Matrix components and scaffolds for sustained islet function

Tissue Engineering - Part B: Reviews

Volumn 17, Issue 4, 2011, Pages 235-247

  Cheng, Jennifer Y C ^a   Raghunath, Michael ^b,c   Whitelock, John ^a   Poole Warren, Laura ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BIO-ARTIFICIAL PANCREAS; BIO-MOLECULAR; CELL INTERACTION; CLINICAL TREATMENTS; ENDOCRINE CELLS; EXTRACELLULAR MATRICES; IN-VITRO; ISLET TRANSPLANTATION; ISOLATION PROCESS; MATRIX COMPONENTS; NATIVE ENVIRONMENT; SCAFFOLD ENGINEERING; SURVIVAL RATE;

BLOOD VESSELS; TISSUE;

SCAFFOLDS (BIOLOGY);

AGRIN; ARGINYLGLYCYLASPARTIC ACID; CHONDROITIN SULFATE; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COLLAGEN TYPE 5; ENTACTIN; FIBROBLAST GROWTH FACTOR 2; FIBRONECTIN; GLYPICAN; HYALURONIC ACID; LAMININ; PERLECAN; PROTEOGLYCAN; SYNDECAN; TISSUE SCAFFOLD; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; VASCULOTROPIN; VITRONECTIN;

ARTICLE; BASEMENT MEMBRANE; BIOARTIFICIAL ORGAN; HUMAN; IMMOBILIZATION; IN VITRO STUDY; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIMULATION;

ANIMALS; COMPUTER SIMULATION; EXTRACELLULAR MATRIX; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; TISSUE SCAFFOLDS;

EID: 79960649572     PISSN: 19373368     EISSN: 19373376     Source Type: Journal    
DOI: 10.1089/ten.teb.2011.0004     Document Type: Article

References (196)

1. Parnaud, G., Hammar, E., Rouiller, D.G., Armanet, M., Halban, P.A., and Bosco, D. Blockade of beta1 integrinlaminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix. Diabetes 55, 1413, 2006.
2. Rozario, T., and DeSimone, D.W. The extracellular matrix in development and morphogenesis: a dynamic view. Dev Biol 341, 126, 2010.
3. Bowers, S.L.K., Banerjee, I., and Baudino, T.A. The extracellular matrix: at the center of it all. J Mol Cell Cardiol 48, 474, 2010.
4. Lelièvre, S., Weaver, V.M., and Bissell, M.J. Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation. Recent Prog Horm Res 51, 417, 1996.
5. Linetsky, E., Bottino, R., Lehmann, R., Alejandro, R., Inverardi, L., and Ricordi, C. Improved human islet isolation using a new enzyme blend, liberase. Diabetes 46, 1120, 1997.
6. Frisch, S.M., and Screaton, R.A. Anoikis mechanisms. Curr Opin Cell Biol 13, 555, 2001.
7. Ryan, E.A., Lakey, J.R., Rajotte, R.V., Korbutt, G.S., Kin, T., Imes, S., et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 50, 710, 2001.
8. Iozzo, R.V. Proteoglycans. New York: CRC Press, 2000.
9. Wang, R.N., Paraskevas, S., and Rosenberg, L. Characterization of integrin expression in islets isolated from hamster, canine, porcine, and human pancreas. J Histochem Cytochem 47, 499, 1999.
10. Stendahl, J.C., Kaufman, D.B., and Stupp, S.I. Extracellular matrix in pancreatic islets: relevance to scaffold design and transplantation. Cell Transplant 18, 1, 2009.
11. McCall-Culbreath, K.D., and Zutter, M.M. Collagen receptor integrins: rising to the challenge. Curr Drug Targets 9, 139, 2008.
12. van Deijnen, J.H., Hulstaert, C.E., Wolters, G.H., and van Schilfgaarde, R. Significance of the peri-insular extracellular matrix for islet isolation from the pancreas of rat, dog, pig, and man. Cell Tissue Res 267, 139, 1992.
13. Deijnen, J.H.V., Suylichem, P.T.V., Wolters, G.H., and Schilfgaarde, R.V. Distribution of collagens type I, type III and type V in the pancreas of rat, dog, pig and man. Cell Tissue Res 277, 115, 1994.
14. Meyer, T., Bü hler, C., Czub, S., Beutner, U., Otto, C., Thiede, A., et al. Selection of donor pigs for pancreatic islet transplantation may depend on the expression level of connective tissue proteins in the islet capsule. Transplant Proc 30, 2471, 1998.
15. Meyer, T., Chodnewska, I., Czub, S., Hamelmann, W., Beutner, U., Otto, C., et al. Extracellular matrix proteins in the porcine pancreas: a structural analysis for directed pancreatic islet isolation. Transplant Proc 30, 354, 1998. (Pubitemid 28207196)
16. Wang, R.N., and Rosenberg, L. Maintenance of beta-cell function and survival following islet isolation requires reestablishment of the islet-matrix relationship. J Endocrinol 163, 181, 1999.
17. Pinkse, G.G.M., Bouwman, W.P., Jiawan-Lalai, R., Terpstra, O.T., Bruijn, J.A., and de Heer, E. Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans. Diabetes 55, 312, 2006.
