S.3    Riddell, R.H.4
  • 12
    • 33645828828 scopus 로고    scopus 로고
    • The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis
    • 10.1111/j.1365-2567.2006.02349.x, 1782268, 16630028
    • Assi K, Pillai R, Gomez-Munoz A, Owen D, Salh B. The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. Immunology 2006, 118:112-21. 10.1111/j.1365-2567.2006.02349.x, 1782268, 16630028.
    • (2006) Immunology , vol.118 , pp. 112-121
    • Assi, K.1    Pillai, R.2    Gomez-Munoz, A.3    Owen, D.4    Salh, B.5
  • 13
    • 0037666792 scopus 로고    scopus 로고
    • Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
    • 10.1074/jbc.M303083200, 12686550
    • Troussard AA, Mawji NM, Ong C, Mui A, St-Arnaud R, Dedhar S. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 2003, 278:22374-8. 10.1074/jbc.M303083200, 12686550.
    • (2003) J Biol Chem , vol.278 , pp. 22374-22378
    • Troussard, A.A.1    Mawji, N.M.2    Ong, C.3    Mui, A.4    St-Arnaud, R.5    Dedhar, S.6
  • 14
    • 33845702137 scopus 로고    scopus 로고
    • Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells
    • 10.1038/sj.onc.1209752, 16799642
    • Oloumi A, Syam S, Dedhar S. Modulation of Wnt3a-mediated nuclear beta-catenin accumulation and activation by integrin-linked kinase in mammalian cells. Oncogene 2006, 25:7747-57. 10.1038/sj.onc.1209752, 16799642.
    • (2006) Oncogene , vol.25 , pp. 7747-7757
    • Oloumi, A.1    Syam, S.2    Dedhar, S.3
  • 15
    • 33646270895 scopus 로고    scopus 로고
    • Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1
    • 10.1136/gut.2005.068429, 1856110, 16299040
    • Motomura Y, Khan WI, El-Sharkawy RT, Verma-Gandhu M, Verdu EF, Gauldie J, Collins SM. Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1. Gut 2006, 55:662-70. 10.1136/gut.2005.068429, 1856110, 16299040.
    • (2006) Gut , vol.55 , pp. 662-670
    • Motomura, Y.1    Khan, W.I.2    El-Sharkawy, R.T.3    Verma-Gandhu, M.4    Verdu, E.F.5    Gauldie, J.6    Collins, S.M.7
  • 16
    • 0031962084 scopus 로고    scopus 로고
    • Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity
    • 10.1074/jbc.273.1.528, 9417112
    • Wu C, Keightley SY, Leung-Hagesteijn C, Radeva G, Coppolino M, Goicoechea S, McDonald JA, Dedhar S. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J Biol Chem 1998, 273:528-36. 10.1074/jbc.273.1.528, 9417112.
    • (1998) J Biol Chem , vol.273 , pp. 528-536
    • Wu, C.1    Keightley, S.Y.2    Leung-Hagesteijn, C.3    Radeva, G.4    Coppolino, M.5    Goicoechea, S.6    McDonald, J.A.7    Dedhar, S.8
  • 18
    • 65749103989 scopus 로고    scopus 로고
    • Regulatory lymphocytes and intestinal inflammation
    • 10.1146/annurev.immunol.021908.132657, 19302043
    • Izcue A, Coombes JL, Powrie F. Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 2009, 27:313-38. 10.1146/annurev.immunol.021908.132657, 19302043.
    • (2009) Annu Rev Immunol , vol.27 , pp. 313-338
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 19
    • 70149100480 scopus 로고    scopus 로고
    • CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta
    • 10.4049/jimmunol.0900191, 3057032, 19635906
    • Bollyky PL, Falk BA, Long SA, Preisinger A, Braun KR, Wu RP, Evanko SP, Buckner JH, Wight TN, Nepom GT. CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta. J Immunol 2009, 183:2232-41. 10.4049/jimmunol.0900191, 3057032, 19635906.
