The discovery of tadalafil: A novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-Hexahydropyrazino[1′,2′ :1,6]pyrido[3,4-b]indole-1,4-dione analogues

Journal of Medicinal Chemistry

Volumn 46, Issue 21, 2003, Pages 4533-4542

  Daugan, Alain ^a   Grondin, Pascal ^a   Ruault, Cécile ^a   Le Monnier de Gouville, Anne Charlotte ^a   Coste, Hervé ^a   Linget, Jean Michel ^a   Kirilovsky, Jorge ^a   Hyafil, François ^a   Labaudinièret, Richard ^a,b  

^a GLAXOSMITHKLINE   (France)

^b GENOME THERAPEUTICS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE DERIVATIVE; PHENYL GROUP; PHOSPHODIESTERASE INHIBITOR; TADALAFIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; RAT; STEREOSPECIFICITY;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; BLOOD PRESSURE; CARBOLINES; CATTLE; CYCLIC GMP; DRUG DESIGN; HYDANTOINS; INDICATORS AND REAGENTS; ISOMERISM; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUSCLE, SMOOTH, VASCULAR; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, INBRED SHR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141992796     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0300577     Document Type: Article

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