18. Kaido, T., Yebra, M., Cirulli, V., Rhodes, C., Diaferia, G., and Montgomery, A.M. Impact of defined matrix interactions on insulin production by cultured human beta-cells. Effects on insulin content, secretion and gene transcription. Diabetes 55, 2723, 2006.
19. Jikko, A., Harris, S.E., Chen, D., Mendrick, D.L., and Damsky, C.H. Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2. J Bone Miner Res 14, 1075, 1999.
20. Pozzi, M., Wary, K.K., Giancotti, F.G., and Gardner, H.A. Integrin alpha 1 beta 1 mediates a unique collagendependent proliferation pathway in vivo. J Cell Biol 142, 587, 1998.
21. Ross, R.S., and Borg, T.K. Integrins and the myocardium. Circ Res 88, 1112, 2001.
22. Ris, F., Hammar, E., Bosco, D., Pilloud, C., Maedler, K., Donath, M.Y., et al. Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro. Diabetologia 45, 841, 2002.
23. Cirulli, V., Beattie, G.M., Klier, G., Ellisman, M., Ricordi, C., Quaranta, V., et al. Expression and function of alpha(v) beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells. J Cell Biol 150, 1445, 2000.
24. Kaido, T., Perez, B., Yebra, M., Hill, J., Cirulli, V., Hayek, A., et al. Alphav-integrin utilization in human beta-cell adhesion, spreading, and motility. J Biol Chem 279, 17731, 2004.
25. Kaido, T., Yebra, M., Cirulli, V., and Montgomery, A.M. Regulation of human beta-cell adhesion, motility, and insulin secretion by collagen IV and its receptor alpha1beta1. J Biol Chem 279, 53762, 2004.
26. Virtanen, I., Banerjee, M., Palgi, J., Korsgren, O., Lukinius, A., Thornell, L.-E., et al. Blood vessels of human islets of Langerhans are surrounded by a double basement membrane. Diabetologia 51, 1181, 2008.
27. Chin, G.S., Lee, S., Hsu, M., Liu, W., Kim, W.J.H., Levinson, H., et al. Discoidin domain receptors and their ligand, col-lagen, are temporally regulated in fetal rat fibroblasts in vitro. Plast Reconstr Surg 107, 769, 2001.
28. Alves, F., Vogel, W., Mossie, K., Millauer, B., Höfler, H., and Ullrich, A. Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. Oncogene 10, 609, 1995.
29. Antonio, J.D.S., Slover, J., Lawler, J., Karnovsky, M.J., and Lander, A.D. Specificity in the interactions of extracellular matrix proteins with subpopulations of the glycosaminoglycan heparin. Biochemistry 32, 4746, 1993.
30. Mayer, U., Mann, K., Fessler, L.I., Fessler, J.H., and Timpl, R. Drosophila laminin binds to mammalian nidogen and to heparan sulfate proteoglycan. Eur J Biochem 245, 745, 1997.
31. Tunggal, P., Smyth, N., Paulsson, M., and Ott, M.C. Laminins: structure and genetic regulation. Microsc Res Tech 51, 214, 2000.
32. Nikolova, G., Jabs, N., Konstantinova, I., Domogatskaya, A., Tryggvason, K., Sorokin, L., et al. The vascular basement membrane: a niche for insulin gene expression and beta-cell proliferation. Dev Cell 10, 397, 2006.
33. Jiang, F.X., Naselli, G., and Harrison, L.C. Distinct Distribution of Laminin and Its Integrin Receptors in the Pancreas. J Histochem Cytochem 50, 1625, 2002.
34. Armanet, M., Wojtusciszyn, A., Morel, P., Parnaud, G., Rousselle, P., Sinigaglia, C., et al. Regulated laminin-332 expression in human islets of Langerhans. FASEB J 23, 4046, 2009.
35. Nomizu, M., Kuratomi, Y., Song, S.Y., Ponce, M.L., Hoffman, M.P., Powell, S.K., et al. Identification of cell binding sequences in mouse laminin gamma1 chain by systematic peptide screening. J Biol Chem 272, 32198, 1997.
36. Mercurio, A.M. Laminin receptors: achieving specificity through cooperation. Trends Cell Biol 5, 419, 1995.
37. Colognato, H., MacCarrick, M., O'Rear, J.J., and Yurchenco, P.D. The laminin alpha2-chain short arm mediates cell adhesion through both the alpha1beta1 and alpha2beta1 integrins. J Biol Chem 272, 29330, 1997.
38. Kü hn, K., and Eble, J. The structural bases of integrinligand interactions. Trends Cell Biol 4, 256, 1994.
39. Mizushima, H., Takamura, H., Miyagi, Y., Kikkawa, Y., Yamanaka, N., Yasumitsu, H., et al. Identification of integrin-dependent and-independent cell adhesion domains in COOH-terminal globular region of laminin-5 alpha 3 chain. Cell Growth Differ 8, 979, 1997.
40. Miner, J.H., and Yurchenco, P.D. Laminin functions in tissue morphogenesis. Annu Rev Cell Dev Biol 20, 255, 2004.
41. Hinek, A. Biological roles of the non-integrin elastin/laminin receptor. Biol Chem 377, 471, 1996.
42. Kikkawa, Y., and Miner, J.H. Review: Lutheran/B-CAM: a laminin receptor on red blood cells and in various tissues. Connect Tissue Res 46, 193, 2005.
