Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis

Journal of Clinical Investigation

Volumn 104, Issue 7, 1999, Pages 885-894

  Olofsson, A Maria ^a   Vestberg, Mikael ^a   Herwald, Heiko ^a   Rygaard, Jørgen ^b   David, Guido ^c   Arfors, Karl E ^d   Linde, Viggo ^e   Flodgaard, Hans ^e   Dedio, Jürgen ^f   Müller Esterl, Werner ^f   Lundgren Åkerlund, Evy ^a  

^a LUND UNIVERSITY   (Sweden)

^b Department of Rheumatology and the Osteoporosis Research Centre   (Denmark)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d Experimental Medicine Inc   (United States)

^e NOVO NORDISK A S   (Denmark)

^f JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GLYPICAN; HEPARIN BINDING PROTEIN; ISOPROTEIN; SYNDECAN;

APOPTOSIS; ARTICLE; CELL PROTECTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRION; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

EID: 0032696674     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI6671     Document Type: Article

References (49)

1. McIntyre, T.M., Modur, V., Prescott, S.M., and Zimmerman, G.A. 1997. Molecular mechanisms of early inflammation. Thromb. Haemost. 78:302-305.
2. Thelen, M., Dewald, B., and Baggiolini, M. 1993. Neutrophil signal transduction and activation of the respiratory burst. Physiol. Rev. 73:797-821.
3. Carlos, T.M., and Harlan, J.M. 1994. Leukocyte-endothelial adhesion molecules. Blood. 84:2068-2101.
4. Borregaard, N., et al. 1993. Human neutrophil granules and secretory vesicles. Eur. J. Haematol. 51:187-198.
5. Pereira, H.A. 1995. CAP37, a neurrophil-derived multifunctional inflammatory mediator. J. Leukoc. Biol. 57:805-812.
6. Gabay, J.E., et al. 1989. Antibiotic proteins of human polymorphonuclear leukocytes. Proc. Natl. Acad. Sci. USA. 86:5610-5614.
7. Pereira, H.A., Erdem, I., Pohl, J., and Spitznagel, J.K. 1993. Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes. Proc. Natl. Acad. Sci. USA. 90:4733-4737.
8. Mercer-Jones, M.A., Peyton, J., Cook, M., Flodgaard, H., and Cheadle, W.G. 1996. Monocyte recruitment increase survival in fecal peritonitis. Surg. Forum. 37:105-108.
9. Pereira, H.A., Shafer, W.M., Pohl, J., Martin, L.E., and Spitznagel, J.K. 1990. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. J. Clin. Invest. 85:1468-1476.
10. Rasmussen, P.B., et al. 1996. Characterization of recombinant human HBP/CAP37/azurocidin, a pleiotropic mediator of inflammation-enhancing LPS-induced cytokine release from monocytes. FEBS Lett. 390:109-112.
11. Chertov, O., et al. 1996. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J. Biol. Chem. 271:2935-2940.
12. Ostergaard, E., and Flodgaard, H. 1992. A neutrophil-derived proteolytic inactive elastase homologue (hHBP) mediates reversible contraction of fibroblasts and endothelial cell monolayers and stimulates monocyte survival and thrombospondin secretion. J. Leukoc. Biol. 51:316-323.
13. Iversen, L.F., et al. 1997. Structure of HBP, a multifunctional protein with a serine proteinase fold. Nat. Struct. Biol. 4:265-268.
14. Almeida, R.P., Melchior, M., Campanelli, D., Nathan, C., and Gabay, J.E. 1991. Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases. Biochem. Biophys. Res. Commun. 177:688-695.
15. Flodgaard, H., et al. 1991. Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophil elastase homologues with strong monocyte and fibroblast chemotactic activities. Eur. J. Biochem. 197:535-547.
16. Morgan, J.G., et al. 1991. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. J. Immunol. 147:3210-3214.
17. Hofmann, K., Titus, G., Montibeller, J.A., and Finn, F.M. 1982. Avidin binding of carboxyl-substituted biotin and analogues. Biochemistry. 21:978-984.
18. Rinderknecht, H. 1962. Ultra-rapid fluorescent labelling of proteins. Nature. 93:167-168.
19. 125I-containing acylating agent. Biochem. J. 133:529-539.
20. Lindmark, A., Flodgaard, H., and Gullberg, U. 1999. Processing of the neutrophil granule serine protease homologue azurocidin. J. Leukoc. Biol. In press.
21. Dedio, J., and Müller-Esterl, W. 1996. Kininogen binding protein p33/gC1qR is localized in the vesicular fraction of endothelial cells. FEBS Lett. 399:255-258.
