Spatial resolution and perception of patterns mediated by a subretinal 16-electrode array in patients blinded by hereditary retinal dystrophies

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 8, 2011, Pages 5995-6003

  Wilke, Robert ^a   Gabel, Veit Peter ^b   Sachs, Helmut ^c   Schmidt, Karl Ulrich Bartz ^a   Gekeler, Florian ^a   Besch, Dorothea ^a   Szurman, Peter ^a   Stett, Alfred ^d   Wilhelm, Barbara ^e   Peters, Tobias ^e   Harscher, Alex ^f   Greppmaier, Udo ^f   Kibbel, Steffen ^f   Benav, Heval ^a   Bruckmann, Anna ^a   Stingl, Katarina ^a   Kusnyerik, Akos ^a,g   Zrenner, Eberhart ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c ACADEMIC TEACHING HOSPITAL DRESDEN FRIEDRICHSTADT   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e Centre for Ophthalmology   (Germany)

^f Retina Implant AG   (Germany)

^g SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BLINDNESS; ELECTRODE; ELECTROSTIMULATION; FEMALE; HUMAN; HUMAN EXPERIMENT; IMPLANT; MALE; MOVEMENT PERCEPTION; PATTERN RECOGNITION; PRIORITY JOURNAL; READING; RETINA DYSTROPHY; SPATIAL DISCRIMINATION; VISION; VISUAL STIMULATION; CLINICAL TRIAL; DEPTH PERCEPTION; IMPLANTATION; METHODOLOGY; MIDDLE AGED; ORIENTATION; PROSTHESIS; PSYCHOPHYSICS; VISUAL PROSTHESIS;

ADULT; BLINDNESS; ELECTRODES, IMPLANTED; HUMANS; MALE; MIDDLE AGED; MOTION PERCEPTION; ORIENTATION; PATTERN RECOGNITION, VISUAL; PROSTHESIS DESIGN; PROSTHESIS IMPLANTATION; PSYCHOPHYSICS; RETINAL DYSTROPHIES; SPACE PERCEPTION; VISUAL PROSTHESIS;

EID: 79960749058     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6946     Document Type: Article

References (54)