43. Simoneau, S., Häk, S., Leucht, C., Dormont, D., Deslys, J.-P., Weiss, S., et al. Different isoforms of the non-integrin laminin receptor are present in mouse brain and bind PrP. Biol Chem 384, 243, 2003.
44. Kantengwa, S., Baetens, D., Sadoul, K., Buck, C.A., Halban, P.A., and Rouiller, D.G. Identification and characterization of alpha 3 beta 1 integrin on primary and transformed rat islet cells. Exp Cell Res 237, 394, 1997.
45. Wang, R., Li, J., Lyte, K., Yashpal, N.K., Fellows, F., and Goodyer, C.G. Role for beta1 integrin and its associated alpha3, alpha5, and alpha6 subunits in development of the human fetal pancreas. Diabetes 54, 2080, 2005.
46. Jiang, F.X., Georges-Labouesse, E., and Harrison, L.C. Regulation of laminin 1-induced pancreatic beta-cell differentiation by alpha6 integrin and alpha-dystroglycan. Mol Med 7, 107, 2001.
47. Vainionpää , N., Kikkawa, Y., Lounatmaa, K., Miner, J.H., Rousselle, P., and Virtanen, I. Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells. Am J Physiol Cell Physiol 290, C764, 2006.
48. Kikkawa, Y., Moulson, C.L., Virtanen, I., and Miner, J.H. Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo. J Biol Chem 277, 44864, 2002.
49. Otonkoski, T., Banerjee, M., and Korsgren, O., Thornell L-E, and Virtanen, I. Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation. Diabetes Obes Metab 10 Suppl 4, 119, 2008.
50. Jackers, P., Minoletti, F., Belotti, D., Clausse, N., Sozzi, G., Sobel, M.E., et al. Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3. Oncogene 13, 495, 1996.
51. Mecham, R.P., and Heuser, J.E. The elastic fiber. In: Hay, E.D., ed. Cell Biology of Extracellular Matrix. New York: Plenum Press, 1991, p. 97.
52. Alberts, B., Johnson, A., Lewis, J., Raff, M., and Walter, K.R.P. Molecular Biology of the Cell, fifth edition. New York: Garland Science, Taylor & Francis Group, 2007.
53. Magnuson, V.L., Young, M., Schattenberg, D.G., Mancini, M.A., Chen, D.L., Steffensen, B., et al. The alternative splicing of fibronectin pre-mRNA is altered during aging and in response to growth factors. J Biol Chem 266, 14654, 1991.
54. de Pereda, J.M., Wiche, G., and Liddington, R.C. Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha6beta4. EMBO J 18, 4087, 1999.
55. Johansson, S., Svineng, G., Wennerberg, K., Armulik, A., and Lohikangas, L. Fibronectin-integrin interactions. Front Biosci 2, d126, 1997.
56. Belkin, A.M., and Smalheiser, N.R. Localization of cranin (dystroglycan) at sites of cell-matrix and cell-cell contact: recruitment to focal adhesions is dependent upon extracellular ligands. Cell Adhes Commun 4, 281, 1996.
57. Hall, H., Bozic, D., Michel, K., and Hubbell, J.A. N-terminal alpha-dystroglycan binds to different extracellular matrix molecules expressed in regenerating peripheral nerves in a protein-mediated manner and promotes neurite extension of PC12 cells. Mol Cell Neurosci 24, 1062, 2003.
58. Bernfield, M., and Sanderson, R.D. Syndecan, a developmentally regulated cell surface proteoglycan that binds extracellular matrix and growth factors. Philos Trans R Soc Lond B Biol Sci 327, 171, 1990.
59. Woods, A., Longley, R.L., Tumova, S., and Couchman, J.R. Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblasts. Arch Biochem Biophys 374, 66, 2000.
60. Geutskens, S.B., Homo-Delarche, F., Pleau, J.-M., Durant, S., Drexhage, H.A., and Savino, W. Extracellular matrix distribution and islet morphology in the early postnatal pancreas: anomalies in the non-obese diabetic mouse. Cell Tissue Res 318, 579, 2004.
61. Lee, B.-W., Jee, J.-H., Heo, J.-S., Choi, S.-H., Jang, K.-T., Noh, J.-H., et al. The favorable outcome of human islet transplantation in Korea: experiences of 10 autologous transplantations. Transplantation 79, 1568, 2005.
62. Mann, K., Deutzmann, R., and Timpl, R. Characterization of proteolytic fragments of the laminin-nidogen complex and their activity in ligand-binding assays. Eur J Biochem 178, 71, 1988.
63. Chakravarti, S., Tam, M.F., and Chung, A.E. The basement membrane glycoprotein entactin promotes cell attachment and binds calcium ions. J Biol Chem 265, 10597, 1990.
64. Dedhar, S., Jewell, K., Rojiani, M., and Gray, V. The receptor for the basement membrane glycoprotein entactin is the integrin alpha 3/beta 1. J Biol Chem 267, 18908, 1992.
65. Yi, X.Y., Wayner, E.A., Kim, Y., and Fish, A.J. Adhesion of cultured human kidney mesangial cells to native entactin: role of integrin receptors. Cell Adhes Commun 5, 237, 1998.
