Semisynthetic latrunculin derivatives as inhibitors of metastatic breast cancer: Biological evaluations, preliminary structure-activity relationship and molecular modeling studies

ChemMedChem

Volumn 5, Issue 2, 2010, Pages 274-285

  Khanfar, Mohammad A ^a   Youssef, Diaa T A ^b   El Sayed, Khalid A ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^b Suez Canal University   (Egypt)

Author keywords

Actin; Antitumor agents; Cancer; Latrunculin A; Structure activity relationships

Indexed keywords

17 O BENZOYLLATRUNCULIN A; 17 O METHYL N (3' HYDROXYPROPYL)LATRUNCULIN A; 17 O METHYL N (7' METHOXYPHENYLACETYL)LATRUNCULIN A; 17 O METHYL N BENZOYLLATRUNCULIN A; 17 O METHYL N BENZYLLATRUNCULIN A; 17 O METHYL N CYCLOPENTANELATRUNCULIN A; 17 O METHYL N ETHYLLATRUNCULIN A; 17 O METHYL N METHYLLATRUNCULIN A; 17 O METHYLLATRUNCULIN A; 17 O PHENYLETHYLLATRUNCULIN A; ANTIMETASTATIC AGENT; ANTIMITOTIC AGENT; G ACTIN; LATRUNCULIN A DERIVATIVE; N BENZYLLATRUNCULIN A; N ETHYLLATRUNCULIN A; N HYDROXYMETHYLLATRUNCULIN A; UNCLASSIFIED DRUG;

ACETYLATION; ACTIN POLYMERIZATION; ALKYLATION; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; ESTERIFICATION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; METASTASIS; MOLECULAR MODEL; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ACTINS; ANIMALS; ANTINEOPLASTIC AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BREAST NEOPLASMS; CELL LINE, TUMOR; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; FEMALE; HUMANS; HYDROGEN BONDING; MODELS, CHEMICAL; MODELS, MOLECULAR; NEOPLASM METASTASIS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 75749095171     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900430     Document Type: Article

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