1. Zrenner E. Will retinal implants restore vision? Science. 2002;295: 1022-1025.
2. Rizzo JF 3rd, Wyatt J, Humayun M, et al. Retinal prosthesis: an encouraging first decade with major challenges ahead. Ophthalmology. 2001;108:13-14.
3. Santos A, Humayun MS, de Juan E Jr, et al. Preservation of the inner retina in retinitis pigmentosa: a morphometric analysis. Arch Ophthalmol. 1997;115:511-515.
4. Stone JL, Barlow WE, Humayun MS, de Juan E Jr, Milam AH. Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa. Arch Ophthalmol. 1992;110:1634-1639.
5. de Balthasar C, Patel S, Roy A, et al. Factors affecting perceptual thresholds in epiretinal prostheses. Invest Ophthalmol Vis Sci. 2008;49:2303-2314.
6. Guven D, Weiland JD, Fujii G, et al. Long-term stimulation by active epiretinal implants in normal and RCD1 dogs. J Neural Eng. 2005;2:S65-73.
7. Zhou JA, Woo SJ, Park SI, et al. A suprachoroidal electrical retinal stimulator design for long-term animal experiments and in vivo assessment of its feasibility and biocompatibility in rabbits. J Biomed Biotechnol. 2008;2008:547428.
8. Yanai D, Weiland JD, Mahadevappa M, Greenberg RJ, Fine I, Humayun MS. Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa. Am J Ophthalmol. 2007;143:820-827.
9. Wong YT, Dommel N, Preston P, et al. Retinal neurostimulator for a multifocal vision prosthesis. IEEE Trans Neural Syst Rehabil Eng. 2007;15:425-434.
10. Hornig R, Laube T, Walter P, et al. A method and technical equipment for an acute human trial to evaluate retinal implant technology. J Neural Eng. 2005;2:S129-S134.
11. Gerding H, Benner FP, Taneri S. Experimental implantation of epiretinal retina implants (EPI-RET) with an IOL-type receiver unit. J Neural Eng. 2007;4:S38-S49.
12. Schanze T, Hesse L, Lau C, et al. An optically powered singlechannel stimulation implant as test system for chronic biocompatibility and biostability of miniaturized retinal vision prostheses. IEEE Trans Biomed Eng. 2007;54:983-992.
13. DeMarco PJ Jr, Yarbrough GL, Yee CW, et al. Stimulation via a subretinally placed prosthetic elicits central activity and induces a trophic effect on visual responses. Invest Ophthalmol Vis Sci. 2007;48:916-926.
14. Terasawa Y, Tashiro H, Uehara A, et al. The development of a multichannel electrode array for retinal prostheses. J Artif Organs. 2006;9:263-266.
15. Mokwa W, Goertz M, Koch C, Krisch I, Trieu HK, Walter P. Intraocular epiretinal prosthesis to restore vision in blind humans. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:5790-5793.
16. Alteheld N, Roessler G, Walter P. Towards the bionic eye: the retina implant-surgical, ophthalmological and histopathological perspectives. Acta Neurochir Suppl. 2007;97:487-493.
17. Alteheld N, Roessler G, Vobig M, Walter P. The retina implant-new approach to a visual prosthesis. Biomed Tech (Berl). 2004;49:99-103.
18. Pardue MT, Ball SL, Phillips MJ, et al. Status of the feline retina 5 years after subretinal implantation. J Rehabil Res Dev. 2006;43: 723-732.
19. Pardue MT, Phillips MJ, Hanzlicek B, Yin H, Chow AY, Ball SL. Neuroprotection of photoreceptors in the RCS rat after implantation of a subretinal implant in the superior or inferior retina. Adv Exp Med Biol. 2006;572:321-326. 20. Chow AY, Chow VY, Packo KH, Pollack JS, Peyman GA, Schuchard R. The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa. Arch Ophthalmol. 2004;122:460-469.
20. Fujikado T, Morimoto T, Kanda H, et al. Evaluation of phosphenes elicited by extraocular stimulation in normals and by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol. 2007;245:1411-1419.
21. Loudin JD, Simanovskii DM, Vijayraghavan K, et al. Optoelectronic retinal prosthesis: system design and performance. J Neural Eng. 2007;4:S72-84.
22. Palanker D, Vankov A, Huie P, Baccus S. Design of a high-resolution optoelectronic retinal prosthesis. J Neural Eng. 2005;2:S105-120.
23. Winter JO, Cogan SF, Rizzo JF 3rd. Retinal prostheses: current challenges and future outlook. J Biomater Sci Polym Ed. 2007;18: 1031-1055.
24. Walter P, Kisvarday ZF, Gortz M, et al. Cortical activation via an implanted wireless retinal prosthesis. Invest Ophthalmol Vis Sci. 2005;46:1780-1785.
25. Zrenner E, Bartz-Schmidt KU, Benav H, et al. Subretinal electronic chips allow blind patients to read letters and combine them to words. Proc R Soc B Biol Sci. 2010;278:1489-1497.
26. Zrenner E, Miliczek KD, Gabel VP, et al. The development of subretinal microphotodiodes for replacement of degenerated photoreceptors. Ophthalmic Res. 1997;29:269-280.
27. Montezuma SR, Loewenstein J, Scholz C, Rizzo JF, 3rd. Biocompatibility of materials implanted into the subretinal space of Yucatan pigs. Invest Ophthalmol Vis Sci. 2006;47:3514-3522.
28. Stett A, Barth W, Weiss S, Haemmerle H, Zrenner E. Electrical multisite stimulation of the isolated chicken retina. Vision Res. 2000;40:1785-1795.