66. Irving-Rodgers, H.F., Ziolkowski, A.F., Parish, C.R., Sado, Y., Ninomiya, Y., Simeonovic, C.J., et al. Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis. Diabetologia 51, 1680, 2008.
67. Marano, R.P.C., and Vilaró , S. The role of fibronectin, laminin, vitronectin and their receptors on cellular adhesion in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 35, 2791, 1994.
68. Blasi, F. uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways? Immunol Today 18, 415, 1997.
69. Felding-Habermann, B., and Cheresh, D.A. Vitronectin and its receptors. Curr Opin Cell Biol 5, 864, 1993.
70. Høga sen, K., Mollnes, T.E., and Harboe, M. Heparinbinding properties of vitronectin are linked to complex formation as illustrated by in vitro polymerization and binding to the terminal complement complex. J Biol Chem 267, 23076, 1992.
71. Smith, J.W., and Cheresh, D.A. Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor. J Biol Chem 265, 2168, 1990.
72. Friedlander, M., Brooks, P.C., Shaffer, R.W., Kincaid, C.M., Varner, J.A., and Cheresh, D.A. Definition of two angiogenic pathways by distinct alpha v integrins. Science 270, 1500, 1995.
73. Griffith, L.G., and Swartz, M.A. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7, 211, 2006.
74. Watkins, D., Cooperstein, S.J., Dixit, P.K., and Lazarow, A. Insulin secretion from toadfish islet tissue stimulated by pyridine nucleotides. Science 162, 283, 1968.
75. Lin, X. Functions of heparan sulfate proteoglycans in cell signaling during development. Development 131, 6009, 2004.
76. Strigini, M. Mechanisms of morphogen movement. J Neurobiol 64, 324, 2005.
77. Costell, M., Carmona, R., Gustafsson, E., González-Iriarte, M., Fä ssler, R., and Muñ oz-Chápuli, R. Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res 91, 158, 2002.
78. Iozzo, R.V. Proteoglycans and neoplastic-mesenchymal cell interactions. Hum Pathol 15, 2, 1984.
79. Chuang, C.Y., Lord, M., Melrose, J., Rees, M.D., Knox, S.M., Freeman, C., et al. Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan. Biochemistry 49, 5524, 2010.
80. Knox, S., Fosang, A.J., Last, K., Melrose, J., and Whitelock, J. Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan. FEBS Lett 579, 5019, 2005.
81. Mongiat, M., Otto, J., Oldershaw, R., Ferrer, F., Sato, J.D., and Iozzo, R.V. Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. J Biol Chem 276, 10263, 2001.
82. Aviezer, D., Hecht, D., Safran, M., Eisinger, M., David, G., and Yayon, A. Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Cell 79, 1005, 1994.
83. Mongiat, M., Taylor, K., Otto, J., Aho, S., Uitto, J., Whitelock, J.M., et al. The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7. J Biol Chem 275, 7095, 2000.
84. Mongiat, M., Fu, J., Oldershaw, R., Greenhalgh, R., Gown, A.M., and Iozzo, R.V. Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. J Biol Chem 278, 17491, 2003.
85. Bengtsson, E., Mö rgelin, M., Sasaki, T., Timpl, R., Heinegard, D., and Aspberg, A. The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. J Biol Chem 277, 15061, 2002.
86. González-Iriarte, M., Carmona, R., Pérez-Pomares, J.M., Maćas, D., Costell, M., and Muñ oz-Chápuli, R. Development of the coronary arteries in a murine model of transposition of great arteries. J Mol Cell Cardiol 35, 795, 2003.
87. Vischer, P., Feitsma, K., Schö n, P., and Vö lker, W. Perlecan is responsible for thrombospondin 1 binding on the cell surface of cultured porcine endothelial cells. Eur J Cell Biol 73, 332, 1997.
88. Bix, G., Fu, J., Gonzalez, E.M., Macro, L., Barker, A., Campbell, S., et al. Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. J Cell Biol 166, 97, 2004.
89. Villar, M.J., and Hassell, J.R., Brandan, E. Interaction of skeletal muscle cells with collagen type IV is mediated by perlecan associated with the cell surface. J Cell Biochem 75, 665, 1999.
90. Ettner, N., Gö hring, W., Sasaki, T., Mann, K., and Timpl, R. The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan. FEBS Lett 430, 217, 1998.
91. Heremans, A., Cock, B.D., Cassiman, J.J., den Berghe, H.V., and David, G. The core protein of the matrix-associated heparan sulfate proteoglycan binds to fibronectin. J Biol Chem 265, 8716, 1990.
92. Whitelock, J.M., Graham, L.D., Melrose, J., Murdoch, A.D., Iozzo, R.V., and Underwood, P.A. Human perlecan immunopurified from different endothelial cell sources has different adhesive properties for vascular cells. Matrix Biol 18, 163, 1999.
93. Knox, S., Merry, C., Stringer, S., Melrose, J., and Whitelock, J. Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors. J Biol Chem 277, 14657, 2002.
94. Whitelock, J.M., Murdoch, A.D., Iozzo, R.V., and Underwood, P.A. The degradation of human endothelial cellderived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases. J Biol Chem 271, 10079, 1996.
