A concerted mechanism for opening the GDP binding pocket and release of the nucleotide in hetero-trimeric G-proteins

Journal of Molecular Biology

Volumn 411, Issue 1, 2011, Pages 298-312

  Louet, Maxime ^a   Perahia, David ^b   Martinez, Jean ^a   Floquet, Nicolas ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b Ecole Normale Superieure de Cachan   (France)

Author keywords

activation mechanism; G proteins; ligand escape; molecular dynamics; normal mode analysis

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE DIPHOSPHATE; NUCLEOTIDE; PHOSPHATE;

ALPHA HELIX; ARTICLE; CELL MEMBRANE; CONFORMATIONAL TRANSITION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIMULATION; X RAY;

EID: 79960700533     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.05.034     Document Type: Article

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