29. Zrenner E, Stett A, Weiss S, et al. Can subretinal microphotodiodes successfully replace degenerated photoreceptors? Vision Res. 1999;39:2555-2567.
30. Eckhorn R, Wilms M, Schanze T, et al. Visual resolution with retinal implants estimated from recordings in cat visual cortex. Vision Res. 2006;46:2675-2690.
31. Guenther E, Troger B, Schlosshauer B, Zrenner E. Long-term survival of retinal cell cultures on retinal implant materials. Vision Res. 1999;39:3988-3994.
32. Gekeler F, Szurman P, Grisanti S, et al. Compound subretinal prostheses with extra-ocular parts designed for human trials: successful long-term implantation in pigs. Graefes Arch Clin Exp Ophthalmol. 2007;245:230-241.
33. Sachs HG, Gekeler F, Schwahn H, et al. Implantation of stimulation electrodes in the subretinal space to demonstrate cortical responses in Yucatan minipig in the course of visual prosthesis development. Eur J Ophthalmol. 2005;15:493-499.
34. Sachs HG, Schanze T, Brunner U, Sailer H, Wiesenack C. Transscleral implantation and neurophysiological testing of subretinal polyimide film electrodes in the domestic pig in visual prosthesis development. J Neural Eng. 2005;2:S57-S64.
35. Stett A, Mai A, Herrmann T. Retinal charge sensitivity and spatial discrimination obtainable by subretinal implants: key lessons learned from isolated chicken retina. J Neural Eng. 2007;4:S7-S16.
36. Zrenner E. The subretinal implant: can microphotodiode arrays replace degenerated retinal photoreceptors to restore vision? Ophthalmologica. 2002;216(suppl 1):8-20; discussion 52-23.
37. Dollberg A, Graf HG, Höfflinger B, et al. A fully testable retinal implant. In: Hamza MH, ed. IASTED Biomedical Engineering. Salzburg, Austria: ACTA Press; 2003.
38. Graf HG, Harendt C, Engelhardt T, et al. High dynamic range CMOS imager technologies for biomedical applications. IEEE J Solid State Circuits. 2009;44:281-289.
39. Bach M, Wilke M, Wilhelm B, Zrenner E, Wilke R. Basic quantitative assessment of visual performance in patients with very low vision. Invest Ophthalmol Vis Sci. 2010;51:1255-1260.
40. Wilke R, Bach M, Wilhelm B, Durst W, Trauzettel-Klosinski S, Zrenner E. Testing visual functions in patients with visual prostheses In: Humayun M, Weiland JD, Chader G, Greenbaum E, eds. Artificial Sight: Basic Research, Biomedical Engineering, and Clinical Advances. New York: Springer; 2007:91-110.
41. Gekeler F, Messias A, Ottinger M, Bartz-Schmidt KU, Zrenner E. Phosphenes electrically evoked with DTL electrodes: a study in patients with retinitis pigmentosa, glaucoma, and homonymous visual field loss and normal subjects. Invest Ophthalmol Vis Sci. 2006;47:4966-4974.
42. Besch D, Sachs H, Szurman P, et al. Extraocular surgery for implantation of an active subretinal visual prosthesis with external connections: feasibility and outcome in seven patients. Br J Ophthalmol. 2008;92:1361-1368.
43. Green DM, Swets JA. Signal Detection Theory and Psychophysics. New York: Wiley; 1966.
44. Besch D, Sachs H, Szurman P, et al. Extraocular surgery for implantation of an active subretinal visual prosthesis with external connections: feasibility and outcome in seven patients. Br J Ophthalmol. 2008;92:1361-1368.
45. Rossi EA, Weiser P, Tarrant J, Roorda A. Visual performance in emmetropia and low myopia after correction of high-order aberrations. J Vis. 2007;7:1-14.
46. Wilke R, Khalili Moghaddam G, Dokos S, Suaning G, Lovell N. Stimulation of the retinal network in bionic vision devices: from multi-electrode arrays to pixelated vision. In: Wong KW, Mendis BSU, Bouzerdoum A, eds. Neural Information Processing Theory and Algorithms. Berlin: Springer; 2010:140-147.
47. Horsager A, Greenberg RJ, Fine I. Spatiotemporal interactions in retinal prosthesis subjects. Invest Ophthalmol Vis Sci. 2010;51: 1223-1233.
48. Greenwald SH, Horsager A, Humayun MS, Greenberg RJ, McMahon MJ, Fine I. Brightness as a function of current amplitude in human retinal electrical stimulation. Invest Ophthalmol Vis Sci. 2009;50: 5017-5025.
49. Horsager A, Greenwald SH, Weiland JD, et al. Predicting visual sensitivity in retinal prosthesis patients. Invest Ophthalmol Vis Sci. 2009;50:1483-1491.
50. Nanduri D, Humayun MS, Greenberg RJ, McMahon MJ, Weiland JD. Retinal prosthesis phosphene shape analysis. Engineering in Medicine and Biology Society. 30th Annual International Conference of the IEEE; Washington, DC: IEEE; 2008:1785-1788.
51. Humayun MS, Weiland JD, Fujii GY, et al. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vision Res. 2003;43:2573-2581.
52. Jones BW, Marc RE. Retinal remodeling during retinal degeneration. Exp Eye Res. 2005;81:123-137.
53. Wilke R, Khalili Moghaddam G, Lovell N, Suaning G, Dokos S. Electric crosstalk impairs spatial resolution of multi-electrode arrays in retinal implants. J Neural Eng. 2011;8:040616.
54. Jensen RJ, Rizzo JF 3rd. Responses of ganglion cells to repetitive electrical stimulation of the retina. J Neural Eng. 2007;4:S1-S6.