95. Bix, G., and Iozzo, R.V. Novel interactions of perlecan: unraveling perlecan's role in angiogenesis. Microsc Res Tech 71, 339, 2008.
96. Parish, C.R., Freeman, C., and Hulett, M.D. Heparanase: a key enzyme involved in cell invasion. Biochim Biophys Acta 1471, M99, 2001.
97. Parish, C.R. The role of heparan sulphate in inflammation. Nat Rev Immunol 6, 633, 2006.
98. Pillarisetti, S. Lipoprotein modulation of subendothelial heparan sulfate proteoglycans (perlecan) and atherogenicity. Trends Cardiovasc Med 10, 60, 2000.
99. Wang, J., Yoshida, T., Nakaki, F., Hiai, H., Okazaki, T., and Honjo, T. Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes. Proc Natl Acad Sci USA 102, 11823, 2005.
100. Bernfield, M., Gö tte, M., Park, P.W., Reizes, O., Fitzgerald, M.L., Lincecum, J., et al. Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem 68, 729, 1999.
101. Antonio JDS, Karnovsky, M.J., Gay, S., Sanderson, R.D., and Lander, A.D. Interactions of syndecan-1 and heparin with human collagens. Glycobiology 4, 327, 1994.
102. Lee, D., Oh, E.S., Woods, A., Couchman, J.R., and Lee, W. Solution structure of a syndecan-4 cytoplasmic domain and its interaction with phosphatidylinositol 4,5-bisphosphate. J Biol Chem 273, 13022, 1998.
103. Tumova, S., Woods, A., and Couchman, J.R. Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences. J Biol Chem 275, 9410, 2000.
104. Salek-Ardakani, S., Arrand, J.R., Shaw, D., and Mackett, M. Heparin and heparan sulfate bind interleukin-10 and modulate its activity. Blood 96, 1879, 2000.
105. Hoogewerf, A.J., Kuschert, G.S., Proudfoot, A.E., Borlat, F., Clark-Lewis, I., Power, C.A., et al. Glycosaminoglycans mediate cell surface oligomerization of chemokines. Biochemistry 36, 13570, 1997.
106. Miller, S.J., Hoggat, A.M., and Faulk, W.P. Heparin regulates ICAM-1 expression in human endothelial cells: an example of non-cytokine-mediated endothelial activation. Thromb Haemost 80, 481, 1998.
107. Wrenshall, L.E., Stevens, R.B., Cerra, F.B., and Platt, J.L. Modulation of macrophage and B cell function by glycosaminoglycans. J Leukoc Biol 66, 391, 1999.
108. Luo, Y., and Shoichet, M.S. A photolabile hydrogel for guided three-dimensional cell growth and migration. Nat Mater 3, 249, 2004.
109. Gotte, M. Syndecans in inflammation. Faseb J 17, 575, 2003.
110. Olofsson, A.M., Vestberg, M., Herwald, H., Rygaard, J., David, G., Arfors, K.E., et al. Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis. J Clin Invest 104, 885, 1999.
111. Kato, M., Wang, H., Kainulainen, V., Fitzgerald, M.L., Ledbetter, S., Ornitz, D.M., et al. Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat Med 4, 691, 1998.
112. Corless, C.L., Mendoza, A., Collins, T., and Lawler, J. Colocalization of thrombospondin and syndecan during murine development. Dev Dyn 193, 346, 1992.
113. Takahashi, I., Noguchi, N., Nata, K., Yamada, S., Kaneiwa, T., Mizumoto, S., et al. Important role of heparan sulfate in postnatal islet growth and insulin secretion. Biochem Biophys Res Commun 383, 113, 2009.
114. Ogawa, T., Tsubota, Y., Hashimoto, J., Kariya, Y., and Miyazaki, K. The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain. Mol Biol Cell 18, 1621, 2007.
115. Vuoriluoto, K., Jokinen, J., Kallio, K., Salmivirta, M., Heino, J., and Ivaska, J. Syndecan-1 supports integrin alpha 2 beta 1-mediated adhesion to collagen. Exp Cell Res 314, 3369, 2008.
116. Hughes, S.J., Clark, A., McShane, P., Contractor, H.H., Gray, D.W.R., and Johnson, P.R.V. Characterisation of collagen VI within the islet-exocrine interface of the human pancreas: implications for clinical islet isolation? Transplantation 81, 423, 2006.
117. Fransson L-A, Belting, M., Cheng, F., Jö nsson, M., Mani, K., and Sandgren, S. Novel aspects of glypican glycobiology. Cell Mol Life Sci 61, 1016, 2004.
118. Filmus, J. Glypicans in growth control and cancer. Glycobiology 11, 19R, 2001.
119. Chiao, E., Fisher, P., Crisponi, L., Deiana, M., Dragatsis, I., Schlessinger, D., et al. Overgrowth of a mouse model of the Simpson-Golabi- Behmel syndrome is independent of IGF signaling. Dev Biol 243, 185, 2002.
120. Gonzalez, A.D., Kaya, M., Shi, W., Song, H., Testa, J.R., Penn, L.Z., et al. OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner. J Cell Biol 141, 1407, 1998.
121. Kleeff, J., Ishiwata, T., Kumbasar, A., Friess, H., Bü chler, M.W., Lander, A.D., et al. The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer. J Clin Invest 102, 1662, 1998.
