Total Synthesis of Altohyrtin A (Spongistatin 1): Part 2

Angewandte Chemie - International Edition

Volumn 37, Issue 1-2, 1998, Pages 190-196

  Hayward, Matthew M ^a   Roth, Rebecca M ^a   Duffy, Kevin J ^a   Dalko, Peter I ^a   Stevens, Kirk L ^a   Guo, Jiasheng ^a   Kishi, Yoshito ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Altohyrtin; Antitumor agents; Natural products; Spongistatin; Total synthesis

Indexed keywords

EID: 0031951004     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-3773(19980202)37:1/2<190::aid-anie190>3.0.co;2-0     Document Type: Article

References (40)

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30. The deproteclion under the specified condition in Scheme 4 was very clean (TLC analysis), hut the yield of the isolated product was only in the ranee of 20-30%. It is not yet established whether this low yield is due to a problem with isolation and/or with unidentified decomposition/side-reaclions.
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34. Through the total synthesis of altohyrtin C (spongistatin 2), Evans has reached the same conclusion: D. A. Evans, B. W. Trotter, B. Côté, P. J. Coleman, L. C. Dias, A. N. Tyler, Angew. Chem. 1997, 109, 2957-2961; Angew. Chem. Int. Ed. Engl. 1997, 36, 2744-2747.
35. Through the total synthesis of altohyrtin C (spongistatin 2), Evans has reached the same conclusion: D. A. Evans, B. W. Trotter, B. Côté, P. J. Coleman, L. C. Dias, A. N. Tyler, Angew. Chem. 1997, 109, 2957-2961; Angew. Chem. Int. Ed. Engl. 1997, 36, 2744-2747.
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