22. David, G., Bai, X.M., Van der Schueren, B., Cassiman, J.J., and Van den Berghe, H. 1992. Developmental changes in heparan sulfate expression: in situ detection with mAbs. J. Cell Biol. 119:961-975.
23. 1: visualization by immunofluorescent and immunogold labeling. Cell Regul. 2:1097-1113.
24. Hjorth, R., Jonsson, A.K., and Vretblad, P. 1981. A rapid method for purification of human granulocytes using percoll. A comparison with dextran sedimentation. J. Immunol. Methods. 43:95-101.
25. Jaffe, E.A., Nachman, R.L., Becker, C.G., and Minick, C.R. 1973. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52:2745-2756.
26. Thornton, S.C., Mueller, S.N., and Levine, E.M. 1983. Human endothelial cells: use of heparin in cloning and long-term serial cultivation. Science. 222:623-625.
27. Murphy-Ullrich, J.E., Westrick, L.G., Esko, J.D., and Mosher, D.F. 1988. Altered metabolism ofthrombospondin by Chinese hamster ovary cells defective in glycosaminoglycan synthesis. J. Biol. Chem. 263:6400-6406.
28. Rickwood, D., Wilson, M.T., and Darley-Usmar, V.M. 1987. Isolation and characteristics of intact mitochondria. In Mitochondria. V.M. Darley-Usmar, editor. IRL Press. Oxford, United Kingdom. 1-6.
29. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680-685.
30. Björnsson, S. 1993. Simultaneous preparation and quantitation of proteoglycans by precipitation with alcian blue. Anal. Biochem. 210:282-291.
31. Shively, J.E., and Conrad, H.E. 1976. Formation of anhydrosugars in the chemical depolymerization of heparin. Biochemistry. 15:3932-3942.
32. Björnsson, S. 1993. Size-dependent separation of proteoglycans by electrophoresis in gels of pure agarose. Anal. Biochem. 210:292-298.
33. Carlemalm, E., and Villiger, W. 1989. Low temperature embedding. In Techniques in immunocytochemistry. Volume 4. G.R. Bullock and P. Petrusz, editors. Academic Press. London, United Kingdom. 29-45.
34. Wiley, H.S., and Cunningham, D.D. 1982. The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis. J. Biol. Chem. 257:4222-4229.
35. Gorczyca, W., Gong, J., Ardelt, B., Traganos, F., and Darzynkiewicz, Z. 1993. The cell cycle-related differences in the susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res. 53:3186-3192.
36. Fuki, I.V., et al. 1997. The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro. J. Clin. Invest. 100:1611-1622.
37. Dedio, J., Jahnen-Dechent, W., Bachmann, M., and Müller-Esterl, W. 1998. The multiligand-binding protein gC1qR, putative C1q receptor, is a mitochondrial protein. J. Immunol. 160:3534-3542.
38. Santos, A., Zamtami, N., and Kroemer, G. 1998. Mitochondria as regulators of apoptosis: doubt no more. Biochim. Biophys. Acta. 1366:151-165.
39. Galzie, Z., Kinsella, A.R., and Smith, J.A. 1997. Fibroblast growth factors and their receptors. Biochem. Cell Biol. 75:669-685.
40. Derynck, R., and Feng, X.H. 1997. TGF-β receptor signaling. Biochim. Biophys. Acta. 1333:105-150.
41. Gleizes, P.E., Noaillac-Depeyre, J., Amalric, F., and Gas, N. 1995. Basic fibroblast growth factor (FGF-2) internalization through the heparan sulfate proteoglycans-mediated pathway: an ultrastructural approach. Eur. J. Cell Biol. 66:47-59.
42. Roghani, M., and Moscatelli, D. 1992. Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms. J. Biol. Chem. 267:22156-22162.
43. Muta, T., et al. 1997. p32 protein, a splicing factor 2-associated protein, is localized in mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation. J. Biol. Chem. 272:24363-24370.
44. Mukherjee, S., Ghosh, R.N., and Maxfield, F.R. 1997. Endocytosis. Physiol. Rev. 77:759-803.
45. Lord, J.M., and Roberts, L.M. 1998. Retrograde transport: going against the flow. Curr. Biol. 8:R56-R58.
46. 2+ responses. Science. 280:1763-1766.
47. Zamzami, N., Brenner, C., Marzod, I., Susin, S.A., and Kroemer, G. 1998. Subcellular and submitochondrial mode of action of the Bcl2-linked oncoproteins. Oncogens. 16:2265-2282.
48. Green, D.R., and Reed, J.C. 1998. Mitochondria and apoptosis. Science. 281:1309-1312.
49. Halestrap, A.P., Kerr, P.M., Javodov, S., and Woodfield, K.Y. 1998. Elucidating the molecular mechanism of the permeability transition pore and its role in the reperfusion injury in the heart. Biochim. Biophys. Acta. 1366:79-94.