122. Whipple, C.A., Lander, A.D., and Korc, M. Discovery of a novel molecule that regulates tumor growth and metastasis. ScientificWorldJournal 8, 1250, 2008.
123. Buchanan, C., Stigliano, I., Garay-Malpartida, H.M., Gomes, L.R., Puricelli, L., Sogayar, M.C., et al. Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways. Breast Cancer Res Treat 119, 559, 2010.
124. Wang, F.H., Yip, Y.C., Zhang, M., Vong, H.T., Chan, K.I., Wai, K.C., et al. Diagnostic utility of glypican-3 for hepatocellular carcinoma on liver needle biopsy. J Clin Pathol 63, 599, 2010.
125. Yuan, D.-H., Xie, H.-H., Wang, Y., Meng, C.-Y., Yang, L.-P., Feng, Y.-C., et al. Expression and significance of glypican-3 in colorectal cancer. Zhonghua Yi Xue Za Zhi 88, 1540, 2008.
126. Zertal-Zidani, S., Bounacer, A., and Scharfmann, R. Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans. Diabetologia 50, 585, 2007.
127. Ló pez-Casillas, F., Cheifetz, S., Doody, J., Andres, J.L., Lane, W.S., and Massagué, J. Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system. Cell 67, 785, 1991.
128. Andres, J.L., Rönnstrand, L., Cheifetz, S., and Massagué, J. Purification of the transforming growth factor-beta (TGFbeta) binding proteoglycan betaglycan. J Biol Chem 266, 23282, 1991.
129. Eickelberg, O., Centrella, M., Reiss, M., Kashgarian, M., and Wells, R.G. Betaglycan inhibits TGF-beta signaling by preventing type I-type II receptor complex formation. Glycosaminoglycan modifications alter betaglycan function. J Biol Chem 277, 823, 2002.
130. Juárez, P., Vilchis-Landeros, M.M., Ponce-Coria, J., Mendoza, V., Hernández-Pando, R., Bobadilla, N.A., et al. Soluble betaglycan reduces renal damage progression in db/db mice. Am J Physiol Renal Physiol 292, F321, 2007.
131. Velasco-Loyden, G., Arribas, J., and Ló pez-Casillas, F. The shedding of betaglycan is regulated by pervanadate and mediated by membrane type matrix metalloprotease-1. J Biol Chem 279, 7721, 2004.
132. Mythreye, K., and Blobe, G.C. The type III TGFbeta receptor regulates directional migration: new tricks for an old dog. Cell Cycle 8, 3069, 2009.
133. Venkatasubbarao, K., Ahmed, M.M., Mohiuddin, M., Swiderski, C., Lee, E., Gower, W.R., et al. Differential expression of transforming growth factor beta receptors in human pancreatic adenocarcinoma. Anticancer Res 20, 43, 2000.
134. Miralles, F., Czernichow, P., Ozaki, K., Itoh, N., and Scharfmann, R. Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci USA 96, 6267, 1999.
135. Sanvito, F., Herrera, P.L., Huarte, J., Nichols, A., Montesano, R., Orci, L., et al. TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro. Development 120, 3451, 1994.
136. Grewal, I.S., Grewal, K.D., Wong, F.S., Wang, H., Picarella, D.E., Janeway, C.A., et al. Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism. J Autoimmun 19, 9, 2002.
137. Bezakova, G., and Ruegg, M.A. New insights into the roles of agrin. Nat Rev Mol Cell Biol 4, 295, 2003.
138. Krö ger, S., and Schrö der, J.E. Agrin in the developing CNS: new roles for a synapse organizer. News Physiol Sci 17, 207, 2002.
139. Gu, W.L., Fu, S.L., Wang, Y.X., Li, Y., Lu, H.Z., Xu, X.M., et al. Chondroitin sulfate proteoglycans regulate the growth, differentiation and migration of multipotent neural precursor cells through the integrin signaling pathway. BMC Neurosci 10, 128, 2009.
140. McCarthy, K.J., and Couchman, J.R. Basement membrane chondroitin sulfate proteoglycans: localization in adult rat tissues. J Histochem Cytochem 38, 1479, 1990.
141. Naso, M.F., Zimmermann, D.R., and Iozzo, R.V. Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter. J Biol Chem 269, 32999, 1994.
142. Wu, Y.J., Pierre DPL, Wu, J., Yee, A.J., and Yang, B.B. The interaction of versican with its binding partners. Cell Res 15, 483, 2005.
143. Wu, Y., Chen, L., Zheng, P.-S., and Yang, B.B. Beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican. J Biol Chem 277, 12294, 2002.
144. Wu, Y., Wu, J., Lee, D.Y., Yee, A., Cao, L., Zhang, Y., et al. Versican protects cells from oxidative stress-induced apoptosis. Matrix Biol 24, 3, 2005.
145. Sakko, A.J., Ricciardelli, C.,Mayne, K., Suwiwat, S., LeBaron, R.G., Marshall, V.R., et al. Modulation of prostate cancer cell attachment to matrix by versican. Cancer Res 63, 4786, 2003.