    • (2009) J Immunol , vol.183 , pp. 2232-2241
    • Bollyky, P.L.1    Falk, B.A.2    Long, S.A.3    Preisinger, A.4    Braun, K.R.5    Wu, R.P.6    Evanko, S.P.7    Buckner, J.H.8    Wight, T.N.9    Nepom, G.T.10
  • 20
    • 0037220898 scopus 로고    scopus 로고
    • Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease
    • 10.1002/path.1245, 12474223
    • Banks C, Bateman A, Payne R, Johnson P, Sheron N. Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease. J Pathol 2003, 199:28-35. 10.1002/path.1245, 12474223.
    • (2003) J Pathol , vol.199 , pp. 28-35
    • Banks, C.1    Bateman, A.2    Payne, R.3    Johnson, P.4    Sheron, N.5
  • 22
    • 0034659767 scopus 로고    scopus 로고
    • Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine
    • Andres PG, Beck PL, Mizoguchi E, Mizoguchi A, Bhan AK, Dawson T, Kuziel WA, Maeda N, MacDermott RP, Podolsky DK, et al. Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine. J Immunol 2000, 164:6303-12.
    • (2000) J Immunol , vol.164 , pp. 6303-6312
    • Andres, P.G.1    Beck, P.L.2    Mizoguchi, E.3    Mizoguchi, A.4    Bhan, A.K.5    Dawson, T.6    Kuziel, W.A.7    Maeda, N.8    MacDermott, R.P.9    Podolsky, D.K.10
  • 25
    • 34547092167 scopus 로고    scopus 로고
    • Evidence for a differential expression of fibronectin splice forms ED-A and ED-B in Crohn's disease (CD) mucosa
    • 10.1007/s00384-006-0188-4, 17136547
    • Brenmoehl J, Lang M, Hausmann M, Leeb SN, Falk W, Scholmerich J, Goke M, Rogler G. Evidence for a differential expression of fibronectin splice forms ED-A and ED-B in Crohn's disease (CD) mucosa. Int J Colorectal Dis 2007, 22:611-23. 10.1007/s00384-006-0188-4, 17136547.
    • (2007) Int J Colorectal Dis , vol.22 , pp. 611-623
    • Brenmoehl, J.1    Lang, M.2    Hausmann, M.3    Leeb, S.N.4    Falk, W.5    Scholmerich, J.6    Goke, M.7    Rogler, G.8
  • 27
    • 73349115588 scopus 로고    scopus 로고
    • Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism
    • Gagne D, Groulx JF, Benoit YD, Basora N, Herring E, Vachon PH, Beaulieu JF. Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism. J Cell Physiol 222:387-400.
    • J Cell Physiol , vol.222 , pp. 387-400
    • Gagne, D.1    Groulx, J.F.2    Benoit, Y.D.3    Basora, N.4    Herring, E.5    Vachon, P.H.6    Beaulieu, J.F.7
  • 28
    • 0028173982 scopus 로고
    • TNF-alpha binds to the N-terminal domain of fibronectin and augments the beta 1-integrin-mediated adhesion of CD4+ T lymphocytes to the glycoprotein
    • Alon R, Cahalon L, Hershkoviz R, Elbaz D, Reizis B, Wallach D, Akiyama SK, Yamada KM, Lider O. TNF-alpha binds to the N-terminal domain of fibronectin and augments the beta 1-integrin-mediated adhesion of CD4+ T lymphocytes to the glycoprotein. J Immunol 1994, 152:1304-13.
    • (1994) J Immunol , vol.152 , pp. 1304-1313
    • Alon, R.1    Cahalon, L.2    Hershkoviz, R.3    Elbaz, D.4    Reizis, B.5    Wallach, D.6    Akiyama, S.K.7    Yamada, K.M.8    Lider, O.9
  • 30
    • 33744984785 scopus 로고    scopus 로고
    • Th17: an effector CD4 T cell lineage with regulatory T cell ties
    • 10.1016/j.immuni.2006.06.002, 16782025
    • Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006, 24:677-88. 10.1016/j.immuni.2006.06.002, 16782025.
    • (2006) Immunity , vol.24 , pp. 677-688
    • Weaver, C.T.1    Harrington, L.E.2    Mangan, P.R.3    Gavrieli, M.4    Murphy, K.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.