Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria

Journal of Natural Products

Volumn 73, Issue 5, 2010, Pages 998-1001

  Oh, Hyuncheol ^a   Jensen, Paul R ^a   Murphy, Brian T ^a   Fiorilla, Catherine ^b   Sullivan, John F ^b   Ramsey, Timothy ^b   Fenical, William ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Norvartis Institute for BioMedical Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOSPHAEROLIDE; CYTOTOXIC AGENT; EREMOPHILANE DERIVATIVE; ESTER; PROTEIN INHIBITOR; PROTEIN MCL 1; SESQUITERPENOID; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ASCOMYCETES; CANCER CHEMOTHERAPY; CELL STRAIN HCT116; CHEMICAL ANALYSIS; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; FERMENTATION; FUNGAL STRAIN; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; SPECTROSCOPY;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; APOPTOSIS; ASCOMYCOTA; BAHAMAS; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; MARINE BIOLOGY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTO-ONCOGENE PROTEINS C-BCL-2; SESQUITERPENES;

CRYPTOSPHAERIA;

EID: 77953015002     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np1000889     Document Type: Article

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