146. Bode-Lesniewska, B., Dours-Zimmermann, M.T., Odermatt, B.F., Briner, J., Heitz, P.U., and Zimmermann, D.R. Distribution of the large aggregating proteoglycan versican in adult human tissues. J Histochem Cytochem 44, 303, 1996.
147. Skandalis, S.S., Kletsas, D., Kyriakopoulou, D., Stavropoulos, M., and Theocharis, D.A. The greatly increased amounts of accumulated versican and decorin with specific post-translational modifications may be closely associated with the malignant phenotype of pancreatic cancer. Biochim Biophys Acta 1760, 1217, 2006.
148. Mauri, P., Scarpa, A., Nascimbeni, A.C., Benazzi, L., Parmagnani, E., Mafficini, A., et al. Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers. FASEB J 19, 1125, 2005.
149. Green, R.A., Martens, P.J., Norden, R., and Poole-Warren, L.A. Stem Cell Engineering (Artmann, G., Hescheler, J., and Minger, S., eds.). Heidelberg, Germany: Springer, 2010.
150. Thivolet, C.H., Chatelain, P., Nicoloso, H., Durand, A., and Bertrand, J. Morphological and functional effects of extracellular matrix on pancreatic islet cell cultures. Exp Cell Res 159, 313, 1985.
151. Bornstein, P., and Sage, E.H. Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol 14, 608, 2002.
152. Green, R.A., Lovell, N.H., and Poole-Warren, L.A. Impact of co-incorporating laminin peptide dopants and neurotrophic growth factors on conducting polymer properties. Acta Biomater 6, 63, 2010.
153. Nilasaroya, A., Poole-Warren, L.A., Whitelock, J.M., and Martens, P.J. Structural and functional characterisation of poly(vinyl alcohol) and heparin hydrogels. Biomaterials 29, 4658, 2008.
154. Montesano, R., Mouron, P., Amherdt, M., and Orci, L. Collagen matrix promotes reorganization of pancreatic endocrine cell monolayers into islet-like organoids. J Cell Biol 97, 935, 1983.
155. Hulinsky, I., Harrington, J., Cooney, S., and Silink,M. Insulin secretion and DNA synthesis of cultured islets of Langerhans are influenced by the matrix. Pancreas 11, 309, 1995.
156. Kaiser, N., Corcos, A.P., Tur-Sinai, A., Ariav, Y., and Cerasi, E. Monolayer culture of adult rat pancreatic islets on extracellular matrix: long term maintenance of differentiated B-cell function. Endocrinology 123, 834, 1988.
157. Hayek, A., Lopez, A.D., and Beattie, G.M. Enhancement of pancreatic islet cell monolayer growth by endothelial cell matrix and insulin. In Vitro Cell Dev Biol 25, 146, 1989.
158. Nolan, A.L. In vitro culture of isolated islets of Langerhans: analysis of function. Methods Mol Biol 560, 65, 2009.
159. Swarm, R.L. Transplantion of murine chondrosarcoma in mice of idfferent inbred strains. J Natl Cancer Inst 31, 953, 1963.
160. Hughes, C.S., Postovit, L.M., and Lajoie, G.A. Matrigel: a complex protein mixture required for optimal growth of cell culture. Proteomics 10, 1886, 2010.
161. Vukicevic, S., Kleinman, H.K., Luyten, F.P., Roberts, A.B., Roche, N.S., and Reddi, A.H. Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Exp Cell Res 202, 1, 1992.
162. Perfetti, R., Henderson, T.E., Wang, Y., Montrose-Rafizadeh, C., and Egan, J.M. Insulin release and insulin mRNA levels in rat islets of Langerhans cultured on extracellular matrix. Pancreas 13, 47, 1996.
163. Nagata, N., Gu, Y., Hori, H., Balamurugan, A.N., Touma, M., Kawakami, Y., et al. Evaluation of insulin secretion of isolated rat islets cultured in extracellular matrix. Cell Transplant 10, 447, 2001.
164. Oberg-Welsh, C. Long-term culture in matrigel enhances the insulin secretion of fetal porcine islet-like cell clusters in vitro. Pancreas 22, 157, 2001.
165. Bonner-Weir, S., Taneja, M., Weir, G.C., Tatarkiewicz, K., Song, K.H., Sharma, A., et al. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 97, 7999, 2000.
166. Gao, R., Ustinov, J., Pulkkinen, M.-A., Lundin, K., Korsgren, O., and Otonkoski, T. Characterization of endocrine pro-genitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes 52, 2007, 2003.
167. Lechner, A., Nolan, A.L., Blacken, R.A., and Habener, J.F. Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. Biochem Biophys Res Commun 327, 581, 2005.
168. Salvay, D.M., Rives, C.B., Zhang, X., Chen, F., Kaufman, D.B., Lowe, W.L., et al. Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation. Transplantation 85, 1456, 2008.
169. Lucas-clerc C, Massart, C., Campion, J.P., Launois, B., and Nicol, M. Long-term culture of human pancreatic-islets in an extracellular-matrix- morphological and metabolic effects. Mol Cell Endocrinol 94, 9, 1993.
170. Daoud, J., Petropavlovskaia, M., Rosenberg, L., and Tabrizian, M. The effect of extracellular matrix components on the preservation of human islet function in vitro. Biomaterials 31, 1676, 2010.
171. Beattie, G.M., Montgomery, A.M.P., Lopez, A.D., Hao, E., Perez, B., Just, M.L., et al. A novel approach to increase human islet cell mass while preserving beta-cell function. Diabetes 51, 3435, 2002.
172. Kumar, C. Tissue, Cell and Organ Engineering. Weinheim, Germany: Wiley-VCH, 2006.
173. Martin, M.J., Muotri, A., Gage, F., and Varki, A. Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat Med 11, 228, 2005.
174. Weber, L.M., and Anseth, K.S. Hydrogel encapsulation environments functionalized with extracellular matrix interactions increase islet insulin secretion. Matrix Biol 27, 667, 2008.
175. Weber, L.M., Hayda, K.N., and Anseth, K.S. Cell-matrix interactions improve beta-cell survival and insulin secretion in three-dimensional culture. Tissue Eng Part A 14, 1959, 2008.
176. Pierschbacher, M.D., and Rouslahti, E. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309, 30, 1984.
177. Horton, M.A. Arg-gly-Asp (RGD) peptides and peptidomimetics as therapeutics: relevance for renal diseases. Exp Nephrol 7, 178, 1999.
178. Shin, H., Jo, S., and Mikos, A.G. Biomimetic materials for tissue engineering. Biomaterials 24, 4353, 2003.
179. Weber, L.M., Hayda, K.N., Haskins, K., and Anseth, K.S. The effects of cell-matrix interactions on encapsulated betacell function within hydrogels functionalized with matrixderived adhesive peptides. Biomaterials 28, 3004, 2007.
180. Uygun, B.E., Stojsih, S.E., and Matthew, H.W.T. Effects of immobilized glycosaminoglycans on the proliferation and differentiation of mesenchymal stem cells. Tissue Eng Part A 15, 3499, 2009.
181. Sakiyama-Elbert, S.E., and Hubbell, J.A. Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix. J Control Release 69, 149, 2000.
182. Taylor, S.J., McDonald, J.W., and Sakiyama-Elbert, S.E. Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury. J Control Release 98, 281, 2004.
183. Murugesan, S., Xie, J., and Linhardt, R.J. Immobilization of heparin: approaches and applications. Curr Top Med Chem 8, 80, 2008.
184. Ferdous, Z., and Grande-Allen, K.J. Utility and control of proteoglycans in tissue engineering. Tissue Eng 13, 1893, 2007.
185. Steffens, G.C.M., Yao, C., Prével, P., Markowicz, M., Schenck, P., Noah, E.M., et al. Modulation of angiogenic potential of collagen matrices by covalent incorporation of heparin and loading with vascular endothelial growth factor. Tissue Eng 10, 1502, 2004.
186. Javazon, E.H., Colter, D.C., Schwarz, E.J., and Prockop, D.J. Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells. Stem Cells 19, 219, 2001.
187. Buruzula, G.K., Matthew, H.W.T., and Eliason, J.F. Differentiation of CD34 + cord blood cells in glycosaminoglycan microcapsules. In: Proceedings of the IEEE 30th Annual Northeast, 2004, p. 114.
188. Cho, C.H., Eliason, J.F., and Matthew, H.W.T. Application of porous glycosaminoglycan-based scaffolds for expansion of human cord blood stem cells in perfusion culture. J Biomed Mater Res A 86, 98, 2008.
189. Madihally, S.V., Flake, A.W., and Matthew, H.W. Maintenance of CD34 expression during proliferation of CD34 + cord blood cells on glycosaminoglycan surfaces. Stem Cells 17, 295, 1999.
190. Stendahl, J.C., Wang, L.-J., Chow, L.W., Kaufman, D.B., and Stupp, S.I. Growth factor delivery from self-assembling nanofibers to facilitate islet transplantation. Transplantation 86, 478, 2008.
191. Cabric, S., Sanchez, J., Johansson, U., Larsson, R., Nilsson, B., Korsgren, O., et al. Anchoring of vascular endothelial growth factor to surface-immobilized heparin on pancreatic islets: implications for stimulating islet angiogenesis. Tissue Eng Part A 16, 961, 2010.
192. Velten, F., Laue, C., and Schrezenmeir, J. The effect of alginate and hyaluronate on the viability and function of immunoisolated neonatal rat islets. Biomaterials 20, 2161, 1999.
193. Kim, S., Kim, S.W., and Bae, Y.H. Synthesis, bioactivity and specificity of glucagon-like peptide-1 (7-37)/polymer conjugate to isolated rat islets. Biomaterials 26, 3597, 2005.
194. Lin, C.-C., and Anseth, K.S. Glucagon-like peptide-1 functionalized PEG hydrogels promote survival and function of encapsulated pancreatic beta-cells. Biomacromolecules 10, 2460, 2009.
195. Linn, T., Schneider, K., Hammes, H.P., Preissner, K.T., Brandhorst, H., Morgenstern, E., et al. Angiogenic capacity of endothelial cells in islets of Langerhans. FASEB J 17, 881, 2003.
196. Sigrist, S., Mechine-Neuville, A., Mandes, K., Calenda, V., Braun, S., Legeay, G., et al. Influence of VEGF on the viability of encapsulated pancreatic rat islets after transplantation in diabetic mice. Cell Transplant 12, 627, 2003.